MOUSE:ASPM

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Aspm (synonyms: Calmbp1, Sha1)
Protein Name(s)	Abnormal spindle-like microcephaly-associated protein homolog Calmodulin-binding protein Sha1 Calmodulin-binding protein 1 Spindle and hydroxyurea checkpoint abnormal protein
External Links
UniProt	Q8CJ27
EMBL	AF533752 AL606536 AC158946 AK050785 AK083710 AF062378
CCDS	CCDS35729.1
RefSeq	NP_033921.3
UniGene	Mm.168523
ProteinModelPortal	Q8CJ27
IntAct	Q8CJ27
MINT	MINT-4088484
STRING	10090.ENSMUSP00000059159
PhosphoSite	Q8CJ27
MaxQB	Q8CJ27
PaxDb	Q8CJ27
PRIDE	Q8CJ27
Ensembl	ENSMUST00000053364
GeneID	12316
KEGG	mmu:12316
UCSC	uc007cwh.1
CTD	259266
MGI	MGI:1334448
eggNOG	COG5022
GeneTree	ENSGT00560000077332
HOGENOM	HOG000034105
HOVERGEN	HBG050595
InParanoid	Q8CJ27
KO	K16743
OMA	QSYYRMH
OrthoDB	EOG73JKTH
TreeFam	TF351180
NextBio	280880
PRO	PR:Q8CJ27
Proteomes	UP000000589
Bgee	Q8CJ27
ExpressionAtlas	Q8CJ27
Genevestigator	Q8CJ27
GO	GO:0005737 GO:0072687 GO:0005874 GO:0030496 GO:0097431 GO:0005634 GO:0000922 GO:0005516 GO:0007420 GO:0021987 GO:0048589 GO:0021873 GO:0051661 GO:0008584 GO:0007067 GO:0045769 GO:0045665 GO:0001764 GO:0097150 GO:0048477 GO:0090263 GO:0002052 GO:0007283 GO:0090306
Gene3D	1.10.418.10
InterPro	IPR016024 IPR029955 IPR022613 IPR001715 IPR000048 IPR027417
PANTHER	PTHR25069:SF115
Pfam	PF11971 PF00612
SMART	SM00033 SM00015
SUPFAM	SSF47576 SSF48371 SSF52540
PROSITE	PS50021 PS50096

