GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:12827191
| Citation |
Missler, M, Zhang, W, Rohlmann, A, Kattenstroth, G, Hammer, RE, Gottmann, K and Südhof, TC (2003) Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis. Nature 423:939-48 |
|---|---|
| Abstract |
Synapses are specialized intercellular junctions in which cell adhesion molecules connect the presynaptic machinery for neurotransmitter release to the postsynaptic machinery for receptor signalling. Neurotransmitter release requires the presynaptic co-assembly of Ca2+ channels with the secretory apparatus, but little is known about how synaptic components are organized. Alpha-neurexins, a family of >1,000 presynaptic cell-surface proteins encoded by three genes, link the pre- and postsynaptic compartments of synapses by binding extracellularly to postsynaptic cell adhesion molecules and intracellularly to presynaptic PDZ domain proteins. Using triple-knockout mice, we show that alpha-neurexins are not required for synapse formation, but are essential for Ca2+-triggered neurotransmitter release. Neurotransmitter release is impaired because synaptic Ca2+ channel function is markedly reduced, although the number of cell-surface Ca2+ channels appears normal. These data suggest that alpha-neurexins organize presynaptic terminals by functionally coupling Ca2+ channels to the presynaptic machinery. |
| Links |
PubMed Online version:10.1038/nature01755 |
| Keywords |
Animals; Brain Stem/cytology; Brain Stem/physiology; Calcium/metabolism; Calcium Channels/physiology; Calcium Signaling; Cell Adhesion; Cell Adhesion Molecules, Neuronal/physiology; Cells, Cultured; Evoked Potentials; Exocytosis/physiology; Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Neocortex/cytology; Neocortex/physiology; Nerve Tissue Proteins/genetics; Nerve Tissue Proteins/physiology; Neuropeptides; Neurotransmitter Agents/metabolism; Recombinant Fusion Proteins/metabolism; Synapses/physiology; Synaptic Transmission; Synaptic Vesicles/physiology |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| edit table |
See also
References
See Help:References for how to manage references in GONUTS.
