RAT:NRP1

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Nrp1
Protein Name(s)	Neuropilin-1 Vascular endothelial cell growth factor 165 receptor
External Links
UniProt	Q9QWJ9
EMBL	AF016296 BC085689
RefSeq	NP_659566.1 XP_006255887.1 XP_008770820.1
UniGene	Rn.10815 Rn.165344
PDB	2ORX 2ORZ
PDBsum	2ORX 2ORZ
ProteinModelPortal	Q9QWJ9
SMR	Q9QWJ9
BioGrid	251596
DIP	DIP-44935N
IntAct	Q9QWJ9
MINT	MINT-1542085
STRING	10116.ENSRNOP00000014492
PhosphoSite	Q9QWJ9
PaxDb	Q9QWJ9
PRIDE	Q9QWJ9
Ensembl	ENSRNOT00000014492
GeneID	246331
KEGG	rno:246331
UCSC	RGD:621588
CTD	8829
RGD	621588
eggNOG	NOG150941
GeneTree	ENSGT00760000119073
HOGENOM	HOG000039978
HOVERGEN	HBG000502
InParanoid	Q9QWJ9
KO	K06724
OMA	GWGSHKT
OrthoDB	EOG7ZWD1D
PhylomeDB	Q9QWJ9
TreeFam	TF316506
Reactome	REACT_230341 REACT_231436 REACT_253285 REACT_254909 REACT_261768
EvolutionaryTrace	Q9QWJ9
NextBio	623769
PRO	PR:Q9QWJ9
Proteomes	UP000002494
Genevestigator	Q9QWJ9
GO	GO:0030424 GO:0009986 GO:0005829 GO:0005769 GO:0005615 GO:0030426 GO:0016021 GO:0005883 GO:0043025 GO:0005886 GO:0097443 GO:0008201 GO:0046872 GO:0017154 GO:0005021 GO:0060978 GO:0048846 GO:0007411 GO:0007413 GO:0060385 GO:0021785 GO:0007155 GO:0002042 GO:0035729 GO:0071679 GO:0060982 GO:0016358 GO:0060666 GO:0035767 GO:0021612 GO:0021828 GO:0048012 GO:0048843 GO:2001237 GO:0043524 GO:0007399 GO:1901166 GO:0009887 GO:0001569 GO:0048008 GO:0050918 GO:0048842 GO:0070374 GO:0050731 GO:1902336 GO:1902946 GO:0061441 GO:0009611 GO:0061299 GO:0031290 GO:1902287 GO:0061549 GO:0097490 GO:0097491 GO:0021637 GO:0048010 GO:1902378
Gene3D	2.60.120.260 2.60.120.290
InterPro	IPR000421 IPR013320 IPR000859 IPR008979 IPR000998 IPR014648 IPR022579 IPR027146
PANTHER	PTHR10127:SF616
Pfam	PF00431 PF11980 PF00754 PF00629
PIRSF	PIRSF036960
PRINTS	PR00020
SMART	SM00042 SM00231 SM00137
SUPFAM	SSF49785 SSF49854 SSF49899
PROSITE	PS01180 PS01285 PS01286 PS50022 PS00740 PS50060

