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YEAST:OGG1

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Species (Taxon ID) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s) OGG1
Protein Name(s) N-glycosylase/DNA lyase

8-oxoguanine DNA glycosylase DNA-(apurinic or apyrimidinic site) lyase AP lyase

External Links
UniProt P53397
EMBL U44855
Z46729
BK006946
PIR S49801
RefSeq NP_013651.1
ProteinModelPortal P53397
SMR P53397
BioGrid 35106
DIP DIP-4538N
MINT MINT-566071
STRING 4932.YML060W
MaxQB P53397
PaxDb P53397
EnsemblFungi [example_ID YML060W]
GeneID 854942
KEGG sce:YML060W
CYGD YML060w
SGD S000004525
eggNOG COG0122
GeneTree ENSGT00640000091554
HOGENOM HOG000180756
InParanoid P53397
KO K03660
OMA ISFMCAQ
OrthoDB EOG7TQV9T
BioCyc YEAST:G3O-32655-MONOMER
Reactome REACT_238104
REACT_261240
NextBio 977995
PRO PR:P53397
Proteomes UP000002311
Genevestigator P53397
GO GO:0031518
GO:0005739
GO:0005634
GO:0003684
GO:0008534
GO:0006285
GO:0000737
GO:0006281
GO:0070987
GO:0006289
GO:0007004
Gene3D 1.10.1670.10
1.10.340.30
InterPro IPR011257
IPR003265
IPR023170
IPR004577
IPR012904
Pfam PF00730
PF07934
SMART SM00478
SUPFAM SSF48150
TIGRFAMs TIGR00588

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0070987

error-free translesion synthesis

PMID:19264809[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P15873

P

Seeded From UniProt

complete

part_of

GO:0031518

CBF3 complex

PMID:19882662[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0008534

oxidized purine nucleobase lesion DNA N-glycosylase activity

PMID:8643552[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0007004

telomere maintenance via telomerase

PMID:19942858[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006285

base-excision repair, AP site formation

PMID:8643552[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

PMID:11239005[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:11239005[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:11239005[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0034039

8-oxo-7,8-dihydroguanine DNA N-glycosylase activity

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1097693
PANTHER:PTN000028426

F

Seeded From UniProt

complete

involved_in

GO:0006285

base-excision repair, AP site formation

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000028426
SGD:S000004525

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1097693
PANTHER:PTN000028426
RGD:621168
SGD:S000004525
UniProtKB:O15527

C

Seeded From UniProt

complete

enables

GO:0003684

damaged DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR012904

F

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011257

F

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011257

P

Seeded From UniProt

complete

involved_in

GO:0006284

base-excision repair

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003265
InterPro:IPR004577

P

Seeded From UniProt

complete

involved_in

GO:0006289

nucleotide-excision repair

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR012904

P

Seeded From UniProt

complete

enables

GO:0008534

oxidized purine nucleobase lesion DNA N-glycosylase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004577
InterPro:IPR012904

F

Seeded From UniProt

complete

enables

GO:0034039

8-oxo-7,8-dihydroguanine DNA N-glycosylase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004577

F

Seeded From UniProt

complete

enables

GO:0140078

class I DNA-(apurinic or apyrimidinic site) endonuclease activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:4.2.99.18

F

Seeded From UniProt

complete

involved_in

GO:0008152

metabolic process

GO_REF:0000037
GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0326
UniProtKB-KW:KW-0511

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0234

P

Seeded From UniProt

complete

enables

GO:0016829

lyase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0456

F

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0227

P

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0511

F

Seeded From UniProt

complete

enables

GO:0016798

hydrolase activity, acting on glycosyl bonds

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0326

F

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ van der Kemp, PA et al. (2009) PCNA monoubiquitylation and DNA polymerase eta ubiquitin-binding domain are required to prevent 8-oxoguanine-induced mutagenesis in Saccharomyces cerevisiae. Nucleic Acids Res. 37 2549-59 PubMed GONUTS page
  2. ↑ Kato, M et al. (2010) Remodeling of the SCF complex-mediated ubiquitination system by compositional alteration of incorporated F-box proteins. Proteomics 10 115-23 PubMed GONUTS page
  3. ↑ 3.0 3.1 van der Kemp, PA et al. (1996) Cloning and expression in Escherichia coli of the OGG1 gene of Saccharomyces cerevisiae, which codes for a DNA glycosylase that excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine. Proc. Natl. Acad. Sci. U.S.A. 93 5197-202 PubMed GONUTS page
  4. ↑ Lu, J & Liu, Y (2010) Deletion of Ogg1 DNA glycosylase results in telomere base damage and length alteration in yeast. EMBO J. 29 398-409 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 Singh, KK et al. (2001) Inactivation of Saccharomyces cerevisiae OGG1 DNA repair gene leads to an increased frequency of mitochondrial mutants. Nucleic Acids Res. 29 1381-8 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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