MOUSE:CAC1A

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Cacna1a (synonyms: Caca1a, Cach4, Cacn3, Cacnl1a4, Ccha1a)
Protein Name(s)	Voltage-dependent P/Q-type calcium channel subunit alpha-1A Brain calcium channel I BI Calcium channel, L type, alpha-1 polypeptide isoform 4 Voltage-gated calcium channel subunit alpha Cav2.1
External Links
UniProt	P97445
EMBL	AY714490 U76716
CCDS	CCDS52618.1
RefSeq	NP_031604.3
UniGene	Mm.334658
ProteinModelPortal	P97445
SMR	P97445
BioGrid	198430
IntAct	P97445
MINT	MINT-4997013
PhosphoSite	P97445
MaxQB	P97445
PaxDb	P97445
PRIDE	P97445
Ensembl	ENSMUST00000121390
GeneID	12286
KEGG	mmu:12286
UCSC	uc009mmn.2
CTD	773
MGI	MGI:109482
eggNOG	COG1226
GeneTree	ENSGT00760000118827
HOGENOM	HOG000231530
HOVERGEN	HBG050763
InParanoid	P97445
KO	K04344
OMA	QPGFWEG
OrthoDB	EOG7T1RBQ
PhylomeDB	P97445
TreeFam	TF312805
Reactome	REACT_225645 REACT_263148
ChiTaRS	Cacna1a
NextBio	280756
PRO	PR:P97445
Proteomes	UP000000589
Bgee	P97445
ExpressionAtlas	P97445
Genevestigator	P97445
GO	GO:0005737 GO:0030425 GO:0043025 GO:0005634 GO:0005891 GO:0003677 GO:0008331 GO:0046872 GO:0005245 GO:0007628 GO:0048266 GO:0070509 GO:0006816 GO:0017156 GO:0048791 GO:0008219 GO:0016049 GO:0030644 GO:0021953 GO:0021679 GO:0021702 GO:0021680 GO:0021590 GO:0048813 GO:0014051 GO:0007214 GO:0006006 GO:0042445 GO:0051899 GO:0086010 GO:0050883 GO:0032353 GO:0043524 GO:0050877 GO:0050905 GO:0050885 GO:0007274 GO:0007270 GO:0042133 GO:0007204 GO:0043113 GO:0014056 GO:0050770 GO:0017158 GO:0042391 GO:0048265 GO:0060024 GO:0021522 GO:0000096 GO:0007416 GO:0007268 GO:0035249 GO:0019226 GO:0021750
Gene3D	1.20.120.350
InterPro	IPR017956 IPR027359 IPR005821 IPR014873 IPR005448 IPR002077
PANTHER	PTHR10037:SF59
Pfam	PF08763 PF00520
PRINTS	PR00167 PR01632
SMART	SM00384 SM01062

