GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:6996564
| Citation |
Benkovic, SJ (1980) On the mechanism of action of folate- and biopterin-requiring enzymes. Annu. Rev. Biochem. 49:227-51 |
|---|---|
| Abstract |
No abstract in PubMed |
| Links |
PubMed Online version:10.1146/annurev.bi.49.070180.001303 |
| Keywords |
Animals; Bacteria/enzymology; Biopterin/pharmacology; Folic Acid/pharmacology; Formaldehyde/metabolism; Formates/metabolism; Glycine Hydroxymethyltransferase/metabolism; Leukemia L1210/enzymology; Liver/enzymology; Methylenetetrahydrofolate Dehydrogenase (NADP)/metabolism; Mice; Mixed Function Oxygenases/metabolism; Molecular Conformation; Oxidation-Reduction; Pteridines/pharmacology; Tetrahydrofolate Dehydrogenase/metabolism |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0006231: dTMP biosynthetic process |
ECO:0000314: |
P |
Thymidylate synthase catalyzes the reductive methylation of dUMP to dTMP with concomitant conversion of 5,10-methylenetetrahydrofolate to dihydrofolate: 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP This provides the sole de novo pathway for production of dTMP and is the only enzyme in folate metabolism in which the 5,10-methylenetetrahydrofolate is oxidised during one-carbon transfer. |
complete | ||||
Notes
See also
References
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