HUMAN:TF65

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	RELA (synonyms: NFKB3)
Protein Name(s)	Transcription factor p65 Nuclear factor NF-kappa-B p65 subunit Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3
External Links
UniProt	Q04206
EMBL	M62399 Z22948 Z22949 Z22953 Z22950 Z22951 L19067 BC033522 AY455868
CCDS	CCDS31609.1 CCDS44651.1
PIR	A40851 I53719 S51782
RefSeq	NP_001138610.1 NP_001230913.1 NP_068810.3
UniGene	Hs.502875
PDB	1NFI 2LSP 2O61 3GUT 3QXY 3RC0 4KV1 4KV4
PDBsum	1NFI 2LSP 2O61 3GUT 3QXY 3RC0 4KV1 4KV4
DisProt	DP00085
ProteinModelPortal	Q04206
SMR	Q04206
BioGrid	111902
DIP	DIP-24238N
IntAct	Q04206
MINT	MINT-106444
STRING	9606.ENSP00000384273
BindingDB	Q04206
ChEMBL	CHEMBL5533
PhosphoSite	Q04206
DMDM	62906901
MaxQB	Q04206
PaxDb	Q04206
PRIDE	Q04206
DNASU	5970
Ensembl	ENST00000308639 ENST00000406246
GeneID	5970
KEGG	hsa:5970
UCSC	uc001off.3 uc001ofh.3
CTD	5970
GeneCards	GC11M065421
HGNC	HGNC:9955
HPA	CAB004264 CAB005030
MIM	164014
neXtProt	NX_Q04206
Orphanet	251636
PharmGKB	PA296
eggNOG	NOG119056
GeneTree	ENSGT00500000044765
HOGENOM	HOG000230474
HOVERGEN	HBG017916
InParanoid	Q04206
KO	K04735
OMA	EFSPMVF
OrthoDB	EOG7VHSWT
PhylomeDB	Q04206
TreeFam	TF325632
Reactome	REACT_118563 REACT_118656 REACT_12555 REACT_13443 REACT_13696 REACT_163994 REACT_169168 REACT_21281 REACT_23950 REACT_24969 REACT_27161
SABIO-RK	Q04206
SignaLink	Q04206
ChiTaRS	RELA
EvolutionaryTrace	Q04206
GeneWiki	RELA
GenomeRNAi	5970
NextBio	23241
PRO	PR:Q04206
Proteomes	UP000005640
Bgee	Q04206
CleanEx	HS_RELA
ExpressionAtlas	Q04206
Genevestigator	Q04206
GO	GO:0005737 GO:0005829 GO:0005654 GO:0005634 GO:0005667 GO:0033613 GO:0003682 GO:0003677 GO:0042802 GO:0051059 GO:0042301 GO:0019901 GO:0047485 GO:0070491 GO:0000978 GO:0001078 GO:0001077 GO:0000980 GO:0003705 GO:0001205 GO:0003700 GO:0008134 GO:0044212 GO:0031625 GO:0006117 GO:0007568 GO:0006968 GO:0070301 GO:0071347 GO:0071354 GO:0071222 GO:0071316 GO:0071375 GO:0071356 GO:0019221 GO:0051607 GO:0038095 GO:0001942 GO:0006954 GO:0045087 GO:0001889 GO:0031293 GO:0002755 GO:0002756 GO:0043066 GO:2001237 GO:0046627 GO:0042177 GO:0000122 GO:0045892 GO:0048011 GO:0070431 GO:0009887 GO:0008284 GO:0032332 GO:0043123 GO:0045084 GO:2000630 GO:0051092 GO:0014040 GO:0045944 GO:0045893 GO:0032481 GO:0050727 GO:0043200 GO:0051591 GO:0033590 GO:0042493 GO:0032868 GO:0070555 GO:0009612 GO:0043278 GO:0032495 GO:0010033 GO:0032570 GO:0010224 GO:0050852 GO:0034166 GO:0034134 GO:0034138 GO:0034142 GO:0034146 GO:0034162 GO:0002224 GO:0038123 GO:0038124 GO:0035666 GO:0016032
Gene3D	2.60.40.10 2.60.40.340
InterPro	IPR013783 IPR014756 IPR002909 IPR000451 IPR008967 IPR011539
Pfam	PF00554
PRINTS	PR00057
SMART	SM00429
SUPFAM	SSF49417 SSF81296
PROSITE	PS01204 PS50254

