MOUSE:NMDE1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Grin2a
Protein Name(s)	Glutamate receptor ionotropic, NMDA 2A GluN2A Glutamate [NMDA] receptor subunit epsilon-1 N-methyl D-aspartate receptor subtype 2A NMDAR2A NR2A
External Links
UniProt	P35436
EMBL	D10217
CCDS	CCDS27943.1
PIR	S29159
RefSeq	NP_032196.2 XP_006521857.1
UniGene	Mm.2953
ProteinModelPortal	P35436
SMR	P35436
BioGrid	200068
DIP	DIP-31567N
IntAct	P35436
MINT	MINT-103939
STRING	10090.ENSMUSP00000111501
GuidetoPHARMACOLOGY	456
PhosphoSite	P35436
PaxDb	P35436
PRIDE	P35436
DNASU	14811
Ensembl	ENSMUST00000032331 ENSMUST00000115835
GeneID	14811
KEGG	mmu:14811
UCSC	uc007ydc.1
CTD	2903
MGI	MGI:95820
eggNOG	NOG282132
GeneTree	ENSGT00760000119186
HOGENOM	HOG000113802
HOVERGEN	HBG052635
InParanoid	P35436
KO	K05209
OMA	PRQLWKK
OrthoDB	EOG72ZCD1
PhylomeDB	P35436
TreeFam	TF314731
Reactome	REACT_198244 REACT_198248 REACT_258217
NextBio	286999
PRO	PR:P35436
Proteomes	UP000000589
Bgee	P35436
Genevestigator	P35436
GO	GO:0030054 GO:0009986 GO:0043197 GO:0005783 GO:0016020 GO:0017146 GO:0043005 GO:0097481 GO:0014069 GO:0045211 GO:0042734 GO:0045202 GO:0008021 GO:0005262 GO:0005261 GO:0005234 GO:0004972 GO:0008270 GO:0070588 GO:0006816 GO:0098655 GO:0033058 GO:0042417 GO:0034220 GO:0035235 GO:0007612 GO:0007611 GO:0040011 GO:0007626 GO:0007613 GO:0042177 GO:0022008 GO:0043065 GO:0008104 GO:0060079 GO:0042391 GO:0060078 GO:0051930 GO:0048167 GO:0050804 GO:0001975 GO:0042493 GO:0045471 GO:0009611 GO:0019233 GO:0042428 GO:0030431 GO:0001964 GO:0007268 GO:0035249 GO:0008542
InterPro	IPR001828 IPR019594 IPR001508 IPR001320 IPR018884 IPR028082
Pfam	PF01094 PF00060 PF10565
PRINTS	PR00177
SMART	SM00918 SM00079
SUPFAM	SSF53822

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0043005	neuron projection	PMID:21664258^[1]	ECO:0000315			C		Synaptosomal fraction from brain of wild type mice, figure 5A. NR2A levels reduced in whole hippocampal homogenate and synaptosomal fraction in homozygous Pten mutant mice and decrease levels of heterozygous Pten mice, figure 6A, B.	complete CACAO 2354
	GO:0009986	cell surface	PMID:17229826^[2]	ECO:0000315			C		Cell surface protein biotinylation and Western blotting was used. Figure 3 A-C, cells treated with reelin showed increase levels of surface NR2A compared to control.	complete CACAO 2396
	GO:0043005	neuron projection	PMID:21558424^[3]	ECO:0000315			C		Figure 6B and D, A decrease of receptor subunit in synaptosome membrane fraction. There was a decrease in NR2A subunit in mutant shank3 mice compared to control .	complete CACAO 3126
	GO:0014069	postsynaptic density	PMID:21664258^[1]	ECO:0000315			C		Figure 3A and C, Western blot showed levels of both the NR2A subunits were significantly decreased in the PSD (postsynaptic density) fraction of heterozygous reeler mice.	complete
part_of	GO:0098839	postsynaptic density membrane	PMID:19726645^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(GO:0043197) part_of:(CL:0002608) part_of:(UBERON:0014556)	Seeded From UniProt	complete
part_of	GO:0099061	integral component of postsynaptic density membrane	PMID:19726645^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(GO:0043197) part_of:(CL:0002608) part_of:(UBERON:0003883)	Seeded From UniProt	complete
enables	GO:0022849	glutamate-gated calcium ion channel activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q12879	F		Seeded From UniProt	complete
involved_in	GO:0097553	calcium ion transmembrane import into cytosol	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q12879	P		Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00959	F		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:21558424^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:21664258^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:17229826^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:26609151^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000540)	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:26609151^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002608) part_of:(GO:0045202)	Seeded From UniProt	complete
part_of	GO:0097060	synaptic membrane	PMID:26609151^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(GO:0009986)	Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:21664258^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:21558424^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:17229826^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	PMID:12427824^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048167	regulation of synaptic plasticity	PMID:12427824^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0042734	presynaptic membrane	PMID:16157280^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00960	F		Seeded From UniProt	complete
part_of	GO:0099061	integral component of postsynaptic density membrane	PMID:19726645^[4]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0000061) part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:19726645^[4]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098839	postsynaptic density membrane	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95820 MGI:MGI:95821 PANTHER:PTN000751216	C		Seeded From UniProt	complete