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0060236	regulation of mitotic spindle organization	PMID:23152892^[1]	ECO:0000314			P		Figure 4.shows "Downregulation of ASPM expression by morpholinos disrupts meiotic spindle organization."	complete CACAO 6033
	GO:0051445	regulation of meiotic cell cycle	PMID:23152892^[1]	ECO:0000315			P		Table 1 shows meiotic progression.	complete CACAO 6050
involved_in	GO:0051445	regulation of meiotic cell cycle	PMID:23152892^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0097431	mitotic spindle pole	PMID:23152892^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0097431	mitotic spindle pole	PMID:22031545^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000337) part_of:(EMAPA:17544)	Seeded From UniProt	complete
part_of	GO:0097431	mitotic spindle pole	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IZT6	C		Seeded From UniProt	complete
part_of	GO:0097431	mitotic spindle pole	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1307111	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097150	neuronal stem cell population maintenance	PMID:19896444^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090306	spindle assembly involved in meiosis	PMID:23152892^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000023)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090263	positive regulation of canonical Wnt signaling pathway	PMID:21937711^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88276	P		Seeded From UniProt	complete
part_of	GO:0072687	meiotic spindle	PMID:23152892^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051661	maintenance of centrosome location	PMID:16798874^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:16910) occurs_in:(CL:0000710)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051653	spindle localization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IZT6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048589	developmental growth	PMID:20823249^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:16894)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048477	oogenesis	PMID:20823249^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4345319	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045769	negative regulation of asymmetric cell division	PMID:16798874^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:16910) regulates_o_results_in_division_of:(CL:0000710)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045665	negative regulation of neuron differentiation	PMID:16798874^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0036449	microtubule minus-end	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IZT6	C		Seeded From UniProt	complete
part_of	GO:0030496	midbody	PMID:20823249^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16910) part_of:(CL:0000710)	Seeded From UniProt	complete
part_of	GO:0030496	midbody	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1307111	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021987	cerebral cortex development	PMID:24220505^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5573152	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021873	forebrain neuroblast division	PMID:16798874^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:16910) results_in_division_of:(CL:0000710)	Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1307111	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008584	male gonad development	PMID:24220505^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5573152	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007420	brain development	PMID:20823249^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	results_in_development_of:(EMAPA:16894)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007283	spermatogenesis	PMID:20823249^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4345319	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007051	spindle organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IZT6	P		Seeded From UniProt	complete
part_of	GO:0005874	microtubule	PMID:23152892^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000023)	Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1307111	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:23152892^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8IZT6	C		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	PMID:23152892^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002052	positive regulation of neuroblast proliferation	PMID:21937711^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88276	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002052	positive regulation of neuroblast proliferation	PMID:21937711^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001764	neuron migration	PMID:21937711^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88276	P	occurs_in:(EMAPA:17544) results_in_movement_of:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001764	neuron migration	PMID:21937711^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:17544) results_in_movement_of:(CL:0000117)	Seeded From UniProt	complete
part_of	GO:0000922	spindle pole	PMID:20823249^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16910) part_of:(CL:0000710)	Seeded From UniProt	complete
part_of	GO:0000922	spindle pole	PMID:16798874^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16910) part_of:(CL:0000710)	Seeded From UniProt	complete
part_of	GO:0097431	mitotic spindle pole	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZZQ1 ensembl:ENSRNOP00000016797	C		Seeded From UniProt	complete
part_of	GO:0030496	midbody	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZZQ1 ensembl:ENSRNOP00000016797	C		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZZQ1 ensembl:ENSRNOP00000016797	C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D3ZZQ1 ensembl:ENSRNOP00000016797	C		Seeded From UniProt	complete
part_of	GO:0097431	mitotic spindle pole	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8IZT6 ensembl:ENSP00000356379	C		Seeded From UniProt	complete
involved_in	GO:0051653	spindle localization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8IZT6 ensembl:ENSP00000356379	P		Seeded From UniProt	complete
part_of	GO:0036449	microtubule minus-end	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8IZT6 ensembl:ENSP00000356379	C		Seeded From UniProt	complete
involved_in	GO:0007051	spindle organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8IZT6 ensembl:ENSP00000356379	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8IZT6 ensembl:ENSP00000356379	C		Seeded From UniProt	complete
involved_in	GO:0007051	spindle organization	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029955	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0112	F		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
involved_in	GO:0051301	cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0132	P		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206	C		Seeded From UniProt	complete
part_of	GO:0005874	microtubule	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0493	C		Seeded From UniProt	complete
part_of	GO:0005819	spindle	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0251	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 Xu, XL et al. (2012) The microtubule-associated protein ASPM regulates spindle assembly and meiotic progression in mouse oocytes. PLoS ONE 7 e49303 PubMed GONUTS page
↑ Asami, M et al. (2011) The role of Pax6 in regulating the orientation and mode of cell division of progenitors in the mouse cerebral cortex. Development 138 5067-78 PubMed GONUTS page
↑ Paik, JH et al. (2009) FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Cell Stem Cell 5 540-53 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Buchman, JJ et al. (2011) ASPM regulates Wnt signaling pathway activity in the developing brain. Genes Dev. 25 1909-14 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Fish, JL et al. (2006) Aspm specifically maintains symmetric proliferative divisions of neuroepithelial cells. Proc. Natl. Acad. Sci. U.S.A. 103 10438-43 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Pulvers, JN et al. (2010) Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germline. Proc. Natl. Acad. Sci. U.S.A. 107 16595-600 PubMed GONUTS page
↑ ^7.0 ^7.1 Fujimori, A et al. (2014) Disruption of Aspm causes microcephaly with abnormal neuronal differentiation. Brain Dev. 36 661-9 PubMed GONUTS page

[PMID:23152892-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 Xu, XL et al. (2012) The microtubule-associated protein ASPM regulates spindle assembly and meiotic progression in mouse oocytes. PLoS ONE 7 e49303 PubMed GONUTS page

[PMID:22031545-2] Asami, M et al. (2011) The role of Pax6 in regulating the orientation and mode of cell division of progenitors in the mouse cerebral cortex. Development 138 5067-78 PubMed GONUTS page

[PMID:19896444-3] Paik, JH et al. (2009) FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Cell Stem Cell 5 540-53 PubMed GONUTS page

[PMID:21937711-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Buchman, JJ et al. (2011) ASPM regulates Wnt signaling pathway activity in the developing brain. Genes Dev. 25 1909-14 PubMed GONUTS page

[PMID:16798874-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Fish, JL et al. (2006) Aspm specifically maintains symmetric proliferative divisions of neuroepithelial cells. Proc. Natl. Acad. Sci. U.S.A. 103 10438-43 PubMed GONUTS page

[PMID:20823249-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Pulvers, JN et al. (2010) Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germline. Proc. Natl. Acad. Sci. U.S.A. 107 16595-600 PubMed GONUTS page

[PMID:24220505-7] 7.0 ^7.1 Fujimori, A et al. (2014) Disruption of Aspm causes microcephaly with abnormal neuronal differentiation. Brain Dev. 36 661-9 PubMed GONUTS page

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MOUSE:ASPM

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