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005634	nucleus	PMID:22065573^[1]	ECO:0000314			C		Fig. 7A	complete CACAO 3237
enables	GO:0001225	RNA polymerase II transcription coactivator binding	PMID:23811396^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q09472	F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:23811396^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	part_of:(GO:0045944) has_input:(ENSEMBL:ENSG00000089250)	Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:23811396^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q09472	F	part_of:(GO:0018394) occurs_in:(GO:0005634)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:23811396^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSG00000089250) part_of:(GO:0038061)	Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:23811396^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	part_of:(GO:1901224) part_of:(GO:0045944) has_input:(ENSEMBL:ENSG00000089250)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:26435691^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(ENSEMBL:ENSG00000100697)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:26435691^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001952) has_input:(ENSEMBL:ENSG00000100697)	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[4]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[4]	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR000451 InterPro:IPR002909 InterPro:IPR008967 InterPro:IPR011539	F		Seeded From UniProt	complete
involved_in	GO:0033209	tumor necrosis factor-mediated signaling pathway	PMID:25411248^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	PMID:25762865^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000235)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:25762865^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_transcription_of:(ENSEMBL:ENSG00000207975) part_of:(GO:0071222) occurs_in:(CL:0000235)	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:Q04207	F		Seeded From UniProt	complete
involved_in	GO:0035924	cellular response to vascular endothelial growth factor stimulus	PMID:23878390^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071356	cellular response to tumor necrosis factor	PMID:23878390^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902894	negative regulation of pri-miRNA transcription by RNA polymerase II	PMID:23878390^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_transcription_of:(ENSEMBL:ENSG00000207761) part_of:(GO:0035924) occurs_in:(CL:0002618)\|regulates_transcription_of(ENSEMBL:ENSG00000207761) part_of:(GO:0071356) occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21518763^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P08047	P	regulates_transcription_of:(ENSEMBL:ENSG00000199130)	Seeded From UniProt	complete
involved_in	GO:0061614	pri-miRNA transcription by RNA polymerase II	PMID:23619365^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_transcription_of:(ENSEMBL:ENSG00000283733) occurs_in:(CL:0000071)	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:21343177^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000575) has_input:(UniProtKB:P10145) happens_during:(GO:0033209)	Seeded From UniProt	complete
involved_in	GO:0033209	tumor necrosis factor-mediated signaling pathway	PMID:21343177^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000575)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21343177^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000575) exists_during:(GO:0038061)	Seeded From UniProt	complete
NOT\|part_of	GO:0005730	nucleolus	PMID:21343177^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21343177^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000575)	Seeded From UniProt	complete
involved_in	GO:1901224	positive regulation of NIK/NF-kappaB signaling	PMID:21343177^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000575) happens_during:(GO:0033209)	Seeded From UniProt	complete
involved_in	GO:1901222	regulation of NIK/NF-kappaB signaling	PMID:21343177^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P62328	P	occurs_in:(CL:0000575) happens_during:(GO:0033209)	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:23178297^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901224	positive regulation of NIK/NF-kappaB signaling	PMID:23178297^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9425125^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:9425125^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:24955228^[13]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:Q8NES8)	Seeded From UniProt	complete
involved_in	GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	PMID:24955228^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(CHEBI:8005) has_regulation_target:(UniProtKB:Q8NES8)	Seeded From UniProt	complete
involved_in	GO:0071224	cellular response to peptidoglycan	PMID:24955228^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:9425125^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	PMID:26268439^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000071) regulates_transcription_of:(ENSEMBL:ENSG00000208005) part_of:(GO:0071333)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:26268439^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_in:(CL:0000071) has_direct_input:(ENSEMBL:ENSG00000208005) occurs_at:(SO:0001952)	Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:26268439^[14]	ECO:0000314	direct assay evidence used in manual assertion		C	coincident_with:(ENSEMBL:ENSG00000208005) coincident_with:(SO:0000170) exists_during:(GO:0071333)	Seeded From UniProt	complete
involved_in	GO:0043620	regulation of DNA-templated transcription in response to stress	PMID:26649771^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:P59861) happens_during:(GO:0071223)	Seeded From UniProt	complete
involved_in	GO:0071223	cellular response to lipoteichoic acid	PMID:26649771^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:18045535^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	has_direct_input:(UniProtKB:P23396) happens_during:(GO:0051092)	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:18045535^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:18045535^[16]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(UniProtKB:P19838:PRO_0000030311)	Seeded From UniProt	complete
part_of	GO:0035525	NF-kappaB p50/p65 complex	PMID:18045535^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:18045535^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P23396	P		Seeded From UniProt	complete
involved_in	GO:0071356	cellular response to tumor necrosis factor	PMID:18045535^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	causally_upstream_of:(GO:0051092)	Seeded From UniProt	complete
involved_in	GO:0050862	positive regulation of T cell receptor signaling pathway	PMID:18045535^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	causally_upstream_of:(GO:0051092)	Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:18045535^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18045535^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0031490	chromatin DNA binding	PMID:25411248^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:25411248^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(UniProtKB:P01584) has_input:(UniProtKB:P10145) happens_during:(GO:0071356)	Seeded From UniProt	complete