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0090211	positive regulation of establishment of blood-brain barrier	PMID:11018070^[1]	ECO:0000314			P	Figure 1g: Quantitative Data was analyzed that showed a significant amount of increase for rhVEGF165 treated group in plasma perfusion in vessels within 3μm of diameters compared to the data for saline-treated control group.	complete CACAO 5478
	GO:0090212	negative regulation of establishment of blood-brain barrier	PMID:PMID	ECO:0000314			P	Figure 4: A coronal section was examined with areas of gross hemorrhage from the rhVEGF165 treated rats at 24 hours after a stroke which corresponded to the MRI section (large hyperintense areas on Gd-DTPA observed after 30 minutes from injecting Gd-DTPA into rhVEGF165 rats), "Suggests that the early increase in BBB leakage to large molecules may be related to the incidence of hemorrhage in this model".	complete CACAO 5479
	GO:0008015	blood circulation	PMID:11018070^[1]	ECO:0000314			P	Figure 7: A transient increase of Cerebal blood flow in the ischemic brain was observed via early administration of rhVEGF165 in rats.	complete CACAO 5480
involved_in	GO:0097475	motor neuron migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97333	P	Seeded From UniProt	complete
involved_in	GO:0048843	negative regulation of axon extension involved in axon guidance	PMID:9288754^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:9288754^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0030426	growth cone	PMID:9288754^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:9288754^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0017154	semaphorin receptor activity	PMID:9288754^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:9288754^[2]	ECO:0000303	author statement without traceable support used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:9288754^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0009611	response to wounding	PMID:15906313^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	PMID:9288754^[2]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005096	P	Seeded From UniProt	complete
involved_in	GO:2000251	positive regulation of actin cytoskeleton reorganization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	P	Seeded From UniProt	complete
involved_in	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	P	Seeded From UniProt	complete
involved_in	GO:0051894	positive regulation of focal adhesion assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	P	Seeded From UniProt	complete
involved_in	GO:0051496	positive regulation of stress fiber assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	P	Seeded From UniProt	complete
involved_in	GO:0051491	positive regulation of filopodium assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	P	Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	P	Seeded From UniProt	complete
involved_in	GO:0048012	hepatocyte growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	P	Seeded From UniProt	complete
involved_in	GO:0048010	vascular endothelial growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	P	Seeded From UniProt	complete
involved_in	GO:0048008	platelet-derived growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	P	Seeded From UniProt	complete
involved_in	GO:0043542	endothelial cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	P	Seeded From UniProt	complete
involved_in	GO:0042327	positive regulation of phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	P	Seeded From UniProt	complete
involved_in	GO:0038190	VEGF-activated neuropilin signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	P	Seeded From UniProt	complete
involved_in	GO:0038189	neuropilin signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	P	Seeded From UniProt	complete
enables	GO:0038085	vascular endothelial growth factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	F	Seeded From UniProt	complete
involved_in	GO:0035767	endothelial cell chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	P	Seeded From UniProt	complete
involved_in	GO:0035729	cellular response to hepatocyte growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	P	Seeded From UniProt	complete
involved_in	GO:0034446	substrate adhesion-dependent cell spreading	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	P	Seeded From UniProt	complete
involved_in	GO:0032489	regulation of Cdc42 protein signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	P	Seeded From UniProt	complete
involved_in	GO:0031532	actin cytoskeleton reorganization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	P	Seeded From UniProt	complete
enables	GO:0019838	growth factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	F	Seeded From UniProt	complete
involved_in	GO:0010595	positive regulation of endothelial cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	P	Seeded From UniProt	complete
involved_in	GO:0007229	integrin-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	P	Seeded From UniProt	complete
involved_in	GO:0006930	substrate-dependent cell migration, cell extension	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	P	Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	C	Seeded From UniProt	complete
enables	GO:0005096	GTPase activator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	F	Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	P	Seeded From UniProt	complete
involved_in	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:1905040	otic placode development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:1904835	dorsal root ganglion morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:1903375	facioacoustic ganglion development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:1902946	protein localization to early endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:1902378	VEGF-activated neuropilin signaling pathway involved in axon guidance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:1902336	positive regulation of retinal ganglion cell axon guidance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:1902287	semaphorin-plexin signaling pathway involved in axon guidance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:1902285	semaphorin-plexin signaling pathway involved in neuron projection guidance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:1901998	toxin transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:1901166	neural crest cell migration involved in autonomic nervous system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0150020	basal dendrite arborization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0150018	basal dendrite development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0099173	postsynapse organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
part_of	GO:0099055	integral component of postsynaptic membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	C	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	C	Seeded From UniProt	complete
involved_in	GO:0097491	sympathetic neuron projection guidance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0097490	sympathetic neuron projection extension	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0097475	motor neuron migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
part_of	GO:0097443	sorting endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	C	Seeded From UniProt	complete
