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PMID:14985927
| Citation |
Spooren, W, Mombereau, C, Maco, M, Gill, R, Kemp, JA, Ozmen, L, Nakanishi, S and Higgins, GA (2004) Pharmacological and genetic evidence indicates that combined inhibition of NR2A and NR2B subunit containing NMDA receptors is required to disrupt prepulse inhibition. Psychopharmacology (Berl.) 175:99-105 |
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| Abstract |
Glutamate signalling through the N-methyl-D-aspartate (NMDA) receptor is of critical importance for normal central nervous system (CNS) function, as indicated by the marked behavioural disturbances produced by non-subtype selective NMDA antagonists such as dizocilpine (MK-801). |
| Links |
PubMed Online version:10.1007/s00213-004-1785-y |
| Keywords |
Animals; Dizocilpine Maleate/administration & dosage; Dizocilpine Maleate/pharmacology; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists/administration & dosage; Excitatory Amino Acid Antagonists/pharmacology; Genotype; Male; Mice; Mice, Knockout; Phenols/administration & dosage; Phenols/pharmacology; Piperidines/administration & dosage; Piperidines/pharmacology; Protein Subunits/antagonists & inhibitors; Protein Subunits/genetics; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors; Receptors, N-Methyl-D-Aspartate/genetics; Startle Reaction/drug effects; Startle Reaction/genetics |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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