YEAST:RPD3

Species (Taxon ID)	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s)	RPD3 (synonyms: MOF6, REC3, SDI2, SDS6)
Protein Name(s)	Histone deacetylase RPD3 Transcriptional regulatory protein RPD3
External Links
UniProt	P32561
EMBL	S66438 X83226 Z46259 Z71605 Z71606 AY692813 BK006947
PIR	S22284
RefSeq	NP_014069.1
ProteinModelPortal	P32561
SMR	P32561
BioGrid	35511
DIP	DIP-681N
IntAct	P32561
MINT	MINT-614075
STRING	4932.YNL330C
MaxQB	P32561
PaxDb	P32561
PeptideAtlas	P32561
EnsemblFungi	[example_ID YNL330C]
GeneID	855386
KEGG	sce:YNL330C
CYGD	YNL330c
SGD	S000005274
eggNOG	COG0123
GeneTree	ENSGT00530000062889
HOGENOM	HOG000225180
InParanoid	P32561
KO	K06067
OMA	YILYHES
OrthoDB	EOG78M0B2
BioCyc	YEAST:G3O-33314-MONOMER
NextBio	979187
Proteomes	UP000002311
Genevestigator	P32561
GO	GO:0005737 GO:0000118 GO:0033698 GO:0032221 GO:0070822 GO:0004407 GO:0032041 GO:0097372 GO:0046969 GO:0046970 GO:0003713 GO:0003714 GO:0070932 GO:0070933 GO:0061188 GO:0061186 GO:0031939 GO:0045128 GO:0051038 GO:0016479 GO:0000122 GO:0016239 GO:0045944 GO:0034503 GO:0030174 GO:0034401 GO:0000083 GO:0000117 GO:0001302 GO:0006368 GO:0061587
Gene3D	3.40.800.20
InterPro	IPR000286 IPR003084 IPR023801
PANTHER	PTHR10625
Pfam	PF00850
PIRSF	PIRSF037913
PRINTS	PR01270 PR01271

