User:Surge Pres

My Annotations

Status	Page	Date/Time	GO Term (Aspect)	Reference	Evidence	Notes	Links
updatedbyinstructor	?	2013-02-20 13:18:16 CST	GO:0030177 positive regulation of Wnt receptor signaling pathway (As shown in the paper they are attempting to demonstrate the NEED for Porcn in the Wnt conical activity and gastrulation and germ layer establishment(Porcn required for the correct processing-acetylation- of Wnt ligands in the ER and for their extracellular distribution and gradient function) as required for the secretion of Wnt3a (isoforms of Porcn seem to be sufficient to obtain functional Wnt3a). Canonical Wnt activity assay as portrayed in Figure 2F Porcn function is dispensable in Wnt3a signal receiving cells and only required in Wnt3a secreting cells, supporting the role of Porcn in Wnt processing and secretion.)	PMID:21554866	IMP: Inferred from Mutant Phenotype		challenge

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Annotations challenged by Surge Pres

Status	Author,Group	Page	GO Term (Aspect)	Reference	Evidence	Links	Page history
requireschanges	Acapello, Team Blot Blot Western Baby	PSEPK:TOLB	GO:0009279 - cell outer membrane (C)	PMID:10940016	ECO:0000315 mutant phenotype evidence used in manual assertion	challenge	C: 6
updatedbyinstructor	Acapello, Team Blot Blot Western Baby	HPV18:VE6	GO:0045892 - negative regulation of DNA-templated transcription (P)	PMID:21849431	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 4
requireschanges	Acapello, Team Blot Blot Western Baby	NVN68:VP2	GO:0043489 - RNA stabilization (P)	PMID:14557646	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 2
updatedbyinstructor	Alemus, Team Blot Blot Western Baby	HPV16:VE2	GO:0044163 - host cytoskeleton (C)	PMID:15020762	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 2
updatedbyinstructor	Alemus, Team Blot Blot Western Baby	9HEPC:Q8V7L6	GO:0052040 - symbiont-mediated perturbation of host programmed cell death (P)	PMID:19951438	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 1
updatedbyinstructor	Alemus, Team Blot Blot Western Baby	HPV11:D7GMV3	GO:0044163 - host cytoskeleton (C)	PMID:15020762	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 4 fixed by Surge Pres
updatedbyinstructor	Nfarmer91, Team Bonfire	CAEEL:TMC1	GO:0005272 - sodium channel activity (F)	PMID:23364694	ECO:0000315 mutant phenotype evidence used in manual assertion	challenge	C: 1

1 annotations fixed by Surge Pres

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