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PMID:3488191

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Citation

Shurin, PA and Van Hare, GF (1986) Therapy of acute otitis media caused by Branhamella catarrhalis. Preliminary report. Drugs 31 Suppl 3:122-4

Abstract

Since 1980, we have observed an increased incidence of otitis media caused by Branhamella catarrhalis. The outcome of therapy of acute otitis media caused by this organism has been studied in a number of randomised clinical trials. 75% of isolates produced beta-lactamase. Failure to sterilise B. catarrhalis-infected middle ear exudates occurred in 3 of 11 patients treated with amoxycillin or bacampicillin, 2 of 19 treated with cefaclor, but in no patients treated with co-trimoxazole (n = 10) or amoxycillin-clavulanic acid (Augmentin), [n = 9]. All treatment failures were associated with beta-lactamase-producing strains of B. catarrhalis. The emergence of antibiotic-resistant strains of B. catarrhalis in acute otitis media indicates the need for a re-evaluation of initial antibiotic therapy of this infection. This may be particularly true for areas where there is a high incidence of strains which elaborate beta-lactamase.

Links

PubMed

Keywords

Amoxicillin/therapeutic use; Clavulanic Acid; Clavulanic Acids/therapeutic use; Drug Combinations/therapeutic use; Humans; Neisseriaceae/isolation & purification; Otitis Media/drug therapy; Otitis Media/etiology; Penicillin Resistance; Sulfamethoxazole/therapeutic use; Trimethoprim/therapeutic use; Trimethoprim, Sulfamethoxazole Drug Combination

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

9CAUD:A0A0K2D0G3

GO:0016032: viral process

ECO:0000250:

UniProtKB:A0A0K2D0G3 UniProtKB:q8h9r7


P

"This packaging process is initiated by recognition and endonucleolytic cleavage of viral concatemeric DNA. Concatemeric DNA, which consists of head-to-tail unit-length molecules, is generally produced via recombination [21] or rolling-circle replication [34, 37]. Next, the cleaved DNA end is linked to the portal vertex of the empty prohead through specific interactions between the terminase and the portal protein [19, 20, 38, 41]. Thus, a packaging motor is assembled, which drives directional translocation of DNA into the prohead, powered by the energy of ATP hydrolysis"

complete
CACAO 11588

9CAUD:A0A0K2D0G3

GO:0005298: proline:sodium symporter activity

ECO:0000250:

UniProtKB:Q8H9R7 UniProtKB:A0A0K2D0G3


F

P03 - large subnit

"The single p03 peak in the chromatogram suggests that the recombinant PaP3 large terminase subunit exists in solution as a monomer, which is also the case for many other phages [13, 16]."

complete
CACAO 11589

9CAUD:A0A0K2D0G3

GO:0098772: molecular function regulator

ECO:0000250:

UniProtKB:UniProtKB:A0A0K2D0G3


F

"these results establish that the PaP3 large terminase subunit possesses a specific endonucleolytic activity on the PaP3 cos sequence, while the small subunit has a stimulatory effect on this activity."

complete
CACAO 11590

9CAUD:Q8H9R7

GO:0016032: viral process

ECO:0000314:

P

"This packaging process is initiated by recognition and endonucleolytic cleavage of viral concatemeric DNA. Concatemeric DNA, which consists of head-to-tail unit-length molecules, is generally produced via recombination [21] or rolling-circle replication [34, 37]. Next, the cleaved DNA end is linked to the portal vertex of the empty prohead through specific interactions between the terminase and the portal protein [19, 20, 38, 41]. Thus, a packaging motor is assembled, which drives directional translocation of DNA into the prohead, powered by the energy of ATP hydrolysis."

complete
CACAO 11593

9CAUD:Q8H9R7

GO:0005198: structural molecule activity

ECO:0000314:

F

p03 - large subunit

"The single p03 peak in the chromatogram suggests that the recombinant PaP3 large terminase subunit exists in solution as a monomer, which is also the case for many other phages [13, 16]."

complete
CACAO 11594

9CAUD:Q8H9R7

GO:0098772: molecular function regulator

ECO:0000314:

F

"these results establish that the PaP3 large terminase subunit possesses a specific endonucleolytic activity on the PaP3 cos sequence, while the small subunit has a stimulatory effect on this activity. These two subunits may act cooperatively on the cos site of multimeric replicating PaP3 DNA and introduce staggered nicks to generate the 20-base ssDNA cohesive ends of the mature phage genome."

complete
CACAO 11595

Notes

See also

References

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