MOUSE:NOX4

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Nox4 (synonyms: Renox)
Protein Name(s)	NADPH oxidase 4 Kidney oxidase-1 KOX-1 Kidney superoxide-producing NADPH oxidase Renal NAD(P)H-oxidase Superoxide-generating NADPH oxidase 4
External Links
UniProt	Q9JHI8
EMBL	AF261944 AB041034 AB042745 AF218723 AF276957 AK050371 AK085509 AK169304 BC021378
CCDS	CCDS21437.1
RefSeq	NP_056575.1 XP_006508075.1
UniGene	Mm.31748
ProteinModelPortal	Q9JHI8
SMR	Q9JHI8
STRING	10090.ENSMUSP00000032781
PeroxiBase	5966
iPTMnet	Q9JHI8
PhosphoSite	Q9JHI8
MaxQB	Q9JHI8
PaxDb	Q9JHI8
PRIDE	Q9JHI8
DNASU	50490
Ensembl	ENSMUST00000032781 ENSMUST00000068829
GeneID	50490
UCSC	uc009ifj.2 uc009ifl.2 uc009ifm.2
CTD	50507
MGI	MGI:1354184
eggNOG	KOG0039 ENOG410XNZY
GeneTree	ENSGT00550000074350
HOGENOM	HOG000216669
HOVERGEN	HBG003760
InParanoid	Q9JHI8
OMA	EADEQRI
OrthoDB	EOG7RZ5PZ
PhylomeDB	Q9JHI8
TreeFam	TF105354
NextBio	307468
PRO	PR:Q9JHI8
Proteomes	UP000000589
Bgee	Q9JHI8
CleanEx	MM_NOX4
ExpressionAtlas	Q9JHI8
Genevisible	Q9JHI8
GO	GO:0016324 GO:0071944 GO:0005789 GO:0005925 GO:0005739 GO:0043020 GO:0048471 GO:0001725 GO:0072341 GO:0016174 GO:0016175 GO:0045453 GO:0055007 GO:0007569 GO:0000902 GO:0071320 GO:0071480 GO:0071333 GO:0071560 GO:0010467 GO:0050667 GO:0008285 GO:0055114 GO:0043065 GO:2000573 GO:0070374 GO:0043406 GO:0051897 GO:2000379 GO:0014911 GO:0051496 GO:0072593 GO:0001666 GO:0042554 GO:0006801
InterPro	IPR000778 IPR013112 IPR017927 IPR013130 IPR013121 IPR017938
Pfam	PF08022 PF01794 PF08030
PRINTS	PR00466
SUPFAM	SSF63380
PROSITE	PS51384