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0008331	high voltage-gated calcium channel activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O00555	F		Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O00555	P		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O00555	P		Seeded From UniProt	complete
enables	GO:0005245	voltage-gated calcium channel activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O00555	F		Seeded From UniProt	complete
enables	GO:0099626	voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	PMID:25741235^[1]	ECO:0006013	patch-clamp recording evidence used in manual assertion		F	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0000956)	Seeded From UniProt	complete
enables	GO:0099626	voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	PMID:25741235^[1]	ECO:0001225	knockout evidence used in manual assertion		F	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0000956)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:25741235^[1]	ECO:0006013	patch-clamp recording evidence used in manual assertion		C	part_of:(UBERON:0000061) part_of:(UBERON:0000956)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:25741235^[1]	ECO:0001225	knockout evidence used in manual assertion		C	part_of:(UBERON:0000061) part_of:(UBERON:0000956)	Seeded From UniProt	complete
involved_in	GO:0070509	calcium ion import	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001295314 RGD:2244 RGD:2245 RGD:2246 RGD:628852 RGD:70973 UniProtKB:Q01668	P		Seeded From UniProt	complete
involved_in	GO:0007268	chemical synaptic transmission	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0263111 MGI:MGI:109482 PANTHER:PTN000004141 RGD:2244	P		Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0263111 MGI:MGI:103013 MGI:MGI:106217 MGI:MGI:109482 MGI:MGI:88294 MGI:MGI:88296 PANTHER:PTN001295293 RGD:2244 RGD:2245 RGD:628852 RGD:70973 RGD:70983 SGD:S000003449 UniProtKB:Q01668 UniProtKB:Q13698 ZFIN:ZDB-GENE-020129-1	P		Seeded From UniProt	complete
enables	GO:0005245	voltage-gated calcium channel activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001991 FB:FBgn0263111 MGI:MGI:103013 MGI:MGI:106217 MGI:MGI:109482 MGI:MGI:1859639 MGI:MGI:88294 MGI:MGI:88296 PANTHER:PTN001295314 RGD:2244 RGD:2245 RGD:2246 RGD:628852 RGD:70973 UniProtKB:O00555 UniProtKB:O60840 UniProtKB:Q01668 UniProtKB:Q13698 UniProtKB:Q13936 UniProtKB:Q15878 WB:WBGene00001187	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904646	cellular response to amyloid-beta	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00555	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904645	response to amyloid-beta	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00555	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901385	regulation of voltage-gated calcium channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2244	P		Seeded From UniProt	complete
part_of	GO:0099059	integral component of presynaptic active zone membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2244	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070588	calcium ion transmembrane transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00555	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070509	calcium ion import	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2244	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060024	rhythmic synaptic transmission	PMID:16474392^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856210	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051899	membrane depolarization	PMID:8158221^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856209	P	occurs_in:(EMAPA:32770) occurs_in:(CL:0000598)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051899	membrane depolarization	PMID:11718712^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856210	P	occurs_in:(EMAPA:16668) occurs_in:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051899	membrane depolarization	PMID:10908603^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856211	P	occurs_in:(EMAPA:17787) occurs_in:(CL:0000121)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050905	neuromuscular process	PMID:10630211^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2159437	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050905	neuromuscular process	PMID:11344116^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180190	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050885	neuromuscular process controlling balance	PMID:4799944^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856211	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050883	musculoskeletal movement, spinal reflex action	PMID:11718712^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856210	P	has_participant:(EMAPA:16668)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050877	nervous system process	PMID:6462226^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856209	P	has_participant:(EMAPA:17787)\|has_participant:(EMAPA:32678)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050877	nervous system process	PMID:1486501^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856211	P	has_participant:(EMAPA:32673)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050804	modulation of chemical synaptic transmission	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00555	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050770	regulation of axonogenesis	PMID:572084^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856209	P	regulates_o_occurs_in:(EMAPA:35502) regulates_o_occurs_in:(CL:0000459)\|regulates_o_occurs_in:(EMAPA:35502) regulates_o_occurs_in:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048813	dendrite morphogenesis	PMID:14973254^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2181384	P	occurs_in:(EMAPA:17787) occurs_in:(CL:0000121)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048813	dendrite morphogenesis	PMID:11160387^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154404	P	occurs_in:(EMAPA:17787) occurs_in:(CL:0000121)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048813	dendrite morphogenesis	PMID:10336181^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856211	P	occurs_in:(EMAPA:17787) occurs_in:(CL:0000121)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter	PMID:10670432^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856209	P	occurs_in:(EMAPA:17544) occurs_in:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048266	behavioral response to pain	PMID:16890369^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180190	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048265	response to pain	PMID:11718712^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856210	P	has_participant:(EMAPA:16668)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043524	negative regulation of neuron apoptotic process	PMID:8929530^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856209	P	occurs_in:(EMAPA:35223) regulates_o_occurs_in:(CL:0000121)\|occurs_in(EMAPA:35219) regulates_o_occurs_in:(CL:0000120)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043524	negative regulation of neuron apoptotic process	PMID:4941467^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856209 MGI:MGI:1856210	P	occurs_in:(EMAPA:35223) regulates_o_occurs_in:(CL:0000121)	Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2244	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043113	receptor clustering	PMID:12624181^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2181384	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:15451373^[21]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:35794) part_of:(CL:0000100)	Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2244	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00555	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042593	glucose homeostasis	PMID:8957685^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856211	P	has_participant:(EMAPA:16896)\|has_participant:(EMAPA:35297)\|has_participant:(EMAPA:35478)\|has_participant:(EMAPA:32869)\|has_participant:(EMAPA:32678)\|has_participant:(EMAPA:35835)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042391	regulation of membrane potential	PMID:9857013^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856209 MGI:MGI:1856210	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042391	regulation of membrane potential	PMID:9614225^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856210	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042391	regulation of membrane potential	PMID:1572065^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856209	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042391	regulation of membrane potential	PMID:1355109^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856209	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042391	regulation of membrane potential	PMID:12401561^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2181384	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042391	regulation of membrane potential	PMID:12151514^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856209	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042391	regulation of membrane potential	PMID:10670432^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856209	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035249	synaptic transmission, glutamatergic	PMID:14973254^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2181384	