Phage Hunters Spring 2016
My Annotations
| Status | Page | Date/Time | GO Term (Aspect) | Reference | Evidence | Notes | Links |
|---|
| unacceptable | 9CAUD:A0A0K2D0M5 | 2016-04-11 03:14:08 CDT | GO:0003677 DNA binding (F) | PMID:3092189 | ECO:0000314 direct assay evidence used in manual assertion | Sequence alignments of the sigma70 family members reveal four conserved regions that can be further divided into subregions eg. sub-region 2.2, which may be involved in the binding of the sigma factor to the core RNA polymerase
| challenge |
| unacceptable | 9CAUD:A0A0K2D0E0 | 2016-04-11 03:43:39 CDT | GO:0008193 tRNA guanylyltransferase activity (F) | PMID:14633974 | ECO:0000314 direct assay evidence used in manual assertion | In Saccharomyces cerevisiae, YGR024c (Thg1p) protein is responsible for this guanylyltransferase reaction. It catalyses the guanylyltransferase step of G(-1) addition using a ppp-tRNA His substrate, and appears to catalyses the activation step using p-tRNA His and ATP. Thus, it catalyses phosphodiester bond formation at the 5' end of RNAs, formally in a 3'-5' direction.
| challenge |
| unacceptable | 9CAUD:A0A0K2D065 | 2016-04-11 04:26:00 CDT | GO:0006281 DNA repair (P) | PMID:1896024 | ECO:0000314 direct assay evidence used in manual assertion | The proteolytic inactivation of the lexA repressor by an activated form of recA may cause a derepression of the 20 or so genes involved in the SOS response, which regulates DNA repair, induced mutagenesis, delayed cell division and prophage induction in response to DNA damage.
| challenge |
| unacceptable | 9CAUD:A0A0K2D065 | 2016-04-11 04:26:01 CDT | GO:0006281 DNA repair (P) | PMID:1896024 | ECO:0000314 direct assay evidence used in manual assertion | The resulting recA mutants exhibited an increased sensitivity to UV irradiation, were impaired in their ability to perform homologous recombination and showed a slightly reduced growth rate when compared with the respective wild-type strains. The Rhizobium recA strains did not have altered symbiotic nitrogen fixation capacity. Therefore, they represent ideal candidates for release experiments with impaired strains.
| challenge |
| unacceptable | 9CAUD:A0A0K2D0M7 | 2016-04-11 04:43:03 CDT | GO:0005524 ATP binding (F) | PMID:8444794 | ECO:0000314 direct assay evidence used in manual assertion | PhoH has an ATP-binding activity was demonstrated by a photoaffinity labeling experiment.
| challenge |
| unacceptable | 9CAUD:A0A0K2D0M9 | 2016-04-11 04:47:08 CDT | GO:0008745 N-acetylmuramoyl-L-alanine amidase activity (F) | other:EC 3.5.1.28 | ECO:0000314 direct assay evidence used in manual assertion | Autolysin hydrolyses the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell wall glycopeptides.
| challenge |
| unacceptable | 9CAUD:A0A0K2D0F3 | 2016-04-11 04:51:21 CDT | GO:0006231 dTMP biosynthetic process (P) | PMID:6996564 | ECO:0000314 direct assay evidence used in manual assertion | Thymidylate synthase catalyzes the reductive methylation of dUMP to dTMP with concomitant conversion of 5,10-methylenetetrahydrofolate to dihydrofolate: 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP This provides the sole de novo pathway for production of dTMP and is the only enzyme in folate metabolism in which the 5,10-methylenetetrahydrofolate is oxidised during one-carbon transfer.
| challenge |
acceptable:0
unacceptable:7
requires_changes:0
flagged:0
Annotations challenged by Lian2
| Status | Author,Group | Page | GO Term (Aspect) | Reference | Evidence | Links | Page history |
|---|
0 annotations fixed by Lian2
What do the icons mean in the status column?
