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PMID:12754515
| Citation |
Miyamoto, H, Katagiri, H and Hensch, T (2003) Experience-dependent slow-wave sleep development. Nat. Neurosci. 6:553-4 |
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| Abstract |
Sleep enhances plasticity in neocortex, and thereby improves sensory learning. Here we show that sleep itself undergoes changes as a consequence of waking experience during a late critical period in cats and mice. Dark-rearing produced a robust and reversible decrement of slow-wave electrical activity during sleep that was restricted to visual cortex and impaired by gene-targeted reduction of NMDA receptor function. |
| Links |
PubMed Online version:10.1038/nn1064 |
| Keywords |
Aging/genetics; Animals; Cats; Dark Adaptation/genetics; Mice; Mice, Knockout; Neuronal Plasticity/genetics; Receptors, N-Methyl-D-Aspartate/deficiency; Receptors, N-Methyl-D-Aspartate/genetics; Sensation/genetics; Sensory Deprivation/physiology; Sleep/genetics; Synaptic Transmission/genetics; Thalamus/growth & development; Thalamus/physiology; Visual Cortex/growth & development; Visual Cortex/physiology; Visual Pathways/growth & development; Visual Pathways/physiology; Wakefulness/genetics |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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