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005739	mitochondrion	PMID:23624625^[1]	ECO:0000314			C		Fig.1 shows immunofluorescence reveals Nox4 localized to neuron mitochondria. Fig.2 shows Nox4 expression is increased in neuron mitochondria-enriched cellular fraction	complete CACAO 11841
	GO:0043025	neuronal cell body	PMID:23624625^[1]	ECO:0000314			C		Fig.5 shows Nox4 silencing attenuates ANG II-induced increase in intracellular superoxide levels. Fig.6 shows Nox4 knockdown inhibits ANG II-induced increase in mitochondrial superoxide levels.	complete CACAO 11843
involved_in	GO:0003015	heart process	PMID:27525436^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P39688	P		Seeded From UniProt	complete
involved_in	GO:0061098	positive regulation of protein tyrosine kinase activity	PMID:27525436^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000746) regulates_o_occurs_in:(CL:0000746) has_input:(UniProtKB:P39688) part_of:(GO:0006979)	Seeded From UniProt	complete
enables	GO:1990782	protein tyrosine kinase binding	PMID:27525436^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P06241	F	occurs_in:(CL:0000746) occurs_in:(GO:0048471)\|occurs_in:(CL:0000746) occurs_in:(GO:0005739)\|occurs_in:(CL:0000746) occurs_in:(GO:0005634)\|occurs_in:(CL:0000746) occurs_in:(GO:0097038)\|occurs_in:(CL:0000746) part_of:(GO:0006979)	Seeded From UniProt	complete
involved_in	GO:2000573	positive regulation of DNA biosynthetic process	PMID:17942966^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072593	reactive oxygen species metabolic process	PMID:17942966^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072593	reactive oxygen species metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9NPH5	P		Seeded From UniProt	complete
part_of	GO:0071944	cell periphery	PMID:18431508^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0071333	cellular response to glucose stimulus	PMID:18431508^[4]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:17942966^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9NPH5	P		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	PMID:17942966^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:18431508^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043406	positive regulation of MAP kinase activity	PMID:17942966^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042554	superoxide anion generation	PMID:10869423^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0016175	superoxide-generating NADPH oxidase activity	PMID:17942966^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:10869423^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007569	cell aging	PMID:10869423^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000902	cell morphogenesis	PMID:10869423^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0283531 MGI:MGI:1354184 MGI:MGI:2450016 MGI:MGI:2681162 PANTHER:PTN001735877 PomBase:SPBC1683.09c RGD:620600 SGD:S000003128 SGD:S000004037 SGD:S000005512 TAIR:locus:2017789 TAIR:locus:2024603 TAIR:locus:2025351 TAIR:locus:2025366 TAIR:locus:2157032 TAIR:locus:2157348 TAIR:locus:2157697 TAIR:locus:2160917 TAIR:locus:2178677 TAIR:locus:2178687 UniProtKB:P04839 UniProtKB:Q96PH1 UniProtKB:Q9NPH5 UniProtKB:Q9NRD8 UniProtKB:Q9SBI0 UniProtKB:Q9Y5S8 WB:WBGene00000253 dictyBase:DDB_G0287101 dictyBase:DDB_G0289653	P		Seeded From UniProt	complete
part_of	GO:0043020	NADPH oxidase complex	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2681162 MGI:MGI:88574 PANTHER:PTN000239643 RGD:620574 RGD:620598 RGD:620600 UniProtKB:P04839 UniProtKB:Q9Y5S8	C		Seeded From UniProt	complete
involved_in	GO:0042554	superoxide anion generation	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1354184 MGI:MGI:2450016 MGI:MGI:2681162 PANTHER:PTN000239643 RGD:620598 UniProtKB:P04839 UniProtKB:Q96PH1 UniProtKB:Q9Y5S8 dictyBase:DDB_G0287101	P		Seeded From UniProt	complete
enables	GO:0016175	superoxide-generating NADPH oxidase activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1354184 MGI:MGI:2450016 MGI:MGI:2681162 PANTHER:PTN000239643 UniProtKB:Q96PH1 UniProtKB:Q9Y5S8 dictyBase:DDB_G0287101 dictyBase:DDB_G0289653	F		Seeded From UniProt	complete
involved_in	GO:0006952	defense response	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0283531 MGI:MGI:88574 PANTHER:PTN000239643 UniProtKB:P04839 ZFIN:ZDB-GENE-091117-14 dictyBase:DDB_G0287101 dictyBase:DDB_G0289653 dictyBase:DDB_G0291117	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2139422 MGI:MGI:2681162 MGI:MGI:88574 PANTHER:PTN001735877 RGD:620574 RGD:620598 RGD:620600 SGD:S000005512 TAIR:locus:2024603 TAIR:locus:2025351 TAIR:locus:2157027 TAIR:locus:2157348 TAIR:locus:2157697 TAIR:locus:2160917 UniProtKB:O81209 UniProtKB:P04839 UniProtKB:Q9Y5S8 WB:WBGene00000253	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000379	positive regulation of reactive oxygen species metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620600	P		Seeded From UniProt	complete
part_of	GO:0097038	perinuclear endoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620600	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072593	reactive oxygen species metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NPH5	P		Seeded From UniProt	complete
enables	GO:0072341	modified amino acid binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NPH5	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0055114	oxidation-reduction process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NPH5	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0055007	cardiac muscle cell differentiation	PMID:16775014^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051496	positive regulation of stress fiber assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620600	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050667	homocysteine metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NPH5	P		Seeded From UniProt	complete
enables	GO:0050664	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620600	F		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620600	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045453	bone resorption	PMID:11098048^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620600	P		Seeded From UniProt	complete
part_of	GO:0043020	NADPH oxidase complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620600	C		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620600	C		Seeded From UniProt	complete
enables	GO:0016175	superoxide-generating NADPH oxidase activity	PMID:11098048^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0016174	NAD(P)H oxidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620600	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014911	positive regulation of smooth muscle cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620600	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010467	gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NPH5	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006801	superoxide metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NPH5	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006801	superoxide metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620600	P		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620600	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620600	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NPH5	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620600	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003015	heart process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NPH5	P		Seeded From UniProt	complete
colocalizes_with	GO:0001725	stress fiber	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620600	C		Seeded From UniProt	complete
involved_in	GO:2000379	positive regulation of reactive oxygen species metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q924V1 ensembl:ENSRNOP00000018990	P		Seeded From UniProt	complete
part_of	GO:0097038	perinuclear endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q924V1 ensembl:ENSRNOP00000018990	C		Seeded From UniProt	complete
involved_in	GO:0071560	cellular response to transforming growth factor beta stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q924V1 ensembl:ENSRNOP00000018990	P		Seeded From UniProt	complete
involved_in	GO:0071480	cellular response to gamma radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q924V1 ensembl:ENSRNOP00000018990	P		Seeded From UniProt	complete
involved_in	GO:0071320	cellular response to cAMP	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q924V1 ensembl:ENSRNOP00000018990	P		Seeded From UniProt	complete
involved_in	GO:0051496	positive regulation of stress fiber assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q924V1 ensembl:ENSRNOP00000018990	P		Seeded From UniProt	complete
enables	GO:0050664	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q924V1 ensembl:ENSRNOP00000018990	F		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q924V1 ensembl:ENSRNOP00000018990	C		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q924V1 ensembl:ENSRNOP00000018990	P		Seeded From UniProt	complete
part_of	GO:0043020	NADPH oxidase complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q924V1 ensembl:ENSRNOP00000018990	C		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q924V1 ensembl:ENSRNOP00000018990	C		Seeded From UniProt	complete
enables	GO:0016174	NAD(P)H oxidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q924V1 ensembl:ENSRNOP00000018990	F		Seeded From UniProt	complete
involved_in	GO:0014911	positive regulation of smooth muscle cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q924V1 ensembl:ENSRNOP00000018990	P		Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q924V1 ensembl:ENSRNOP00000018990	P		Seeded From UniProt	complete
involved_in	GO:0006801	superoxide metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q924V1 ensembl:ENSRNOP00000018990	P		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q924V1 ensembl:ENSRNOP00000018990	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q924V1 ensembl:ENSRNOP00000018990	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q924V1 ensembl:ENSRNOP00000018990	C		Seeded From UniProt	complete
part_of	GO:0001725	stress fiber	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q924V1 ensembl:ENSRNOP00000018990	C		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q924V1 ensembl:ENSRNOP00000018990	P		Seeded From UniProt	complete
involved_in	GO:0072593	reactive oxygen species metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NPH5 ensembl:ENSP00000263317	P		Seeded From UniProt	complete
enables	GO:0072341	modified amino acid binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NPH5 ensembl:ENSP00000263317	F		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NPH5 ensembl:ENSP00000263317	P		Seeded From UniProt	complete
involved_in	GO:0050667	homocysteine metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NPH5 ensembl:ENSP00000263317	P		Seeded From UniProt	complete
involved_in	GO:0010467	gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NPH5 ensembl:ENSP00000263317	P		Seeded From UniProt	complete
involved_in	GO:0006801	superoxide metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NPH5 ensembl:ENSP00000263317	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NPH5 ensembl:ENSP00000263317	C		Seeded From UniProt	complete
involved_in	GO:0003015	heart process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NPH5 ensembl:ENSP00000263317	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000778	C		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000778 InterPro:IPR013112 InterPro:IPR013121 InterPro:IPR017927	F		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000778 InterPro:IPR013112 InterPro:IPR013121 InterPro:IPR017927	P		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0118	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Case, AJ et al. (2013) Mitochondrial-localized NADPH oxidase 4 is a source of superoxide in angiotensin II-stimulated neurons. Am. J. Physiol. Heart Circ. Physiol. 305 H19-28 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Matsushima, S et al. (2016) Tyrosine kinase FYN negatively regulates NOX4 in cardiac remodeling. J. Clin. Invest. 126 3403-16 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Wagner, B et al. (2007) Mitogenic signaling via platelet-derived growth factor beta in metanephric mesenchymal cells. J. Am. Soc. Nephrol. 18 2903-11 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Sharma, K et al. (2008) Adiponectin regulates albuminuria and podocyte function in mice. J. Clin. Invest. 118 1645-56 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Geiszt, M et al. (2000) Identification of renox, an NAD(P)H oxidase in kidney. Proc. Natl. Acad. Sci. U.S.A. 97 8010-4 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Li, J et al. (2006) The NADPH oxidase NOX4 drives cardiac differentiation: Role in regulating cardiac transcription factors and MAP kinase activation. Mol. Biol. Cell 17 3978-88 PubMed GONUTS page
↑ ^8.0 ^8.1 Yang, S et al. (2001) A new superoxide-generating oxidase in murine osteoclasts. J. Biol. Chem. 276 5452-8 PubMed GONUTS page