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035249	synaptic transmission, glutamatergic	PMID:10322048^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856209	P	occurs_in:(EMAPA:17540)	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2244	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032353	negative regulation of hormone biosynthetic process	PMID:11182254^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856211	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031335	regulation of sulfur amino acid metabolic process	PMID:1485534^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856211	P	occurs_in:(EMAPA:17787)\|occurs_in:(EMAPA:18207)\|occurs_in:(EMAPA:32845)\|occurs_in:(EMAPA:17544)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030644	cellular chloride ion homeostasis	PMID:8565963^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856209	P	occurs_in:(EMAPA:16894)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030644	cellular chloride ion homeostasis	PMID:10899223^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856210	P	occurs_in:(EMAPA:17787) occurs_in:(CL:0000121)	Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:15451373^[21]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:35794) part_of:(CL:0000100)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021953	central nervous system neuron differentiation	PMID:6945603^[34]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856209	P	occurs_in:(EMAPA:35502) results_in_acquisition_of_features_of:(CL:0000459)\|occurs_in(EMAPA:35502) results_in_acquisition_of_features_of:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021750	vestibular nucleus development	PMID:8719615^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856210	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021702	cerebellar Purkinje cell differentiation	PMID:7834360^[36]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856210	P	occurs_in:(EMAPA:35223) results_in_acquisition_of_features_of:(CL:0000121)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021702	cerebellar Purkinje cell differentiation	PMID:1306163^[37]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856209 MGI:MGI:1856210	P	occurs_in:(EMAPA:35223) results_in_acquisition_of_features_of:(CL:0000121)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021702	cerebellar Purkinje cell differentiation	PMID:10630211^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856209	P	occurs_in:(EMAPA:17787) results_in_acquisition_of_features_of:(CL:0000121)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021680	cerebellar Purkinje cell layer development	PMID:1306163^[37]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856209 MGI:MGI:1856210	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021679	cerebellar molecular layer development	PMID:7697385^[38]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856209 MGI:MGI:1856210	P	results_in_development_of:(EMAPA:35221)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021590	cerebellum maturation	PMID:11344116^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180190	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021522	spinal cord motor neuron differentiation	PMID:17156092^[39]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856209 MGI:MGI:1856211	P	occurs_in:(EMAPA:17577) results_in_acquisition_of_features_of:(CL:0000100)	Seeded From UniProt	complete
enables	GO:0019905	syntaxin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00555	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019233	sensory perception of pain	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2244	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019226	transmission of nerve impulse	PMID:1572065^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856209	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019226	transmission of nerve impulse	PMID:1469420^[40]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856211	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019226	transmission of nerve impulse	PMID:1355109^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856209	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0017158	regulation of calcium ion-dependent exocytosis	PMID:8632762^[41]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000336)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0017156	calcium ion regulated exocytosis	PMID:12065603^[42]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2181384	P	occurs_in:(CL:0000166)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014056	regulation of acetylcholine secretion, neurotransmission	PMID:12624181^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2181384	P	regulates_o_occurs_in:(EMAPA:17701) regulates_o_occurs_in:(CL:0000100)\|regulates_o_occurs_in:(EMAPA:17813) regulates_o_occurs_in:(CL:0000100)\|regulates_o_occurs_in:(EMAPA:36627) regulates_o_occurs_in:(CL:0000100)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014056	regulation of acetylcholine secretion, neurotransmission	PMID:10686170^[43]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856209	P	regulates_o_occurs_in:(EMAPA:17813) regulates_o_occurs_in:(CL:0000100)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014051	gamma-aminobutyric acid secretion	PMID:10670432^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856209	P	occurs_in:(EMAPA:17544) occurs_in:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010817	regulation of hormone levels	PMID:8957685^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856211	P	occurs_in:(EMAPA:17787) has_input:(MGI:MGI:98823)\|occurs_in(EMAPA:32678) has_input:(MGI:MGI:98823)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010817	regulation of hormone levels	PMID:8229069^[44]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856211	P	occurs_in:(EMAPA:17577) has_input:(MGI:MGI:98823)	Seeded From UniProt	complete
enables	GO:0008331	high voltage-gated calcium channel activity	PMID:11756409^[45]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:102522	F		Seeded From UniProt	complete
enables	GO:0008331	high voltage-gated calcium channel activity	PMID:9742139^[46]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856210	F	occurs_in:(EMAPA:17787) occurs_in:(CL:0000121)	Seeded From UniProt	complete
enables	GO:0008331	high voltage-gated calcium channel activity	PMID:15548652^[47]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2181384	F	occurs_in:(EMAPA:35840)	Seeded From UniProt	complete
enables	GO:0008331	high voltage-gated calcium channel activity	PMID:12624181^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2181384	F	occurs_in:(EMAPA:17701) occurs_in:(CL:0000100)\|occurs_in:(EMAPA:17813) occurs_in:(CL:0000100)\|occurs_in:(EMAPA:36627) occurs_in:(CL:0000100)	Seeded From UniProt	complete
enables	GO:0008331	high voltage-gated calcium channel activity	PMID:12401561^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2181384	F	occurs_in:(EMAPA:35211) occurs_in:(CL:0000121)	Seeded From UniProt	complete
enables	GO:0008331	high voltage-gated calcium channel activity	PMID:12065603^[42]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2181384	F	occurs_in:(CL:0000166)	Seeded From UniProt	complete
enables	GO:0008331	high voltage-gated calcium channel activity	PMID:12040045^[48]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856209 MGI:MGI:1856211	F	occurs_in:(EMAPA:35211) occurs_in:(CL:0000121)	Seeded From UniProt	complete
enables	GO:0008331	high voltage-gated calcium channel activity	PMID:11718712^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856210	F	occurs_in:(EMAPA:16668) occurs_in:(CL:0000540)	Seeded From UniProt	complete
enables	GO:0008331	high voltage-gated calcium channel activity	PMID:11344116^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180190	F	occurs_in:(EMAPA:17787) occurs_in:(CL:0000120)	Seeded From UniProt	complete
enables	GO:0008331	high voltage-gated calcium channel activity	PMID:10908603^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856211	F	occurs_in:(EMAPA:17787) occurs_in:(CL:0000121)	Seeded From UniProt	complete
enables	GO:0008331	high voltage-gated calcium channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00555	F		Seeded From UniProt	complete
