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PMID:19951438
| Citation |
Berg, CP, Schlosser, SF, Neukirchen, DK, Papadakis, C, Gregor, M, Wesselborg, S and Stein, GM (2009) Hepatitis C virus core protein induces apoptosis-like caspase independent cell death. Virol. J. 6:213 |
|---|---|
| Abstract |
Hepatitis C virus (HCV) associated liver diseases may be related to apoptotic processes. Thus, we investigated the role of different HCV proteins in apoptosis induction as well as their potency to interact with different apoptosis inducing agents. |
| Links |
PubMed PMC3224943 Online version:10.1186/1743-422X-6-213 |
| Keywords |
Apoptosis; Caspases/metabolism; Cell Line, Tumor; Cell Nucleus/genetics; Diploidy; Enzyme Activation; Hepacivirus/genetics; Hepacivirus/metabolism; Humans; Mitochondria/metabolism; Receptors, Death Domain/metabolism; Viral Core Proteins/genetics; Viral Core Proteins/metabolism |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0052040: modulation by symbiont of host programmed cell death |
ECO:0000314: |
P |
Figure 5. Shows that zVAD inhibits all other proteins that use caspase to induce apoptosis in hepatic cells, but it only partially inhibits the core protein, meaning that the core protein induces apoptosis independently from caspase. |
complete | ||||
|
involved_in |
GO:0052040: modulation by symbiont of host programmed cell death |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
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