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Category:Team Nameless

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StatusPageUserDate/TimeGO Term (Aspect)ReferenceEvidenceNotesLinks
updatedbyinstructorLAMBD:GAMHarsharn.kaur, Team Nameless2012-11-18 16:52:33 CSTGO:0060703 deoxyribonuclease inhibitor activity (F)PMID:4275917ECO:0000314 direct assay evidence used in manual assertion

Figure 3: "The gamma protein was purified on the basis of its capacity

to inhibit the ATP-dependent, double-strand exonuclease activity of the RecBC DNase.In the presence of inhibitor, the nuclease reaction proceeded at a constant, but reduced rate throughout the time of incubation due to the presence of inactive gamma protein that can compete with active material".

challenge
updatedbyinstructorLAMBD:GAMHarsharn.kaur, Team Nameless2012-11-18 15:53:32 CSTGO:0060703 deoxyribonuclease inhibitor activity (F)PMID:4275917ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 2 provides the evidence that "product of the gam gene of phage lambda (gamma protein) is probably itself an inhibitor of the RecBC DNase".

challenge
updatedbyinstructorMOUSE:ASPMAndrew.james4500, Team Nameless2012-11-18 12:45:37 CSTGO:0051445 regulation of meiotic cell cycle (P)PMID:23152892ECO:0000315 mutant phenotype evidence used in manual assertion

Table 1 shows meiotic progression.

challenge
updatedbyinstructorHAEIF:C1J7J7Andrew.james4500, Team Nameless2012-11-18 12:42:25 CSTGO:0009103 lipopolysaccharide biosynthetic process (P)PMID:19289512ECO:0000315 mutant phenotype evidence used in manual assertion

Figures 3 and 4 show the mutant strains containing the added glucose and galactose.

challenge
unacceptableYEAST:MOT1Courtney.kast4500, Team Nameless2012-11-18 11:38:28 CSTGO:2000233 negative regulation of rRNA processing (P)PMID:17296733ECO:0000314 direct assay evidence used in manual assertion

Figure 2: Reduced rRNA synthesis and processing in mot1 cells

challenge
updatedbyinstructorHUMAN:DDX5Courtney.kast4500, Team Nameless2012-11-18 11:31:47 CSTGO:0009299 mRNA transcription (P)PMID:23143267ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 1 and 2 show Ddx5 is required for c-fos gene transcriptional activation in response to estradiol. Figure 1: Ddx5 depletion impairs c-fos mRNA production in response to estradiol treatment. Figure 2: Ddx5 depletion impairs c-fos transcriptional induction by estradiol.

challenge
unacceptableHUMAN:RAD18Colin.Taylor4500, Team Nameless2012-11-15 12:56:18 CSTGO:0006513 protein monoubiquitination (P)PMID:3078399ECO:0000316 genetic interaction evidence used in manual assertion

Figure 2 shows that Rad18 inhibits Rad6’s ubiquitin chain-formation activity to direct Rad6 toward PCNA monoubiquitination.

challenge
acceptableRAT:THY1Courtney.kast4500, Team Nameless2012-11-14 08:38:44 CSTGO:0046777 protein autophosphorylation (P)PMID:19723805ECO:0000314 direct assay evidence used in manual assertion

Fig. 2. Thy-1 stimulates FAK autophosphorylation

challenge
updatedbyinstructorENTFL:Q04114Courtney.kast4500, Team Nameless2012-11-11 19:22:33 CSTGO:0045892 negative regulation of transcription, DNA-dependent (P)PMID:22544272ECO:0000314 direct assay evidence used in manual assertion

Figure 3 shows how PrgX has regulatory effects on prgQ transcript

challenge
updatedbyinstructorHUMAN:RANB9Courtney.kast4500, Team Nameless2012-11-11 19:15:12 CSTGO:0070373 negative regulation of ERK1 and ERK2 cascade (P)PMID:23118896ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 2 shows RanBPM is a negative regulator of ERK1/2 activation through use of western blots and antibody precitpitation via enhanced phosphorylation

challenge
unacceptableMOUSE:1433GCourtney.kast4500, Team Nameless2012-11-04 17:49:32 CSTGO:0005488 binding (F)PMID:21390248ECO:0000315 mutant phenotype evidence used in manual assertion

The result showed enhanced binding of 14-3-3γ and η with LRRK2, compared to 14-3-3ζ, ε and θ (Figure 2D)

challenge
requireschangesPROMH:B4EVY7Colin.Taylor4500, Team Nameless2012-11-04 14:20:49 CSTGO:0071978 bacterial-type flagellar swarming motility (P)PMID:23111869ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 5 shows that wild type and mutants of this gene effect the ability of swarming motility of the organism.

challenge
updatedbyinstructorPROMH:B4F159Colin.Taylor4500, Team Nameless2012-11-04 14:17:45 CSTGO:0071978 bacterial-type flagellar swarming motility (P)PMID:23111869ECO:0000316 genetic interaction evidence used in manual assertion

Figure 1 shows mutants compared to each other. Each mutant shows different patterns on the plate of swarming.

challenge
unacceptableNEUCR:PACCColin.Taylor4500, Team Nameless2012-11-03 15:31:58 CDTGo:0004373 glycogen (starch) synthase activity (F)PMID:3432076ECO:0000315 mutant phenotype evidence used in manual assertion

Table 3 suggest that alkaline pH induces pacC expression and a concomitant decrease in glycogen levels by down-regulating the gsn gene.

challenge
unacceptableRAT:NRP1Harsharn.kaur, Team Nameless2012-10-29 21:45:10 CDTGO:0008015 blood circulation (P)PMID:11018070ECO:0000314 direct assay evidence used in manual assertion

Figure 7: A transient increase of Cerebal blood flow in the ischemic brain was observed via early administration of rhVEGF165 in rats.

challenge
unacceptableRAT:NRP1Harsharn.kaur, Team Nameless2012-10-29 21:21:10 CDTGO:0090212 negative regulation of establishment of blood-brain barrier (P)PMID:ECO:0000314 direct assay evidence used in manual assertion

Figure 4: A coronal section was examined with areas of gross hemorrhage from the rhVEGF165 treated rats at 24 hours after a stroke which corresponded to the MRI section (large hyperintense areas on Gd-DTPA observed after 30 minutes from injecting Gd-DTPA into rhVEGF165 rats), "Suggests that the early increase in BBB leakage to large molecules may be related to the incidence of hemorrhage in this model".

challenge
unacceptableRAT:NRP1Harsharn.kaur, Team Nameless2012-10-29 20:02:45 CDTGO:0090211 positive regulation of establishment of blood-brain barrier (P)PMID:11018070ECO:0000314 direct assay evidence used in manual assertion

Figure 1g: Quantitative Data was analyzed that showed a significant amount of increase for rhVEGF165 treated group in plasma perfusion in vessels within 3μm of diameters compared to the data for saline-treated control group.

challenge
correctedthroughchallengesHELAM:I1XB05Courtney.kast4500, Team Nameless2012-10-03 15:38:43 CDTGO:0016049 cell growth (P)PMID:23020757ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 3b shows the function of AK2 in promoting cell growth and viability

challenge
acceptableHELAM:I1XB05Courtney.kast4500, Team Nameless2012-10-03 15:38:43 CDTGO:0035172 hemocyte proliferation (P)PMID:23020757ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 5 shows that AK2 is necessary for the proliferation of circulating haemocytes.

challenge

Pages in category "Team Nameless"

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