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HUMAN:NTH

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) NTHL1 (ECO:0000255 with HAMAP-Rule:MF_03183) (synonyms: NTH1, OCTS3)
Protein Name(s) Endonuclease III-like protein 1 (ECO:0000255 with HAMAP-Rule:MF_03183)

hNTH1 Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase (ECO:0000255 with HAMAP-Rule:MF_03183) DNA glycosylase/AP lyase (ECO:0000255 with HAMAP-Rule:MF_03183)

External Links
UniProt P78549
EMBL U79718
AB014460
AF498098
AC005600
AB001575
U81285
BC003014
BC000391
Y09687
CCDS CCDS10457.1
RefSeq NP_001305122.1
NP_001305123.1
NP_002519.1
UniGene Hs.66196
ProteinModelPortal P78549
SMR P78549
BioGrid 110968
IntAct P78549
STRING 9606.ENSP00000219066
iPTMnet P78549
PhosphoSitePlus P78549
BioMuta NTHL1
DMDM 29840795
EPD P78549
MaxQB P78549
PaxDb P78549
PeptideAtlas P78549
PRIDE P78549
Ensembl ENST00000219066
GeneID 4913
KEGG hsa:4913
UCSC uc002col.1
CTD 4913
DisGeNET 4913
EuPathDB HostDB:ENSG00000065057.7
GeneCards NTHL1
HGNC HGNC:8028
HPA CAB025152
MalaCards NTHL1
MIM 602656
616415
neXtProt NX_P78549
OpenTargets ENSG00000065057
PharmGKB PA31811
eggNOG KOG1921
COG0177
GeneTree ENSGT00510000047513
HOGENOM HOG000252209
HOVERGEN HBG052675
InParanoid P78549
KO K10773
OMA WQQFTHL
OrthoDB EOG091G0IVB
PhylomeDB P78549
TreeFam TF314967
BRENDA 4.2.99.18
Reactome R-HSA-110328
R-HSA-110329
R-HSA-110357
SABIO-RK P78549
GeneWiki NTHL1
GenomeRNAi 4913
PRO PR:P78549
Proteomes UP000005640
Bgee ENSG00000065057
CleanEx HS_NTHL1
ExpressionAtlas P78549
Genevisible P78549
GO GO:0005739
GO:0005654
GO:0005634
GO:0051539
GO:0140078
GO:0140080
GO:0019104
GO:0003906
GO:0003690
GO:0004519
GO:0046872
GO:0008534
GO:0000703
GO:0006285
GO:0045008
GO:0006296
CDD cd00056
Gene3D 1.10.1670.10
HAMAP MF_03183
InterPro IPR011257
IPR004036
IPR003651
IPR003265
IPR000445
IPR023170
IPR030841
Pfam PF00633
PF00730
SMART SM00478
SM00525
SUPFAM SSF48150
PROSITE PS01155

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0000790

nuclear chromatin

PMID:29522130[1]

ECO:0000314

C

Figure 2B explains that NTHL1 is primarily localized in the nucleus. To prove this, they treated cells that over expressed NTHL1-GFP and then treated it with cytoskeletal (CSK) buffer for extraction. NTHL1-GFP ended up surviving the extraction while just GFP alone did not, proving that NTHL1-GFP is localized in the nucleus.

complete
CACAO 13271

enables

GO:0019104

DNA N-glycosylase activity

PMID:10882850[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006296

nucleotide-excision repair, DNA incision, 5'-to lesion

PMID:8990169[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006285

base-excision repair, AP site formation

PMID:15358233[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:12531031[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003906

DNA-(apurinic or apyrimidinic site) endonuclease activity

PMID:8990169[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003690

double-stranded DNA binding

PMID:15358233[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006296

nucleotide-excision repair, DNA incision, 5'-to lesion

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1313275
PANTHER:PTN000040498
UniProtKB:P78549

P

Seeded From UniProt

complete

involved_in

GO:0006285

base-excision repair, AP site formation

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000040498
PomBase:SPAC30D11.07
SGD:S000000013
SGD:S000005403
UniProtKB:P78549

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1313275
PANTHER:PTN000040500
PomBase:SPAC30D11.07
SGD:S000000013
SGD:S000005403
UniProtKB:P78549

C

Seeded From UniProt

complete

enables

GO:0003906

DNA-(apurinic or apyrimidinic site) endonuclease activity

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1313275
PANTHER:PTN000040498
SGD:S000000013
SGD:S000005403
TAIR:locus:2061345
UniProtKB:P78549

F

Seeded From UniProt

complete

enables

GO:0000703

oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000040498
PomBase:SPAC30D11.07
SGD:S000000013
SGD:S000005403
WB:WBGene00011201

