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PMID:15731593
| Citation |
Sato, Y, Kobayashi, E, Murayama, T, Mishina, M and Seo, N (2005) Effect of N-methyl-D-aspartate receptor epsilon1 subunit gene disruption of the action of general anesthetic drugs in mice. Anesthesiology 102:557-61 |
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| Abstract |
Recent molecular strategies demonstrated that the N-methyl-d-aspartate (NMDA) receptor is a major target site of anesthetic agents. In a previous article, the authors showed that knocking out the NMDA receptor epsilon1 subunit gene markedly reduced the hypnotic effect of ketamine in mice. In the current study, the authors examined the in vivo contribution of the NMDA receptor epsilon1 subunit to the action of other anesthetic drugs. |
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| Keywords |
Anesthetics/pharmacology; Animals; Diazepam/pharmacology; Male; Methyl Ethers/pharmacology; Mice; Mice, Inbred C57BL; Mice, Knockout; Midazolam/pharmacology; Nitrous Oxide/pharmacology; Pentobarbital/pharmacology; Propofol/pharmacology; Receptors, N-Methyl-D-Aspartate/genetics; Receptors, N-Methyl-D-Aspartate/physiology |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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