involved_in	GO:0060291	long-term synaptic potentiation	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95820 MGI:MGI:95821 PANTHER:PTN000751216	P		Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95820 MGI:MGI:95821 MGI:MGI:95822 MGI:MGI:95823 PANTHER:PTN000751216 RGD:2737	P		Seeded From UniProt	complete
part_of	GO:0017146	NMDA selective glutamate receptor complex	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95820 MGI:MGI:95821 MGI:MGI:95822 PANTHER:PTN000751216 RGD:2737 RGD:2738 RGD:2739 RGD:2740 UniProtKB:O15399 UniProtKB:Q12879 UniProtKB:Q13224 UniProtKB:Q14957	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004620 FB:FBgn0052704 MGI:MGI:95808 MGI:MGI:95813 MGI:MGI:95816 PANTHER:PTN000437926 RGD:621531 TAIR:locus:2207165 UniProtKB:Q12879 UniProtKB:Q13224 UniProtKB:Q16478 WB:WBGene00001612	C		Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95820 MGI:MGI:95821 MGI:MGI:95822 MGI:MGI:95823 PANTHER:PTN000751216 RGD:2737 RGD:2738 RGD:2739 RGD:2740 UniProtKB:O15399 UniProtKB:Q13224 UniProtKB:Q14957	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000463	positive regulation of excitatory postsynaptic potential	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2737	P		Seeded From UniProt	complete
enables	GO:1904315	transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2737	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903539	protein localization to postsynaptic membrane	PMID:15317856^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95822	P	has_input:(MGI:MGI:95819)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903539	protein localization to postsynaptic membrane	PMID:15317856^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928285	P	has_input:(MGI:MGI:95819)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900273	positive regulation of long-term synaptic potentiation	PMID:16901514^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0099507	ligand-gated ion channel activity involved in regulation of presynaptic membrane potential	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2737	F		Seeded From UniProt	complete
part_of	GO:0099056	integral component of presynaptic membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2737	C		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2737	C		Seeded From UniProt	complete
part_of	GO:0098688	parallel fiber to Purkinje cell synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2737	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097553	calcium ion transmembrane import into cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12879	P		Seeded From UniProt	complete
enables	GO:0097110	scaffold protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2737	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071294	cellular response to zinc ion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2737	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071230	cellular response to amino acid stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2737	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060291	long-term synaptic potentiation	PMID:20661302^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109137 MGI:MGI:1346858 MGI:MGI:95821	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060079	excitatory postsynaptic potential	PMID:8987814^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95822	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060079	excitatory postsynaptic potential	PMID:9147327^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928506	P	occurs_in:(EMAPA:32770) regulates_o_occurs_in:(CL:0000598)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060079	excitatory postsynaptic potential	PMID:8987814^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928506	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060079	excitatory postsynaptic potential	PMID:8699248^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928285	P	occurs_in:(EMAPA:35219) regulates_o_occurs_in:(CL:0000120)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060079	excitatory postsynaptic potential	PMID:16157280^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060079	excitatory postsynaptic potential	PMID:16045501^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060079	excitatory postsynaptic potential	PMID:14645471^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928287	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060079	excitatory postsynaptic potential	PMID:11530236^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928287	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060079	excitatory postsynaptic potential	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2737	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060078	regulation of postsynaptic membrane potential	PMID:16157280^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051930	regulation of sensory perception of pain	PMID:10771345^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928285	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051262	protein tetramerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2737	P		Seeded From UniProt	complete
enables	GO:0051117	ATPase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2737	F		Seeded From UniProt	complete
