name: ATF6-mediated unfolded protein response
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def: "A series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor ATF6 (activating transcription factor 6). Begins with activation of ATF6 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. Under conditions of endoplasmic reticulum stress, ATF6 translocates to the Golgi where it is processed by proteases to release a cytoplasmic domain (ATF6f), which operates as a transcriptional activator of many genes required to restore folding capacity." [GOC:bf, GOC:PARL, PMID:22013210]
synonym: "activating transcription factor 6 signaling in unfolded protein response" EXACT [GOC:bf]
synonym: "ATF6 branch of UPR" EXACT [GOC:bf]
synonym: "ATF6 signal transduction pathway" BROAD [GOC:bf]
synonym: "ATF6 signaling in response to endoplasmic reticulum stress" RELATED [GOC:bf]
synonym: "ATF6-alpha UPR branch" NARROW [GOC:bf]
synonym: "ATF6-beta UPR branch" NARROW [GOC:bf]
synonym: "endoplasmic reticulum unfolded protein response; ATF6 signaling" EXACT [GOC:bf]
synonym: "UPR signaling by ATF6 stress sensor" EXACT [GOC:bf]
is_a: GO:0006984 ! ER-nucleus signaling pathway
is_a: GO:0030968 ! endoplasmic reticulum unfolded protein response
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Pages in category "GO:0036500 ! ATF6-mediated unfolded protein response"
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