enables	GO:0042805	actinin binding	PMID:25411248^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O43707	F	occurs_in:(GO:0005634) occurs_in:(CL:0000653)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:25411248^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000653) exists_during:(GO:0071356)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:25411248^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000653)	Seeded From UniProt	complete
involved_in	GO:1901223	negative regulation of NIK/NF-kappaB signaling	PMID:18212740^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:18212740^[17]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:18212740^[17]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:P19838)	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:18212740^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18212740^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22065573^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	PMID:17785205^[18]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O15379	F		Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	PMID:17785205^[18]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q92769	F		Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	PMID:17785205^[18]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q13547	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21097510^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21097510^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17350185^[20]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(NCBI_Gene:3569)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:1406630^[21]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(NCBI_Gene:50802)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:1406630^[21]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0000165)	Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:17350185^[20]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:17350185^[20]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	PMID:1406630^[21]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:17350185^[20]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:17350185^[20]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(NCBI_Gene:652)	Seeded From UniProt	complete
involved_in	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	PMID:21310825^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000630	positive regulation of miRNA metabolic process	PMID:22357537^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0071316) occurs_in:(CL:0002539)\|part_of(GO:0071354) occurs_in:(CL:0002539)\|part_of(GO:1904385) occurs_in:(CL:0002539)	Seeded From UniProt	complete
	GO:2000778	positive regulation of interleukin-6 secretion	PMID:26961863^[24]	ECO:0000315			P		Figure 3 c shows increased secretions when NF-κB isn't inhibited (vs when it is, hence the IMP)	complete
involved_in	GO:1904385	cellular response to angiotensin	PMID:22357537^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002539)	Seeded From UniProt	complete
involved_in	GO:0071354	cellular response to interleukin-6	PMID:22357537^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002539)	Seeded From UniProt	complete
involved_in	GO:0071316	cellular response to nicotine	PMID:22357537^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002539)	Seeded From UniProt	complete
involved_in	GO:0070555	response to interleukin-1	PMID:15489227^[25]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q04207	P		Seeded From UniProt	complete
enables	GO:0070491	repressing transcription factor binding	PMID:10660609^[26]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q08117	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:10660609^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21310825^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0033613	activating transcription factor binding	PMID:15489227^[25]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q16594	F		Seeded From UniProt	complete
involved_in	GO:1904996	positive regulation of leukocyte adhesion to vascular endothelial cell	PMID:25515214^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_agent:(CL:0000084) has_agent:(CL:2000044) part_of:(GO:0071345)	Seeded From UniProt	complete
involved_in	GO:0071356	cellular response to tumor necrosis factor	PMID:23091055^[28]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071356	cellular response to tumor necrosis factor	PMID:18073330^[29]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071347	cellular response to interleukin-1	PMID:18073330^[29]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070301	cellular response to hydrogen peroxide	PMID:21830064^[30]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	PMID:8717528^[31]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0051059	NF-kappaB binding	PMID:8441377^[32]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P19838	F		Seeded From UniProt	complete
enables	GO:0051059	NF-kappaB binding	PMID:8441377^[32]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q00653	F		Seeded From UniProt	complete
involved_in	GO:0050727	regulation of inflammatory response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04207	P		Seeded From UniProt	complete
enables	GO:0047485	protein N-terminus binding	PMID:7739562^[33]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P25963	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:23091055^[28]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17350185^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:18073330^[29]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:O15519)	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:17350185^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:17350185^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:17350185^[20]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PMID:12761501^[34]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:23091055^[28]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:10747850^[35]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:9437432^[36]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042301	phosphate ion binding	PMID:10521409^[37]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:12748188^[38]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q96BH1	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:15465828^[39]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P49841	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:10521409^[37]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O14920	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:10521409^[37]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O15111	F		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	PMID:15876188^[40]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010224	response to UV-B	PMID:15616591^[41]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	PMID:10747850^[35]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:23091055^[28]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:10849440^[42]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q92750	F		Seeded From UniProt	complete