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0000083	regulation of transcription involved in G1/S phase of mitotic cell cycle	PMID:19823668^[1]	ECO:0000021		SGD:S000005609	P			complete
part_of	GO:0070210	Rpd3L-Expanded complex	PMID:19040720^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0033698	Rpd3L complex	PMID:19040720^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070211	Snt2C complex	PMID:19040720^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:24881874^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0006995) regulates_transcription_of:(SGD:S000003148) regulates_transcription_of:(SGD:S000001214) regulates_transcription_of:(SGD:S000000174) regulates_transcription_of:(SGD:S000002308) regulates_transcription_of:(SGD:S000000332)	Seeded From UniProt	complete
part_of	GO:0034399	nuclear periphery	PMID:25817432^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0006974)	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:24358376^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_direct_input:(UniProtKB:P21190) has_input:(CHEBI:30089)	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:24358376^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20398213^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0034605) has_direct_input:(UniProtKB:P06115)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20398213^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0034605) has_direct_input:(UniProtKB:P54114)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20398213^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0034605) has_direct_input:(UniProtKB:Q12412)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20398213^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0034605) has_direct_input:(UniProtKB:Q00764)	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:20398213^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0034605) has_direct_input:(UniProtKB:P28007)	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:20398213^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0034605) has_direct_input:(UniProtKB:P26784)	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:20398213^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0034605) has_direct_input:(UniProtKB:P42846)	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:20398213^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0034605) has_direct_input:(UniProtKB:Q01589)	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:20398213^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0034605) has_direct_input:(UniProtKB:P32478)	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:20398213^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0034605) has_direct_input:(UniProtKB:P38112)	Seeded From UniProt	complete
involved_in	GO:0070933	histone H4 deacetylation	PMID:8962081^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070933	histone H4 deacetylation	PMID:9572144^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070932	histone H3 deacetylation	PMID:8962081^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0070822	Sin3-type complex	PMID:9234741^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0061587	transfer RNA gene-mediated silencing	PMID:23707796^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061188	negative regulation of chromatin silencing at rDNA	PMID:10512855^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061188	negative regulation of chromatin silencing at rDNA	PMID:10388812^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061188	negative regulation of chromatin silencing at rDNA	PMID:10082585^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061186	negative regulation of chromatin silencing at silent mating-type cassette	PMID:19372273^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061186	negative regulation of chromatin silencing at silent mating-type cassette	PMID:10512855^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061186	negative regulation of chromatin silencing at silent mating-type cassette	PMID:10388812^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051038	negative regulation of transcription involved in meiotic cell cycle	PMID:17158929^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17296735^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000003162	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17210643^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000004674	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17296735^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17210643^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15254041^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17706600^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045128	negative regulation of reciprocal meiotic recombination	PMID:18515193^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034503	protein localization to nucleolar rDNA repeats	PMID:17203076^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0033698	Rpd3L complex	PMID:16286008^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0033698	Rpd3L complex	PMID:16314178^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0033698	Rpd3L complex	PMID:16286007^[24]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0032221	Rpd3S complex	PMID:16286008^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0032221	Rpd3S complex	PMID:16286007^[24]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0031939	negative regulation of chromatin silencing at telomere	PMID:19372273^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031939	negative regulation of chromatin silencing at telomere	PMID:10512855^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031939	negative regulation of chromatin silencing at telomere	PMID:10388812^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031939	negative regulation of chromatin silencing at telomere	PMID:20133733^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030174	regulation of DNA-dependent DNA replication initiation	PMID:15143171^[26]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000006324	P		Seeded From UniProt	complete