enables	GO:0008331	high voltage-gated calcium channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2244	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008219	cell death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00555	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007628	adult walking behavior	PMID:9882694^[49]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:103013	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007628	adult walking behavior	PMID:8719807^[50]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98823	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007628	adult walking behavior	PMID:8719807^[50]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856211	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007628	adult walking behavior	PMID:4941467^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856209 MGI:MGI:1856210	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007628	adult walking behavior	PMID:4799944^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856211	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007628	adult walking behavior	PMID:16890369^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180190	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007628	adult walking behavior	PMID:13950100^[51]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856209	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007628	adult walking behavior	PMID:12401561^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2181384	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007628	adult walking behavior	PMID:11344116^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180190	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007628	adult walking behavior	PMID:11160387^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154404	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007628	adult walking behavior	PMID:10611370^[52]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2181384	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007416	synapse assembly	PMID:14973254^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2181384	P	occurs_in:(EMAPA:17787) occurs_in:(CL:0000121)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007416	synapse assembly	PMID:10336181^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856211	P	occurs_in:(EMAPA:17787) occurs_in:(CL:0000121)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007274	neuromuscular synaptic transmission	PMID:10686170^[43]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856209	P	occurs_in:(EMAPA:17813)\|occurs_in:(EMAPA:17701)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007270	neuron-neuron synaptic transmission	PMID:16540584^[53]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856209	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007268	chemical synaptic transmission	PMID:15548652^[47]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2181384	P	occurs_in:(EMAPA:35600)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007268	chemical synaptic transmission	PMID:12040045^[48]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856209 MGI:MGI:1856211	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007268	chemical synaptic transmission	PMID:10611370^[52]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2181384	P	occurs_in:(EMAPA:32768)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007268	chemical synaptic transmission	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2244	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007214	gamma-aminobutyric acid signaling pathway	PMID:8565963^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856209	P	occurs_in:(EMAPA:16894)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007204	positive regulation of cytosolic calcium ion concentration	PMID:8632762^[41]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000336)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00555	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006816	calcium ion transport	PMID:9857013^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856209 MGI:MGI:1856210	P	occurs_in:(EMAPA:17787) occurs_in:(CL:0000121)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006816	calcium ion transport	PMID:9614225^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856210	P	occurs_in:(EMAPA:17787) occurs_in:(CL:0000121)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006816	calcium ion transport	PMID:12827191^[54]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006816	calcium ion transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2244	P		Seeded From UniProt	complete
part_of	GO:0005891	voltage-gated calcium channel complex	PMID:10328888^[55]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005891	voltage-gated calcium channel complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2244	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00555	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2244	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00555	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00555	C		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2244	F		Seeded From UniProt	complete
enables	GO:0005245	voltage-gated calcium channel activity	PMID:9857013^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856209 MGI:MGI:1856210	F	occurs_in:(EMAPA:17787) occurs_in:(CL:0000121)	Seeded From UniProt	complete
enables	GO:0005245	voltage-gated calcium channel activity	PMID:9614225^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856210	F	occurs_in:(EMAPA:17787) occurs_in:(CL:0000121)	Seeded From UniProt	complete
enables	GO:0005245	voltage-gated calcium channel activity	PMID:12827191^[54]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005245	voltage-gated calcium channel activity	PMID:12151514^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856209	F	occurs_in:(EMAPA:17540) occurs_in:(CL:0000117)	Seeded From UniProt	complete
enables	GO:0005245	voltage-gated calcium channel activity	PMID:10611370^[52]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2181384	F	occurs_in:(EMAPA:17787) occurs_in:(CL:0000121)\|occurs_in:(EMAPA:17787) occurs_in:(CL:0000120)	Seeded From UniProt	complete
enables	GO:0005245	voltage-gated calcium channel activity	PMID:8632762^[41]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000336)	Seeded From UniProt	complete
enables	GO:0005245	voltage-gated calcium channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00555	F		Seeded From UniProt	complete
enables	GO:0005245	voltage-gated calcium channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2244	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001505	regulation of neurotransmitter levels	PMID:8100981^[56]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856211	P	occurs_in:(EMAPA:17787) has_participant:(MGI:MGI:88297)\|occurs_in(EMAPA:17787) has_participant:(MGI:MGI:98326)\|occurs_in(EMAPA:16910) has_participant:(MGI:MGI:88297)\|occurs_in(EMAPA:16910) has_participant:(MGI:MGI:98326)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001505	regulation of neurotransmitter levels	PMID:6167317^[57]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856211	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001505	regulation of neurotransmitter levels	PMID:1686215^[58]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856209	P	occurs_in:(EMAPA:17544) has_participant:(MGI:MGI:104629)\|occurs_in(EMAPA:17549) has_participant:(MGI:MGI:104629)\|occurs_in(EMAPA:17563) has_participant:(MGI:MGI:104629)\|occurs_in(EMAPA:17550) has_participant:(MGI:MGI:104629)	Seeded From UniProt	complete
involved_in	GO:0099509	regulation of presynaptic cytosolic calcium ion concentration	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0099626	P		Seeded From UniProt	complete
involved_in	GO:0099509	regulation of presynaptic cytosolic calcium ion concentration	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0099626	P		Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	F		Seeded From UniProt	complete
enables	GO:0005245	voltage-gated calcium channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002077 InterPro:IPR005448	F		Seeded From UniProt	complete
part_of	GO:0005891	voltage-gated calcium channel complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002077 InterPro:IPR005448	C		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	C		Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	P		Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002077 InterPro:IPR005448	P		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0107	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0034765	regulation of ion transmembrane transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0851	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0109	P		Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0107	P		Seeded From UniProt	complete
enables	GO:0005244	voltage-gated ion channel activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0851	F		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Vecchia, D et al. (2015) Abnormal cortical synaptic transmission in CaV2.1 knockin mice with the S218L missense mutation which causes a severe familial hemiplegic migraine syndrome in humans. Front Cell Neurosci 9 8 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Walter, JT et al. (2006) Decreases in the precision of Purkinje cell pacemaking cause cerebellar dysfunction and ataxia. Nat. Neurosci. 9 389-97 PubMed GONUTS page
↑ Helekar, SA & Noebels, JL (1994) Analysis of voltage-gated and synaptic conductances contributing to network excitability defects in the mutant mouse tottering. J. Neurophysiol. 71 1-10 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Ogasawara, M et al. (2001) Characterization of acute somatosensory pain transmission in P/Q-type Ca(2+) channel mutant mice, leaner. FEBS Lett. 508 181-6 PubMed GONUTS page
↑ ^6.0 ^6.1 Mori, Y et al. (2000) Reduced voltage sensitivity of activation of P/Q-type Ca2+ channels is associated with the ataxic mouse mutation rolling Nagoya (tg(rol)). J. Neurosci. 20 5654-62 PubMed GONUTS page
↑ ^7.0 ^7.1 Campbell, DB et al. (1999) Tottering mouse motor dysfunction is abolished on the Purkinje cell degeneration (pcd) mutant background. Exp. Neurol. 160 268-78 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Fletcher, CF et al. (2001) Dystonia and cerebellar atrophy in Cacna1a null mice lacking P/Q calcium channel activity. FASEB J. 15 1288-90 PubMed GONUTS page
↑ ^9.0 ^9.1 Oda, S (1973) [The observation of rolling mouse Nagoya (rol), a new neurological mutant, and its maintenance (author's transl)]. Jikken Dobutsu 22 281-8 PubMed GONUTS page
