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HUMAN:RANB9
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | RANBP9 (synonyms: RANBPM) | |
| Protein Name(s) | Ran-binding protein 9
RanBP9 BPM-L BPM90 Ran-binding protein M RanBPM RanBP7 | |
| External Links | ||
| UniProt | Q96S59 | |
| EMBL | AB055311 AK313334 AL441883 Z93020 Z93020 AL441883 BC019886 BC052781 BC063849 AB008515 AF306510 | |
| CCDS | CCDS4529.1 | |
| RefSeq | NP_005484.2 XP_006715008.1 | |
| UniGene | Hs.708182 | |
| ProteinModelPortal | Q96S59 | |
| SMR | Q96S59 | |
| BioGrid | 115359 | |
| IntAct | Q96S59 | |
| MINT | MINT-243263 | |
| STRING | 9606.ENSP00000011619 | |
| PhosphoSite | Q96S59 | |
| DMDM | 61215334 | |
| MaxQB | Q96S59 | |
| PaxDb | Q96S59 | |
| PRIDE | Q96S59 | |
| Ensembl | ENST00000011619 ENST00000539980 | |
| GeneID | 10048 | |
| KEGG | hsa:10048 | |
| UCSC | uc003nba.3 | |
| CTD | 10048 | |
| GeneCards | GC06M013621 | |
| H-InvDB | HIX0032741 | |
| HGNC | HGNC:13727 | |
| HPA | CAB033767 HPA050007 | |
| MIM | 603854 | |
| neXtProt | NX_Q96S59 | |
| PharmGKB | PA34215 | |
| eggNOG | NOG316575 | |
| GeneTree | ENSGT00530000063160 | |
| HOGENOM | HOG000008133 | |
| HOVERGEN | HBG053444 | |
| InParanoid | Q96S59 | |
| OMA | YSNPWAS | |
| OrthoDB | EOG76MK7Z | |
| PhylomeDB | Q96S59 | |
| TreeFam | TF331658 | |
| Reactome | REACT_22205 | |
| SignaLink | Q96S59 | |
| ChiTaRS | RANBP9 | |
| GeneWiki | RANBP9 | |
| GenomeRNAi | 10048 | |
| NextBio | 35467774 | |
| PRO | PR:Q96S59 | |
| Proteomes | UP000005640 | |
| Bgee | Q96S59 | |
| CleanEx | HS_RANBP9 | |
| ExpressionAtlas | Q96S59 | |
| Genevestigator | Q96S59 | |
| GO | GO:0005829 GO:0005875 GO:0005634 GO:0019899 GO:0008536 GO:0007411 GO:0007020 GO:0006461 | |
| InterPro | IPR001870 IPR013320 IPR013144 IPR024964 IPR006595 IPR006594 IPR013720 IPR003877 | |
| Pfam | PF10607 PF08513 PF00622 | |
| SMART | SM00757 SM00668 SM00667 SM00449 | |
| SUPFAM | SSF49899 | |
| PROSITE | PS50188 PS50897 PS50896 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0070373 |
negative regulation of ERK1 and ERK2 cascade |
ECO:0000315 |
P |
Figure 2 shows RanBPM is a negative regulator of ERK1/2 activation through use of western blots and antibody precitpitation via enhanced phosphorylation |
complete | |||||
| GO:0005829 |
cytosol |
ECO:0000315 |
C |
Fig 1. Deletion of RanBPM C-terminus does not alter its sub cellular localization. Fig 2. RanBPM N-terminal region contains several determinants that regulate its subcellular localization. |
complete | |||||
|
part_of |
GO:0000151 |
ubiquitin ligase complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070373 |
negative regulation of ERK1 and ERK2 cascade |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019899 |
enzyme binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007020 |
microtubule nucleation |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008536 |
Ran GTPase binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007020 |
microtubule nucleation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0065003 |
protein-containing complex assembly |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005875 |
microtubule associated complex |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007411 |
axon guidance |
Reactome:R-HSA-422475 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-8851877 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0000165 |
MAPK cascade |
Reactome:R-HSA-5673001 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Atabakhsh, E & Schild-Poulter, C (2012) RanBPM is an inhibitor of ERK signaling. PLoS ONE 7 e47803 PubMed GONUTS page
- ↑ Salemi, LM et al. (2015) Characterization of RanBPM molecular determinants that control its subcellular localization. PLoS ONE 10 e0117655 PubMed GONUTS page
- ↑ Lampert, F et al. (2018) The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation. Elife 7 PubMed GONUTS page
- ↑ 4.0 4.1 Kobayashi, N et al. (2007) RanBPM, Muskelin, p48EMLP, p44CTLH, and the armadillo-repeat proteins ARMC8alpha and ARMC8beta are components of the CTLH complex. Gene 396 236-47 PubMed GONUTS page
- ↑ Francis, O et al. (2013) Molecular phylogeny of a RING E3 ubiquitin ligase, conserved in eukaryotic cells and dominated by homologous components, the muskelin/RanBPM/CTLH complex. PLoS ONE 8 e75217 PubMed GONUTS page
- ↑ 6.0 6.1 Menon, RP et al. (2004) The C terminus of fragile X mental retardation protein interacts with the multi-domain Ran-binding protein in the microtubule-organising centre. J. Mol. Biol. 343 43-53 PubMed GONUTS page
- ↑ Kabil, O et al. (2006) Human cystathionine beta-synthase is a target for sumoylation. Biochemistry 45 13528-36 PubMed GONUTS page
- ↑ 8.0 8.1 Wang, Y et al. (2002) HIPK2 associates with RanBPM. Biochem. Biophys. Res. Commun. 297 148-53 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 9.3 Nakamura, M et al. (1998) When overexpressed, a novel centrosomal protein, RanBPM, causes ectopic microtubule nucleation similar to gamma-tubulin. J. Cell Biol. 143 1041-52 PubMed GONUTS page