involved_in	GO:0030174	regulation of DNA-dependent DNA replication initiation	PMID:19417103^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030174	regulation of DNA-dependent DNA replication initiation	PMID:15143171^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030174	regulation of DNA-dependent DNA replication initiation	PMID:12453428^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016479	negative regulation of transcription by RNA polymerase I	PMID:19270272^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016479	negative regulation of transcription by RNA polymerase I	PMID:14609951^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016239	positive regulation of macroautophagy	PMID:22539722^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006368	transcription elongation from RNA polymerase II promoter	PMID:19948887^[32]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000004470	P		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	PMID:12110674^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	PMID:9572144^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	PMID:9512514^[34]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	PMID:8962081^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	PMID:12110674^[33]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	PMID:9150136^[35]	ECO:0000353	physical interaction evidence used in manual assertion	SGD:S000005364	F		Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	PMID:9150136^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:14737171^[36]	ECO:0000353	physical interaction evidence used in manual assertion	SGD:S000000859	F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:14737171^[36]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001302	replicative cell aging	PMID:10512855^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:11069890^[37]	ECO:0000353	physical interaction evidence used in manual assertion	SGD:S000000316	P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:11069890^[37]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000003162 SGD:S000006272	P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:17121596^[38]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:16314178^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:15141165^[39]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0000118	histone deacetylase complex	PMID:8962081^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000117	regulation of transcription involved in G2/M transition of mitotic cell cycle	PMID:17908798^[40]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000005899	P		Seeded From UniProt	complete
involved_in	GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle	PMID:19823668^[1]	ECO:0000353	physical interaction evidence used in manual assertion	SGD:S000005609	P		Seeded From UniProt	complete
involved_in	GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle	PMID:19823668^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000000038 SGD:S000006037	P		Seeded From UniProt	complete
involved_in	GO:0070933	histone H4 deacetylation	PMID:21873635^[41]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108086 MGI:MGI:1097691 MGI:MGI:1343091 PANTHER:PTN002578320 PomBase:SPAC3G9.07c SGD:S000005274 SGD:S000006272 UniProtKB:G5EB64 UniProtKB:Q13547	P		Seeded From UniProt	complete
involved_in	GO:0070932	histone H3 deacetylation	PMID:21873635^[41]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108086 MGI:MGI:1097691 PANTHER:PTN002578320 RGD:1309799 RGD:619976 RGD:619977 SGD:S000005274 TAIR:locus:2098115 UniProtKB:G5EB64 UniProtKB:Q13547	P		Seeded From UniProt	complete
part_of	GO:0070822	Sin3-type complex	PMID:21873635^[41]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015805 PANTHER:PTN000066122 PomBase:SPBC36.05c SGD:S000005274 UniProtKB:Q13547 UniProtKB:Q92769	C		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[41]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002578320 PomBase:SPBC36.05c SGD:S000005274 SGD:S000006272 UniProtKB:O15379 UniProtKB:Q13547 UniProtKB:Q92769 WB:WBGene00001834	P		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	PMID:21873635^[41]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015805 FB:FBgn0025825 MGI:MGI:108086 MGI:MGI:1097691 PANTHER:PTN002578320 PomBase:SPAC3G9.07c PomBase:SPBC36.05c RGD:1309799 RGD:619976 SGD:S000003162 SGD:S000005274 TAIR:locus:2162017 UniProtKB:G5EB64 UniProtKB:O15379 UniProtKB:Q13547 UniProtKB:Q7K6A1 UniProtKB:Q92769 WB:WBGene00001834 dictyBase:DDB_G0270338	F		Seeded From UniProt	complete
part_of	GO:0000118	histone deacetylase complex	PMID:21873635^[41]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015805 MGI:MGI:108086 PANTHER:PTN002578320 PomBase:SPAC3G9.07c PomBase:SPBC36.05c SGD:S000003162 SGD:S000005274 SGD:S000006272 UniProtKB:Q13547 UniProtKB:Q92769 WB:WBGene00001834	C		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003084	F		Seeded From UniProt	complete
involved_in	GO:0016575	histone deacetylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003084	P		Seeded From UniProt	complete
enables	GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.5.1.98	F		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.5.1.98	F		Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0156	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Huang, D et al. (2009) Dual regulation by pairs of cyclin-dependent protein kinases and histone deacetylases controls G1 transcription in budding yeast. PLoS Biol. 7 e1000188 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Shevchenko, A et al. (2008) Chromatin Central: towards the comparative proteome by accurate mapping of the yeast proteomic environment. Genome Biol. 9 R167 PubMed GONUTS page
↑ Jin, M et al. (2014) Transcriptional regulation by Pho23 modulates the frequency of autophagosome formation. Curr. Biol. 24 1314-1322 PubMed GONUTS page
↑ Gallina, I et al. (2015) Cmr1/WDR76 defines a nuclear genotoxic stress body linking genome integrity and protein quality control. Nat Commun 6 6533 PubMed GONUTS page
↑ ^5.0 ^5.1 Yeheskely-Hayon, D et al. (2013) The roles of the catalytic and noncatalytic activities of Rpd3L and Rpd3S in the regulation of gene transcription in yeast. PLoS ONE 8 e85088 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 ^6.9 Ruiz-Roig, C et al. (2010) The Rpd3L HDAC complex is essential for the heat stress response in yeast. Mol. Microbiol. 76 1049-62 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Rundlett, SE et al. (1996) HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription. Proc. Natl. Acad. Sci. U.S.A. 93 14503-8 PubMed GONUTS page
