HUMAN:DDIT3

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	DDIT3 (synonyms: CHOP, CHOP10, GADD153)
Protein Name(s)	DNA damage-inducible transcript 3 protein DDIT-3 C/EBP zeta C/EBP-homologous protein CHOP C/EBP-homologous protein 10 CHOP-10 CCAAT/enhancer-binding protein homologous protein Growth arrest and DNA damage-inducible protein GADD153
External Links
UniProt	P35638
EMBL	S40706 S62138 AY461580 AY880949 AC022506 BC003637
CCDS	CCDS55838.1 CCDS8943.1
PIR	JC1169 S33798
RefSeq	NP_001181982.1 NP_001181983.1 NP_001181984.1 NP_001181986.1 NP_004074.2
UniGene	Hs.505777
DisProt	DP00624
ProteinModelPortal	P35638
SMR	P35638
BioGrid	108016
IntAct	P35638
MINT	MINT-1434413
STRING	9606.ENSP00000340671
PhosphoSite	P35638
DMDM	544022
MaxQB	P35638
PaxDb	P35638
PRIDE	P35638
DNASU	1649
Ensembl	ENST00000346473 ENST00000547303 ENST00000551116 ENST00000552740 ENST00000618206
GeneID	1649
KEGG	hsa:1649
UCSC	uc001soi.3 uc009zps.3
CTD	1649
GeneCards	GC12M057910
HGNC	HGNC:2726
MIM	126337 613488
neXtProt	NX_P35638
Orphanet	99967
PharmGKB	PA27193
eggNOG	NOG279524
GeneTree	ENSGT00390000006305
HOGENOM	HOG000089934
HOVERGEN	HBG051328
InParanoid	P35638
KO	K04452
OMA	DRMVNLH
OrthoDB	EOG7QC7Z1
PhylomeDB	P35638
TreeFam	TF105006
Reactome	REACT_18355 REACT_18423
SignaLink	P35638
ChiTaRS	DDIT3
GeneWiki	DNA_damage-inducible_transcript_3
GenomeRNAi	1649
NextBio	6792
PRO	PR:P35638
Proteomes	UP000005640
Bgee	P35638
CleanEx	HS_DDIT3
ExpressionAtlas	P35638
Genevestigator	P35638
GO	GO:0005829 GO:0005770 GO:0005654 GO:0005634 GO:0003677 GO:0046982 GO:0043565 GO:0003700 GO:0003714 GO:0008134 GO:0044212 GO:0006987 GO:0001955 GO:0007050 GO:0045454 GO:0044267 GO:0006974 GO:0030968 GO:0006983 GO:0070059 GO:0042789 GO:0090090 GO:2000016 GO:0045662 GO:0043433 GO:0045892 GO:0032757 GO:0043525 GO:0045944 GO:1990440 GO:0045893 GO:0043161 GO:0043620 GO:0044324 GO:0006355 GO:0051209 GO:0034976 GO:0042594 GO:0006986 GO:0016055
InterPro	IPR004827 IPR016670
PANTHER	PTHR16833
Pfam	PF07716
PIRSF	PIRSF016571
SMART	SM00338
PROSITE	PS50217

