HPV16:VE2

Species (Taxon ID)	Human papillomavirus type 16. (333760)
Gene Name(s)	E2
Protein Name(s)	Regulatory protein E2
External Links
UniProt	P03120
EMBL	K02718 AF536179
PIR	A03669
RefSeq	NP_041328.1
PDB	1BY9 1DTO 1R8P 1ZZF 2NNU 2Q79 3MI7
PDBsum	1BY9 1DTO 1R8P 1ZZF 2NNU 2Q79 3MI7
ProteinModelPortal	P03120
SMR	P03120
DIP	DIP-44574N
IntAct	P03120
MINT	MINT-95621
BindingDB	P03120
ChEMBL	CHEMBL4656
GeneID	1489080
EvolutionaryTrace	P03120
Proteomes	UP000009251
GO	GO:0042025 GO:0072686 GO:0003677 GO:0000166 GO:0003700 GO:0006260 GO:0039651 GO:0006275 GO:0006351
Gene3D	2.170.200.10 3.30.70.330
InterPro	IPR012677 IPR000427 IPR001866
Pfam	PF00511 PF00508
ProDom	PD000672
SUPFAM	SSF51332 SSF54957

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0044163	host cytoskeleton	PMID:15020762	ECO:0000314			C		Figure 1 C shows that HPV 16 and E2 protein is involved in binding to mitotic spindles and pulling apart replicating DNA strands	complete CACAO 6495
NOT	GO:0075512	clathrin-mediated endocytosis of virus by host cell	PMID:1370493	ECO:0000315			P		"E1 fusion protein uses first heterodimerization with p62 as a means to become incorporated into the viral envelope and then dissociation from the cleaved p62 (e2), and reorganization, possibly within itself as a way to become activated (Membrane Fusion Process, pg.9)." See Table 1 of Papaer	complete CACAO 9564
part_of	GO:0044163	host cytoskeleton	PMID:15020762	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000427 InterPro:IPR033668 InterPro:IPR035975	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000427 InterPro:IPR035975	F		Seeded From UniProt	complete
involved_in	GO:0006275	regulation of DNA replication	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000427 InterPro:IPR001866 InterPro:IPR035975 InterPro:IPR036050	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000427 InterPro:IPR001866 InterPro:IPR033668 InterPro:IPR035975 InterPro:IPR036050	P		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001866 InterPro:IPR036050	P		Seeded From UniProt	complete
part_of	GO:0042025	host cell nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000427 InterPro:IPR035975	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000242304	F		Seeded From UniProt	complete
part_of	GO:0042025	host cell nucleus	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000242304	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000242304	F		Seeded From UniProt	complete
involved_in	GO:0039693	viral DNA genome replication	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000242304	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000242304	F		Seeded From UniProt	complete
involved_in	GO:0006275	regulation of DNA replication	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000242304	P		Seeded From UniProt	complete
involved_in	GO:0006351	transcription, DNA-templated	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000242304	P		Seeded From UniProt	complete
involved_in	GO:0006260	DNA replication	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0235	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0042025	host cell nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1048 UniProtKB-SubCell:SL-0414	C		Seeded From UniProt	complete
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References

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