↑ ^8.0 ^8.1 Rundlett, SE et al. (1998) Transcriptional repression by UME6 involves deacetylation of lysine 5 of histone H4 by RPD3. Nature 392 831-5 PubMed GONUTS page
↑ Kasten, MM et al. (1997) A large protein complex containing the yeast Sin3p and Rpd3p transcriptional regulators. Mol. Cell. Biol. 17 4852-8 PubMed GONUTS page
↑ Good, PD et al. (2013) Silencing near tRNA genes is nucleosome-mediated and distinct from boundary element function. Gene 526 7-15 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Kim, S et al. (1999) Modulation of life-span by histone deacetylase genes in Saccharomyces cerevisiae. Mol. Biol. Cell 10 3125-36 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Sun, ZW & Hampsey, M (1999) A general requirement for the Sin3-Rpd3 histone deacetylase complex in regulating silencing in Saccharomyces cerevisiae. Genetics 152 921-32 PubMed GONUTS page
↑ Smith, JS et al. (1999) A genetic screen for ribosomal DNA silencing defects identifies multiple DNA replication and chromatin-modulating factors. Mol. Cell. Biol. 19 3184-97 PubMed GONUTS page
↑ ^14.0 ^14.1 Zhou, J et al. (2009) Histone deacetylase Rpd3 antagonizes Sir2-dependent silent chromatin propagation. Nucleic Acids Res. 37 3699-713 PubMed GONUTS page
↑ Inai, T et al. (2007) Interplay between chromatin and trans-acting factors on the IME2 promoter upon induction of the gene at the onset of meiosis. Mol. Cell. Biol. 27 1254-63 PubMed GONUTS page
↑ ^16.0 ^16.1 Sharma, VM et al. (2007) Histone deacetylases RPD3 and HOS2 regulate the transcriptional activation of DNA damage-inducible genes. Mol. Cell. Biol. 27 3199-210 PubMed GONUTS page
↑ ^17.0 ^17.1 Sertil, O et al. (2007) Direct role for the Rpd3 complex in transcriptional induction of the anaerobic DAN/TIR genes in yeast. Mol. Cell. Biol. 27 2037-47 PubMed GONUTS page
↑ Zhang, Z & Reese, JC (2004) Redundant mechanisms are used by Ssn6-Tup1 in repressing chromosomal gene transcription in Saccharomyces cerevisiae. J. Biol. Chem. 279 39240-50 PubMed GONUTS page
↑ Xin, X et al. (2007) Regulation of the HAP1 gene involves positive actions of histone deacetylases. Biochem. Biophys. Res. Commun. 362 120-5 PubMed GONUTS page
↑ Merker, JD et al. (2008) The histone methylase Set2p and the histone deacetylase Rpd3p repress meiotic recombination at the HIS4 meiotic recombination hotspot in Saccharomyces cerevisiae. DNA Repair (Amst.) 7 1298-308 PubMed GONUTS page
↑ Tsang, CK et al. (2007) Nutrient starvation promotes condensin loading to maintain rDNA stability. EMBO J. 26 448-58 PubMed GONUTS page
↑ ^22.0 ^22.1 Keogh, MC et al. (2005) Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex. Cell 123 593-605 PubMed GONUTS page
↑ ^23.0 ^23.1 Carrozza, MJ et al. (2005) Stable incorporation of sequence specific repressors Ash1 and Ume6 into the Rpd3L complex. Biochim. Biophys. Acta 1731 77-87; discussion 75-6 PubMed GONUTS page
↑ ^24.0 ^24.1 Carrozza, MJ et al. (2005) Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription. Cell 123 581-92 PubMed GONUTS page
↑ Ehrentraut, S et al. (2010) Rpd3-dependent boundary formation at telomeres by removal of Sir2 substrate. Proc. Natl. Acad. Sci. U.S.A. 107 5522-7 PubMed GONUTS page
↑ ^26.0 ^26.1 Aparicio, JG et al. (2004) The Rpd3-Sin3 histone deacetylase regulates replication timing and enables intra-S origin control in Saccharomyces cerevisiae. Mol. Cell. Biol. 24 4769-80 PubMed GONUTS page
↑ Knott, SR et al. (2009) Genome-wide replication profiles indicate an expansive role for Rpd3L in regulating replication initiation timing or efficiency, and reveal genomic loci of Rpd3 function in Saccharomyces cerevisiae. Genes Dev. 23 1077-90 PubMed GONUTS page
↑ Vogelauer, M et al. (2002) Histone acetylation regulates the time of replication origin firing. Mol. Cell 10 1223-33 PubMed GONUTS page
↑ Hontz, RD et al. (2009) Genetic identification of factors that modulate ribosomal DNA transcription in Saccharomyces cerevisiae. Genetics 182 105-19 PubMed GONUTS page
↑ Tsang, CK et al. (2003) Chromatin-mediated regulation of nucleolar structure and RNA Pol I localization by TOR. EMBO J. 22 6045-56 PubMed GONUTS page
↑ Yi, C et al. (2012) Function and molecular mechanism of acetylation in autophagy regulation. Science 336 474-7 PubMed GONUTS page
↑ Quan, TK & Hartzog, GA (2010) Histone H3K4 and K36 methylation, Chd1 and Rpd3S oppose the functions of Saccharomyces cerevisiae Spt4-Spt5 in transcription. Genetics 184 321-34 PubMed GONUTS page
↑ ^33.0 ^33.1 Adachi, N et al. (2002) A conserved motif common to the histone acetyltransferase Esa1 and the histone deacetylase Rpd3. J. Biol. Chem. 277 35688-95 PubMed GONUTS page
↑ Kadosh, D & Struhl, K (1998) Histone deacetylase activity of Rpd3 is important for transcriptional repression in vivo. Genes Dev. 12 797-805 PubMed GONUTS page
↑ ^35.0 ^35.1 Kadosh, D & Struhl, K (1997) Repression by Ume6 involves recruitment of a complex containing Sin3 corepressor and Rpd3 histone deacetylase to target promoters. Cell 89 365-71 PubMed GONUTS page
↑ ^36.0 ^36.1 De Nadal, E et al. (2004) The MAPK Hog1 recruits Rpd3 histone deacetylase to activate osmoresponsive genes. Nature 427 370-4 PubMed GONUTS page
↑ ^37.0 ^37.1 Watson, AD et al. (2000) Ssn6-Tup1 interacts with class I histone deacetylases required for repression. Genes Dev. 14 2737-44 PubMed GONUTS page
↑ Agricola, E et al. (2006) H4 acetylation does not replace H3 acetylation in chromatin remodelling and transcription activation of Adr1-dependent genes. Mol. Microbiol. 62 1433-46 PubMed GONUTS page
↑ Schröder, M et al. (2004) The unfolded protein response represses differentiation through the RPD3-SIN3 histone deacetylase. EMBO J. 23 2281-92 PubMed GONUTS page
↑ Veis, J et al. (2007) Activation of the G2/M-specific gene CLB2 requires multiple cell cycle signals. Mol. Cell. Biol. 27 8364-73 PubMed GONUTS page
↑ ^41.0 ^41.1 ^41.2 ^41.3 ^41.4 ^41.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:19823668-1] 1.0 ^1.1 ^1.2 Huang, D et al. (2009) Dual regulation by pairs of cyclin-dependent protein kinases and histone deacetylases controls G1 transcription in budding yeast. PLoS Biol. 7 e1000188 PubMed GONUTS page

