GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

HUMAN:DDX5

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) DDX5 (synonyms: G17P1, HELR, HLR1)
Protein Name(s) Probable ATP-dependent RNA helicase DDX5

DEAD box protein 5 RNA helicase p68

External Links
UniProt P17844
EMBL X52104
AF015812
BT006943
AK297192
AB451257
AC009994
CH471109
CH471109
BC016027
X15729
AJ010931
CCDS CCDS11659.1
PIR JC1087
RefSeq NP_004387.1
XP_005257168.1
XP_006721801.1
UniGene Hs.279806
PDB 3FE2
4A4D
PDBsum 3FE2
4A4D
ProteinModelPortal P17844
SMR P17844
BioGrid 108021
DIP DIP-29844N
IntAct P17844
MINT MINT-5000516
STRING 9606.ENSP00000225792
PhosphoSite P17844
DMDM 129383
SWISS-2DPAGE P17844
MaxQB P17844
PaxDb P17844
PeptideAtlas P17844
PRIDE P17844
DNASU 1655
Ensembl ENST00000225792
ENST00000450599
GeneID 1655
KEGG hsa:1655
UCSC uc002jej.2
uc010wqa.1
CTD 1655
GeneCards GC17M062494
HGNC HGNC:2746
HPA CAB005868
HPA020043
MIM 180630
neXtProt NX_P17844
PharmGKB PA27228
eggNOG COG0513
GeneTree ENSGT00760000119219
HOGENOM HOG000268804
HOVERGEN HBG015893
InParanoid P17844
KO K12823
PhylomeDB P17844
TreeFam TF300332
ChiTaRS DDX5
EvolutionaryTrace P17844
GeneWiki DDX5
GenomeRNAi 1655
NextBio 35473161
PRO PR:P17844
Proteomes UP000005640
Bgee P17844
CleanEx HS_DDX5
ExpressionAtlas P17844
Genevestigator P17844
GO GO:0071013
GO:0070062
GO:0016020
GO:0005730
GO:0005634
GO:0030529
GO:0050681
GO:0005524
GO:0004004
GO:0030331
GO:0044822
GO:0036002
GO:0003724
GO:0003713
GO:0016049
GO:0007623
GO:0001701
GO:0072332
GO:0000398
GO:0000122
GO:0043517
GO:0033148
GO:0045944
GO:0000381
GO:0060765
GO:0045667
GO:2001014
GO:0045069
GO:0006351
Gene3D 3.40.50.300
InterPro IPR011545
IPR014001
IPR001650
IPR027417
IPR012587
IPR000629
IPR014014
Pfam PF00270
PF00271
PF08061
SMART SM00487
SM00490
SUPFAM SSF52540
PROSITE PS00039
PS51192
PS51194
PS51195

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0009299

mRNA transcription

PMID:23143267[1]

ECO:0000315

P

Figure 1 and 2 show Ddx5 is required for c-fos gene transcriptional activation in response to estradiol. Figure 1: Ddx5 depletion impairs c-fos mRNA production in response to estradiol treatment. Figure 2: Ddx5 depletion impairs c-fos transcriptional induction by estradiol.

complete
CACAO 6145

involved_in

GO:0000380

alternative mRNA splicing, via spliceosome

PMID:24275493[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006357

regulation of transcription by RNA polymerase II

PMID:24275493[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030520

intracellular estrogen receptor signaling pathway

PMID:24275493[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030521

androgen receptor signaling pathway

PMID:24275493[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

NOT|involved_in

GO:1902893

regulation of pri-miRNA transcription by RNA polymerase II

PMID:18548003[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030509

BMP signaling pathway

PMID:18548003[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • occurs_in:(UBERON:0002012)
  • occurs_in:(CL:0000359)

Seeded From UniProt

complete

involved_in

GO:1903800

positive regulation of production of miRNAs involved in gene silencing by miRNA

PMID:18548003[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

  • occurs_in:(UBERON:0002012)
  • occurs_in:(CL:0000359)
  • part_of:(GO:0030509)