NOT\|acts_upstream_of_or_within	GO:0050966	detection of mechanical stimulus involved in sensory perception of pain	PMID:16190898^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928285	P		Seeded From UniProt	complete
enables	GO:0050839	cell adhesion molecule binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2737	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048511	rhythmic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2737	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048169	regulation of long-term neuronal synaptic plasticity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2737	P		Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2737	F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2737	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045471	response to ethanol	PMID:11530236^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928287	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045471	response to ethanol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12879	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045471	response to ethanol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2737	P		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	PMID:12890763^[20]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	PMID:12676993^[21]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	PMID:12103442^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:16710293^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:14645471^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:14622577^[24]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2737	F		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	PMID:16221859^[25]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00959	C		Seeded From UniProt	complete
part_of	GO:0043195	terminal bouton	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2737	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	PMID:17803966^[26]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1096575 MGI:MGI:95819	P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:26627310^[27]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2737	C		Seeded From UniProt	complete
part_of	GO:0042734	presynaptic membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2737	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042493	response to drug	PMID:14750973^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928285	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042428	serotonin metabolic process	PMID:11160454^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928285	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042417	dopamine metabolic process	PMID:11160454^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928285	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042391	regulation of membrane potential	PMID:9712642^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928285	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042391	regulation of membrane potential	PMID:7816096^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928285	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042177	negative regulation of protein catabolic process	PMID:15317856^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95822	P	regulates_o_has_input:(MGI:MGI:95819)	Seeded From UniProt	complete
enables	GO:0042165	neurotransmitter binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2737	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0040011	locomotion	PMID:14750973^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928285	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0040011	locomotion	PMID:11160454^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928285	P		Seeded From UniProt	complete
enables	GO:0035254	glutamate receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2737	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035235	ionotropic glutamate receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2737	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033058	directional locomotion	PMID:8987814^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95822	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030431	sleep	PMID:12754515^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928285	P		Seeded From UniProt	complete
enables	GO:0022849	glutamate-gated calcium ion channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12879	F		Seeded From UniProt	complete
enables	GO:0022843	voltage-gated cation channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2737	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0022008	neurogenesis	PMID:12941447^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928285	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2737	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019233	sensory perception of pain	PMID:10694228^[34]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928285	P		Seeded From UniProt	complete
part_of	GO:0017146	NMDA selective glutamate receptor complex	PMID:9003035^[35]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35438	C		Seeded From UniProt	complete
