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HUMAN:DDIT3

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) DDIT3 (synonyms: CHOP, CHOP10, GADD153)
Protein Name(s) DNA damage-inducible transcript 3 protein

DDIT-3 C/EBP zeta C/EBP-homologous protein CHOP C/EBP-homologous protein 10 CHOP-10 CCAAT/enhancer-binding protein homologous protein Growth arrest and DNA damage-inducible protein GADD153

External Links
UniProt P35638
EMBL S40706
S62138
AY461580
AY880949
AC022506
BC003637
CCDS CCDS55838.1
CCDS8943.1
PIR JC1169
S33798
RefSeq NP_001181982.1
NP_001181983.1
NP_001181984.1
NP_001181986.1
NP_004074.2
UniGene Hs.505777
DisProt DP00624
ProteinModelPortal P35638
SMR P35638
BioGrid 108016
IntAct P35638
MINT MINT-1434413
STRING 9606.ENSP00000340671
PhosphoSite P35638
DMDM 544022
MaxQB P35638
PaxDb P35638
PRIDE P35638
DNASU 1649
Ensembl ENST00000346473
ENST00000547303
ENST00000551116
ENST00000552740
ENST00000618206
GeneID 1649
KEGG hsa:1649
UCSC uc001soi.3
uc009zps.3
CTD 1649
GeneCards GC12M057910
HGNC HGNC:2726
MIM 126337
613488
neXtProt NX_P35638
Orphanet 99967
PharmGKB PA27193
eggNOG NOG279524
GeneTree ENSGT00390000006305
HOGENOM HOG000089934
HOVERGEN HBG051328
InParanoid P35638
KO K04452
OMA DRMVNLH
OrthoDB EOG7QC7Z1
PhylomeDB P35638
TreeFam TF105006
Reactome REACT_18355
REACT_18423
SignaLink P35638
ChiTaRS DDIT3
GeneWiki DNA_damage-inducible_transcript_3
GenomeRNAi 1649
NextBio 6792
PRO PR:P35638
Proteomes UP000005640
Bgee P35638
CleanEx HS_DDIT3
ExpressionAtlas P35638
Genevestigator P35638
GO GO:0005829
GO:0005770
GO:0005654
GO:0005634
GO:0003677
GO:0046982
GO:0043565
GO:0003700
GO:0003714
GO:0008134
GO:0044212
GO:0006987
GO:0001955
GO:0007050
GO:0045454
GO:0044267
GO:0006974
GO:0030968
GO:0006983
GO:0070059
GO:0042789
GO:0090090
GO:2000016
GO:0045662
GO:0043433
GO:0045892
GO:0032757
GO:0043525
GO:0045944
GO:1990440
GO:0045893
GO:0043161
GO:0043620
GO:0044324
GO:0006355
GO:0051209
GO:0034976
GO:0042594
GO:0006986
GO:0016055
InterPro IPR004827
IPR016670
PANTHER PTHR16833
Pfam PF07716
PIRSF PIRSF016571
SMART SM00338
PROSITE PS50217

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0007050

cell cycle arrest

PMID:22496745[1]

ECO:0000314

P

Figure 4 shows an assay of cells subjected to the condition of DDIT3 within the cytoplasm or the nucleus. After the cells were cultured for 12 hours, the nuclei were extracted and the gene expression pattern was analyzed. When DDIT3 is present in the nucleus, a much greater portion of cells accumulate in the G1 phase expression pattern, indicating that DDIT3 being present in the nucleus encourages cell cycle arrest in G1.

complete
CACAO 4646

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049[2]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049[2]

ECO:0000255

match to sequence model evidence used in manual assertion

InterPro:IPR004827

F

Seeded From UniProt

complete

involved_in

GO:0120163

negative regulation of cold-induced thermogenesis

PMID:26370079[3]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P35639

P

Seeded From UniProt

complete

involved_in

GO:2001244

positive regulation of intrinsic apoptotic signaling pathway

PMID:27031958[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043525

positive regulation of neuron apoptotic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62857

P

Seeded From UniProt

complete

involved_in

GO:0010506

regulation of autophagy

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62857

P

Seeded From UniProt

complete

involved_in

GO:2001244

positive regulation of intrinsic apoptotic signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62857