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0045786	negative regulation of cell cycle	PMID:22496745^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Figure 4 fibrosarcoma cells (HT1080) with stable expression of DDIT3morEGFP treated with tamoxifen to induce nuclear translocation show increased % of cells in G1 (see Talk page)	complete CACAO 4646
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[2]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[2]	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR004827	F		Seeded From UniProt	complete
involved_in	GO:0120163	negative regulation of cold-induced thermogenesis	PMID:26370079^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35639	P		Seeded From UniProt	complete
involved_in	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	PMID:27031958^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043525	positive regulation of neuron apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62857	P		Seeded From UniProt	complete
involved_in	GO:0010506	regulation of autophagy	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62857	P		Seeded From UniProt	complete
involved_in	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62857	P		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:P53566	F		Seeded From UniProt	complete
involved_in	GO:0043433	negative regulation of DNA-binding transcription factor activity	PMID:18534616^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P35222)	Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	PMID:18534616^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P14410)	Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	PMID:18534616^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P05412)	Seeded From UniProt	complete
involved_in	GO:0051259	protein complex oligomerization	PMID:18534616^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:18534616^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
NOT\|enables	GO:0042803	protein homodimerization activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62857	F		Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:24939851^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:O14763)	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:24939851^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P18847	F	has_regulation_target:(UniProtKB:O14763)	Seeded From UniProt	complete
involved_in	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	PMID:24939851^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:O14763)	Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:15322075^[7]	ECO:0000305	curator inference used in manual assertion	GO:0032993	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15322075^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0034976)	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:15322075^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(GO:0005634) exists_during:(GO:0034976)	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:15322075^[7]	ECO:0000305	curator inference used in manual assertion	GO:0032993 GO:1990440	F	has_regulation_target:(UniProtKB:O14763) part_of:(GO:1990440)	Seeded From UniProt	complete
involved_in	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	PMID:15322075^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:O14763) causally_upstream_of:(GO:0070059)	Seeded From UniProt	complete
part_of	GO:0036488	CHOP-C/EBP complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35639	C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:18940792^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P08243) part_of:(GO:0034976)	Seeded From UniProt	complete
part_of	GO:1990617	CHOP-ATF4 complex	PMID:18940792^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P18848	C		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:15775988^[9]	ECO:0000303	author statement without traceable support used in manual assertion		F	has_direct_input:(UniProtKB:P18848)\|has_direct_input:(UniProtKB:P17676)	Seeded From UniProt	complete
involved_in	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	PMID:15775988^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P17676	P	has_regulation_target:(UniProtKB:Q96RU7)	Seeded From UniProt	complete
involved_in	GO:0051898	negative regulation of protein kinase B signaling	PMID:22761832^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0034976)	Seeded From UniProt	complete
involved_in	GO:0043525	positive regulation of neuron apoptotic process	PMID:22761832^[10]	ECO:0000305	curator inference used in manual assertion	GO:1990440	P	part_of:(GO:0034976)	Seeded From UniProt	complete
involved_in	GO:1902237	positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	PMID:22761832^[10]	ECO:0000305	curator inference used in manual assertion	GO:1990440	P	occurs_in:(CL:0000540)	Seeded From UniProt	complete
involved_in	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	PMID:22761832^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q9BXH1) occurs_in:(CL:0000540) part_of:(GO:0043525)\|has_regulation_target(UniProtKB:O43521) occurs_in:(CL:0000540) part_of:(GO:0043525)	Seeded From UniProt	complete
enables	GO:0043522	leucine zipper domain binding	PMID:11478948^[11]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:P18848)	Seeded From UniProt	complete
enables	GO:0008140	cAMP response element binding protein binding	PMID:11478948^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P18848	F	part_of:(GO:0000122)	Seeded From UniProt	complete
part_of	GO:1990617	CHOP-ATF4 complex	PMID:11478948^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0032792	negative regulation of CREB transcription factor activity	PMID:8622660^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P18847)	Seeded From UniProt	complete
involved_in	GO:1903026	negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding	PMID:8622660^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P18847)	Seeded From UniProt	complete
enables	GO:0043522	leucine zipper domain binding	PMID:8622660^[12]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:P18847)	Seeded From UniProt	complete
part_of	GO:1990622	CHOP-ATF3 complex	PMID:8622660^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:8622660^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P18847	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:11478948^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P18848	P		Seeded From UniProt	complete
involved_in	GO:0032792	negative regulation of CREB transcription factor activity	PMID:11478948^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P18848	P	has_regulation_target:(UniProtKB:P18848)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11478948^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
colocalizes_with	GO:0035976	transcription factor AP-1 complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35639	C		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:22065586^[13]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:22065586^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:22065586^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35639	F	has_direct_input:(UniProtKB:O75807) part_of:(GO:0030968)\|has_direct_input(UniProtKB:Q96HE7) part_of:(GO:0030968)	Seeded From UniProt	complete
