PMID:6462226

Citation	Noebels, JL A single gene error of noradrenergic axon growth synchronizes central neurones. Nature 310:409-11
Abstract	One strategy for deciphering inherited neurological disease is to examine the expression of individual genes controlling the assembly and physiology of specific cell groups within the developing mammalian central nervous system (CNS). This neurogenetic approach, using defined single-locus mutations arising on coisogeneic mouse strains, has recently been used to analyse a major class of neuronal membrane diseases involving abnormal excitability, the epilepsies, and to identify examples of hereditary variation in signalling properties at central synapses. An interesting mutation, the Tottering (tg) gene, causes a delayed onset, recessive neurological disorder in the mouse featuring a stereotyped triad of ataxia, intermittent myoclonus and cortical spike-wave discharges accompanied by behavioural absence seizures which resemble petit mal epilepsy. Axon branches of the locus coeruleus, a noradrenergic brain-stem nucleus, hyperinnervate specific target regions of the tg brain. The number of parent coerulean perikarya is unaffected, indicating a true proliferation of the terminal axonal arbor. With the exception of this unusually precise error of axonal growth, no other cytopathology has been identified in the tg brain. Here I present evidence that selective lesions of the central noradrenergic axons early in development limit the expression of the disease.
Links	PubMed
Keywords	Action Potentials/drug effects; Animals; Ataxia/drug therapy; Hydroxydopamines/pharmacology; Hydroxydopamines/therapeutic use; Locus Coeruleus/physiopathology; Mice; Mice, Neurologic Mutants; Norepinephrine/physiology; Seizures/drug therapy; Sympathetic Nervous System/drug effects
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