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PMID:7503811
| Citation |
Rabbitts, TH, Forster, A, Larson, R and Nathan, P (1993) Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma. Nat. Genet. 4:175-80 |
|---|---|
| Abstract |
The search for tumour-specific markers is one of the chief goals in cancer biology. We show that the translocation t(12;16)(q13:p11) in malignant myxoid liposarcoma can be a fusion of the CHOP dominant negative transcription factor gene with a novel gene, FUS, which can result in fusion of the FUS glycine-rich protein with the whole CHOP coding region. The data support the concept that protein fusion may commonly occur in solid tumours resulting in tumour-specific markers of potential clinical importance. The data also indicate the importance of transcription disruption in the pathogenesis of solid tumours. |
| Links |
PubMed Online version:10.1038/ng0693-175 |
| Keywords |
Amino Acid Sequence; Base Sequence; CCAAT-Enhancer-Binding Proteins; Chromosomes, Human, Pair 12/ultrastructure; Chromosomes, Human, Pair 16/ultrastructure; DNA/genetics; DNA, Neoplasm/genetics; DNA-Binding Proteins/genetics; Gene Expression Regulation, Neoplastic; Genes, Dominant; Heterogeneous-Nuclear Ribonucleoproteins; Humans; Liposarcoma/genetics; Molecular Sequence Data; Neoplasm Proteins/genetics; Nuclear Proteins/genetics; Polymerase Chain Reaction; RNA-Binding Protein FUS; Ribonucleoproteins/genetics; Transcription Factor CHOP; Transcription Factors/genetics; Transcription, Genetic; Translocation, Genetic |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0006355: regulation of transcription, DNA-templated |
ECO:0000304: author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003714: transcription corepressor activity |
ECO:0000304: author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
See also
References
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