involved_in	GO:0097374	sensory neuron axon guidance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0090259	regulation of retinal ganglion cell axon guidance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0071679	commissural neuron axon guidance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0071526	semaphorin-plexin signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0061551	trigeminal ganglion development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0061549	sympathetic ganglion development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0061441	renal artery morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0061299	retina vasculature morphogenesis in camera-type eye	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0060982	coronary artery morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0060978	angiogenesis involved in coronary vascular morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0060385	axonogenesis involved in innervation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0051491	positive regulation of filopodium assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0050918	positive chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0048846	axon extension involved in axon guidance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0048844	artery morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0048843	negative regulation of axon extension involved in axon guidance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0048842	positive regulation of axon extension involved in axon guidance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0048841	regulation of axon extension involved in axon guidance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0048666	neuron development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0048485	sympathetic nervous system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0048010	vascular endothelial growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0043542	endothelial cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	C	Seeded From UniProt	complete
involved_in	GO:0042327	positive regulation of phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0038190	VEGF-activated neuropilin signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0038189	neuropilin signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
enables	GO:0038085	vascular endothelial growth factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	F	Seeded From UniProt	complete
involved_in	GO:0036486	ventral trunk neural crest cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0035924	cellular response to vascular endothelial growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0032489	regulation of Cdc42 protein signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0031290	retinal ganglion cell axon guidance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0030517	negative regulation of axon extension	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	C	Seeded From UniProt	complete
involved_in	GO:0021828	gonadotrophin-releasing hormone neuronal migration to the hypothalamus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0021785	branchiomotor neuron axon guidance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0021675	nerve development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0021649	vestibulocochlear nerve structural organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0021637	trigeminal nerve structural organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0021636	trigeminal nerve morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0021612	facial nerve structural organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	F	Seeded From UniProt	complete
enables	GO:0019838	growth factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	F	Seeded From UniProt	complete
enables	GO:0017154	semaphorin receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	F	Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0016358	dendrite development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0010595	positive regulation of endothelial cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0008045	motor neuron axon guidance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0007413	axonal fasciculation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0007229	integrin-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	C	Seeded From UniProt	complete
part_of	GO:0005883	neurofilament	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	C	Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	C	Seeded From UniProt	complete
enables	GO:0005021	vascular endothelial growth factor-activated receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	F	Seeded From UniProt	complete
involved_in	GO:0003148	outflow tract septum morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0002042	cell migration involved in sprouting angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0002040	sprouting angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0001764	neuron migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0001569	branching involved in blood vessel morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97333 ensembl:ENSMUSP00000026917	P	Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR014648 InterPro:IPR027146	P	Seeded From UniProt	complete
enables	GO:0005021	vascular endothelial growth factor-activated receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR014648 InterPro:IPR027146	F	Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR014648 InterPro:IPR027146	P	Seeded From UniProt	complete
involved_in	GO:0009887	animal organ morphogenesis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027146	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000998	C	Seeded From UniProt	complete
enables	GO:0017154	semaphorin receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR014648 InterPro:IPR027146	F	Seeded From UniProt	complete
enables	GO:0019838	growth factor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027146	F	Seeded From UniProt	complete
involved_in	GO:0035767	endothelial cell chemotaxis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027146	P	Seeded From UniProt	complete
involved_in	GO:0038084	vascular endothelial growth factor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR014648	P	Seeded From UniProt	complete
involved_in	GO:0048010	vascular endothelial growth factor receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027146	P	Seeded From UniProt	complete
involved_in	GO:0071526	semaphorin-plexin signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027146	P	Seeded From UniProt	complete
enables	GO:0017154	semaphorin receptor activity	PMID:9288754^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0358	F	Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C	Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0037	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Zhang, ZG et al. (2000) VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain. J. Clin. Invest. 106 829-38 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Kolodkin, AL et al. (1997) Neuropilin is a semaphorin III receptor. Cell 90 753-62 PubMed GONUTS page
↑ Fernando, RN et al. (2005) Distribution and cellular localization of insulin-regulated aminopeptidase in the rat central nervous system. J. Comp. Neurol. 487 372-90 PubMed GONUTS page

[PMID:11018070-1] 1.0 ^1.1 Zhang, ZG et al. (2000) VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain. J. Clin. Invest. 106 829-38 PubMed GONUTS page

[PMID:9288754-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Kolodkin, AL et al. (1997) Neuropilin is a semaphorin III receptor. Cell 90 753-62 PubMed GONUTS page

[PMID:15906313-3] Fernando, RN et al. (2005) Distribution and cellular localization of insulin-regulated aminopeptidase in the rat central nervous system. J. Comp. Neurol. 487 372-90 PubMed GONUTS page

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[2]

[3]

RAT:NRP1

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