involved_in	GO:0006968	cellular defense response	PMID:8717528^[31]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:12924514^[43]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21474709^[44]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21830064^[30]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:3140380^[45]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:12048232^[46]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21830064^[30]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21474709^[44]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19058135^[47]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:3140380^[45]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17350185^[20]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:3091258^[48]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0000165)	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:12048232^[46]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:19058135^[47]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:23091055^[28]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:18073330^[29]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[49]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0011274 FB:FBgn0260632 MGI:MGI:103289 PANTHER:PTN000652441 UniProtKB:Q04206 UniProtKB:Q04864	P		Seeded From UniProt	complete
involved_in	GO:0038061	NIK/NF-kappaB signaling	PMID:21873635^[49]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103289 PANTHER:PTN000652441	P		Seeded From UniProt	complete
involved_in	GO:0034097	response to cytokine	PMID:21873635^[49]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000652441 RGD:727889	P		Seeded From UniProt	complete
involved_in	GO:0007249	I-kappaB kinase/NF-kappaB signaling	PMID:21873635^[49]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000652441 RGD:1311231	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:21873635^[49]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000652441 UniProtKB:Q04206	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[49]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103289 MGI:MGI:103290 PANTHER:PTN000652441 RGD:727889 UniProtKB:Q01201 UniProtKB:Q04206	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	PMID:21873635^[49]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000652441 UniProtKB:Q01201	C		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:21873635^[49]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103290 PANTHER:PTN000652441 UniProtKB:Q04206	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[49]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000652441 ZFIN:ZDB-GENE-040825-4	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:21873635^[49]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0260632 MGI:MGI:103290 PANTHER:PTN000652441 UniProtKB:Q04206	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:21873635^[49]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103290 PANTHER:PTN000652441 UniProtKB:Q04206	P		Seeded From UniProt	complete
involved_in	GO:0070431	nucleotide-binding oligomerization domain containing 2 signaling pathway	PMID:12527755^[50]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:15790681^[51]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:7959007^[52]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:15790681^[51]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15790681^[51]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:15790681^[51]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:7959007^[52]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:8246997^[53]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q04206	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:10498867^[54]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q04206	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04207 ensembl:ENSMUSP00000025867	P		Seeded From UniProt	complete
involved_in	GO:0099527	postsynapse to nucleus signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04207 ensembl:ENSMUSP00000025867	P		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04207 ensembl:ENSMUSP00000025867	C		Seeded From UniProt	complete
enables	GO:0071532	ankyrin repeat binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04207 ensembl:ENSMUSP00000025867	F		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04207 ensembl:ENSMUSP00000025867	P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04207 ensembl:ENSMUSP00000025867	P		Seeded From UniProt	complete
involved_in	GO:0050727	regulation of inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04207 ensembl:ENSMUSP00000025867	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04207 ensembl:ENSMUSP00000025867	P		Seeded From UniProt	complete
involved_in	GO:0045084	positive regulation of interleukin-12 biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04207 ensembl:ENSMUSP00000025867	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04207 ensembl:ENSMUSP00000025867	F		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04207 ensembl:ENSMUSP00000025867	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04207 ensembl:ENSMUSP00000025867	P		Seeded From UniProt	complete
enables	GO:0042805	actinin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04207 ensembl:ENSMUSP00000025867	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04207 ensembl:ENSMUSP00000025867	F		Seeded From UniProt	complete
involved_in	GO:0042177	negative regulation of protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04207 ensembl:ENSMUSP00000025867	P		Seeded From UniProt	complete
involved_in	GO:0035994	response to muscle stretch	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04207 ensembl:ENSMUSP00000025867	P		Seeded From UniProt	complete
involved_in	GO:0035729	cellular response to hepatocyte growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04207 ensembl:ENSMUSP00000025867	P		Seeded From UniProt	complete
involved_in	GO:0033234	negative regulation of protein sumoylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04207 ensembl:ENSMUSP00000025867	P		Seeded From UniProt	complete
involved_in	GO:0032495	response to muramyl dipeptide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04207 ensembl:ENSMUSP00000025867	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04207 ensembl:ENSMUSP00000025867	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04207 ensembl:ENSMUSP00000025867	F		Seeded From UniProt	complete
involved_in	GO:0009887	animal organ morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04207 ensembl:ENSMUSP00000025867	P		Seeded From UniProt	complete
involved_in	GO:0009617	response to bacterium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04207 ensembl:ENSMUSP00000025867	P		Seeded From UniProt	complete
involved_in	GO:0006952	defense response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04207 ensembl:ENSMUSP00000025867	P		Seeded From UniProt	complete
involved_in	GO:0006351	transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04207 ensembl:ENSMUSP00000025867	P		Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04207 ensembl:ENSMUSP00000025867	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04207 ensembl:ENSMUSP00000025867	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04207 ensembl:ENSMUSP00000025867	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04207 ensembl:ENSMUSP00000025867	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04207 ensembl:ENSMUSP00000025867	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04207 ensembl:ENSMUSP00000025867	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04207 ensembl:ENSMUSP00000025867	F		Seeded From UniProt	complete
involved_in	GO:0001942	hair follicle development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04207 ensembl:ENSMUSP00000025867	P		Seeded From UniProt	complete