[PMID:19040720-2] 2.0 ^2.1 ^2.2 Shevchenko, A et al. (2008) Chromatin Central: towards the comparative proteome by accurate mapping of the yeast proteomic environment. Genome Biol. 9 R167 PubMed GONUTS page

[PMID:24881874-3] Jin, M et al. (2014) Transcriptional regulation by Pho23 modulates the frequency of autophagosome formation. Curr. Biol. 24 1314-1322 PubMed GONUTS page

[PMID:25817432-4] Gallina, I et al. (2015) Cmr1/WDR76 defines a nuclear genotoxic stress body linking genome integrity and protein quality control. Nat Commun 6 6533 PubMed GONUTS page

[PMID:24358376-5] 5.0 ^5.1 Yeheskely-Hayon, D et al. (2013) The roles of the catalytic and noncatalytic activities of Rpd3L and Rpd3S in the regulation of gene transcription in yeast. PLoS ONE 8 e85088 PubMed GONUTS page

[PMID:20398213-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 ^6.9 Ruiz-Roig, C et al. (2010) The Rpd3L HDAC complex is essential for the heat stress response in yeast. Mol. Microbiol. 76 1049-62 PubMed GONUTS page

[PMID:8962081-7] 7.0 ^7.1 ^7.2 ^7.3 Rundlett, SE et al. (1996) HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription. Proc. Natl. Acad. Sci. U.S.A. 93 14503-8 PubMed GONUTS page