involved_in	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35639	P	has_regulation_target:(UniProtKB:O75807)	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:8510758^[14]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:2000016	negative regulation of determination of dorsal identity	PMID:16434966^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:16434966^[15]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35639	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:22065586^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0044324	regulation of transcription involved in anterior/posterior axis specification	PMID:16434966^[15]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P35639	P		Seeded From UniProt	complete
involved_in	GO:0043433	negative regulation of DNA-binding transcription factor activity	PMID:16434966^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034976	response to endoplasmic reticulum stress	PMID:19061639^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:16434966^[15]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9NQB0	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:16434966^[15]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q01978	F		Seeded From UniProt	complete
involved_in	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	PMID:15322075^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	PMID:20829347^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	PMID:18940792^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:15322075^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:15775988^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:18940792^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	PMID:17872950^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034976	response to endoplasmic reticulum stress	PMID:20829347^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034976	response to endoplasmic reticulum stress	PMID:18940792^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032757	positive regulation of interleukin-8 production	PMID:20829347^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006986	response to unfolded protein	PMID:18940792^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:17872950^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:22761832^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20829347^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22761832^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:18940792^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:1990622	CHOP-ATF3 complex	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000423833 UniProtKB:P35638	C		Seeded From UniProt	complete
part_of	GO:1990617	CHOP-ATF4 complex	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000423833 UniProtKB:P35638	C		Seeded From UniProt	complete
involved_in	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109247 PANTHER:PTN000423833 UniProtKB:P35638	P		Seeded From UniProt	complete
part_of	GO:0036488	CHOP-C/EBP complex	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109247 PANTHER:PTN000423833 RGD:62391	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109247 PANTHER:PTN000423833 RGD:62391	C		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000423833 UniProtKB:P35638	F		Seeded From UniProt	complete
involved_in	GO:0045454	cell redox homeostasis	PMID:14667815^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042789	mRNA transcription by RNA polymerase II	PMID:14667815^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:14667815^[20]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:2000016	negative regulation of determination of dorsal identity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35639 ensembl:ENSMUSP00000026475	P		Seeded From UniProt	complete
involved_in	GO:1990442	intrinsic apoptotic signaling pathway in response to nitrosative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35639 ensembl:ENSMUSP00000026475	P		Seeded From UniProt	complete
involved_in	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35639 ensembl:ENSMUSP00000026475	P		Seeded From UniProt	complete
involved_in	GO:1901216	positive regulation of neuron death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35639 ensembl:ENSMUSP00000026475	P		Seeded From UniProt	complete
involved_in	GO:0120163	negative regulation of cold-induced thermogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35639 ensembl:ENSMUSP00000026475	P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35639 ensembl:ENSMUSP00000026475	P		Seeded From UniProt	complete
involved_in	GO:0072655	establishment of protein localization to mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35639 ensembl:ENSMUSP00000026475	P		Seeded From UniProt	complete
involved_in	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35639 ensembl:ENSMUSP00000026475	P		Seeded From UniProt	complete
involved_in	GO:0051209	release of sequestered calcium ion into cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35639 ensembl:ENSMUSP00000026475	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35639 ensembl:ENSMUSP00000026475	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35639 ensembl:ENSMUSP00000026475	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35639 ensembl:ENSMUSP00000026475	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35639 ensembl:ENSMUSP00000026475	P		Seeded From UniProt	complete
involved_in	GO:0045662	negative regulation of myoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35639 ensembl:ENSMUSP00000026475	P		Seeded From UniProt	complete
involved_in	GO:0045599	negative regulation of fat cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35639 ensembl:ENSMUSP00000026475	P		Seeded From UniProt	complete
involved_in	GO:0044324	regulation of transcription involved in anterior/posterior axis specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35639 ensembl:ENSMUSP00000026475	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35639 ensembl:ENSMUSP00000026475	F		Seeded From UniProt	complete
involved_in	GO:0043525	positive regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35639 ensembl:ENSMUSP00000026475	P		Seeded From UniProt	complete
involved_in	GO:0043392	negative regulation of DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35639 ensembl:ENSMUSP00000026475	P		Seeded From UniProt	complete
involved_in	GO:0042594	response to starvation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35639 ensembl:ENSMUSP00000026475	P		Seeded From UniProt	complete
part_of	GO:0036488	CHOP-C/EBP complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35639 ensembl:ENSMUSP00000026475	C		Seeded From UniProt	complete
part_of	GO:0035976	transcription factor AP-1 complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35639 ensembl:ENSMUSP00000026475	C		Seeded From UniProt	complete