part_of	GO:0017146	NMDA selective glutamate receptor complex	PMID:7929101^[36]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35439	C		Seeded From UniProt	complete
part_of	GO:0017146	NMDA selective glutamate receptor complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12879	C		Seeded From UniProt	complete
part_of	GO:0017146	NMDA selective glutamate receptor complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2737	C		Seeded From UniProt	complete
enables	GO:0016595	glutamate binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2737	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:9003035^[35]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:8840015^[37]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:18054859^[38]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:17114649^[39]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2737	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010942	positive regulation of cell death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2737	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009611	response to wounding	PMID:9512392^[40]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95822	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009611	response to wounding	PMID:9822733^[41]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928285	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008542	visual learning	PMID:7816096^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928285	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2737	F		Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	PMID:20418887^[42]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17549)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007613	memory	PMID:9458051^[43]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928287	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007613	memory	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2737	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007612	learning	PMID:9427357^[44]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928506	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007612	learning	PMID:11160454^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928285	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007611	learning or memory	PMID:9712642^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928285	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007611	learning or memory	PMID:16045501^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007268	chemical synaptic transmission	PMID:9147327^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928506	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007268	chemical synaptic transmission	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2737	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006816	calcium ion transport	PMID:1374164^[45]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95819	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006816	calcium ion transport	PMID:16045501^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006816	calcium ion transport	PMID:14645471^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928287	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006816	calcium ion transport	PMID:11160454^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928285	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12879	C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2737	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q12879	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:16814779^[46]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17787)	Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	PMID:14645471^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928287	F		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	PMID:11160454^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928285	F		Seeded From UniProt	complete
contributes_to	GO:0005262	calcium channel activity	PMID:1374164^[45]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95819	F		Seeded From UniProt	complete
enables	GO:0005261	cation channel activity	PMID:9427357^[44]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928506	F		Seeded From UniProt	complete
enables	GO:0005261	cation channel activity	PMID:8699248^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928285	F		Seeded From UniProt	complete
contributes_to	GO:0005261	cation channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2737	F		Seeded From UniProt	complete
