User:Cdiop

My Annotations

Status	Page	Date/Time	GO Term (Aspect)	Reference	Evidence	Notes	Links
unacceptable	ANAPL:R0L0G3	2016-04-11 10:40:21 CDT	GO:0005126 cytokine receptor binding (F)	PMID:27060655		Seeded from Uniprot	challenge
unacceptable	RABIT:GHR	2016-04-11 10:51:00 CDT	GO:0019838 growth factor binding (F)	PMID:27058125	ECO:0000315 mutant phenotype evidence used in manual assertion	seeded from uniprot	challenge
unacceptable	HORSE:F6YG75	2016-04-19 05:37:12 CDT	GO:0000139 Golgi membrane (C)	PMID:27037728	ECO:0000315 mutant phenotype evidence used in manual assertion	Fine mapping using custom-produced SNP arrays for ECA20 and ECA22 regions identified two marker loci with high levels of significance: SNP BIEC2-530826 (map position 32,787,619) on ECA20 in an intron of the DQA1 gene in the Major Histocompatibility Complex (MHC) class II region (P=4.6e-06), and SNP BIEC2-589604 (map position 25,951,536) on ECA22 in a 200 kb region containing four candidate genes: PROCR, EDEM2, EIF6, and MMP24 (P=2.14e-06).	challenge
unacceptable	CAPHI:Q68G91	2016-04-11 01:26:58 CDT	GO:0005515 protein binding (F)	PMID:24352451		Seeded from Uniprot	challenge
updatedbyinstructor	PLAFA:A0A0P0ZF19	2016-04-19 02:32:35 CDT	GO:0003924 GTPase activity (F)	PMID:26540393	ECO:0000314 direct assay evidence used in manual assertion	Fig. 9	challenge
unacceptable	BOVIN:HS71A	2016-04-12 05:43:28 CDT	GO:0009408 response to heat (P)	PMID:27051194	ECO:0000314 direct assay evidence used in manual assertion	Three SSCP patterns and consequently two alleles namely A and B were documented in one fragment of the gene. Genotype AA, thus, was found to be most thermotolerant genotype with the highest HTC.	challenge
unacceptable	RAT:MK03	2016-04-19 05:27:50 CDT	GO:0070372 regulation of ERK1 and ERK2 cascade (P)	PMID:27066371	ECO:0000314 direct assay evidence used in manual assertion	Fig.4 shows the effects of active components of Radix Scrophulariae (ACRS) on phospho-specific extracellular signal regulated kinase (ERK 1/2).	challenge
unacceptable	RAT:THTPA	2016-04-12 08:48:34 CDT	GO:0015888 thiamine transport (P)	PMID:27065466	ECO:0000314 direct assay evidence used in manual assertion	Both cell membrane thiamin transporters and mitochondrial thiamin pyrophosphate transporter expression levels were suppressed after 2 days of induced Sepsis. Sepsis inhibits carrier-mediated intestinal thiamin uptake as a function of sepsis severity	challenge
unacceptable	RAT:OPRK	2016-04-12 09:00:24 CDT	GO:2000474 regulation of opioid receptor signaling pathway (P)	PMID:27064940	ECO:0000314 direct assay evidence used in manual assertion	The inhibitory effects of dynorphin on pulsatile GnRH secretion may occur either indirectly by actions upon KOR within the KNDy population and/or directly via activation of KOR on GnRH cells.	challenge
unacceptable	DROME:Q9W4K0	2016-04-19 05:47:44 CDT	GO:0005783 endoplasmic reticulum (C)	PMID:9649432	ECO:0000314 direct assay evidence used in manual assertion	Fig.1A shows an immunoblot of CHOP protein from lysates of untreated and tunicamycin-treated primary MEFs that are wild type or nullizygous for chop.	challenge
unacceptable	DROME:Q9V3I2	2016-04-19 04:50:42 CDT	GO:0005769 early endosome (C)	PMID:27064279	ECO:0000314 direct assay evidence used in manual assertion	Figure 3. showed that full-length APP and C99, but not C83, induced the enlargement of Rab5+ early endosomes in PC12M cells.	challenge
updatedbyinstructor	ARATH:CML4	2016-04-19 04:56:44 CDT	GO:0031303 integral component of endosome membrane (C)	PMID:27029353	ECO:0000314 direct assay evidence used in manual assertion	Fig. 2	challenge
updatedbyinstructor	ARATH:CML5	2016-04-19 05:00:03 CDT	GO:0031303 integral component of endosome membrane (C)	PMID:27029353	ECO:0000314 direct assay evidence used in manual assertion	Fig. 3	challenge
unacceptable	RABIT:G1SZC8	2016-04-19 05:21:07 CDT	GO:0061581 corneal epithelial cell migration (P)	PMID:27058125	ECO:0000314 direct assay evidence used in manual assertion	Figure 3. shows the ADAM17 activity in unexposed and NM-exposed corneas. Figure 4.B shows the immunofluorescence of corneas using an anti-human ADAM17 ectodomain antibody. This visualizes active ADAM17 immunoreactivity.	challenge
updatedbyinstructor	MOUSE:NOX4	2016-04-19 05:54:21 CDT	GO:0005739 mitochondrion (C)	PMID:23624625	ECO:0000314 direct assay evidence used in manual assertion	Fig.1 shows immunofluorescence reveals Nox4 localized to neuron mitochondria. Fig.2 shows Nox4 expression is increased in neuron mitochondria-enriched cellular fraction	challenge
unacceptable	MOUSE:NOX4	2016-04-19 05:59:47 CDT	GO:0043025 neuronal cell body (C)	PMID:23624625	ECO:0000314 direct assay evidence used in manual assertion	Fig.5 shows Nox4 silencing attenuates ANG II-induced increase in intracellular superoxide levels. Fig.6 shows Nox4 knockdown inhibits ANG II-induced increase in mitochondrial superoxide levels.	challenge

acceptable:0
unacceptable:12
requires_changes:0
flagged:0

Annotations challenged by Cdiop

Status	Author,Group	Page	GO Term (Aspect)	Reference	Evidence	Links	Page history

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