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PMID:8100981
| Citation |
Matsui, K, Masui, A, Kato, N and Adachi, K (1993) Levels of somatostatin and cholecystokinin in the brain of ataxic mutant mice. Life Sci. 53:333-40 |
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| Abstract |
Changes in immunoreactive somatostatin (SOM) and cholecystokinin (CCK-8) levels in the cerebellum and cerebrum were investigated in three types of genetically-determined ataxic mutant mice: rolling mouse Nagoya (RMN), weaver, and Purkinje cell degeneration (PCD) mice. The cerebellar pathology in each of these types differs. The concentration of both SOM and CCK-8 (ng/mg weight) was significantly higher in the cerebellum and the cerebrum of the three types of ataxic mutant mice than in these regions in the respective controls. SOM and CCK-8 content (ng/organ) was significantly higher in PCD and RMN than in controls but this was not in the weaver mice. The possible involvement of both peptides in manifestations of ataxia is discussed. |
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| Keywords |
Animals; Ataxia/metabolism; Brain/metabolism; Cerebellum/metabolism; Cholecystokinin/metabolism; Immunoenzyme Techniques; Male; Mice; Mice, Neurologic Mutants; Somatostatin/metabolism |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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