contributes_to	GO:0005234	extracellularly glutamate-gated ion channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2737	F		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2737	F		Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	PMID:1377365^[47]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95819	F		Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	PMID:9512392^[40]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928506	F		Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	PMID:9427357^[44]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928506	F		Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	PMID:8699248^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928285	F	occurs_in:(EMAPA:35219) occurs_in:(CL:0000120)	Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	PMID:7816096^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928285	F		Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	PMID:14750973^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928285	F		Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	PMID:12754515^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928285	F		Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	PMID:11487658^[48]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928285	F		Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	PMID:11160454^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928285	F		Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2737	F		Seeded From UniProt	complete
contributes_to	GO:0004972	NMDA glutamate receptor activity	PMID:7929101^[36]	ECO:0000316	genetic interaction evidence used in manual assertion	RGD:2736	F		Seeded From UniProt	complete
contributes_to	GO:0004972	NMDA glutamate receptor activity	PMID:1374164^[45]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95819	F		Seeded From UniProt	complete
enables	GO:0004970	ionotropic glutamate receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2737	F		Seeded From UniProt	complete
contributes_to	GO:0004970	ionotropic glutamate receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2737	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001975	response to amphetamine	PMID:15731593^[49]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928285	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001964	startle response	PMID:14985927^[50]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95821	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001964	startle response	PMID:11488959^[51]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928285	P		Seeded From UniProt	complete
NOT\|acts_upstream_of_or_within	GO:0001964	startle response	PMID:9718984^[52]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928285	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001508	action potential	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2737	P		Seeded From UniProt	complete
involved_in	GO:0019722	calcium-mediated signaling	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0022849	P		Seeded From UniProt	complete
involved_in	GO:0019722	calcium-mediated signaling	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0022849	P		Seeded From UniProt	complete
involved_in	GO:0019722	calcium-mediated signaling	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0022849	P		Seeded From UniProt	complete
involved_in	GO:0099505	regulation of presynaptic membrane potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0099507	P		Seeded From UniProt	complete
involved_in	GO:0097553	calcium ion transmembrane import into cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12879 ensembl:ENSP00000332549	P		Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12879 ensembl:ENSP00000332549	P		Seeded From UniProt	complete
enables	GO:0022849	glutamate-gated calcium ion channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12879 ensembl:ENSP00000332549	F		Seeded From UniProt	complete
part_of	GO:0017146	NMDA selective glutamate receptor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12879 ensembl:ENSP00000332549	C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12879 ensembl:ENSP00000332549	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q12879 ensembl:ENSP00000332549	C		Seeded From UniProt	complete
enables	GO:0004970	ionotropic glutamate receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001320 InterPro:IPR019594	F		Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001508	F		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001508	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001320 InterPro:IPR001508 InterPro:IPR019594	C		Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001508	F		Seeded From UniProt	complete
involved_in	GO:0007626	locomotory behavior	PMID:12427824^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-MMU-9006510	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0120038	plasma membrane bounded cell projection part	PMID:26627310^[27]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0017146	NMDA selective glutamate receptor complex	PMID:26627310^[27]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0628 UniProtKB-SubCell:SL-0219	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Ventruti, A et al. (2011) Reelin deficiency causes specific defects in the molecular composition of the synapses in the adult brain. Neuroscience 189 32-42 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Qiu, S & Weeber, EJ (2007) Reelin signaling facilitates maturation of CA1 glutamatergic synapses. J. Neurophysiol. 97 2312-21 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Wang, X et al. (2011) Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3. Hum. Mol. Genet. 20 3093-108 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Akashi, K et al. (2009) NMDA receptor GluN2B (GluR epsilon 2/NR2B) subunit is crucial for channel function, postsynaptic macromolecular organization, and actin cytoskeleton at hippocampal CA3 synapses. J. Neurosci. 