Category:GO:0008534 ! oxidized purine nucleobase lesion DNA N-glycosylase activity

name: oxidized purine nucleobase lesion DNA N-glycosylase activity
namespace: molecular_function
alt_id: GO:0003907
def: "Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site." [GOC:elh, PMID:11554296]
comment: Consider also annotating to the molecular function term 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906'.
synonym: "2,6-diamino-4-hydroxy-5(N-methyl)formamidopyrimidine-DNA glycosylase activity" RELATED [EC:3.2.2.23]
synonym: "2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase activity" RELATED [EC:3.2.2.23]
synonym: "8-oxoguanine DNA glycosylase activity" BROAD []
synonym: "bifunctional DNA glycosylase activity" BROAD []
synonym: "deoxyribonucleate glycosidase activity" RELATED [EC:3.2.2.23]
synonym: "DNA glycohydrolase [2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimide releasing]" RELATED [EC:3.2.2.23]
synonym: "DNA glycosylase/AP-lyase activity" BROAD []
synonym: "DNA glycosylase/beta-lyase activity" BROAD []
synonym: "DNA-formamidopyrimidine glycosylase activity" RELATED []
synonym: "Fapy-DNA glycosylase activity" RELATED [EC:3.2.2.23]
synonym: "formamidopyrimidine-DNA glycosylase activity" RELATED []
synonym: "Fpg protein" RELATED [EC:3.2.2.23]
synonym: "oxidized purine base lesion DNA N-glycosylase activity" EXACT []
synonym: "purine-specific oxidized base lesion DNA N-glycosylase activity" RELATED []
xref: EC:3.2.2.23
xref: MetaCyc:3.2.2.23-RXN
is_a: GO:0000702 ! oxidized base lesion DNA N-glycosylase activity

AmiGO <GOterm>GO:0008534</GOterm>
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