User:Duquefeg

My Annotations

Status	Page	Date/Time	GO Term (Aspect)	Reference	Evidence	Notes	Links
correctedthroughchallenges	?	2013-04-09 21:35:43 CDT	GO:0042325 regulation of phosphorylation (Figure 6 (a)(b)(c)(d) Together suggest that Atr works upstream of Chk1regulating its phosphorylation after UV damage.)	PMID:10859164	IDA: Inferred from Direct Assay		challenge
unacceptable	PSEF5:Q4KFF4	2013-04-11 10:12:10 CDT	GO:0003677 DNA binding (F)	PMID:18776018	ECO:0000304 author statement supported by traceable reference used in manual assertion	Figure 1. indicated the presence of conserved Anr binding sites in the promoter regions of uspL, uspM, and uspO.	challenge
unacceptable	HUMAN:KDM1A	2013-04-13 00:34:39 CDT	GO:0003713 transcription coactivator activity (F)	PMID:23386436	ECO:0000314 direct assay evidence used in manual assertion	Figure. 2 Shows that MAOIs such as tranylcypromine (TCP) were originally designed to target the MAO-A/B. While these compounds also inhibit LSD1. compound OG-L002, which is highly specific to LSD1 (IC50, ~0.02 µM), potently inhibited the expression of viral IE (ICP27 and ICP4) (genesmRNAs were quantitated by quantitative reverse transcription-PCR (qRT-PCR)). LSD1 shows to be an important co-activator for HCF-1 complex. The inhibition of LSD1 results in the inactivity of this enzyme.	challenge
unacceptable	HUMAN:KDM1A	2013-04-13 00:56:28 CDT	GO:0036208 negative regulation of histone gene expression (P)	PMID:23386436	ECO:0000270 expression pattern evidence used in manual assertion	Figure. 2 Shows that MAOIs such as tranylcypromine (TCP) were originally designed to target the MAO-A/B. While these compounds also inhibit LSD1. compound OG-L002, which is highly specific to LSD1 (IC50, ~0.02 µM), potently inhibited the expression of viral IE (ICP27 and ICP4) (genesmRNAs were quantitated by quantitative reverse transcription-PCR (qRT-PCR)). The inhibition of LSD1 results in the inactivity of this enzyme, resulting in the repression of HSV-1 IE gene expression. Therefore suggesting that its original activity was to down regulate the IE gene expression	challenge

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unacceptable:3
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Annotations challenged by Duquefeg

Status	Author,Group	Page	GO Term (Aspect)	Reference	Evidence	Links	Page history
updatedbyinstructor	Surge Pres, Team Yang Jed	?	GO:0030177 - positive regulation of Wnt signaling pathway (As shown in the paper they are attempting to demonstrate the NEED for Porcn in the Wnt conical activity and gastrulation and germ layer establishment(Porcn required for the correct processing-acetylation- of Wnt ligands in the ER and for their extracellular distribution and gradient function) as required for the secretion of Wnt3a (isoforms of Porcn seem to be sufficient to obtain functional Wnt3a). Canonical Wnt activity assay as portrayed in Figure 2F Porcn function is dispensable in Wnt3a signal receiving cells and only required in Wnt3a secreting cells, supporting the role of Porcn in Wnt processing and secretion.)	PMID:21554866	IMP: Inferred from Mutant Phenotype	challenge	C: 3 fixed by Duquefeg
updatedbyinstructor	Rgruettner, Team Science Dance	MOUSE:KLF4	GO:0006351 - DNA-templated transcription (P)	PMID:23372771	ECO:0000315 mutant phenotype evidence used in manual assertion	challenge	C: 1 fixed by Duquefeg

2 annotations fixed by Duquefeg

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