LAMBD:GAM

Species (Taxon ID)	Escherichia phage lambda (Bacteriophage lambda). (10710)
Gene Name(s)	gam (synonyms: gamma)
Protein Name(s)	Host-nuclease inhibitor protein gam
External Links
UniProt	P03702
EMBL	V00638 V00638 J02459 S46756
PIR	D93737
RefSeq	NP_040618.1
PDB	2UUZ 2UV1
PDBsum	2UUZ 2UV1
ProteinModelPortal	P03702
SMR	P03702
DIP	DIP-572N
GeneID	2703509
KEGG	vg:2703509
OrthoDB	VOG09000123
EvolutionaryTrace	P03702
Proteomes	UP000001711
GO	GO:0060703 GO:0016032
InterPro	IPR009274
Pfam	PF06064
ProDom	PD084412

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0060703	deoxyribonuclease inhibitor activity	PMID:4275917	ECO:0000315			F		Figure 2 provides the evidence that "product of the gam gene of phage lambda (gamma protein) is probably itself an inhibitor of the RecBC DNase".	complete CACAO 6233
	GO:0060703	deoxyribonuclease inhibitor activity	PMID:4275917	ECO:0000314			F		Figure 3: "The gamma protein was purified on the basis of its capacity to inhibit the ATP-dependent, double-strand exonuclease activity of the RecBC DNase.In the presence of inhibitor, the nuclease reaction proceeded at a constant, but reduced rate throughout the time of incubation due to the presence of inactive gamma protein that can compete with active material".	complete CACAO 6268
enables	GO:0060703	deoxyribonuclease inhibitor activity	PMID:4275917	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0060703	deoxyribonuclease inhibitor activity	PMID:4275917	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032076	negative regulation of deoxyribonuclease activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0060703	P		Seeded From UniProt	complete
involved_in	GO:0032076	negative regulation of deoxyribonuclease activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0060703	P		Seeded From UniProt	complete
involved_in	GO:0032076	negative regulation of deoxyribonuclease activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0060703	P		Seeded From UniProt	complete
enables	GO:0060703	deoxyribonuclease inhibitor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009274	F		Seeded From UniProt	complete
involved_in	GO:0099016	DNA end degradation evasion by virus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1256	P		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
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References

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