↑ Noebels, JL () A single gene error of noradrenergic axon growth synchronizes central neurones. Nature 310 409-11 PubMed GONUTS page
↑ Yamaguchi, T et al. (1992) Rolling mouse Nagoya as a mutant animal model of basal ganglia dysfunction: determination of absolute rates of local cerebral glucose utilization. Brain Res. 598 38-44 PubMed GONUTS page
↑ Noebels, JL & Sidman, RL (1979) Inherited epilepsy: spike-wave and focal motor seizures in the mutant mouse tottering. Science 204 1334-6 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Miyazaki, T et al. (2004) P/Q-type Ca2+ channel alpha1A regulates synaptic competition on developing cerebellar Purkinje cells. J. Neurosci. 24 1734-43 PubMed GONUTS page
↑ ^14.0 ^14.1 Zwingman, TA et al. (2001) Rocker is a new variant of the voltage-dependent calcium channel gene Cacna1a. J. Neurosci. 21 1169-78 PubMed GONUTS page
↑ ^15.0 ^15.1 Rhyu, IJ et al. (1999) Morphologic investigation of rolling mouse Nagoya (tg(rol)/tg(rol)) cerebellar Purkinje cells: an ataxic mutant, revisited. Neurosci. Lett. 266 49-52 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Ayata, C et al. (2000) Impaired neurotransmitter release and elevated threshold for cortical spreading depression in mice with mutations in the alpha1A subunit of P/Q type calcium channels. Neuroscience 95 639-45 PubMed GONUTS page
↑ ^17.0 ^17.1 Luvisetto, S et al. (2006) Pain sensitivity in mice lacking the Ca(v)2.1alpha1 subunit of P/Q-type Ca2+ channels. Neuroscience 142 823-32 PubMed GONUTS page
↑ Fletcher, CF et al. (1996) Absence epilepsy in tottering mutant mice is associated with calcium channel defects. Cell 87 607-17 PubMed GONUTS page
↑ ^19.0 ^19.1 Meier, H & MacPike, AD () Three syndromes produced by two mutant genes in the mouse. Clinical, pathological, and ultrastructural bases of tottering, leaner, and heterozygous mice. J. Hered. 62 297-302 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 Urbano, FJ et al. (2003) Altered properties of quantal neurotransmitter release at endplates of mice lacking P/Q-type Ca2+ channels. Proc. Natl. Acad. Sci. U.S.A. 100 3491-6 PubMed GONUTS page
↑ ^21.0 ^21.1 Murakami, M et al. (2004) Antinociceptive effect of different types of calcium channel inhibitors and the distribution of various calcium channel alpha 1 subunits in the dorsal horn of spinal cord in mice. Brain Res. 1024 122-9 PubMed GONUTS page
↑ ^22.0 ^22.1 Nakayama, T & Nagai, Y (1996) Alterations in local cerebral glucose metabolism and endogenous thyrotropin-releasing hormone levels in rolling mouse Nagoya and effect of thyrotropin-releasing hormone tartrate. Jpn. J. Pharmacol. 72 241-6 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 Wakamori, M et al. (1998) Single tottering mutations responsible for the neuropathic phenotype of the P-type calcium channel. J. Biol. Chem. 273 34857-67 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 Lorenzon, NM et al. (1998) Altered calcium channel currents in Purkinje cells of the neurological mutant mouse leaner. J. Neurosci. 18 4482-9 PubMed GONUTS page
↑ ^25.0 ^25.1 Helekar, SA & Noebels, JL (1992) A burst-dependent hippocampal excitability defect elicited by potassium at the developmental onset of spike-wave seizures in the Tottering mutant. Brain Res. Dev. Brain Res. 65 205-10 PubMed GONUTS page
↑ ^26.0 ^26.1 Kostopoulos, GK & Psarropoulou, CT (1992) Possible mechanisms underlying hyperexcitability in the epileptic mutant mouse tottering. J. Neural Transm. Suppl. 35 109-24 PubMed GONUTS page
↑ ^27.0 ^27.1 ^27.2 Cavelier, P et al. (2002) Cerebellar slice cultures from mice lacking the P/Q calcium channel: electroresponsiveness of Purkinje cells. Neurosci. Lett. 333 64-8 PubMed GONUTS page
↑ ^28.0 ^28.1 Zhang, Y et al. (2002) Mutations in high-voltage-activated calcium channel genes stimulate low-voltage-activated currents in mouse thalamic relay neurons. J. Neurosci. 22 6362-71 PubMed GONUTS page
↑ Caddick, SJ et al. (1999) Excitatory but not inhibitory synaptic transmission is reduced in lethargic (Cacnb4(lh)) and tottering (Cacna1atg) mouse thalami. J. Neurophysiol. 81 2066-74 PubMed GONUTS page
↑ Sawada, K et al. (2001) Topological relationship between corticotropin-releasing factor-immunoreactive cerebellar afferents and tyrosine hydroxylase-immunoreactive Purkinje cells in a hereditary ataxic mutant, rolling mouse Nagoya. Neuroscience 102 925-35 PubMed GONUTS page
↑ Myojin, K et al. (1992) Sulfur amino acid levels and related enzyme activities in various brain regions (and other tissues) in normal mice and rolling mice Nagoya. Acta Med. Okayama 46 401-5 PubMed GONUTS page
↑ ^32.0 ^32.1 Tehrani, MH & Barnes, EM Jr (1995) Reduced function of gamma-aminobutyric acidA receptors in tottering mouse brain: role of cAMP-dependent protein kinase. Epilepsy Res. 22 13-21 PubMed GONUTS page
↑ Dove, LS et al. (2000) Altered calcium homeostasis in cerebellar Purkinje cells of leaner mutant mice. J. Neurophysiol. 84 513-24 PubMed GONUTS page
↑ Levitt, P & Noebels, JL (1981) Mutant mouse tottering: selective increase of locus ceruleus axons in a defined single-locus mutation. Proc. Natl. Acad. Sci. U.S.A. 78 4630-4 PubMed GONUTS page
↑ Grüsser-Cornehls, U et al. (1995) Electrophysiology and GABA-immunocytochemistry in the vestibular nuclei of normal (C57BL/6J) and Leaner mutant mice. Brain Res. 703 51-62 PubMed GONUTS page
↑ Heckroth, JA & Abbott, LC (1994) Purkinje cell loss from alternating sagittal zones in the cerebellum of leaner mutant mice. Brain Res. 658 93-104 PubMed GONUTS page
↑ ^37.0 ^37.1 Isaacs, KR & Abbott, LC (1992) Development of the paramedian lobule of the cerebellum in wild-type and tottering mice. Dev. Neurosci. 14 386-93 PubMed GONUTS page
↑ Isaacs, KR & Abbott, LC (1995) Cerebellar volume decreases in the tottering mouse are specific to the molecular layer. Brain Res. Bull. 36 309-14 PubMed GONUTS page
↑ Koyanagi, Y et al. (2006) Increased serotonergic innervation of lumbosacral motoneurons of rolling mouse Nagoya in correlation with abnormal hindlimb extension. Anat Histol Embryol 35 387-92 PubMed GONUTS page
↑ Tomoda, H et al. (1992) Striatal dysfunction in Rolling mouse Nagoya: an electrophysiological study. J. Neurol. Sci. 112 106-12 PubMed GONUTS page
↑ ^41.0 ^41.1 ^41.2 Wick, PF et al. (1996) Effects of expression of a mouse brain L-type calcium channel alpha 1 subunit on secretion from bovine adrenal chromaffin cells. Mol. Pharmacol. 49 295-302 PubMed GONUTS page
↑ ^42.0 ^42.1 Aldea, M et al. (2002) A perforated patch-clamp study of calcium currents and exocytosis in chromaffin cells of wild-type and alpha(1A) knockout mice. J. Neurochem. 81 911-21 PubMed GONUTS page
↑ ^43.0 ^43.1 Plomp, JJ et al. (2000) Abnormal transmitter release at neuromuscular junctions of mice carrying the tottering alpha(1A) Ca(2+) channel mutation. Brain 123 Pt 3 463-71 PubMed GONUTS page
↑ Endo, S et al. (1993) Serotonergic regulation of the spinal cord content of thyrotropin releasing hormone in the cerebellar ataxia mutant mouse. J. Neurol. Sci. 118 194-201 PubMed GONUTS page
↑ Tsunemi, T et al. (2002) Novel Cav2.1 splice variants isolated from Purkinje cells do not generate P-type Ca2+ current. J. Biol. Chem. 277 7214-21 PubMed GONUTS page
↑ Dove, LS et al. (1998) Whole-cell and single-channel analysis of P-type calcium currents in cerebellar Purkinje cells of leaner mutant mice. J. Neurosci. 18 7687-99 PubMed GONUTS page
↑ ^47.0 ^47.1 Inchauspe, CG et al. (2004) Functional compensation of P/Q by N-type channels blocks short-term plasticity at the calyx of Held presynaptic terminal. J. Neurosci. 24 10379-83 PubMed GONUTS page
↑ ^48.0 ^48.1 Matsushita, K et al. (2002) Bidirectional alterations in cerebellar synaptic transmission of tottering and rolling Ca2+ channel mutant mice. J. Neurosci. 22 4388-98 PubMed GONUTS page
↑ Campbell, DB & Hess, EJ (1999) L-type calcium channels contribute to the tottering mouse dystonic episodes. Mol. Pharmacol. 55 23-31 PubMed GONUTS page
↑ ^50.0 ^50.1 Kinoshita, K et al. (1995) Anti-ataxic effects of TRH and its analogue, TA-0910, in Rolling mouse Nagoya by metabolic normalization of the ventral tegmental area. Br. J. Pharmacol. 116 3274-8 PubMed GONUTS page
↑ GREEN, MC & SIDMAN, RL () Tottering--a neuromusclar mutation in the mouse. And its linkage with oligosyndacylism. J. Hered. 53 233-7 PubMed GONUTS page
↑ ^52.0 ^52.1 ^52.2 Jun, K et al. (1999) Ablation of P/Q-type Ca(2+) channel currents, altered synaptic transmission, and progressive ataxia in mice lacking the alpha(1A)-subunit. Proc. Natl. Acad. Sci. U.S.A. 96 15245-50 PubMed GONUTS page
↑ Sasaki, S et al. (2006) Impaired feedforward inhibition of the thalamocortical projection in epileptic Ca2+ channel mutant mice, tottering. J. Neurosci. 26 3056-65 PubMed GONUTS page
↑ ^54.0 ^54.1 Missler, M et al. (2003) Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis. Nature 423 939-48 PubMed GONUTS page
↑ Burgess, DL et al. (1999) beta subunit reshuffling modifies N- and P/Q-type Ca2+ channel subunit compositions in lethargic mouse brain. Mol. Cell. Neurosci. 13 293-311 PubMed GONUTS page
↑ Matsui, K et al. (1993) Levels of somatostatin and cholecystokinin in the brain of ataxic mutant mice. Life Sci. 53 333-40 PubMed GONUTS page
↑ Muramoto, O et al. (1981) Neurotransmitter abnormality in Rolling mouse Nagoya, an ataxic mutant mouse. Brain Res. 215 295-304 PubMed GONUTS page
↑ Patel, VK et al. (1991) Increased methionine-enkephalin levels in genetically epileptic (tg/tg) mice. Brain Res. Bull. 27 849-52 PubMed GONUTS page

