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PMID:1686215
| Citation |
Patel, VK, Abbott, LC, Rattan, AK and Tejwani, GA (1991) Increased methionine-enkephalin levels in genetically epileptic (tg/tg) mice. Brain Res. Bull. 27:849-52 |
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| Abstract |
Recent experimental data indicate that endogenous brain ligands for the opioid receptors such as enkephalins, beta-endorphin (beta-End) and dynorphin (Dyn) may be involved in both generalized and partial seizures. The "tottering" (tg/tg) mouse provides an electrophysiological representation of generalized spontaneous human epilepsy. These mice exhibit behavioral absence seizures with accompanying spike-wave discharges. Methionine-enkephalin (M-Enk), beta-End and Dyn levels in various regions of brain were measured by radioimmunoassay (RIA) in 15-18-week-old tg/tg and control (+/+) mice to elucidate the relation between seizures and the opioid system. beta-End and Dyn levels were similar in tg/tg and +/+ mice. However, M-Enk levels were significantly increased in the striatum, cortex, pons and medulla of the tg/tg mice. Our data suggest that in the tottering mouse model of generalized epilepsy there is an alteration of enkephalinergic pathways and not of the endorphinergic or dynorphinergic pathways. |
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| Keywords |
Animals; Brain/metabolism; Dynorphins/metabolism; Enkephalin, Methionine/metabolism; Epilepsy/genetics; Epilepsy/metabolism; Mice; Mice, Inbred C57BL; Mice, Neurologic Mutants; Osmolar Concentration; Radioimmunoassay; Tissue Distribution; beta-Endorphin/metabolism |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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