F

Seeded From UniProt

complete

enables

GO:0140078

class I DNA-(apurinic or apyrimidinic site) endonuclease activity

PMID:8990169[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0019104

DNA N-glycosylase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35980
ensembl:ENSMUSP00000047413

F

Seeded From UniProt

complete

involved_in

GO:0006296

nucleotide-excision repair, DNA incision, 5'-to lesion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35980
ensembl:ENSMUSP00000047413

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35980
ensembl:ENSMUSP00000047413

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35980
ensembl:ENSMUSP00000047413

C

Seeded From UniProt

complete

enables

GO:0003906

DNA-(apurinic or apyrimidinic site) endonuclease activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35980
ensembl:ENSMUSP00000047413

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000445

F

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011257

F

Seeded From UniProt

complete

enables

GO:0003906

DNA-(apurinic or apyrimidinic site) endonuclease activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030841

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030841

C

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011257
InterPro:IPR030841

P

Seeded From UniProt

complete

involved_in

GO:0006284

base-excision repair

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003265

P

Seeded From UniProt

complete

involved_in

GO:0006285

base-excision repair, AP site formation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030841

P

Seeded From UniProt

complete

enables

GO:0019104

DNA N-glycosylase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030841

F

Seeded From UniProt

complete

enables

GO:0051539

4 iron, 4 sulfur cluster binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003651

F

Seeded From UniProt

complete

enables

GO:0140078

class I DNA-(apurinic or apyrimidinic site) endonuclease activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:4.2.99.18

F

Seeded From UniProt

complete

enables

GO:0000703

oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000166053

F

Seeded From UniProt

complete

enables

GO:0051539

4 iron, 4 sulfur cluster binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000166053

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000166053

F

Seeded From UniProt

complete

involved_in

GO:0006285

base-excision repair, AP site formation

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000166053

P

Seeded From UniProt

complete

enables

GO:0003906

DNA-(apurinic or apyrimidinic site) endonuclease activity

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000166053

F

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000166053

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000166053

C

Seeded From UniProt

complete

enables

GO:0004519

endonuclease activity

PMID:9831664[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0045008

depyrimidination

Reactome:R-HSA-110329
Reactome:R-HSA-110328

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

enables

GO:0008534

oxidized purine nucleobase lesion DNA N-glycosylase activity

Reactome:R-HSA-110229

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-110352
Reactome:R-HSA-110229
Reactome:R-HSA-110227
Reactome:R-HSA-110226
Reactome:R-HSA-110224
Reactome:R-HSA-110213
Reactome:R-HSA-110212
Reactome:R-HSA-110211
Reactome:R-HSA-110208

ECO:0000304

author statement supported by traceable reference used in manual assertion









C

Seeded From UniProt

complete

enables

GO:0000703

oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity

Reactome:R-HSA-110227
Reactome:R-HSA-110226
Reactome:R-HSA-110224

ECO:0000304

author statement supported by traceable reference used in manual assertion



F

Seeded From UniProt

complete

enables

GO:0016798

hydrolase activity, acting on glycosyl bonds

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0326

F

Seeded From UniProt

complete

enables

GO:0051539

4 iron, 4 sulfur cluster binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0004

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496
UniProtKB-SubCell:SL-0173

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0227

P

Seeded From UniProt

complete

enables

GO:0016829

lyase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0456

F

Seeded From UniProt

complete

involved_in

GO:0008152

metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0326

P

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0234

P

Seeded From UniProt

complete

enables

GO:0051536

iron-sulfur cluster binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0411

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Limpose, KL et al. (2018) Overexpression of the base excision repair NTHL1 glycosylase causes genomic instability and early cellular hallmarks of cancer. Nucleic Acids Res. PubMed GONUTS page
  2. ↑ Luna, L et al. (2000) Cell-cycle regulation, intracellular sorting and induced overexpression of the human NTH1 DNA glycosylase involved in removal of formamidopyrimidine residues from DNA. Mutat. Res. 460 95-104 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Aspinwall, R et al. (1997) Cloning and characterization of a functional human homolog of Escherichia coli endonuclease III. Proc. Natl. Acad. Sci. U.S.A. 94 109-14 PubMed GONUTS page
  4. ↑ 4.0 4.1 Oyama, M et al. (2004) Human NTH1 physically interacts with p53 and proliferating cell nuclear antigen. Biochem. Biophys. Res. Commun. 321 183-91 PubMed GONUTS page
  5. ↑ Ikeda, S et al. (2002) Differential intracellular localization of the human and mouse endonuclease III homologs and analysis of the sorting signals. DNA Repair (Amst.) 1 847-54 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 6.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  7. ↑ Imai, K et al. (1998) Genomic structure and sequence of a human homologue (NTHL1/NTH1) of Escherichia coli endonuclease III with those of the adjacent parts of TSC2 and SLC9A3R2 genes. Gene 222 287-95 PubMed GONUTS page
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