[PMID:25741235-1] 1.0 ^1.1 ^1.2 ^1.3 Vecchia, D et al. (2015) Abnormal cortical synaptic transmission in CaV2.1 knockin mice with the S218L missense mutation which causes a severe familial hemiplegic migraine syndrome in humans. Front Cell Neurosci 9 8 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:16474392-3] Walter, JT et al. (2006) Decreases in the precision of Purkinje cell pacemaking cause cerebellar dysfunction and ataxia. Nat. Neurosci. 9 389-97 PubMed GONUTS page

[PMID:8158221-4] Helekar, SA & Noebels, JL (1994) Analysis of voltage-gated and synaptic conductances contributing to network excitability defects in the mutant mouse tottering. J. Neurophysiol. 71 1-10 PubMed GONUTS page

[PMID:11718712-5] 5.0 ^5.1 ^5.2 ^5.3 Ogasawara, M et al. (2001) Characterization of acute somatosensory pain transmission in P/Q-type Ca(2+) channel mutant mice, leaner. FEBS Lett. 508 181-6 PubMed GONUTS page

[PMID:10908603-6] 6.0 ^6.1 Mori, Y et al. (2000) Reduced voltage sensitivity of activation of P/Q-type Ca2+ channels is associated with the ataxic mouse mutation rolling Nagoya (tg(rol)). J. Neurosci. 20 5654-62 PubMed GONUTS page

[PMID:10630211-7] 7.0 ^7.1 Campbell, DB et al. (1999) Tottering mouse motor dysfunction is abolished on the Purkinje cell degeneration (pcd) mutant background. Exp. Neurol. 160 268-78 PubMed GONUTS page

[PMID:11344116-8] 8.0 ^8.1 ^8.2 ^8.3 Fletcher, CF et al. (2001) Dystonia and cerebellar atrophy in Cacna1a null mice lacking P/Q calcium channel activity. FASEB J. 15 1288-90 PubMed GONUTS page

[PMID:4799944-9] 9.0 ^9.1 Oda, S (1973) [The observation of rolling mouse Nagoya (rol), a new neurological mutant, and its maintenance (author's transl)]. Jikken Dobutsu 22 281-8 PubMed GONUTS page

[PMID:6462226-10] Noebels, JL () A single gene error of noradrenergic axon growth synchronizes central neurones. Nature 310 409-11 PubMed GONUTS page

[PMID:1486501-11] Yamaguchi, T et al. (1992) Rolling mouse Nagoya as a mutant animal model of basal ganglia dysfunction: determination of absolute rates of local cerebral glucose utilization. Brain Res. 598 38-44 PubMed GONUTS page

[PMID:572084-12] Noebels, JL & Sidman, RL (1979) Inherited epilepsy: spike-wave and focal motor seizures in the mutant mouse tottering. Science 204 1334-6 PubMed GONUTS page

[PMID:14973254-13] 13.0 ^13.1 ^13.2 Miyazaki, T et al. (2004) P/Q-type Ca2+ channel alpha1A regulates synaptic competition on developing cerebellar Purkinje cells. J. Neurosci. 24 1734-43 PubMed GONUTS page