involved_in	GO:0001889	liver development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04207 ensembl:ENSMUSP00000025867	P		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04207 ensembl:ENSMUSP00000025867	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04207 ensembl:ENSMUSP00000025867	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04207 ensembl:ENSMUSP00000025867	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04207 ensembl:ENSMUSP00000025867	C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04207 ensembl:ENSMUSP00000025867	P		Seeded From UniProt	complete
involved_in	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	P		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	P		Seeded From UniProt	complete
involved_in	GO:0051591	response to cAMP	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	P		Seeded From UniProt	complete
involved_in	GO:0046627	negative regulation of insulin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	C		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	F		Seeded From UniProt	complete
involved_in	GO:0043278	response to morphine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	P		Seeded From UniProt	complete
involved_in	GO:0043200	response to amino acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	P		Seeded From UniProt	complete
involved_in	GO:0042542	response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	P		Seeded From UniProt	complete
involved_in	GO:0034097	response to cytokine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	P		Seeded From UniProt	complete
involved_in	GO:0033590	response to cobalamin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	C		Seeded From UniProt	complete
involved_in	GO:0032868	response to insulin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	P		Seeded From UniProt	complete
involved_in	GO:0032570	response to progesterone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	P		Seeded From UniProt	complete
involved_in	GO:0032332	positive regulation of chondrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	P		Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	P		Seeded From UniProt	complete
involved_in	GO:0014040	positive regulation of Schwann cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	P		Seeded From UniProt	complete
involved_in	GO:0010035	response to inorganic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	P		Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	P		Seeded From UniProt	complete
involved_in	GO:0009612	response to mechanical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	F		Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	P		Seeded From UniProt	complete
involved_in	GO:0006117	acetaldehyde metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	C		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011539 InterPro:IPR037059	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000451 InterPro:IPR008967 InterPro:IPR011539 InterPro:IPR030495 InterPro:IPR037059	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000451 InterPro:IPR030495	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000451 InterPro:IPR030495	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000451 InterPro:IPR008967 InterPro:IPR011539 InterPro:IPR037059	P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030495	P		Seeded From UniProt	complete
part_of	GO:0071159	NF-kappaB complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030495	C		Seeded From UniProt	complete
involved_in	GO:0070498	interleukin-1-mediated signaling pathway	Reactome:R-HSA-9020702	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	Reactome:R-HSA-445989	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050852	T cell receptor signaling pathway	Reactome:R-HSA-202403	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	Reactome:R-HSA-193639	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038095	Fc-epsilon receptor signaling pathway	Reactome:R-HSA-2454202	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032481	positive regulation of type I interferon production	Reactome:R-HSA-1834949	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031293	membrane protein intracellular domain proteolysis	Reactome:R-HSA-193692	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-9604480 Reactome:R-HSA-5607728 Reactome:R-HSA-5607724 Reactome:R-HSA-5228811 Reactome:R-HSA-2730894 Reactome:R-HSA-209125 Reactome:R-HSA-209063 Reactome:R-HSA-209061 Reactome:R-HSA-202541 Reactome:R-HSA-193705 Reactome:R-HSA-193700 Reactome:R-HSA-193691 Reactome:R-HSA-168166 Reactome:R-HSA-168140 Reactome:R-HSA-1168643 Reactome:R-HSA-1168642 Reactome:R-HSA-1168640 Reactome:R-HSA-1168638 Reactome:R-HSA-1168633	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-9604480 Reactome:R-HSA-8865237 Reactome:R-HSA-5660980 Reactome:R-HSA-5660666 Reactome:R-HSA-5660660 Reactome:R-HSA-5624473 Reactome:R-HSA-4755536 Reactome:R-HSA-3857308 Reactome:R-HSA-3857305 Reactome:R-HSA-2730894 Reactome:R-HSA-193691 Reactome:R-HSA-168166 Reactome:R-HSA-1168633	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0002223	stimulatory C-type lectin receptor signaling pathway	Reactome:R-HSA-5621481	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Siednienko, J et al. (2011) Nuclear factor κB subunits RelB and cRel negatively regulate Toll-like receptor 3-mediated β-interferon production via induction of transcriptional repressor protein YY1. J. Biol. Chem. 286 44750-63 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Li, Y et al. (2013) Role of p300 in regulating neuronal nitric oxide synthase gene expression through nuclear factor-κB-mediated way in neuronal cells. Neuroscience 248 681-9 PubMed GONUTS page
↑ ^3.0 ^3.1 Guan, Y et al. (2015) NF-κB-DICER-miRs Axis Regulates TNF-α Expression in Responses to Endotoxin Stress. Int. J. Biol. Sci. 11 1257-68 PubMed GONUTS page
↑ ^4.0 ^4.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Zhao, X et al. (2015) α-Actinin 4 potentiates nuclear factor κ-light-chain-enhancer of activated B-cell (NF-κB) activity in podocytes independent of its cytoplasmic actin binding function. J. Biol. Chem. 290 338-49 PubMed GONUTS page
↑ ^6.0 ^6.1 Zhang, W et al. (2015) MicroRNA-181b regulates endotoxin tolerance by targeting IL-6 in macrophage RAW264.7 cells. J Inflamm (Lond) 12 18 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Wang, P et al. (2013) MicroRNA 329 suppresses angiogenesis by targeting CD146. Mol. Cell. Biol. 33 3689-99 PubMed GONUTS page
↑ Xu, Z et al. (2011) miR-365, a novel negative regulator of interleukin-6 gene expression, is cooperatively regulated by Sp1 and NF-kappaB. J. Biol. Chem. 286 21401-12 PubMed GONUTS page
↑ Halkein, J et al. (2013) MicroRNA-146a is a therapeutic target and biomarker for peripartum cardiomyopathy. J. Clin. Invest. 123 2143-54 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 Qiu, P et al. (2011) Thymosin beta4 inhibits TNF-alpha-induced NF-kappaB activation, IL-8 expression, and the sensitizing effects by its partners PINCH-1 and ILK. FASEB J. 25 1815-26 PubMed GONUTS page
↑ ^11.0 ^11.1 Lian, S et al. (2013) PRL-3 activates NF-κB signaling pathway by interacting with RAP1. Biochem. Biophys. Res. Commun. 430 196-201 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Tell, G et al. (1998) Structural and functional properties of the N transcriptional activation domain of thyroid transcription factor-1: similarities with the acidic activation domains. Biochem. J. 329 ( Pt 2) 395-403 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Kim, KH et al. (2014) Beta-Defensin 124 Is Required for Efficient Innate Immune Responses in Prostate Epithelial RWPE-1 Cells. Korean J Urol 55 417-25 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Caporali, A et al. (2015) p75(NTR)-dependent activation of NF-κB regulates microRNA-503 transcription and pericyte-endothelial crosstalk in diabetes after limb ischaemia. Nat Commun 6 8024 PubMed GONUTS page