involved_in	GO:0034976	response to endoplasmic reticulum stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35639 ensembl:ENSMUSP00000026475	P		Seeded From UniProt	complete
involved_in	GO:0030968	endoplasmic reticulum unfolded protein response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35639 ensembl:ENSMUSP00000026475	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35639 ensembl:ENSMUSP00000026475	F		Seeded From UniProt	complete
involved_in	GO:0006983	ER overload response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35639 ensembl:ENSMUSP00000026475	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35639 ensembl:ENSMUSP00000026475	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35639 ensembl:ENSMUSP00000026475	P		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35639 ensembl:ENSMUSP00000026475	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35639 ensembl:ENSMUSP00000026475	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35639 ensembl:ENSMUSP00000026475	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35639 ensembl:ENSMUSP00000026475	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35639 ensembl:ENSMUSP00000026475	F		Seeded From UniProt	complete
involved_in	GO:0001955	blood vessel maturation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35639 ensembl:ENSMUSP00000026475	P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35639 ensembl:ENSMUSP00000026475	P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004827	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004827	P		Seeded From UniProt	complete
involved_in	GO:0036500	ATF6-mediated unfolded protein response	PMID:22934019^[21] Reactome:R-HSA-381033	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0036499	PERK-mediated unfolded protein response	PMID:22934019^[21] PMID:14685163^[22] Reactome:R-HSA-381042	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	PMID:22934019^[21] PMID:14685163^[22]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0036488	CHOP-C/EBP complex	PMID:14685163^[22]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:14685163^[22]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:1339368^[23]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:7503811^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	PMID:7503811^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043620	regulation of DNA-templated transcription in response to stress	PMID:19816510^[25]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:14685163^[22]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-1791107	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006986	response to unfolded protein	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0834	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Jauhiainen, A et al. (2012) Distinct cytoplasmic and nuclear functions of the stress induced protein DDIT3/CHOP/GADD153. PLoS ONE 7 e33208 PubMed GONUTS page
↑ ^2.0 ^2.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ Okla, M et al. (2015) Activation of Toll-like receptor 4 (TLR4) attenuates adaptive thermogenesis via endoplasmic reticulum stress. J. Biol. Chem. 290 26476-90 PubMed GONUTS page
↑ Cai, D et al. (2016) Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine. Cell Death Dis 7 e2161 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Singh, VK et al. (2008) Intrinsically disordered human C/EBP homologous protein regulates biological activity of colon cancer cells during calcium stress. J. Mol. Biol. 380 313-26 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Edagawa, M et al. (2014) Role of activating transcription factor 3 (ATF3) in endoplasmic reticulum (ER) stress-induced sensitization of p53-deficient human colon cancer cells to tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis through up-regulation of death receptor 5 (DR5) by zerumbone and celecoxib. J. Biol. Chem. 289 21544-61 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 Yamaguchi, H & Wang, HG (2004) CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells. J. Biol. Chem. 279 45495-502 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 Su, N & Kilberg, MS (2008) C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene. J. Biol. Chem. 283 35106-17 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Ohoka, N et al. (2005) TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death. EMBO J. 24 1243-55 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 Ghosh, AP et al. (2012) CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress. PLoS ONE 7 e39586 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 Gachon, F et al. (2001) The cAMP response element binding protein-2 (CREB-2) can interact with the C/EBP-homologous protein (CHOP). FEBS Lett. 502 57-62 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 Chen, BP et al. (1996) Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10. Mol. Cell. Biol. 16 1157-68 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 Oh, YT et al. (2012) Oncogenic Ras and B-Raf proteins positively regulate death receptor 5 expression through co-activation of ERK and JNK signaling. J. Biol. Chem. 287 257-67 PubMed GONUTS page
↑ Crozat, A et al. (1993) Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma. Nature 363 640-4 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 Horndasch, M et al. (2006) The C/EBP homologous protein CHOP (GADD153) is an inhibitor of Wnt/TCF signals. Oncogene 25 3397-407 PubMed GONUTS page
↑ Chami, M et al. (2008) Role of SERCA1 truncated isoform in the proapoptotic calcium transfer from ER to mitochondria during ER stress. Mol. Cell 32 641-51 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 Park, SH et al. (2010) Endoplasmic reticulum stress-activated C/EBP homologous protein enhances nuclear factor-kappaB signals via repression of peroxisome proliferator-activated receptor gamma. J. Biol. Chem. 285 35330-9 PubMed GONUTS page
↑ ^18.0 ^18.1 Ohoka, N et al. (2007) Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion. J. Biol. Chem. 282 35687-94 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 ^19.4 ^19.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 Barski, OA et al. (2004) Regulation of aldehyde reductase expression by STAF and CHOP. Genomics 83 119-29 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 Brown, MK & Naidoo, N (2012) The endoplasmic reticulum stress response in aging and age-related diseases. Front Physiol 3 263 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 ^22.3 ^22.4 Oyadomari, S & Mori, M (2004) Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ. 11 381-9 PubMed GONUTS page
↑ Park, JS et al. (1992) Isolation, characterization and chromosomal localization of the human GADD153 gene. Gene 116 259-67 PubMed GONUTS page
↑ ^24.0 ^24.1 Rabbitts, TH et al. (1993) Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma. Nat. Genet. 4 175-80 PubMed GONUTS page
↑ Wang, M et al. (2010) Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis. Cell Death Differ. 17 488-98 PubMed GONUTS page