[PMID:11160387-14] 14.0 ^14.1 Zwingman, TA et al. (2001) Rocker is a new variant of the voltage-dependent calcium channel gene Cacna1a. J. Neurosci. 21 1169-78 PubMed GONUTS page

[PMID:10336181-15] 15.0 ^15.1 Rhyu, IJ et al. (1999) Morphologic investigation of rolling mouse Nagoya (tg(rol)/tg(rol)) cerebellar Purkinje cells: an ataxic mutant, revisited. Neurosci. Lett. 266 49-52 PubMed GONUTS page

[PMID:10670432-16] 16.0 ^16.1 ^16.2 Ayata, C et al. (2000) Impaired neurotransmitter release and elevated threshold for cortical spreading depression in mice with mutations in the alpha1A subunit of P/Q type calcium channels. Neuroscience 95 639-45 PubMed GONUTS page

[PMID:16890369-17] 17.0 ^17.1 Luvisetto, S et al. (2006) Pain sensitivity in mice lacking the Ca(v)2.1alpha1 subunit of P/Q-type Ca2+ channels. Neuroscience 142 823-32 PubMed GONUTS page

[PMID:8929530-18] Fletcher, CF et al. (1996) Absence epilepsy in tottering mutant mice is associated with calcium channel defects. Cell 87 607-17 PubMed GONUTS page

[PMID:4941467-19] 19.0 ^19.1 Meier, H & MacPike, AD () Three syndromes produced by two mutant genes in the mouse. Clinical, pathological, and ultrastructural bases of tottering, leaner, and heterozygous mice. J. Hered. 62 297-302 PubMed GONUTS page

[PMID:12624181-20] 20.0 ^20.1 ^20.2 Urbano, FJ et al. (2003) Altered properties of quantal neurotransmitter release at endplates of mice lacking P/Q-type Ca2+ channels. Proc. Natl. Acad. Sci. U.S.A. 100 3491-6 PubMed GONUTS page

[PMID:15451373-21] 21.0 ^21.1 Murakami, M et al. (2004) Antinociceptive effect of different types of calcium channel inhibitors and the distribution of various calcium channel alpha 1 subunits in the dorsal horn of spinal cord in mice. Brain Res. 1024 122-9 PubMed GONUTS page

[PMID:8957685-22] 22.0 ^22.1 Nakayama, T & Nagai, Y (1996) Alterations in local cerebral glucose metabolism and endogenous thyrotropin-releasing hormone levels in rolling mouse Nagoya and effect of thyrotropin-releasing hormone tartrate. Jpn. J. Pharmacol. 72 241-6 PubMed GONUTS page

[PMID:9857013-23] 23.0 ^23.1 ^23.2 Wakamori, M et al. (1998) Single tottering mutations responsible for the neuropathic phenotype of the P-type calcium channel. J. Biol. Chem. 273 34857-67 PubMed GONUTS page

[PMID:9614225-24] 24.0 ^24.1 ^24.2 Lorenzon, NM et al. (1998) Altered calcium channel currents in Purkinje cells of the neurological mutant mouse leaner. J. Neurosci. 18 4482-9 PubMed GONUTS page

[PMID:1572065-25] 25.0 ^25.1 Helekar, SA & Noebels, JL (1992) A burst-dependent hippocampal excitability defect elicited by potassium at the developmental onset of spike-wave seizures in the Tottering mutant. Brain Res. Dev. Brain Res. 65 205-10 PubMed GONUTS page

[PMID:1355109-26] 26.0 ^26.1 Kostopoulos, GK & Psarropoulou, CT (1992) Possible mechanisms underlying hyperexcitability in the epileptic mutant mouse tottering. J. Neural Transm. Suppl. 35 109-24 PubMed GONUTS page

[PMID:12401561-27] 27.0 ^27.1 ^27.2 Cavelier, P et al. (2002) Cerebellar slice cultures from mice lacking the P/Q calcium channel: electroresponsiveness of Purkinje cells. Neurosci. Lett. 333 64-8 PubMed GONUTS page

[PMID:12151514-28] 28.0 ^28.1 Zhang, Y et al. (2002) Mutations in high-voltage-activated calcium channel genes stimulate low-voltage-activated currents in mouse thalamic relay neurons. J. Neurosci. 22 6362-71 PubMed GONUTS page

[PMID:10322048-29] Caddick, SJ et al. (1999) Excitatory but not inhibitory synaptic transmission is reduced in lethargic (Cacnb4(lh)) and tottering (Cacna1atg) mouse thalami. J. Neurophysiol. 81 2066-74 PubMed GONUTS page

[PMID:11182254-30] Sawada, K et al. (2001) Topological relationship between corticotropin-releasing factor-immunoreactive cerebellar afferents and tyrosine hydroxylase-immunoreactive Purkinje cells in a hereditary ataxic mutant, rolling mouse Nagoya. Neuroscience 102 925-35 PubMed GONUTS page

[PMID:1485534-31] Myojin, K et al. (1992) Sulfur amino acid levels and related enzyme activities in various brain regions (and other tissues) in normal mice and rolling mice Nagoya. Acta Med. Okayama 46 401-5 PubMed GONUTS page

[PMID:8565963-32] 32.0 ^32.1 Tehrani, MH & Barnes, EM Jr (1995) Reduced function of gamma-aminobutyric acidA receptors in tottering mouse brain: role of cAMP-dependent protein kinase. Epilepsy Res. 22 13-21 PubMed GONUTS page

[PMID:10899223-33] Dove, LS et al. (2000) Altered calcium homeostasis in cerebellar Purkinje cells of leaner mutant mice. J. Neurophysiol. 84 513-24 PubMed GONUTS page

[PMID:6945603-34] Levitt, P & Noebels, JL (1981) Mutant mouse tottering: selective increase of locus ceruleus axons in a defined single-locus mutation. Proc. Natl. Acad. Sci. U.S.A. 78 4630-4 PubMed GONUTS page

[PMID:8719615-35] Grüsser-Cornehls, U et al. (1995) Electrophysiology and GABA-immunocytochemistry in the vestibular nuclei of normal (C57BL/6J) and Leaner mutant mice. Brain Res. 703 51-62 PubMed GONUTS page

