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CHICK:NTH

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Species (Taxon ID) Gallus gallus (Chicken). (9031)
Gene Name(s) NTHL1 (ECO:0000255 with HAMAP-Rule:MF_03183)
Protein Name(s) Endonuclease III-like protein 1 (ECO:0000255 with HAMAP-Rule:MF_03183)

Bifunctional DNA N-glycoslyase/DNA-(apurinic or apyrimidinic site) lyase (ECO:0000255 with HAMAP-Rule:MF_03183) DNA glycoslyase/AP lyase (ECO:0000255 with HAMAP-Rule:MF_03183)

External Links
UniProt A7M7B9
EMBL AB284187
AB358957
AADN03006815
RefSeq NP_001073043.1
UniGene Gga.11851
Gga.50978
ProteinModelPortal A7M7B9
STRING 9031.ENSGALP00000008999
Ensembl ENSGALT00000009013
GeneID 416551
KEGG gga:416551
CTD 4913
eggNOG COG0177
GeneTree ENSGT00510000047513
HOVERGEN HBG052675
KO K10773
OMA WRNKVKY
OrthoDB EOG76MK8Z
TreeFam TF314967
Reactome REACT_237284
NextBio 20819992
Proteomes UP000000539
GO GO:0005739
GO:0005634
GO:0051539
GO:0019104
GO:0003906
GO:0003690
GO:0046872
GO:0006285
GO:0006296
Gene3D 1.10.1670.10
1.10.340.30
HAMAP MF_03183
InterPro IPR011257
IPR004036
IPR004035
IPR003651
IPR003265
IPR000445
IPR003583
IPR023170
IPR005759
Pfam PF00633
PF00730
PIRSF PIRSF001435
SMART SM00478
SM00525
SM00278
SUPFAM SSF48150
PROSITE PS00764
PS01155

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0006296

nucleotide-excision repair, DNA incision, 5'-to lesion

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1313275
PANTHER:PTN000040498
UniProtKB:P78549

P

Seeded From UniProt

complete

involved_in

GO:0006285

base-excision repair, AP site formation

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000040498
PomBase:SPAC30D11.07
SGD:S000000013
SGD:S000005403
UniProtKB:P78549

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1313275
PANTHER:PTN000040500
PomBase:SPAC30D11.07
SGD:S000000013
SGD:S000005403
UniProtKB:P78549

C

Seeded From UniProt

complete

enables

GO:0003906

DNA-(apurinic or apyrimidinic site) endonuclease activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1313275
PANTHER:PTN000040498
SGD:S000000013
SGD:S000005403
TAIR:locus:2061345
UniProtKB:P78549

F

Seeded From UniProt

complete

enables

GO:0000703

oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000040498
PomBase:SPAC30D11.07
SGD:S000000013
SGD:S000005403
WB:WBGene00011201

F

Seeded From UniProt

complete

enables

GO:0019104

DNA N-glycosylase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35980
ensembl:ENSMUSP00000047413

F

Seeded From UniProt

complete

involved_in

GO:0006296

nucleotide-excision repair, DNA incision, 5'-to lesion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35980
ensembl:ENSMUSP00000047413

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35980
ensembl:ENSMUSP00000047413

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35980
ensembl:ENSMUSP00000047413

C

Seeded From UniProt

complete

enables

GO:0003906

DNA-(apurinic or apyrimidinic site) endonuclease activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35980
ensembl:ENSMUSP00000047413

F

Seeded From UniProt

complete

enables

GO:0140078

class I DNA-(apurinic or apyrimidinic site) endonuclease activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P78549
ensembl:ENSP00000219066

F

Seeded From UniProt

complete

enables

GO:0019104

DNA N-glycosylase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P78549
ensembl:ENSP00000219066

F

Seeded From UniProt

complete

involved_in

GO:0006296

nucleotide-excision repair, DNA incision, 5'-to lesion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P78549
ensembl:ENSP00000219066

P

Seeded From UniProt

complete

involved_in

GO:0006285

base-excision repair, AP site formation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P78549
ensembl:ENSP00000219066

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P78549
ensembl:ENSP00000219066

C

Seeded From UniProt

complete

enables

GO:0003906

DNA-(apurinic or apyrimidinic site) endonuclease activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P78549
ensembl:ENSP00000219066

F

Seeded From UniProt

complete

enables

GO:0003690

double-stranded DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P78549
ensembl:ENSP00000219066

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000445

F

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011257

F

Seeded From UniProt

complete

enables

GO:0003906

DNA-(apurinic or apyrimidinic site) endonuclease activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030841

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030841

C

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011257
InterPro:IPR030841

P

Seeded From UniProt

complete

involved_in

GO:0006284

base-excision repair

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003265

P

Seeded From UniProt

complete

involved_in

GO:0006285

base-excision repair, AP site formation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030841

P

Seeded From UniProt

complete

enables

GO:0019104

DNA N-glycosylase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030841

F

Seeded From UniProt

complete

enables

GO:0140078

class I DNA-(apurinic or apyrimidinic site) endonuclease activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:4.2.99.18

F

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000166053

C

Seeded From UniProt

complete

enables

GO:0000703

oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000166053

F

Seeded From UniProt

complete

enables

GO:0003906

DNA-(apurinic or apyrimidinic site) endonuclease activity

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000166053

F

Seeded From UniProt

complete

enables

GO:0051539

4 iron, 4 sulfur cluster binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000166053

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000166053

C

Seeded From UniProt

complete

involved_in

GO:0006285

base-excision repair, AP site formation

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000166053

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000166053

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496
UniProtKB-SubCell:SL-0173

C

Seeded From UniProt

complete

enables

GO:0016829

lyase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0456

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0051539

4 iron, 4 sulfur cluster binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0004

F

Seeded From UniProt

complete

enables

GO:0016798

hydrolase activity, acting on glycosyl bonds

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0326

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0227

P

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0234

P

Seeded From UniProt

complete

involved_in

GO:0008152

metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0326

P

Seeded From UniProt

complete

enables

GO:0051536

iron-sulfur cluster binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0411

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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