Seeded From UniProt

complete

involved_in

GO:0000956

nuclear-transcribed mRNA catabolic process

PMID:23788676[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003730

mRNA 3'-UTR binding

PMID:23788676[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0043021

ribonucleoprotein complex binding

PMID:23788676[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0000381

regulation of alternative mRNA splicing, via spliceosome

PMID:23022728[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0070878

primary miRNA binding

PMID:18548003[3]

ECO:0000314

direct assay evidence used in manual assertion

F

  • occurs_in:(UBERON:0002012)
  • occurs_in:(CL:0000359)
  • has_input:(RNAcentral:URS000018AA08_9606)

Seeded From UniProt

complete

enables

GO:0046332

SMAD binding

PMID:18548003[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P84022

F

Seeded From UniProt

complete

enables

GO:0070412

R-SMAD binding

PMID:18548003[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q99717

F

Seeded From UniProt

complete

enables

GO:0035500

MH2 domain binding

PMID:18548003[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q15797

F

Seeded From UniProt

complete

involved_in

GO:0061614

pri-miRNA transcription by RNA polymerase II

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q61656

P

Seeded From UniProt

complete

enables

GO:1990841

promoter-specific chromatin binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q61656

F

Seeded From UniProt

complete

involved_in

GO:0045445

myoblast differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q61656

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:24910439[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0001837

epithelial to mesenchymal transition

PMID:24910439[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000380

alternative mRNA splicing, via spliceosome

PMID:24910439[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009299

mRNA transcription

PMID:23143267[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:16791210[7]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:19946888[8]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:19056867[9]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001088)

Seeded From UniProt

complete

involved_in

GO:2001014

regulation of skeletal muscle cell differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q61656

P

Seeded From UniProt

complete

involved_in

GO:0072332

intrinsic apoptotic signaling pathway by p53 class mediator

PMID:15660129[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0071013

catalytic step 2 spliceosome

PMID:11991638[11]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0060765

regulation of androgen receptor signaling pathway

PMID:18829551[12]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0050681

androgen receptor binding

PMID:18829551[12]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0045667

regulation of osteoblast differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q61656

P

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22658674[13]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22681889[14]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0043517

positive regulation of DNA damage response, signal transduction by p53 class mediator

PMID:15660129[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0036002

pre-mRNA binding

PMID:21343338[15]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

PMID:10837141[16]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:2451786[17]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003724

RNA helicase activity

PMID:21343338[15]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003724

RNA helicase activity

PMID:1996094[18]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0000398

mRNA splicing, via spliceosome

PMID:11991638[11]

ECO:0000305

curator inference used in manual assertion

GO:0071013

P

Seeded From UniProt

complete

involved_in

GO:0000381

regulation of alternative mRNA splicing, via spliceosome

PMID:21343338[15]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:15298701[19]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:1990904

ribonucleoprotein complex

PMID:18809582[20]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0048306

calcium-dependent protein binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6AYI1
ensembl:ENSRNOP00000041663

F

Seeded From UniProt

complete

involved_in

GO:0045069

regulation of viral genome replication

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6AYI1
ensembl:ENSRNOP00000041663

P

Seeded From UniProt

complete

enables

GO:0019899

enzyme binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6AYI1
ensembl:ENSRNOP00000041663

F

Seeded From UniProt

complete

enables

GO:0005516

calmodulin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6AYI1
ensembl:ENSRNOP00000041663

F

Seeded From UniProt

complete

enables

GO:0004004

ATP-dependent RNA helicase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6AYI1
ensembl:ENSRNOP00000041663

F

Seeded From UniProt

complete

enables

GO:0003676

nucleic acid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011545

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011545

F

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-9023861
Reactome:R-HSA-9023860
Reactome:R-HSA-9009536
Reactome:R-HSA-9009533
Reactome:R-HSA-9009526
Reactome:R-HSA-72160
Reactome:R-HSA-72143
Reactome:R-HSA-72139
Reactome:R-HSA-72130
Reactome:R-HSA-72127
Reactome:R-HSA-72124
Reactome:R-HSA-72107
Reactome:R-HSA-3900194
Reactome:R-HSA-3900177
Reactome:R-HSA-156661