[PMID:7834360-36] Heckroth, JA & Abbott, LC (1994) Purkinje cell loss from alternating sagittal zones in the cerebellum of leaner mutant mice. Brain Res. 658 93-104 PubMed GONUTS page

[PMID:1306163-37] 37.0 ^37.1 Isaacs, KR & Abbott, LC (1992) Development of the paramedian lobule of the cerebellum in wild-type and tottering mice. Dev. Neurosci. 14 386-93 PubMed GONUTS page

[PMID:7697385-38] Isaacs, KR & Abbott, LC (1995) Cerebellar volume decreases in the tottering mouse are specific to the molecular layer. Brain Res. Bull. 36 309-14 PubMed GONUTS page

[PMID:17156092-39] Koyanagi, Y et al. (2006) Increased serotonergic innervation of lumbosacral motoneurons of rolling mouse Nagoya in correlation with abnormal hindlimb extension. Anat Histol Embryol 35 387-92 PubMed GONUTS page

[PMID:1469420-40] Tomoda, H et al. (1992) Striatal dysfunction in Rolling mouse Nagoya: an electrophysiological study. J. Neurol. Sci. 112 106-12 PubMed GONUTS page

[PMID:8632762-41] 41.0 ^41.1 ^41.2 Wick, PF et al. (1996) Effects of expression of a mouse brain L-type calcium channel alpha 1 subunit on secretion from bovine adrenal chromaffin cells. Mol. Pharmacol. 49 295-302 PubMed GONUTS page

[PMID:12065603-42] 42.0 ^42.1 Aldea, M et al. (2002) A perforated patch-clamp study of calcium currents and exocytosis in chromaffin cells of wild-type and alpha(1A) knockout mice. J. Neurochem. 81 911-21 PubMed GONUTS page

[PMID:10686170-43] 43.0 ^43.1 Plomp, JJ et al. (2000) Abnormal transmitter release at neuromuscular junctions of mice carrying the tottering alpha(1A) Ca(2+) channel mutation. Brain 123 Pt 3 463-71 PubMed GONUTS page

[PMID:8229069-44] Endo, S et al. (1993) Serotonergic regulation of the spinal cord content of thyrotropin releasing hormone in the cerebellar ataxia mutant mouse. J. Neurol. Sci. 118 194-201 PubMed GONUTS page

[PMID:11756409-45] Tsunemi, T et al. (2002) Novel Cav2.1 splice variants isolated from Purkinje cells do not generate P-type Ca2+ current. J. Biol. Chem. 277 7214-21 PubMed GONUTS page

[PMID:9742139-46] Dove, LS et al. (1998) Whole-cell and single-channel analysis of P-type calcium currents in cerebellar Purkinje cells of leaner mutant mice. J. Neurosci. 18 7687-99 PubMed GONUTS page

[PMID:15548652-47] 47.0 ^47.1 Inchauspe, CG et al. (2004) Functional compensation of P/Q by N-type channels blocks short-term plasticity at the calyx of Held presynaptic terminal. J. Neurosci. 24 10379-83 PubMed GONUTS page

[PMID:12040045-48] 48.0 ^48.1 Matsushita, K et al. (2002) Bidirectional alterations in cerebellar synaptic transmission of tottering and rolling Ca2+ channel mutant mice. J. Neurosci. 22 4388-98 PubMed GONUTS page

[PMID:9882694-49] Campbell, DB & Hess, EJ (1999) L-type calcium channels contribute to the tottering mouse dystonic episodes. Mol. Pharmacol. 55 23-31 PubMed GONUTS page

[PMID:8719807-50] 50.0 ^50.1 Kinoshita, K et al. (1995) Anti-ataxic effects of TRH and its analogue, TA-0910, in Rolling mouse Nagoya by metabolic normalization of the ventral tegmental area. Br. J. Pharmacol. 116 3274-8 PubMed GONUTS page

[PMID:13950100-51] GREEN, MC & SIDMAN, RL () Tottering--a neuromusclar mutation in the mouse. And its linkage with oligosyndacylism. J. Hered. 53 233-7 PubMed GONUTS page

[PMID:10611370-52] 52.0 ^52.1 ^52.2 Jun, K et al. (1999) Ablation of P/Q-type Ca(2+) channel currents, altered synaptic transmission, and progressive ataxia in mice lacking the alpha(1A)-subunit. Proc. Natl. Acad. Sci. U.S.A. 96 15245-50 PubMed GONUTS page

[PMID:16540584-53] Sasaki, S et al. (2006) Impaired feedforward inhibition of the thalamocortical projection in epileptic Ca2+ channel mutant mice, tottering. J. Neurosci. 26 3056-65 PubMed GONUTS page

[PMID:12827191-54] 54.0 ^54.1 Missler, M et al. (2003) Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis. Nature 423 939-48 PubMed GONUTS page

[PMID:10328888-55] Burgess, DL et al. (1999) beta subunit reshuffling modifies N- and P/Q-type Ca2+ channel subunit compositions in lethargic mouse brain. Mol. Cell. Neurosci. 13 293-311 PubMed GONUTS page

[PMID:8100981-56] Matsui, K et al. (1993) Levels of somatostatin and cholecystokinin in the brain of ataxic mutant mice. Life Sci. 53 333-40 PubMed GONUTS page

[PMID:6167317-57] Muramoto, O et al. (1981) Neurotransmitter abnormality in Rolling mouse Nagoya, an ataxic mutant mouse. Brain Res. 215 295-304 PubMed GONUTS page

[PMID:1686215-58] Patel, VK et al. (1991) Increased methionine-enkephalin levels in genetically epileptic (tg/tg) mice. Brain Res. Bull. 27 849-52 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

[21]

[22]

[23]

[24]

[25]

[26]

[27]

[28]

[29]

[30]

[31]

[32]

[33]

[34]

[35]

[36]

[37]

[38]

[39]

[40]

[41]

[42]

[43]

[44]

[45]

[46]

[47]

[48]

[49]

[50]

[51]

[52]

[53]

[54]

[55]

[56]

[57]

[58]

MOUSE:CAC1A

Contents

Annotations

Notes

References

a

b

c

d

e

g

h

i

m

n

o

p

r

s

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools