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PMID:12401561
| Citation |
Cavelier, P, Beekenkamp, H, Shin, HS, Jun, K and Bossu, JL (2002) Cerebellar slice cultures from mice lacking the P/Q calcium channel: electroresponsiveness of Purkinje cells. Neurosci. Lett. 333:64-8 |
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| Abstract |
To investigate the role of P/Q type Ca(2+) channels in determining the firing pattern of Purkinje cells (PCs) we compared the somatically evoked discharge of action potentials (APs) in PCs from 3 to 4 week old cerebellar slice cultures obtained with ataxic mice lacking alpha(1A)-subunit (alpha(-/-)) and with normal mice (non-ataxic alpha(+/-) or alpha(+/+)) using the whole-cell configuration of the patch-clamp recording method. Whereas evoked responses of PCs in normal mice were mainly fast APs, those of PCs from ataxic mice were mainly low-threshold Ca(2+) spikes (LTS). Furthermore, a sustained plateau potential due to the activation of cadmium sensitive Ca(2+) conductances was not observed in PCs from ataxic mice by blocking K(+) channels. These results confirm that P/Q Ca(2+) channels elicit Ca(2+)-dependent plateau potentials and control the propagation of the dendritic LTS to the soma. |
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| Keywords |
Action Potentials/physiology; Animals; Calcium Channels, N-Type/deficiency; Calcium Channels, N-Type/genetics; Calcium Channels, N-Type/physiology; Cerebellum/physiology; Mice; Mice, Knockout; Mice, Transgenic; Organ Culture Techniques; Perfusion; Purkinje Cells/physiology |
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Significance
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