P

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

GO_REF:0000113

ECO:0005556

multiple sequence alignment evidence used in manual assertion

UniProtKB:P53566

F

Seeded From UniProt

complete

involved_in

GO:0043433

negative regulation of DNA-binding transcription factor activity

PMID:18534616[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_regulation_target:(UniProtKB:P35222)

Seeded From UniProt

complete

involved_in

GO:0051091

positive regulation of DNA-binding transcription factor activity

PMID:18534616[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_regulation_target:(UniProtKB:P14410)

Seeded From UniProt

complete

involved_in

GO:0051091

positive regulation of DNA-binding transcription factor activity

PMID:18534616[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_regulation_target:(UniProtKB:P05412)

Seeded From UniProt

complete

involved_in

GO:0051259

protein complex oligomerization

PMID:18534616[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

PMID:18534616[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

NOT|enables

GO:0042803

protein homodimerization activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62857

F

Seeded From UniProt

complete

enables

GO:0000976

transcription regulatory region sequence-specific DNA binding

PMID:24939851[6]

ECO:0000314

direct assay evidence used in manual assertion

F

has_direct_input:(UniProtKB:O14763)

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:24939851[6]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P18847

F

has_regulation_target:(UniProtKB:O14763)

Seeded From UniProt

complete

involved_in

GO:1990440

positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

PMID:24939851[6]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(UniProtKB:O14763)

Seeded From UniProt

complete

enables

GO:0044212

transcription regulatory region DNA binding

PMID:15322075[7]

ECO:0000305

curator inference used in manual assertion

GO:0032993

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:15322075[7]

ECO:0000314

direct assay evidence used in manual assertion

C

exists_during:(GO:0034976)

Seeded From UniProt

complete

part_of

GO:0032993

protein-DNA complex

PMID:15322075[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:15322075[7]

ECO:0000305

curator inference used in manual assertion

GO:0032993
GO:1990440

F

Seeded From UniProt

complete

involved_in

GO:1990440

positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

PMID:15322075[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0036488

CHOP-C/EBP complex

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P35639

C

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:18940792[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:1990617

CHOP-ATF4 complex

PMID:18940792[8]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P18848

C

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

PMID:15775988[9]

ECO:0000303

author statement without traceable support used in manual assertion

F

has_direct_input:(UniProtKB:P18848)|has_direct_input:(UniProtKB:P17676)

Seeded From UniProt

complete

involved_in

GO:1990440

positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

PMID:15775988[9]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P17676

P

has_regulation_target:(UniProtKB:Q96RU7)

Seeded From UniProt

complete

involved_in

GO:0051898

negative regulation of protein kinase B signaling

PMID:22761832[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

part_of:(GO:0034976)

Seeded From UniProt

complete

involved_in

GO:0043525

positive regulation of neuron apoptotic process

PMID:22761832[10]

ECO:0000305

curator inference used in manual assertion

GO:1990440

P

part_of:(GO:0034976)

Seeded From UniProt

complete

involved_in

GO:1902237

positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

PMID:22761832[10]

ECO:0000305

curator inference used in manual assertion

GO:1990440

P

occurs_in:(CL:0000540)

Seeded From UniProt

complete

involved_in

GO:1990440

positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

PMID:22761832[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0043522

leucine zipper domain binding

PMID:11478948[11]

ECO:0000314

direct assay evidence used in manual assertion

F

has_direct_input:(UniProtKB:P18848)

Seeded From UniProt

complete

enables

GO:0008140

cAMP response element binding protein binding

PMID:11478948[11]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P18848

F

part_of:(GO:0000122)

Seeded From UniProt

complete

part_of

GO:1990617

CHOP-ATF4 complex

PMID:11478948[11]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0032792

negative regulation of CREB transcription factor activity

PMID:8622660[12]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(UniProtKB:P18847)

Seeded From UniProt

complete

involved_in

GO:1903026

negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding

PMID:8622660[12]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(UniProtKB:P18847)

Seeded From UniProt

complete

enables

GO:0043522

leucine zipper domain binding

PMID:8622660[12]

ECO:0000314

direct assay evidence used in manual assertion

F

has_direct_input:(UniProtKB:P18847)

Seeded From UniProt

complete

part_of

GO:1990622

CHOP-ATF3 complex

PMID:8622660[12]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

PMID:8622660[12]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P18847

F

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:11478948[11]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P18848