↑ ^15.0 ^15.1 Kim, JH et al. (2015) Expression of Beta-Defensin 131 Promotes an Innate Immune Response in Human Prostate Epithelial Cells. PLoS ONE 10 e0144776 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 ^16.6 ^16.7 ^16.8 Wan, F et al. (2007) Ribosomal protein S3: a KH domain subunit in NF-kappaB complexes that mediates selective gene regulation. Cell 131 927-39 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 ^17.4 Ramsey, CS et al. (2008) Copine-I represses NF-kappaB transcription by endoproteolysis of p65. Oncogene 27 3516-26 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 Wang, J et al. (2007) LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB. Cancer Cell 12 239-51 PubMed GONUTS page
↑ ^19.0 ^19.1 McNally, RS et al. (2011) DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB. J. Biol. Chem. 286 4098-106 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 ^20.3 ^20.4 ^20.5 ^20.6 ^20.7 ^20.8 ^20.9 Zhu, NL et al. (2007) TNF-alpha represses transcription of human Bone Morphogenetic Protein-4 in lung epithelial cells. Gene 393 70-80 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 Kunsch, C et al. (1992) Selection of optimal kappa B/Rel DNA-binding motifs: interaction of both subunits of NF-kappa B with DNA is required for transcriptional activation. Mol. Cell. Biol. 12 4412-21 PubMed GONUTS page
↑ ^22.0 ^22.1 Lamb, LE et al. (2011) The androgen receptor induces integrin α6β1 to promote prostate tumor cell survival via NF-κB and Bcl-xL Independently of PI3K signaling. Cancer Res. 71 2739-49 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 ^23.3 Maegdefessel, L et al. (2012) MicroRNA-21 blocks abdominal aortic aneurysm development and nicotine-augmented expansion. Sci Transl Med 4 122ra22 PubMed GONUTS page
↑ Shirasuna, K et al. (2016) AGEs and HMGB1 Increase Inflammatory Cytokine Production from Human Placental Cells, Resulting in an Enhancement of Monocyte Migration. Am. J. Reprod. Immunol. 75 557-68 PubMed GONUTS page
↑ ^25.0 ^25.1 Buss, H et al. (2004) Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding kinase 1 (TBK1), and an unknown kinase and couples p65 to TATA-binding protein-associated factor II31-mediated interleukin-8 transcription. J. Biol. Chem. 279 55633-43 PubMed GONUTS page
↑ ^26.0 ^26.1 Tetsuka, T et al. (2000) Inhibition of nuclear factor-kappaB-mediated transcription by association with the amino-terminal enhancer of split, a Groucho-related protein lacking WD40 repeats. J. Biol. Chem. 275 4383-90 PubMed GONUTS page
↑ Wu, D et al. (2015) Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-κB activation. J. Cereb. Blood Flow Metab. 35 412-23 PubMed GONUTS page
↑ ^28.0 ^28.1 ^28.2 ^28.3 ^28.4 Wang, W et al. (2012) The zinc finger protein ZNF268 is overexpressed in human cervical cancer and contributes to tumorigenesis via enhancing NF-κB signaling. J. Biol. Chem. 287 42856-66 PubMed GONUTS page
↑ ^29.0 ^29.1 ^29.2 ^29.3 Benayoun, B et al. (2008) NF-kappaB-dependent expression of the antiapoptotic factor c-FLIP is regulated by calpain 3, the protein involved in limb-girdle muscular dystrophy type 2A. FASEB J. 22 1521-9 PubMed GONUTS page
↑ ^30.0 ^30.1 ^30.2 DangLi, R et al. (2012) ROS-induced ZNF580 expression: a key role for H2O2/NF-κB signaling pathway in vascular endothelial inflammation. Mol. Cell. Biochem. 359 183-91 PubMed GONUTS page
↑ ^31.0 ^31.1 Baldwin, AS Jr (1996) The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu. Rev. Immunol. 14 649-83 PubMed GONUTS page
↑ ^32.0 ^32.1 Duckett, CS et al. (1993) Dimerization of NF-KB2 with RelA(p65) regulates DNA binding, transcriptional activation, and inhibition by an I kappa B-alpha (MAD-3). Mol. Cell. Biol. 13 1315-22 PubMed GONUTS page
↑ Brockman, JA et al. (1995) Coupling of a signal response domain in I kappa B alpha to multiple pathways for NF-kappa B activation. Mol. Cell. Biol. 15 2809-18 PubMed GONUTS page
↑ Matsuda, A et al. (2003) Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Oncogene 22 3307-18 PubMed GONUTS page
↑ ^35.0 ^35.1 Anto, RJ et al. (2000) L-929 cells harboring ectopically expressed RelA resist curcumin-induced apoptosis. J. Biol. Chem. 275 15601-4 PubMed GONUTS page
↑ Chen, YQ et al. (1998) A novel DNA recognition mode by the NF-kappa B p65 homodimer. Nat. Struct. Biol. 5 67-73 PubMed GONUTS page
↑ ^37.0 ^37.1 ^37.2 Sakurai, H et al. (1999) IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain. J. Biol. Chem. 274 30353-6 PubMed GONUTS page
↑ Asamitsu, K et al. (2003) RING finger protein AO7 supports NF-kappaB-mediated transcription by interacting with the transactivation domain of the p65 subunit. J. Biol. Chem. 278 26879-87 PubMed GONUTS page
↑ Buss, H et al. (2004) Phosphorylation of serine 468 by GSK-3beta negatively regulates basal p65 NF-kappaB activity. J. Biol. Chem. 279 49571-4 PubMed GONUTS page
↑ Marui, N et al. (2005) Activation of RelA homodimers by tumour necrosis factor alpha: a possible transcriptional activator in human vascular endothelial cells. Biochem. J. 390 317-24 PubMed GONUTS page
↑ Thyss, R et al. (2005) NF-kappaB/Egr-1/Gadd45 are sequentially activated upon UVB irradiation to mediate epidermal cell death. EMBO J. 24 128-37 PubMed GONUTS page
↑ Yamit-Hezi, A et al. (2000) Interaction of TAFII105 with selected p65/RelA dimers is associated with activation of subset of NF-kappa B genes. J. Biol. Chem. 275 18180-7 PubMed GONUTS page
↑ Lidén, J et al. (2003) Organic dust activates NF-kappaB in lung epithelial cells. Respir Med 97 882-92 PubMed GONUTS page
↑ ^44.0 ^44.1 Noguchi, K et al. (2011) TRIM40 promotes neddylation of IKKγ and is downregulated in gastrointestinal cancers. Carcinogenesis 32 995-1004 PubMed GONUTS page
↑ ^45.0 ^45.1 Baeuerle, PA & Baltimore, D (1988) I kappa B: a specific inhibitor of the NF-kappa B transcription factor. Science 242 540-6 PubMed GONUTS page
↑ ^46.0 ^46.1 Udalova, IA et al. (2002) Quantitative prediction of NF-kappa B DNA-protein interactions. Proc. Natl. Acad. Sci. U.S.A. 99 8167-72 PubMed GONUTS page
↑ ^47.0 ^47.1 Ishaq, M et al. (2009) The DEAD-box RNA helicase DDX1 interacts with RelA and enhances nuclear factor kappaB-mediated transcription. J. Cell. Biochem. 106 296-305 PubMed GONUTS page
↑ Sen, R & Baltimore, D (1986) Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell 46 705-16 PubMed GONUTS page
↑ ^49.00 ^49.01 ^49.02 ^49.03 ^49.04 ^49.05 ^49.06 ^49.07 ^49.08 ^49.09 ^49.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Girardin, SE et al. (2003) Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J. Biol. Chem. 278 8869-72 PubMed GONUTS page
↑ ^51.0 ^51.1 ^51.2 ^51.3 Bettelli, E et al. (2005) Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells. Proc. Natl. Acad. Sci. U.S.A. 102 5138-43 PubMed GONUTS page
↑ ^52.0 ^52.1 Shimizu, H & Yamamoto, K (1994) NF-kappa B and C/EBP transcription factor families synergistically function in mouse serum amyloid A gene expression induced by inflammatory cytokines. Gene 149 305-10 PubMed GONUTS page
↑ Ganchi, PA et al. (1993) A novel NF-kappa B complex containing p65 homodimers: implications for transcriptional control at the level of subunit dimerization. Mol. Cell. Biol. 13 7826-35 PubMed GONUTS page
↑ Yang, JP et al. (1999) NF-kappaB subunit p65 binds to 53BP2 and inhibits cell death induced by 53BP2. Oncogene 18 5177-86 PubMed GONUTS page

