User:Spanch1

My Annotations

Status	Page	Date/Time	GO Term (Aspect)	Reference	Evidence	Notes	Links
unacceptable	9CAUD:A0A0K2D0G3	2016-04-11 09:39:18 CDT	GO:0016032 viral process (P)	PMID:3488191	ECO:0000250 sequence similarity evidence used in manual assertion	"This packaging process is initiated by recognition and endonucleolytic cleavage of viral concatemeric DNA. Concatemeric DNA, which consists of head-to-tail unit-length molecules, is generally produced via recombination [21] or rolling-circle replication [34, 37]. Next, the cleaved DNA end is linked to the portal vertex of the empty prohead through specific interactions between the terminase and the portal protein [19, 20, 38, 41]. Thus, a packaging motor is assembled, which drives directional translocation of DNA into the prohead, powered by the energy of ATP hydrolysis"	challenge
unacceptable	9CAUD:A0A0K2D0G3	2016-04-11 09:39:18 CDT	GO:0005298 proline:sodium symporter activity (F)	PMID:3488191	ECO:0000250 sequence similarity evidence used in manual assertion	P03 - large subnit "The single p03 peak in the chromatogram suggests that the recombinant PaP3 large terminase subunit exists in solution as a monomer, which is also the case for many other phages [13, 16]."	challenge
unacceptable	9CAUD:A0A0K2D0G3	2016-04-11 09:39:18 CDT	GO:0098772 molecular function regulator (F)	PMID:3488191	ECO:0000250 sequence similarity evidence used in manual assertion	"these results establish that the PaP3 large terminase subunit possesses a specific endonucleolytic activity on the PaP3 cos sequence, while the small subunit has a stimulatory effect on this activity."	challenge
unacceptable	9CAUD:Q8H9R7	2016-04-11 09:35:16 CDT	GO:0016032 viral process (P)	PMID:3488191	ECO:0000314 direct assay evidence used in manual assertion	"This packaging process is initiated by recognition and endonucleolytic cleavage of viral concatemeric DNA. Concatemeric DNA, which consists of head-to-tail unit-length molecules, is generally produced via recombination [21] or rolling-circle replication [34, 37]. Next, the cleaved DNA end is linked to the portal vertex of the empty prohead through specific interactions between the terminase and the portal protein [19, 20, 38, 41]. Thus, a packaging motor is assembled, which drives directional translocation of DNA into the prohead, powered by the energy of ATP hydrolysis."	challenge
requireschanges	9CAUD:Q8H9R7	2016-04-11 09:35:17 CDT	GO:0005198 structural molecule activity (F)	PMID:3488191	ECO:0000314 direct assay evidence used in manual assertion	p03 - large subunit "The single p03 peak in the chromatogram suggests that the recombinant PaP3 large terminase subunit exists in solution as a monomer, which is also the case for many other phages [13, 16]."	challenge
unacceptable	9CAUD:Q8H9R7	2016-04-11 09:35:17 CDT	GO:0098772 molecular function regulator (F)	PMID:3488191	ECO:0000314 direct assay evidence used in manual assertion	"these results establish that the PaP3 large terminase subunit possesses a specific endonucleolytic activity on the PaP3 cos sequence, while the small subunit has a stimulatory effect on this activity. These two subunits may act cooperatively on the cos site of multimeric replicating PaP3 DNA and introduce staggered nicks to generate the 20-base ssDNA cohesive ends of the mature phage genome."	challenge

acceptable:0
unacceptable:5
requires_changes:1
flagged:0

Annotations challenged by Spanch1

Status	Author,Group	Page	GO Term (Aspect)	Reference	Evidence	Links	Page history
acceptable	Jermstadsb, Team TRUMP2016	BPT4:TERL	GO:0016887 - ATP hydrolysis activity (F)	PMID:19109896	ECO:0000315 mutant phenotype evidence used in manual assertion	challenge	C: 5
unacceptable	Lian2, Team Purple B	9CAUD:A0A0K2D0M9	GO:0008745 - N-acetylmuramoyl-L-alanine amidase activity (F)	other:EC 3.5.1.28	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 1
unacceptable	Hoang5, Team Purple A	9CAUD:A0A0K2D0M7	GO:0008168 - methyltransferase activity (F)	PMID:10615135	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 3
unacceptable	Mnguy1, Team Blue B	9CAUD:A0A0K2CZZ1	GO:0004604 - phosphoadenylyl-sulfate reductase (thioredoxin) activity (F)	PMID:7588765	ECO:0000250 sequence similarity evidence used in manual assertion	challenge	C: 6
unacceptable	E63, Team Blue A	9CAUD:A0A0K2D000	GO:0004146 - dihydrofolate reductase activity (F)	PMID:10731419	ECO:0000250 sequence similarity evidence used in manual assertion	challenge	C: 5
unacceptable	Spanch1, Team Red B	9CAUD:A0A0K2D0G3	GO:0016032 - viral process (P)	PMID:3488191	ECO:0000250 sequence similarity evidence used in manual assertion	challenge	C: 2
unacceptable	Yachuwbg, Team Atlantis	9CAUD:S5Y0G8	GO:0016301 - kinase activity (F)	GO_REF:0000100	ECO:0000250 sequence similarity evidence used in manual assertion	challenge	C: 2
unacceptable	Chensi1, Team Red A	9CAUD:J9PUX9	GO:0098015 - virus tail (C)	PMID:23649177	ECO:0000250 sequence similarity evidence used in manual assertion	challenge	C: 1
unacceptable	Chensi1, Team Red A	9CAUD:A0A0K2CZR9	GO:0098015 - virus tail (C)	Blast:Blast	ECO:0000250 sequence similarity evidence used in manual assertion	challenge	C: 1
unacceptable	Iac1, Team Purple B	BPDPK:Q8SD18	GO:0006508 - proteolysis (P)	PMID:22429790	ECO:0000250 sequence similarity evidence used in manual assertion	challenge	C: 2
unacceptable	Iac1, Team Purple B	BPDPK:Q8SD18	GO:0006508 - proteolysis (P)	PMID:11916376	ECO:0000250 sequence similarity evidence used in manual assertion	challenge	C: 2
unacceptable	Mnguy1, Team Blue B	9BACI:A0A0J8FEV2	GO:0016301 - kinase activity (BlastP result showed sequence alignment had a 41% identity and an e value of 5E-58.)	PMID:11292795	ISS: Inferred from Sequence Similarity UniProtKB:D5NZZ3	challenge	C: 2

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