[PMID:22496745-1] Jauhiainen, A et al. (2012) Distinct cytoplasmic and nuclear functions of the stress induced protein DDIT3/CHOP/GADD153. PLoS ONE 7 e33208 PubMed GONUTS page

[PMID:19274049-2] 2.0 ^2.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:26370079-3] Okla, M et al. (2015) Activation of Toll-like receptor 4 (TLR4) attenuates adaptive thermogenesis via endoplasmic reticulum stress. J. Biol. Chem. 290 26476-90 PubMed GONUTS page

[PMID:27031958-4] Cai, D et al. (2016) Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine. Cell Death Dis 7 e2161 PubMed GONUTS page

[PMID:18534616-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Singh, VK et al. (2008) Intrinsically disordered human C/EBP homologous protein regulates biological activity of colon cancer cells during calcium stress. J. Mol. Biol. 380 313-26 PubMed GONUTS page

[PMID:24939851-6] 6.0 ^6.1 ^6.2 Edagawa, M et al. (2014) Role of activating transcription factor 3 (ATF3) in endoplasmic reticulum (ER) stress-induced sensitization of p53-deficient human colon cancer cells to tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis through up-regulation of death receptor 5 (DR5) by zerumbone and celecoxib. J. Biol. Chem. 289 21544-61 PubMed GONUTS page

[PMID:15322075-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 Yamaguchi, H & Wang, HG (2004) CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells. J. Biol. Chem. 279 45495-502 PubMed GONUTS page

[PMID:18940792-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 Su, N & Kilberg, MS (2008) C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene. J. Biol. Chem. 283 35106-17 PubMed GONUTS page

[PMID:15775988-9] 9.0 ^9.1 ^9.2 Ohoka, N et al. (2005) TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death. EMBO J. 24 1243-55 PubMed GONUTS page

[PMID:22761832-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 Ghosh, AP et al. (2012) CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress. PLoS ONE 7 e39586 PubMed GONUTS page

[PMID:11478948-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 Gachon, F et al. (2001) The cAMP response element binding protein-2 (CREB-2) can interact with the C/EBP-homologous protein (CHOP). FEBS Lett. 502 57-62 PubMed GONUTS page

[PMID:8622660-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 Chen, BP et al. (1996) Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10. Mol. Cell. Biol. 16 1157-68 PubMed GONUTS page

[PMID:22065586-13] 13.0 ^13.1 ^13.2 ^13.3 Oh, YT et al. (2012) Oncogenic Ras and B-Raf proteins positively regulate death receptor 5 expression through co-activation of ERK and JNK signaling. J. Biol. Chem. 287 257-67 PubMed GONUTS page

[PMID:8510758-14] Crozat, A et al. (1993) Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma. Nature 363 640-4 PubMed GONUTS page

[PMID:16434966-15] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 Horndasch, M et al. (2006) The C/EBP homologous protein CHOP (GADD153) is an inhibitor of Wnt/TCF signals. Oncogene 25 3397-407 PubMed GONUTS page

[PMID:19061639-16] Chami, M et al. (2008) Role of SERCA1 truncated isoform in the proapoptotic calcium transfer from ER to mitochondria during ER stress. Mol. Cell 32 641-51 PubMed GONUTS page

[PMID:20829347-17] 17.0 ^17.1 ^17.2 ^17.3 Park, SH et al. (2010) Endoplasmic reticulum stress-activated C/EBP homologous protein enhances nuclear factor-kappaB signals via repression of peroxisome proliferator-activated receptor gamma. J. Biol. Chem. 285 35330-9 PubMed GONUTS page

[PMID:17872950-18] 18.0 ^18.1 Ohoka, N et al. (2007) Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion. J. Biol. Chem. 282 35687-94 PubMed GONUTS page

[PMID:21873635-19] 19.0 ^19.1 ^19.2 ^19.3 ^19.4 ^19.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:14667815-20] 20.0 ^20.1 ^20.2 Barski, OA et al. (2004) Regulation of aldehyde reductase expression by STAF and CHOP. Genomics 83 119-29 PubMed GONUTS page

[PMID:22934019-21] 21.0 ^21.1 ^21.2 Brown, MK & Naidoo, N (2012) The endoplasmic reticulum stress response in aging and age-related diseases. Front Physiol 3 263 PubMed GONUTS page

[PMID:14685163-22] 22.0 ^22.1 ^22.2 ^22.3 ^22.4 Oyadomari, S & Mori, M (2004) Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ. 11 381-9 PubMed GONUTS page

[PMID:1339368-23] Park, JS et al. (1992) Isolation, characterization and chromosomal localization of the human GADD153 gene. Gene 116 259-67 PubMed GONUTS page

[PMID:7503811-24] 24.0 ^24.1 Rabbitts, TH et al. (1993) Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma. Nat. Genet. 4 175-80 PubMed GONUTS page

[PMID:19816510-25] Wang, M et al. (2010) Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis. Cell Death Differ. 17 488-98 PubMed GONUTS page

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