[PMID:22065573-1] 1.0 ^1.1 Siednienko, J et al. (2011) Nuclear factor κB subunits RelB and cRel negatively regulate Toll-like receptor 3-mediated β-interferon production via induction of transcriptional repressor protein YY1. J. Biol. Chem. 286 44750-63 PubMed GONUTS page

[PMID:23811396-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Li, Y et al. (2013) Role of p300 in regulating neuronal nitric oxide synthase gene expression through nuclear factor-κB-mediated way in neuronal cells. Neuroscience 248 681-9 PubMed GONUTS page

[PMID:26435691-3] 3.0 ^3.1 Guan, Y et al. (2015) NF-κB-DICER-miRs Axis Regulates TNF-α Expression in Responses to Endotoxin Stress. Int. J. Biol. Sci. 11 1257-68 PubMed GONUTS page

[PMID:19274049-4] 4.0 ^4.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:25411248-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Zhao, X et al. (2015) α-Actinin 4 potentiates nuclear factor κ-light-chain-enhancer of activated B-cell (NF-κB) activity in podocytes independent of its cytoplasmic actin binding function. J. Biol. Chem. 290 338-49 PubMed GONUTS page

[PMID:25762865-6] 6.0 ^6.1 Zhang, W et al. (2015) MicroRNA-181b regulates endotoxin tolerance by targeting IL-6 in macrophage RAW264.7 cells. J Inflamm (Lond) 12 18 PubMed GONUTS page

[PMID:23878390-7] 7.0 ^7.1 ^7.2 Wang, P et al. (2013) MicroRNA 329 suppresses angiogenesis by targeting CD146. Mol. Cell. Biol. 33 3689-99 PubMed GONUTS page

[PMID:21518763-8] Xu, Z et al. (2011) miR-365, a novel negative regulator of interleukin-6 gene expression, is cooperatively regulated by Sp1 and NF-kappaB. J. Biol. Chem. 286 21401-12 PubMed GONUTS page

[PMID:23619365-9] Halkein, J et al. (2013) MicroRNA-146a is a therapeutic target and biomarker for peripartum cardiomyopathy. J. Clin. Invest. 123 2143-54 PubMed GONUTS page

[PMID:21343177-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 Qiu, P et al. (2011) Thymosin beta4 inhibits TNF-alpha-induced NF-kappaB activation, IL-8 expression, and the sensitizing effects by its partners PINCH-1 and ILK. FASEB J. 25 1815-26 PubMed GONUTS page

[PMID:23178297-11] 11.0 ^11.1 Lian, S et al. (2013) PRL-3 activates NF-κB signaling pathway by interacting with RAP1. Biochem. Biophys. Res. Commun. 430 196-201 PubMed GONUTS page

[PMID:9425125-12] 12.0 ^12.1 ^12.2 Tell, G et al. (1998) Structural and functional properties of the N transcriptional activation domain of thyroid transcription factor-1: similarities with the acidic activation domains. Biochem. J. 329 ( Pt 2) 395-403 PubMed GONUTS page

[PMID:24955228-13] 13.0 ^13.1 ^13.2 Kim, KH et al. (2014) Beta-Defensin 124 Is Required for Efficient Innate Immune Responses in Prostate Epithelial RWPE-1 Cells. Korean J Urol 55 417-25 PubMed GONUTS page

[PMID:26268439-14] 14.0 ^14.1 ^14.2 Caporali, A et al. (2015) p75(NTR)-dependent activation of NF-κB regulates microRNA-503 transcription and pericyte-endothelial crosstalk in diabetes after limb ischaemia. Nat Commun 6 8024 PubMed GONUTS page

[PMID:26649771-15] 15.0 ^15.1 Kim, JH et al. (2015) Expression of Beta-Defensin 131 Promotes an Innate Immune Response in Human Prostate Epithelial Cells. PLoS ONE 10 e0144776 PubMed GONUTS page

[PMID:18045535-16] 16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 ^16.6 ^16.7 ^16.8 Wan, F et al. (2007) Ribosomal protein S3: a KH domain subunit in NF-kappaB complexes that mediates selective gene regulation. Cell 131 927-39 PubMed GONUTS page

