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CAEEL:TMC1
Contents
| Species (Taxon ID) | Caenorhabditis elegans. (6239) | |
| Gene Name(s) | tmc-1 | |
| Protein Name(s) | Transmembrane channel-like protein 1 | |
| External Links | ||
| UniProt | D3KZG3 | |
| EMBL | FO080889 FO080360 | |
| RefSeq | NP_508221.3 | |
| UniGene | Cel.364 | |
| ProteinModelPortal | D3KZG3 | |
| STRING | 6239.T13G4.3 | |
| TCDB | 1.A.17.4.7 | |
| PaxDb | D3KZG3 | |
| PRIDE | D3KZG3 | |
| EnsemblMetazoa | [example_ID T13G4.3] | |
| GeneID | 188483 | |
| KEGG | cel:CELE_T13G4.3 | |
| CTD | 188483 | |
| WormBase | T13G4.3 | |
| eggNOG | ENOG410IF2J ENOG410XTGF | |
| GeneTree | ENSGT00760000119171 | |
| InParanoid | D3KZG3 | |
| OMA | CWDIETT | |
| OrthoDB | EOG7S4X54 | |
| PRO | PR:D3KZG3 | |
| Proteomes | UP000001940 | |
| GO | GO:0005887 GO:0043025 GO:0031513 GO:0005216 GO:0005272 GO:0050906 GO:0034220 GO:0007606 GO:0035725 | |
| InterPro | IPR012496 | |
| Pfam | PF07810 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0005272 |
sodium channel activity |
ECO:0000315 |
F |
Figure 4 shows sodium-sensitive cation currents in TMC-1 expressing cells indicating its role as a sodium channel. In supplementary figure 8 the authors also confirm TMC-1's localization to the plasma membrane using fluorescence imaging, further supporting the finding of its role as a sodium channel complex. |
complete | |||||
|
enables |
GO:0005272 |
sodium channel activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043025 |
neuronal cell body |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(WBbt:0005665) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0097730 |
non-motile cilium |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(WBbt:0005665) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050906 |
detection of stimulus involved in sensory perception |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0034220 |
ion transmembrane transport |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007606 |
sensory perception of chemical stimulus |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005216 |
ion channel activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008381 |
mechanosensitive ion channel activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2151016 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005216 |
ion channel activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001151822 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035725 |
sodium ion transmembrane transport |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005272 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006811 |
ion transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Chatzigeorgiou, M et al. (2013) tmc-1 encodes a sodium-sensitive channel required for salt chemosensation in C. elegans. Nature 494 95-9 PubMed GONUTS page
- ↑ 2.0 2.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