[PMID:23624625-1] 1.0 ^1.1 Case, AJ et al. (2013) Mitochondrial-localized NADPH oxidase 4 is a source of superoxide in angiotensin II-stimulated neurons. Am. J. Physiol. Heart Circ. Physiol. 305 H19-28 PubMed GONUTS page

[PMID:27525436-2] 2.0 ^2.1 ^2.2 Matsushima, S et al. (2016) Tyrosine kinase FYN negatively regulates NOX4 in cardiac remodeling. J. Clin. Invest. 126 3403-16 PubMed GONUTS page

[PMID:17942966-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Wagner, B et al. (2007) Mitogenic signaling via platelet-derived growth factor beta in metanephric mesenchymal cells. J. Am. Soc. Nephrol. 18 2903-11 PubMed GONUTS page

[PMID:18431508-4] 4.0 ^4.1 ^4.2 Sharma, K et al. (2008) Adiponectin regulates albuminuria and podocyte function in mice. J. Clin. Invest. 118 1645-56 PubMed GONUTS page

[PMID:10869423-5] 5.0 ^5.1 ^5.2 ^5.3 Geiszt, M et al. (2000) Identification of renox, an NAD(P)H oxidase in kidney. Proc. Natl. Acad. Sci. U.S.A. 97 8010-4 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:16775014-7] Li, J et al. (2006) The NADPH oxidase NOX4 drives cardiac differentiation: Role in regulating cardiac transcription factors and MAP kinase activation. Mol. Biol. Cell 17 3978-88 PubMed GONUTS page

[PMID:11098048-8] 8.0 ^8.1 Yang, S et al. (2001) A new superoxide-generating oxidase in murine osteoclasts. J. Biol. Chem. 276 5452-8 PubMed GONUTS page

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MOUSE:NOX4

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