P

Seeded From UniProt

complete

involved_in

GO:0032792

negative regulation of CREB transcription factor activity

PMID:11478948[11]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P18848

P

has_regulation_target:(UniProtKB:P18848)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:11478948[11]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007050

cell cycle arrest

PMID:22496745[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

colocalizes_with

GO:0035976

transcription factor AP-1 complex

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P35639

C

Seeded From UniProt

complete

enables

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

PMID:22065586[13]

ECO:0000314

direct assay evidence used in manual assertion

F

occurs_at:(SO:0001952)

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:22065586[13]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

PMID:22065586[13]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0044212

transcription regulatory region DNA binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P35639

F

Seeded From UniProt

complete

involved_in

GO:1990440

positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P35639

P

has_regulation_target:(UniProtKB:O75807)

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:8510758[14]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:2000016

negative regulation of determination of dorsal identity

PMID:16434966[15]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0090090

negative regulation of canonical Wnt signaling pathway

PMID:16434966[15]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P35639

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:22065586[13]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0044324

regulation of transcription involved in anterior/posterior axis specification

PMID:16434966[15]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P35639

P

Seeded From UniProt

complete

involved_in

GO:0043433

negative regulation of DNA-binding transcription factor activity

PMID:16434966[15]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034976

response to endoplasmic reticulum stress

PMID:19061639[16]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

PMID:16434966[15]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9NQB0

F

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

PMID:16434966[15]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q01978

F

Seeded From UniProt

complete

involved_in

GO:0070059

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

PMID:15322075[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070059

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

PMID:20829347[17]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070059

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

PMID:18940792[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:15322075[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:15775988[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:18940792[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

PMID:17872950[18]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034976

response to endoplasmic reticulum stress

PMID:20829347[17]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034976

response to endoplasmic reticulum stress

PMID:18940792[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032757

positive regulation of interleukin-8 production

PMID:20829347[17]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006986

response to unfolded protein

PMID:18940792[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

PMID:17872950[18]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

PMID:22761832[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:20829347[17]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:22761832[10]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:18940792[8]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:1990622

CHOP-ATF3 complex

PMID:21873635[19]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000423833
UniProtKB:P35638

C

Seeded From UniProt

complete

part_of

GO:1990617

CHOP-ATF4 complex

PMID:21873635[19]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000423833
UniProtKB:P35638

C

Seeded From UniProt

complete

involved_in

GO:0070059

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

PMID:21873635[19]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:109247
PANTHER:PTN000423833
UniProtKB:P35638

P

Seeded From UniProt

complete

part_of

GO:0036488

CHOP-C/EBP complex

PMID:21873635[19]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:109247
PANTHER:PTN000423833
RGD:62391

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[19]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:109247
PANTHER:PTN000423833
RGD:62391

C

Seeded From UniProt

complete

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

PMID:21873635[19]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000423833
UniProtKB:P35638

F

Seeded From UniProt

complete

involved_in

GO:0045454

cell redox homeostasis

PMID:14667815[20]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042789

mRNA transcription by RNA polymerase II

PMID:14667815[20]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:14667815[20]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:2000016

negative regulation of determination of dorsal identity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P35639
ensembl:ENSMUSP00000026475

P

Seeded From UniProt

complete

involved_in

GO:1990442

intrinsic apoptotic signaling pathway in response to nitrosative stress

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P35639
ensembl:ENSMUSP00000026475

P

Seeded From UniProt

complete

involved_in

GO:1990440

positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P35639
ensembl:ENSMUSP00000026475

P

Seeded From UniProt

complete

involved_in

GO:1901216

positive regulation of neuron death

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P35639
ensembl:ENSMUSP00000026475

P

Seeded From UniProt

complete

involved_in

GO:0120163

negative regulation of cold-induced thermogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P35639
ensembl:ENSMUSP00000026475

P

Seeded From UniProt

complete

involved_in

GO:0090090

negative regulation of canonical Wnt signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P35639
ensembl:ENSMUSP00000026475

P

Seeded From UniProt

complete

involved_in

GO:0072655

establishment of protein localization to mitochondrion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P35639
ensembl:ENSMUSP00000026475

P

Seeded From UniProt

complete

involved_in

GO:0070059

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P35639
ensembl:ENSMUSP00000026475

P

Seeded From UniProt

complete

involved_in

GO:0051209

release of sequestered calcium ion into cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P35639
ensembl:ENSMUSP00000026475