29 10869-82 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Takei, Y et al. (2015) Defects in Synaptic Plasticity, Reduced NMDA-Receptor Transport, and Instability of Postsynaptic Density Proteins in Mice Lacking Microtubule-Associated Protein 1A. J. Neurosci. 35 15539-54 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Rossi, P et al. (2002) NMDA receptor 2 (NR2) C-terminal control of NR open probability regulates synaptic transmission and plasticity at a cerebellar synapse. J. Neurosci. 22 9687-97 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Zhao, MG et al. (2005) Roles of NMDA NR2B subtype receptor in prefrontal long-term potentiation and contextual fear memory. Neuron 47 859-72 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Abe, M et al. (2004) NMDA receptor GluRepsilon/NR2 subunits are essential for postsynaptic localization and protein stability of GluRzeta1/NR1 subunit. J. Neurosci. 24 7292-304 PubMed GONUTS page
↑ Berberich, S et al. (2007) The role of NMDAR subtypes and charge transfer during hippocampal LTP induction. Neuropharmacology 52 77-86 PubMed GONUTS page
↑ Jin, SX & Feig, LA (2010) Long-term potentiation in the CA1 hippocampus induced by NR2A subunit-containing NMDA glutamate receptors is mediated by Ras-GRF2/Erk map kinase signaling. PLoS ONE 5 e11732 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Kadotani, H et al. (1996) Motor discoordination results from combined gene disruption of the NMDA receptor NR2A and NR2C subunits, but not from single disruption of the NR2A or NR2C subunit. J. Neurosci. 16 7859-67 PubMed GONUTS page
↑ ^13.0 ^13.1 Ito, I et al. (1997) Synapse-selective impairment of NMDA receptor functions in mice lacking NMDA receptor epsilon 1 or epsilon 2 subunit. J. Physiol. (Lond.) 500 ( Pt 2) 401-8 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Takahashi, T et al. (1996) Functional correlation of NMDA receptor epsilon subunits expression with the properties of single-channel and synaptic currents in the developing cerebellum. J. Neurosci. 16 4376-82 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Toyoda, H et al. (2005) Roles of NMDA receptor NR2A and NR2B subtypes for long-term depression in the anterior cingulate cortex. Eur. J. Neurosci. 22 485-94 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 Köhr, G et al. (2003) Intracellular domains of NMDA receptor subtypes are determinants for long-term potentiation induction. J. Neurosci. 23 10791-9 PubMed GONUTS page
↑ ^17.0 ^17.1 Gordey, M et al. (2001) Altered effects of ethanol in NR2A(DeltaC/DeltaC) mice expressing C-terminally truncated NR2A subunit of NMDA receptor. Neuroscience 105 987-97 PubMed GONUTS page
↑ Minami, T et al. (2000) Characterization of nociceptin/orphanin FQ-induced pain responses in conscious mice: neonatal capsaicin treatment and N-methyl-D-aspartate receptor GluRepsilon subunit knockout mice. Neuroscience 97 133-42 PubMed GONUTS page
↑ Abe, T et al. (2005) Fyn kinase-mediated phosphorylation of NMDA receptor NR2B subunit at Tyr1472 is essential for maintenance of neuropathic pain. Eur. J. Neurosci. 22 1445-54 PubMed GONUTS page
↑ Tao, YX et al. (2003) Impaired NMDA receptor-mediated postsynaptic function and blunted NMDA receptor-dependent persistent pain in mice lacking postsynaptic density-93 protein. J. Neurosci. 23 6703-12 PubMed GONUTS page
↑ Fukaya, M et al. (2003) Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout mice. Proc. Natl. Acad. Sci. U.S.A. 100 4855-60 PubMed GONUTS page
↑ Oshima, S et al. (2002) Early onset of NMDA receptor GluR epsilon 1 (NR2A) expression and its abundant postsynaptic localization in developing motoneurons of the mouse hypoglossal nucleus. Neurosci. Res. 43 239-50 PubMed GONUTS page
↑ Nakazawa, T et al. (2006) NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity. EMBO J. 25 2867-77 PubMed GONUTS page
↑ Bamji, SX et al. (2003) Role of beta-catenin in synaptic vesicle localization and presynaptic assembly. Neuron 40 719-31 PubMed GONUTS page
↑ Van de Ven, TJ et al. (2005) The nonkinase phorbol ester receptor alpha 1-chimerin binds the NMDA receptor NR2A subunit and regulates dendritic spine density. J. Neurosci. 25 9488-96 PubMed GONUTS page
↑ Taniura, H et al. (2007) Tex261 modulates the excitotoxic cell death induced by N-methyl-D-aspartate (NMDA) receptor activation. Biochem. Biophys. Res. Commun. 362 1096-100 PubMed GONUTS page
↑ ^27.0 ^27.1 ^27.2 Berg, JM et al. (2015) JAKMIP1, a Novel Regulator of Neuronal Translation, Modulates Synaptic Function and Autistic-like Behaviors in Mouse. Neuron 88 1173-1191 PubMed GONUTS page
↑ ^28.0 ^28.1 ^28.2 Miyamoto, Y et al. (2004) Behavioural adaptations to addictive drugs in mice lacking the NMDA receptor epsilon1 subunit. Eur. J. Neurosci. 19 151-8 PubMed GONUTS page
↑ ^29.0 ^29.1 ^29.2 ^29.3 ^29.4 ^29.5 ^29.6 Miyamoto, Y et al. (2001) Hyperfunction of dopaminergic and serotonergic neuronal systems in mice lacking the NMDA receptor epsilon1 subunit. J. Neurosci. 21 750-7 PubMed GONUTS page
