PMID:11718712

Citation	Ogasawara, M, Kurihara, T, Hu, Q and Tanabe, T (2001) Characterization of acute somatosensory pain transmission in P/Q-type Ca(2+) channel mutant mice, leaner. FEBS Lett. 508:181-6
Abstract	To study the role of the Ca(v)2.1/alpha(1A) (P/Q-type) Ca(2+) channel in somatosensory pain processing, behavioral and electrophysiological studies were conducted using the leaner (tg(la)/tg(la)) mouse. Behavioral analyses in tg(la)/tg(la) revealed reduced responses to mechanical stimuli, and enhanced responses to heat stimuli. Electrophysiological analyses showed that tg(la)/tg(la) had a significantly reduced ability to evoke dorsal root potentials, suggesting a functional deficit in the spinal dorsal horn local circuitry responsible for presynaptic inhibition of primary sensory fibers. These results suggest the critical importance of the P/Q-type channel in modulation of acute somatosensory pain transmission in spinal cord.
Links	PubMed
Keywords	Action Potentials/drug effects; Animals; Animals, Newborn; Calcium Channel Blockers/pharmacology; Calcium Channels, N-Type/genetics; Calcium Channels, N-Type/metabolism; Capsaicin/pharmacology; Electrophysiology; Evoked Potentials, Somatosensory/drug effects; Hot Temperature; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Mutation/genetics; Opioid Peptides/pharmacology; Pain/chemically induced; Pain/genetics; Pain/metabolism; Pain Insensitivity, Congenital/genetics; Pain Measurement; Receptors, GABA-A/metabolism; Receptors, Tachykinin/antagonists & inhibitors; Spinal Nerve Roots/drug effects; Spinal Nerve Roots/physiology; Time Factors
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