ECO:0000304

author statement supported by traceable reference used in manual assertion















C

Seeded From UniProt

complete

involved_in

GO:0000398

mRNA splicing, via spliceosome

Reactome:R-HSA-72163

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0694

F

Seeded From UniProt

complete

part_of

GO:0005681

spliceosomal complex

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0747

C

Seeded From UniProt

complete

enables

GO:0004386

helicase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0347

F

Seeded From UniProt

complete

involved_in

GO:0008380

RNA splicing

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0508

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

involved_in

GO:0006397

mRNA processing

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0507

P

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

involved_in

GO:0048511

rhythmic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0090

P

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0188

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Zonta, E et al. (2013) The RNA helicase DDX5/p68 is a key factor promoting c-fos expression at different levels from transcription to mRNA export. Nucleic Acids Res. 41 554-64 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 Samaan, S et al. (2014) The Ddx5 and Ddx17 RNA helicases are cornerstones in the complex regulatory array of steroid hormone-signaling pathways. Nucleic Acids Res. 42 2197-207 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Davis, BN et al. (2008) SMAD proteins control DROSHA-mediated microRNA maturation. Nature 454 56-61 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Geißler, V et al. (2013) The RNA helicase Ddx5/p68 binds to hUpf3 and enhances NMD of Ddx17/p72 and Smg5 mRNA. Nucleic Acids Res. 41 7875-88 PubMed GONUTS page
  5. ↑ Dardenne, E et al. (2012) Splicing switch of an epigenetic regulator by RNA helicases promotes tumor-cell invasiveness. Nat. Struct. Mol. Biol. 19 1139-46 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 Dardenne, E et al. (2014) RNA helicases DDX5 and DDX17 dynamically orchestrate transcription, miRNA, and splicing programs in cell differentiation. Cell Rep 7 1900-13 PubMed GONUTS page
  7. ↑ Sigal, A et al. (2006) Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins. Nat. Methods 3 525-31 PubMed GONUTS page
  8. ↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
  9. ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
  10. ↑ 10.0 10.1 Bates, GJ et al. (2005) The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressor. EMBO J. 24 543-53 PubMed GONUTS page
  11. ↑ 11.0 11.1 Jurica, MS et al. (2002) Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. RNA 8 426-39 PubMed GONUTS page
  12. ↑ 12.0 12.1 Clark, EL et al. (2008) The RNA helicase p68 is a novel androgen receptor coactivator involved in splicing and is overexpressed in prostate cancer. Cancer Res. 68 7938-46 PubMed GONUTS page
  13. ↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
  14. ↑ Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
  15. ↑ 15.0 15.1 15.2 Kar, A et al. (2011) RNA helicase p68 (DDX5) regulates tau exon 10 splicing by modulating a stem-loop structure at the 5' splice site. Mol. Cell. Biol. 31 1812-21 PubMed GONUTS page
  16. ↑ Nicol, SM et al. (2000) The nuclear DEAD box RNA helicase p68 interacts with the nucleolar protein fibrillarin and colocalizes specifically in nascent nucleoli during telophase. Exp. Cell Res. 257 272-80 PubMed GONUTS page
  17. ↑ Ford, MJ et al. (1988) Nuclear protein with sequence homology to translation initiation factor eIF-4A. Nature 332 736-8 PubMed GONUTS page
  18. ↑ Iggo, RD et al. (1991) p68 RNA helicase: identification of a nucleolar form and cloning of related genes containing a conserved intron in yeasts. Mol. Cell. Biol. 11 1326-33 PubMed GONUTS page
  19. ↑ Wilson, BJ et al. (2004) The p68 and p72 DEAD box RNA helicases interact with HDAC1 and repress transcription in a promoter-specific manner. BMC Mol. Biol. 5 11 PubMed GONUTS page
  20. ↑ Maggi, LB Jr et al. (2008) Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome. Mol. Cell. Biol. 28 7050-65 PubMed GONUTS page
Retrieved from "https://gowiki.tamu.edu/wiki/index.php?title=HUMAN:DDX5&oldid=5954998"