↑ ^30.0 ^30.1 Kiyama, Y et al. (1998) Increased thresholds for long-term potentiation and contextual learning in mice lacking the NMDA-type glutamate receptor epsilon1 subunit. J. Neurosci. 18 6704-12 PubMed GONUTS page
↑ ^31.0 ^31.1 ^31.2 Sakimura, K et al. (1995) Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor epsilon 1 subunit. Nature 373 151-5 PubMed GONUTS page
↑ ^32.0 ^32.1 Miyamoto, H et al. (2003) Experience-dependent slow-wave sleep development. Nat. Neurosci. 6 553-4 PubMed GONUTS page
↑ Kitamura, T et al. (2003) Enhancement of neurogenesis by running wheel exercises is suppressed in mice lacking NMDA receptor epsilon 1 subunit. Neurosci. Res. 47 55-63 PubMed GONUTS page
↑ Inoue, M et al. (2000) Enhanced nociception by exogenous and endogenous substance P given into the spinal cord in mice lacking NR(2)A/epsilon(1), an NMDA receptor subunit. Br. J. Pharmacol. 129 239-41 PubMed GONUTS page
↑ ^35.0 ^35.1 Chazot, PL & Stephenson, FA (1997) Biochemical evidence for the existence of a pool of unassembled C2 exon-containing NR1 subunits of the mammalian forebrain NMDA receptor. J. Neurochem. 68 507-16 PubMed GONUTS page
↑ ^36.0 ^36.1 Chazot, PL et al. (1994) Molecular characterization of N-methyl-D-aspartate receptors expressed in mammalian cells yields evidence for the coexistence of three subunit types within a discrete receptor molecule. J. Biol. Chem. 269 24403-9 PubMed GONUTS page
↑ Snell, LD et al. (1996) Regional and subunit specific changes in NMDA receptor mRNA and immunoreactivity in mouse brain following chronic ethanol ingestion. Brain Res. Mol. Brain Res. 40 71-8 PubMed GONUTS page
↑ Samuels, BA et al. (2007) Cdk5 promotes synaptogenesis by regulating the subcellular distribution of the MAGUK family member CASK. Neuron 56 823-37 PubMed GONUTS page
↑ Munton, RP et al. (2007) Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Mol. Cell Proteomics 6 283-93 PubMed GONUTS page
↑ ^40.0 ^40.1 Kadotani, H et al. (1998) Attenuation of focal cerebral infarct in mice lacking NMDA receptor subunit NR2C. Neuroreport 9 471-5 PubMed GONUTS page
↑ Morikawa, E et al. (1998) Attenuation of focal ischemic brain injury in mice deficient in the epsilon1 (NR2A) subunit of NMDA receptor. J. Neurosci. 18 9727-32 PubMed GONUTS page
↑ Shmelkov, SV et al. (2010) Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive-like behaviors in mice. Nat. Med. 16 598-602, 1p following 602 PubMed GONUTS page
↑ Sprengel, R et al. (1998) Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo. Cell 92 279-89 PubMed GONUTS page
↑ ^44.0 ^44.1 ^44.2 Kishimoto, Y et al. (1997) Conditioned eyeblink response is impaired in mutant mice lacking NMDA receptor subunit NR2A. Neuroreport 8 3717-21 PubMed GONUTS page
↑ ^45.0 ^45.1 ^45.2 Meguro, H et al. (1992) Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNAs. Nature 357 70-4 PubMed GONUTS page
↑ Miyazaki, T et al. (2006) Disturbance of cerebellar synaptic maturation in mutant mice lacking BSRPs, a novel brain-specific receptor-like protein family. FEBS Lett. 580 4057-64 PubMed GONUTS page
↑ Kutsuwada, T et al. (1992) Molecular diversity of the NMDA receptor channel. Nature 358 36-41 PubMed GONUTS page
↑ Chen, JJ et al. (2001) Maintenance of serotonin in the intestinal mucosa and ganglia of mice that lack the high-affinity serotonin transporter: Abnormal intestinal motility and the expression of cation transporters. J. Neurosci. 21 6348-61 PubMed GONUTS page
↑ Sato, Y et al. (2005) Effect of N-methyl-D-aspartate receptor epsilon1 subunit gene disruption of the action of general anesthetic drugs in mice. Anesthesiology 102 557-61 PubMed GONUTS page
↑ Spooren, W et al. (2004) Pharmacological and genetic evidence indicates that combined inhibition of NR2A and NR2B subunit containing NMDA receptors is required to disrupt prepulse inhibition. Psychopharmacology (Berl.) 175 99-105 PubMed GONUTS page
↑ Takeuchi, T et al. (2001) Roles of the glutamate receptor epsilon2 and delta2 subunits in the potentiation and prepulse inhibition of the acoustic startle reflex. Eur. J. Neurosci. 14 153-60 PubMed GONUTS page
↑ Munemoto, Y et al. (1998) Auditory pathway and auditory brainstem response in mice lacking NMDA receptor epsilon 1 and epsilon 4 subunits. Neurosci. Lett. 251 101-4 PubMed GONUTS page

[PMID:21664258-1] 1.0 ^1.1 ^1.2 ^1.3 Ventruti, A et al. (2011) Reelin deficiency causes specific defects in the molecular composition of the synapses in the adult brain. Neuroscience 189 32-42 PubMed GONUTS page

[PMID:17229826-2] 2.0 ^2.1 ^2.2 Qiu, S & Weeber, EJ (2007) Reelin signaling facilitates maturation of CA1 glutamatergic synapses. J. Neurophysiol. 97 2312-21 PubMed GONUTS page

[PMID:21558424-3] 3.0 ^3.1 ^3.2 Wang, X et al. (2011) Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3. Hum. Mol. Genet. 20 3093-108 PubMed GONUTS page

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[PMID:11487658-48] Chen, JJ et al. (2001) Maintenance of serotonin in the intestinal mucosa and ganglia of mice that lack the high-affinity serotonin transporter: Abnormal intestinal motility and the expression of cation transporters. J. Neurosci. 21 6348-61 PubMed GONUTS page

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MOUSE:NMDE1

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