[PMID:9572144-8] 8.0 ^8.1 Rundlett, SE et al. (1998) Transcriptional repression by UME6 involves deacetylation of lysine 5 of histone H4 by RPD3. Nature 392 831-5 PubMed GONUTS page

[PMID:9234741-9] Kasten, MM et al. (1997) A large protein complex containing the yeast Sin3p and Rpd3p transcriptional regulators. Mol. Cell. Biol. 17 4852-8 PubMed GONUTS page

[PMID:23707796-10] Good, PD et al. (2013) Silencing near tRNA genes is nucleosome-mediated and distinct from boundary element function. Gene 526 7-15 PubMed GONUTS page

[PMID:10512855-11] 11.0 ^11.1 ^11.2 ^11.3 Kim, S et al. (1999) Modulation of life-span by histone deacetylase genes in Saccharomyces cerevisiae. Mol. Biol. Cell 10 3125-36 PubMed GONUTS page

[PMID:10388812-12] 12.0 ^12.1 ^12.2 Sun, ZW & Hampsey, M (1999) A general requirement for the Sin3-Rpd3 histone deacetylase complex in regulating silencing in Saccharomyces cerevisiae. Genetics 152 921-32 PubMed GONUTS page

[PMID:10082585-13] Smith, JS et al. (1999) A genetic screen for ribosomal DNA silencing defects identifies multiple DNA replication and chromatin-modulating factors. Mol. Cell. Biol. 19 3184-97 PubMed GONUTS page

[PMID:19372273-14] 14.0 ^14.1 Zhou, J et al. (2009) Histone deacetylase Rpd3 antagonizes Sir2-dependent silent chromatin propagation. Nucleic Acids Res. 37 3699-713 PubMed GONUTS page

[PMID:17158929-15] Inai, T et al. (2007) Interplay between chromatin and trans-acting factors on the IME2 promoter upon induction of the gene at the onset of meiosis. Mol. Cell. Biol. 27 1254-63 PubMed GONUTS page

[PMID:17296735-16] 16.0 ^16.1 Sharma, VM et al. (2007) Histone deacetylases RPD3 and HOS2 regulate the transcriptional activation of DNA damage-inducible genes. Mol. Cell. Biol. 27 3199-210 PubMed GONUTS page

[PMID:17210643-17] 17.0 ^17.1 Sertil, O et al. (2007) Direct role for the Rpd3 complex in transcriptional induction of the anaerobic DAN/TIR genes in yeast. Mol. Cell. Biol. 27 2037-47 PubMed GONUTS page

[PMID:15254041-18] Zhang, Z & Reese, JC (2004) Redundant mechanisms are used by Ssn6-Tup1 in repressing chromosomal gene transcription in Saccharomyces cerevisiae. J. Biol. Chem. 279 39240-50 PubMed GONUTS page

[PMID:17706600-19] Xin, X et al. (2007) Regulation of the HAP1 gene involves positive actions of histone deacetylases. Biochem. Biophys. Res. Commun. 362 120-5 PubMed GONUTS page

[PMID:18515193-20] Merker, JD et al. (2008) The histone methylase Set2p and the histone deacetylase Rpd3p repress meiotic recombination at the HIS4 meiotic recombination hotspot in Saccharomyces cerevisiae. DNA Repair (Amst.) 7 1298-308 PubMed GONUTS page

[PMID:17203076-21] Tsang, CK et al. (2007) Nutrient starvation promotes condensin loading to maintain rDNA stability. EMBO J. 26 448-58 PubMed GONUTS page

[PMID:16286008-22] 22.0 ^22.1 Keogh, MC et al. (2005) Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex. Cell 123 593-605 PubMed GONUTS page

[PMID:16314178-23] 23.0 ^23.1 Carrozza, MJ et al. (2005) Stable incorporation of sequence specific repressors Ash1 and Ume6 into the Rpd3L complex. Biochim. Biophys. Acta 1731 77-87; discussion 75-6 PubMed GONUTS page

[PMID:16286007-24] 24.0 ^24.1 Carrozza, MJ et al. (2005) Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription. Cell 123 581-92 PubMed GONUTS page

