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CAEEL:TMC1

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Species (Taxon ID) Caenorhabditis elegans. (6239)
Gene Name(s) tmc-1
Protein Name(s) Transmembrane channel-like protein 1
External Links
UniProt D3KZG3
EMBL FO080889
FO080360
RefSeq NP_508221.3
UniGene Cel.364
ProteinModelPortal D3KZG3
STRING 6239.T13G4.3
TCDB 1.A.17.4.7
PaxDb D3KZG3
PRIDE D3KZG3
EnsemblMetazoa [example_ID T13G4.3]
GeneID 188483
KEGG cel:CELE_T13G4.3
CTD 188483
WormBase T13G4.3
eggNOG ENOG410IF2J
ENOG410XTGF
GeneTree ENSGT00760000119171
InParanoid D3KZG3
OMA CWDIETT
OrthoDB EOG7S4X54
PRO PR:D3KZG3
Proteomes UP000001940
GO GO:0005887
GO:0043025
GO:0031513
GO:0005216
GO:0005272
GO:0050906
GO:0034220
GO:0007606
GO:0035725
InterPro IPR012496
Pfam PF07810

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005216

ion channel activity

PMID:23364694[1]

IDA: Inferred from Direct Assay

-

F

Seeded From UniProt

GO:0005272

sodium channel activity

PMID:23364694[1]

IMP: Inferred from Mutant Phenotype

F

Figure 4 shows sodium-sensitive cation currents in TMC-1 expressing cells indicating its role as a sodium channel. In supplementary figure 8 the authors also confirm TMC-1's localization to the plasma membrane using fluorescence imaging, further supporting the finding of its role as a sodium channel complex.

complete
CACAO 6444

GO:0005272

sodium channel activity

PMID:23364694[1]

IMP: Inferred from Mutant Phenotype

-

F

Seeded From UniProt

GO:0005886

plasma membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-1003

C

Seeded From UniProt

GO:0005886

plasma membrane

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

GO:0005887

integral component of plasma membrane

PMID:23364694[1]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0006810

transport

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0813

P

Seeded From UniProt

GO:0006811

ion transport

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0406

P

Seeded From UniProt

GO:0007606

sensory perception of chemical stimulus

PMID:23364694[1]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0016020

membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

Seeded From UniProt

GO:0016021

integral component of membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR012496

C

Seeded From UniProt

GO:0016021

integral component of membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

Seeded From UniProt

GO:0031513

nonmotile primary cilium

PMID:23364694[1]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0034220

ion transmembrane transport

PMID:23364694[1]

IDA: Inferred from Direct Assay

-

P

Seeded From UniProt

GO:0035725

sodium ion transmembrane transport

GO_REF:0000108

IEA: Inferred from Electronic Annotation

GO:0005272

P

Seeded From UniProt

GO:0043025

neuronal cell body

PMID:23364694[1]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0050906

detection of stimulus involved in sensory perception

PMID:23364694[1]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt


Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Chatzigeorgiou, M et al. (2013) tmc-1 encodes a sodium-sensitive channel required for salt chemosensation in C. elegans. Nature 494 95-9 PubMed GONUTS page