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PMID:6945603
| Citation |
Levitt, P and Noebels, JL (1981) Mutant mouse tottering: selective increase of locus ceruleus axons in a defined single-locus mutation. Proc. Natl. Acad. Sci. U.S.A. 78:4630-4 |
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| Abstract |
The central catecholamine neuron system in the mutant mouse tottering was examined by fluorescence histochemistry and biochemical analysis of catecholamine content. This single-locus neurological mutation expresses a reproducible alteration in central nervous system physiology characterized by spontaneous spike-wave and focal motor seizures in the absence of any previously recognized disturbance of cellular organization or brain size. Histochemical analysis showed a significant increase in the number of noradrenergic axons in terminal fields innervated by the nucleus locus ceruleus when compared with the wild type. A concomitant 100-200% rise in norepinephrine levels is found in the same areas, including hippocampus, cerebellum, and dorsal lateral geniculate. Catecholamine fibers and transmitter content in areas innervated by a second major noradrenergic system arising from the brainstem lateral tegmental neurons are unaltered. The terminal axons and transmitter content were both unchanged in nuclei receiving a dense dopaminergic innervation. Despite the hypertrophy of the locus ceruleus axonal plexus, the number and size of locus ceruleus cell somata were identical in both wild-type and tottering mice. These findings are consistent with a specific gene-linked alteration of developmental events controlling the number of axons produced by a single neuronal population in the mammalian brain. |
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| Keywords |
Animals; Brain/pathology; Catecholamines/physiology; Dopamine/physiology; Hypertrophy; Locus Coeruleus/pathology; Mice; Mice, Neurologic Mutants/anatomy & histology; Microscopy, Fluorescence; Neural Pathways/pathology; Norepinephrine/physiology |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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