[PMID:20133733-25] Ehrentraut, S et al. (2010) Rpd3-dependent boundary formation at telomeres by removal of Sir2 substrate. Proc. Natl. Acad. Sci. U.S.A. 107 5522-7 PubMed GONUTS page

[PMID:15143171-26] 26.0 ^26.1 Aparicio, JG et al. (2004) The Rpd3-Sin3 histone deacetylase regulates replication timing and enables intra-S origin control in Saccharomyces cerevisiae. Mol. Cell. Biol. 24 4769-80 PubMed GONUTS page

[PMID:19417103-27] Knott, SR et al. (2009) Genome-wide replication profiles indicate an expansive role for Rpd3L in regulating replication initiation timing or efficiency, and reveal genomic loci of Rpd3 function in Saccharomyces cerevisiae. Genes Dev. 23 1077-90 PubMed GONUTS page

[PMID:12453428-28] Vogelauer, M et al. (2002) Histone acetylation regulates the time of replication origin firing. Mol. Cell 10 1223-33 PubMed GONUTS page

[PMID:19270272-29] Hontz, RD et al. (2009) Genetic identification of factors that modulate ribosomal DNA transcription in Saccharomyces cerevisiae. Genetics 182 105-19 PubMed GONUTS page

[PMID:14609951-30] Tsang, CK et al. (2003) Chromatin-mediated regulation of nucleolar structure and RNA Pol I localization by TOR. EMBO J. 22 6045-56 PubMed GONUTS page

[PMID:22539722-31] Yi, C et al. (2012) Function and molecular mechanism of acetylation in autophagy regulation. Science 336 474-7 PubMed GONUTS page

[PMID:19948887-32] Quan, TK & Hartzog, GA (2010) Histone H3K4 and K36 methylation, Chd1 and Rpd3S oppose the functions of Saccharomyces cerevisiae Spt4-Spt5 in transcription. Genetics 184 321-34 PubMed GONUTS page

[PMID:12110674-33] 33.0 ^33.1 Adachi, N et al. (2002) A conserved motif common to the histone acetyltransferase Esa1 and the histone deacetylase Rpd3. J. Biol. Chem. 277 35688-95 PubMed GONUTS page

[PMID:9512514-34] Kadosh, D & Struhl, K (1998) Histone deacetylase activity of Rpd3 is important for transcriptional repression in vivo. Genes Dev. 12 797-805 PubMed GONUTS page

[PMID:9150136-35] 35.0 ^35.1 Kadosh, D & Struhl, K (1997) Repression by Ume6 involves recruitment of a complex containing Sin3 corepressor and Rpd3 histone deacetylase to target promoters. Cell 89 365-71 PubMed GONUTS page

[PMID:14737171-36] 36.0 ^36.1 De Nadal, E et al. (2004) The MAPK Hog1 recruits Rpd3 histone deacetylase to activate osmoresponsive genes. Nature 427 370-4 PubMed GONUTS page

[PMID:11069890-37] 37.0 ^37.1 Watson, AD et al. (2000) Ssn6-Tup1 interacts with class I histone deacetylases required for repression. Genes Dev. 14 2737-44 PubMed GONUTS page

[PMID:17121596-38] Agricola, E et al. (2006) H4 acetylation does not replace H3 acetylation in chromatin remodelling and transcription activation of Adr1-dependent genes. Mol. Microbiol. 62 1433-46 PubMed GONUTS page

[PMID:15141165-39] Schröder, M et al. (2004) The unfolded protein response represses differentiation through the RPD3-SIN3 histone deacetylase. EMBO J. 23 2281-92 PubMed GONUTS page

[PMID:17908798-40] Veis, J et al. (2007) Activation of the G2/M-specific gene CLB2 requires multiple cell cycle signals. Mol. Cell. Biol. 27 8364-73 PubMed GONUTS page

[PMID:21873635-41] 41.0 ^41.1 ^41.2 ^41.3 ^41.4 ^41.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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