P

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P35639
ensembl:ENSMUSP00000026475

F

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P35639
ensembl:ENSMUSP00000026475

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P35639
ensembl:ENSMUSP00000026475

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P35639
ensembl:ENSMUSP00000026475

P

Seeded From UniProt

complete

involved_in

GO:0045662

negative regulation of myoblast differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P35639
ensembl:ENSMUSP00000026475

P

Seeded From UniProt

complete

involved_in

GO:0045599

negative regulation of fat cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P35639
ensembl:ENSMUSP00000026475

P

Seeded From UniProt

complete

involved_in

GO:0044324

regulation of transcription involved in anterior/posterior axis specification

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P35639
ensembl:ENSMUSP00000026475

P

Seeded From UniProt

complete

enables

GO:0044212

transcription regulatory region DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P35639
ensembl:ENSMUSP00000026475

F

Seeded From UniProt

complete

involved_in

GO:0043525

positive regulation of neuron apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P35639
ensembl:ENSMUSP00000026475

P

Seeded From UniProt

complete

involved_in

GO:0043392

negative regulation of DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P35639
ensembl:ENSMUSP00000026475

P

Seeded From UniProt

complete

involved_in

GO:0042594

response to starvation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P35639
ensembl:ENSMUSP00000026475

P

Seeded From UniProt

complete

part_of

GO:0036488

CHOP-C/EBP complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P35639
ensembl:ENSMUSP00000026475

C

Seeded From UniProt

complete

part_of

GO:0035976

transcription factor AP-1 complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P35639
ensembl:ENSMUSP00000026475

C

Seeded From UniProt

complete

involved_in

GO:0034976

response to endoplasmic reticulum stress

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P35639
ensembl:ENSMUSP00000026475

P

Seeded From UniProt

complete

involved_in

GO:0030968

endoplasmic reticulum unfolded protein response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P35639
ensembl:ENSMUSP00000026475

P

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P35639
ensembl:ENSMUSP00000026475

F

Seeded From UniProt

complete

involved_in

GO:0006983

ER overload response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P35639
ensembl:ENSMUSP00000026475

P

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P35639
ensembl:ENSMUSP00000026475

P

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P35639
ensembl:ENSMUSP00000026475

P

Seeded From UniProt

complete

part_of

GO:0005770

late endosome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P35639
ensembl:ENSMUSP00000026475

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P35639
ensembl:ENSMUSP00000026475

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P35639
ensembl:ENSMUSP00000026475

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P35639
ensembl:ENSMUSP00000026475

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P35639
ensembl:ENSMUSP00000026475

F

Seeded From UniProt

complete

involved_in

GO:0001955

blood vessel maturation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P35639
ensembl:ENSMUSP00000026475

P

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P35639
ensembl:ENSMUSP00000026475

P

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004827

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004827

P

Seeded From UniProt

complete

involved_in

GO:0036500

ATF6-mediated unfolded protein response

PMID:22934019[21]
Reactome:R-HSA-381033

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

involved_in

GO:0036499

PERK-mediated unfolded protein response

PMID:22934019[21]
PMID:14685163[22]
Reactome:R-HSA-381042

ECO:0000304

author statement supported by traceable reference used in manual assertion



P

Seeded From UniProt

complete

involved_in

GO:0070059

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

PMID:22934019[21]
PMID:14685163[22]

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

part_of

GO:0036488

CHOP-C/EBP complex

PMID:14685163[22]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:14685163[22]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