[PMID:18212740-17] 17.0 ^17.1 ^17.2 ^17.3 ^17.4 Ramsey, CS et al. (2008) Copine-I represses NF-kappaB transcription by endoproteolysis of p65. Oncogene 27 3516-26 PubMed GONUTS page

[PMID:17785205-18] 18.0 ^18.1 ^18.2 Wang, J et al. (2007) LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB. Cancer Cell 12 239-51 PubMed GONUTS page

[PMID:21097510-19] 19.0 ^19.1 McNally, RS et al. (2011) DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB. J. Biol. Chem. 286 4098-106 PubMed GONUTS page

[PMID:17350185-20] 20.0 ^20.1 ^20.2 ^20.3 ^20.4 ^20.5 ^20.6 ^20.7 ^20.8 ^20.9 Zhu, NL et al. (2007) TNF-alpha represses transcription of human Bone Morphogenetic Protein-4 in lung epithelial cells. Gene 393 70-80 PubMed GONUTS page

[PMID:1406630-21] 21.0 ^21.1 ^21.2 Kunsch, C et al. (1992) Selection of optimal kappa B/Rel DNA-binding motifs: interaction of both subunits of NF-kappa B with DNA is required for transcriptional activation. Mol. Cell. Biol. 12 4412-21 PubMed GONUTS page

[PMID:21310825-22] 22.0 ^22.1 Lamb, LE et al. (2011) The androgen receptor induces integrin α6β1 to promote prostate tumor cell survival via NF-κB and Bcl-xL Independently of PI3K signaling. Cancer Res. 71 2739-49 PubMed GONUTS page

[PMID:22357537-23] 23.0 ^23.1 ^23.2 ^23.3 Maegdefessel, L et al. (2012) MicroRNA-21 blocks abdominal aortic aneurysm development and nicotine-augmented expansion. Sci Transl Med 4 122ra22 PubMed GONUTS page

[PMID:26961863-24] Shirasuna, K et al. (2016) AGEs and HMGB1 Increase Inflammatory Cytokine Production from Human Placental Cells, Resulting in an Enhancement of Monocyte Migration. Am. J. Reprod. Immunol. 75 557-68 PubMed GONUTS page

[PMID:15489227-25] 25.0 ^25.1 Buss, H et al. (2004) Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding kinase 1 (TBK1), and an unknown kinase and couples p65 to TATA-binding protein-associated factor II31-mediated interleukin-8 transcription. J. Biol. Chem. 279 55633-43 PubMed GONUTS page

[PMID:10660609-26] 26.0 ^26.1 Tetsuka, T et al. (2000) Inhibition of nuclear factor-kappaB-mediated transcription by association with the amino-terminal enhancer of split, a Groucho-related protein lacking WD40 repeats. J. Biol. Chem. 275 4383-90 PubMed GONUTS page

[PMID:25515214-27] Wu, D et al. (2015) Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-κB activation. J. Cereb. Blood Flow Metab. 35 412-23 PubMed GONUTS page

[PMID:23091055-28] 28.0 ^28.1 ^28.2 ^28.3 ^28.4 Wang, W et al. (2012) The zinc finger protein ZNF268 is overexpressed in human cervical cancer and contributes to tumorigenesis via enhancing NF-κB signaling. J. Biol. Chem. 287 42856-66 PubMed GONUTS page

[PMID:18073330-29] 29.0 ^29.1 ^29.2 ^29.3 Benayoun, B et al. (2008) NF-kappaB-dependent expression of the antiapoptotic factor c-FLIP is regulated by calpain 3, the protein involved in limb-girdle muscular dystrophy type 2A. FASEB J. 22 1521-9 PubMed GONUTS page

[PMID:21830064-30] 30.0 ^30.1 ^30.2 DangLi, R et al. (2012) ROS-induced ZNF580 expression: a key role for H2O2/NF-κB signaling pathway in vascular endothelial inflammation. Mol. Cell. Biochem. 359 183-91 PubMed GONUTS page

[PMID:8717528-31] 31.0 ^31.1 Baldwin, AS Jr (1996) The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu. Rev. Immunol. 14 649-83 PubMed GONUTS page

[PMID:8441377-32] 32.0 ^32.1 Duckett, CS et al. (1993) Dimerization of NF-KB2 with RelA(p65) regulates DNA binding, transcriptional activation, and inhibition by an I kappa B-alpha (MAD-3). Mol. Cell. Biol. 13 1315-22 PubMed GONUTS page

[PMID:7739562-33] Brockman, JA et al. (1995) Coupling of a signal response domain in I kappa B alpha to multiple pathways for NF-kappa B activation. Mol. Cell. Biol. 15 2809-18 PubMed GONUTS page

[PMID:12761501-34] Matsuda, A et al. (2003) Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Oncogene 22 3307-18 PubMed GONUTS page

[PMID:10747850-35] 35.0 ^35.1 Anto, RJ et al. (2000) L-929 cells harboring ectopically expressed RelA resist curcumin-induced apoptosis. J. Biol. Chem. 275 15601-4 PubMed GONUTS page

[PMID:9437432-36] Chen, YQ et al. (1998) A novel DNA recognition mode by the NF-kappa B p65 homodimer. Nat. Struct. Biol. 5 67-73 PubMed GONUTS page

[PMID:10521409-37] 37.0 ^37.1 ^37.2 Sakurai, H et al. (1999) IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain. J. Biol. Chem. 274 30353-6 PubMed GONUTS page

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