GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
Cacao
| 0000306. | PMID:21554866 | IMP: Inferred from Mutant Phenotype | ||||||
| This annotation made on page: By: Surge Pres (group Team Yang Jed) on 2013-02-20 13:18:16 CST. | ||||||||
You must be logged in to challenge this annotation.
| Entry Type | Challenging User,Group | Time/Date | Challenge Reason | Points/Assessment |
|---|---|---|---|---|
| Challenge | Duquefeg, Team The Monstars | 2013-04-02 15:59:34 CDT | The GO ID for this annotation is wrong. Taking the following into consideration: Species (Taxon ID) Mus musculus (Mouse). (10090) Gene Name(s) Porcn Protein Name(s) Porcupine homolog (Drosophila) Porcupine homolog (Drosophila), isoform CRA_h PMID:21554866 What I believe to be the correct GO ID for Porcn gene in Mus musculus is the Following: GO:0030177 positive regulation of Wnt receptor signaling pathway Ontology: Biological Process Type Synonym exact upregulation of Wnt receptor signaling pathway exact up-regulation of Wnt receptor signaling pathway exact up regulation of Wnt receptor signaling pathway narrow stimulation of Wnt receptor signaling pathway exact positive regulation of Wnt receptor signalling pathway exact upregulation of frizzled signaling pathway exact up-regulation of frizzled signaling pathway exact up regulation of frizzled signaling pathway exact positive regulation of frizzled signalling pathway narrow stimulation of frizzled signaling pathway exact positive regulation of frizzled signaling pathway narrow activation of frizzled signaling pathway narrow activation of Wnt receptor signaling pathway Notes: As shown in the paper they are attempting to demonstrate the NEED for Porcn in the Wnt conical activity and gastrulation and germ layer establishment(Porcn required for the correct processing-acetylation- of Wnt ligands in the ER and for their extracellular distribution and gradient function) as required for the secretion of Wnt3a (isoforms of Porcn seem to be sufficient to obtain functional Wnt3a). Canonical Wnt activity assay as portrayed in Figure 2F Porcn function is dispensable in Wnt3a signal receiving cells and only required in Wnt3a secreting cells, supporting the role of Porcn in Wnt processing and secretion. | 5 |
| Challenge | 3.144.6.9, alpha1 | 2013-04-02 15:56:26 CDT | The GO ID for this annotation is wrong. Taking the following into consideration: Species (Taxon ID) Mus musculus (Mouse). (10090) Gene Name(s) Porcn Protein Name(s) Porcupine homolog (Drosophila) Porcupine homolog (Drosophila), isoform CRA_h PMID:21554866 What I believe to be the correct GO ID for Porcn gene in Mus musculus is the Following: GO:0030177 positive regulation of Wnt receptor signaling pathway Ontology: Biological Process Type Synonym exact upregulation of Wnt receptor signaling pathway exact up-regulation of Wnt receptor signaling pathway exact up regulation of Wnt receptor signaling pathway narrow stimulation of Wnt receptor signaling pathway exact positive regulation of Wnt receptor signalling pathway exact upregulation of frizzled signaling pathway exact up-regulation of frizzled signaling pathway exact up regulation of frizzled signaling pathway exact positive regulation of frizzled signalling pathway narrow stimulation of frizzled signaling pathway exact positive regulation of frizzled signaling pathway narrow activation of frizzled signaling pathway narrow activation of Wnt receptor signaling pathway Notes: As shown in the paper they are attempting to demonstrate the NEED for Porcn in the Wnt conical activity and gastrulation and germ layer establishment(Porcn required for the correct processing-acetylation- of Wnt ligands in the ER and for their extracellular distribution and gradient function) as required for the secretion of Wnt3a (isoforms of Porcn seem to be sufficient to obtain functional Wnt3a). Canonical Wnt activity assay as portrayed in Figure 2F Porcn function is dispensable in Wnt3a signal receiving cells and only required in Wnt3a secreting cells, supporting the role of Porcn in Wnt processing and secretion. | None, yet. |
| Challenge | Dylan.browning, Team Phatty Acidz | 2013-02-26 20:47:30 CST | Invalid GO Term | 0 |
| Private Assessment | Bmcintosh | 2013-06-22 15:41:39 CDT | You need to be an instructor to view these notes. | Updated by Instructor ✔ Protein ✔ Publication ✔ Qualifier ✔ Go term ✔ Evidence ✔ With/From ✔ Notes ✔ Unique/Original |
| Public Assessment | JimHu | 2013-04-02 20:07:46 CDT | Challenge is correct. Don't have to put the whole GO term stanza in. | Corrected Through Challenges ✔ Protein ✔ Publication ✔ Qualifier ✔ Go term ✔ Evidence ✔ With/From ✔ Notes ✔ Unique/Original |
| Public Assessment | DanielRenfro | 2013-04-02 15:59:35 CDT | This annotation has been flagged because it has been edited since last assessment | Flagged |
| Public Assessment | DanielRenfro | 2013-04-02 15:56:26 CDT | This annotation has been flagged because it has been edited since last assessment | Flagged |
| Public Assessment | Suzialeksander | 2013-02-28 12:38:37 CST | Please look on the protein page to view the current GO term, which the student changed to GO:0000306 before the end of the annotation round. | Requires Changes |
| Public Assessment | DanielRenfro | 2013-02-26 20:47:30 CST | This annotation has been flagged because it has been edited since last assessment | Flagged |
| Private Assessment | Suzialeksander | 2013-02-26 19:48:44 CST | You need to be an instructor to view these notes. | Requires Changes ✔ Protein ✔ Publication ✗ Go term ✔ With/From ✔ Unique/Original |
| Private Assessment | Bmcintosh | 2013-02-26 19:36:47 CST | You need to be an instructor to view these notes. | Flagged |