PMID:1339368[23]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

PMID:7503811[24]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003714

transcription corepressor activity

PMID:7503811[24]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0043620

regulation of DNA-templated transcription in response to stress

PMID:19816510[25]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

PMID:14685163[22]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-1791107

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007050

cell cycle arrest

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0338

P

Seeded From UniProt

complete

involved_in

GO:0006986

response to unfolded protein

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0834

P

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0053

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

involved_in

GO:0016055

Wnt signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0879

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Jauhiainen, A et al. (2012) Distinct cytoplasmic and nuclear functions of the stress induced protein DDIT3/CHOP/GADD153. PLoS ONE 7 e33208 PubMed GONUTS page
  2. 2.0 2.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
  3. Okla, M et al. (2015) Activation of Toll-like receptor 4 (TLR4) attenuates adaptive thermogenesis via endoplasmic reticulum stress. J. Biol. Chem. 290 26476-90 PubMed GONUTS page
  4. Cai, D et al. (2016) Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine. Cell Death Dis 7 e2161 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 5.4 Singh, VK et al. (2008) Intrinsically disordered human C/EBP homologous protein regulates biological activity of colon cancer cells during calcium stress. J. Mol. Biol. 380 313-26 PubMed GONUTS page
  6. 6.0 6.1 6.2 Edagawa, M et al. (2014) Role of activating transcription factor 3 (ATF3) in endoplasmic reticulum (ER) stress-induced sensitization of p53-deficient human colon cancer cells to tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis through up-regulation of death receptor 5 (DR5) by zerumbone and celecoxib. J. Biol. Chem. 289 21544-61 PubMed GONUTS page
  7. 7.0 7.1 7.2 7.3 7.4 7.5 7.6 Yamaguchi, H & Wang, HG (2004) CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells. J. Biol. Chem. 279 45495-502 PubMed GONUTS page
  8. 8.0 8.1 8.2 8.3 8.4 8.5 8.6 Su, N & Kilberg, MS (2008) C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene. J. Biol. Chem. 283 35106-17 PubMed GONUTS page
  9. 9.0 9.1 9.2 Ohoka, N et al. (2005) TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death. EMBO J. 24 1243-55 PubMed GONUTS page
  10. 10.0 10.1 10.2 10.3 10.4 10.5 Ghosh, AP et al. (2012) CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress. PLoS ONE 7 e39586 PubMed GONUTS page
  11. 11.0 11.1 11.2 11.3 11.4 11.5 Gachon, F et al. (2001) The cAMP response element binding protein-2 (CREB-2) can interact with the C/EBP-homologous protein (CHOP). FEBS Lett. 502 57-62 PubMed GONUTS page
  12. 12.0 12.1 12.2 12.3 12.4 Chen, BP et al. (1996) Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10. Mol. Cell. Biol. 16 1157-68 PubMed GONUTS page
  13. 13.0 13.1 13.2 13.3 Oh, YT et al. (2012) Oncogenic Ras and B-Raf proteins positively regulate death receptor 5 expression through co-activation of ERK and JNK signaling. J. Biol. Chem. 287 257-67 PubMed GONUTS page
  14. Crozat, A et al. (1993) Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma. Nature 363 640-4 PubMed GONUTS page
  15. 15.0 15.1 15.2 15.3 15.4 15.5 Horndasch, M et al. (2006) The C/EBP homologous protein CHOP (GADD153) is an inhibitor of Wnt/TCF signals. Oncogene 25 3397-407 PubMed GONUTS page
  16. Chami, M et al. (2008) Role of SERCA1 truncated isoform in the proapoptotic calcium transfer from ER to mitochondria during ER stress. Mol. Cell 32 641-51 PubMed GONUTS page
  17. 17.0 17.1 17.2 17.3 Park, SH et al. (2010) Endoplasmic reticulum stress-activated C/EBP homologous protein enhances nuclear factor-kappaB signals via repression of peroxisome proliferator-activated receptor gamma. J. Biol. Chem. 285 35330-9 PubMed GONUTS page
  18. 18.0 18.1 Ohoka, N et al. (2007) Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion. J. Biol. Chem. 282 35687-94 PubMed GONUTS page
  19. 19.0 19.1 19.2 19.3 19.4 19.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  20. 20.0 20.1 20.2 Barski, OA et al. (2004) Regulation of aldehyde reductase expression by STAF and CHOP. Genomics 83 119-29 PubMed GONUTS page
  21. 21.0 21.1 21.2 Brown, MK & Naidoo, N (2012) The endoplasmic reticulum stress response in aging and age-related diseases. Front Physiol 3 263 PubMed GONUTS page
  22. 22.0 22.1 22.2 22.3 22.4 Oyadomari, S & Mori, M (2004) Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ. 11 381-9 PubMed GONUTS page
  23. Park, JS et al. (1992) Isolation, characterization and chromosomal localization of the human GADD153 gene. Gene 116 259-67 PubMed GONUTS page
  24. 24.0 24.1 Rabbitts, TH et al. (1993) Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma. Nat. Genet. 4 175-80 PubMed GONUTS page
  25. Wang, M et al. (2010) Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis. Cell Death Differ. 17 488-98 PubMed GONUTS page