BOVIN:HS71A

Species (Taxon ID)	Bos taurus (Bovine). (9913)
Gene Name(s)	HSPA1A (synonyms: HSP70-1)
Protein Name(s)	Heat shock 70 kDa protein 1A Heat shock 70 kDa protein 1 HSP70.1
External Links
UniProt	Q27975
EMBL	U09861 AY149618 AY149619 AY662497 U02891
PIR	S53357
RefSeq	NP_776975.1
UniGene	Bt.49659
ProteinModelPortal	Q27975
SMR	Q27975
BioGrid	159138
IntAct	Q27975
PaxDb	Q27975
PRIDE	Q27975
Ensembl	ENSBTAT00000017500
GeneID	281825
KEGG	bta:281825
CTD	3303
eggNOG	COG0443
GeneTree	ENSGT00750000117237
HOGENOM	HOG000228135
HOVERGEN	HBG051845
InParanoid	Q27975
KO	K03283
OMA	MAKSTAI
OrthoDB	EOG7PCJGF
TreeFam	TF105042
Reactome	REACT_205580 REACT_213591 REACT_218726 REACT_227515
NextBio	20805735
PRO	PR:Q27975
Proteomes	UP000009136
ExpressionAtlas	Q27975
GO	GO:0005524
Gene3D	1.20.1270.10 2.60.34.10
InterPro	IPR018181 IPR029048 IPR029047 IPR013126
Pfam	PF00012
PRINTS	PR00301
SUPFAM	SSF100920 SSF100934
PROSITE	PS00297 PS00329 PS01036

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0009408	response to heat	PMID:27051194^[1]	ECO:0000314			P	Three SSCP patterns and consequently two alleles namely A and B were documented in one fragment of the gene. Genotype AA, thus, was found to be most thermotolerant genotype with the highest HTC.	complete CACAO 11730
involved_in	GO:0007041	lysosomal transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61696	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11785981^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0097718	disordered domain specific binding	PMID:11785981^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P21758	F	Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DMV8	C	Seeded From UniProt	complete
involved_in	GO:1901673	regulation of mitotic spindle assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DMV8	P	Seeded From UniProt	complete
involved_in	GO:0090063	positive regulation of microtubule nucleation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DMV8	P	Seeded From UniProt	complete
involved_in	GO:0042026	protein refolding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DMV8	P	Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DMV8	F	Seeded From UniProt	complete
involved_in	GO:0097201	negative regulation of transcription from RNA polymerase II promoter in response to stress	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P0DMV8	P	Seeded From UniProt	complete
involved_in	GO:1901673	regulation of mitotic spindle assembly	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000453125 UniProtKB:P0DMV8 UniProtKB:P0DMV9	P	Seeded From UniProt	complete
enables	GO:0051787	misfolded protein binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95835 PANTHER:PTN002321897 RGD:2843 UniProtKB:P11021	F	Seeded From UniProt	complete
involved_in	GO:0051085	chaperone cofactor-dependent protein refolding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10241 MGI:MGI:105384 PANTHER:PTN002321897	P	Seeded From UniProt	complete
enables	GO:0051082	unfolded protein binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10241 MGI:MGI:105384 PANTHER:PTN002321897 RGD:2843 RGD:621725 SGD:S000000004 SGD:S000000171 SGD:S000000905 SGD:S000001106 SGD:S000001556 SGD:S000002388 SGD:S000003571 SGD:S000003947 SGD:S000005153 UniProtKB:P0DMV8 UniProtKB:P0DMV9 UniProtKB:P11142 UniProtKB:P17066 UniProtKB:P34931 UniProtKB:P54652	F	Seeded From UniProt	complete
enables	GO:0044183	protein folding chaperone	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10241 PANTHER:PTN002321897 UniProtKB:P0DMV8 UniProtKB:P0DMV9	F	Seeded From UniProt	complete
enables	GO:0042623	ATPase activity, coupled	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:105384 PANTHER:PTN002321897 RGD:621725 UniProtKB:P0DMV8 UniProtKB:P0DMV9 UniProtKB:P17066	F	Seeded From UniProt	complete
involved_in	GO:0042026	protein refolding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002321897 SGD:S000000004 SGD:S000000756 SGD:S000003806 UniProtKB:P0DMV8 UniProtKB:P0DMV9 UniProtKB:P11142 UniProtKB:P17066 UniProtKB:P34931 UniProtKB:P54652	P	Seeded From UniProt	complete
involved_in	GO:0034620	cellular response to unfolded protein	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10241 PANTHER:PTN002321897 UniProtKB:P0DMV8	P	Seeded From UniProt	complete
involved_in	GO:0034605	cellular response to heat	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	CGD:CAL0000184706 PANTHER:PTN002321897 RGD:621725 SGD:S000000905 UniProtKB:A5I640 UniProtKB:P0DMV8 UniProtKB:P0DMV9 UniProtKB:P17066	P	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000453103 RGD:2840 UniProtKB:P0DMV8 UniProtKB:P0DMV9	C	Seeded From UniProt	complete
involved_in	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000453125 UniProtKB:P0DMV8	P	Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000453103 UniProtKB:P0DMV8 UniProtKB:P0DMV9	F	Seeded From UniProt	complete
enables	GO:0031072	heat shock protein binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002321897 RGD:1311806 UniProtKB:K7NTP5 UniProtKB:O73885 UniProtKB:P0DMV8 UniProtKB:P0DMV9 UniProtKB:P11142 UniProtKB:P17066 UniProtKB:P34931 UniProtKB:Q8IB24	F	Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10241 EcoGene:EG12130 EcoGene:EG13653 PANTHER:PTN002321897 PomBase:SPAC664.11 RGD:621725 SGD:S000000004 SGD:S000000171 SGD:S000002388 SGD:S000003571 SGD:S000003806 SGD:S000005153 UniProtKB:P0DMV8 UniProtKB:P0DMV9 UniProtKB:P11021 UniProtKB:P11142 WB:WBGene00002005	F	Seeded From UniProt	complete
colocalizes_with	GO:0008180	COP9 signalosome	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000453103 UniProtKB:P0DMV8 UniProtKB:P17066 UniProtKB:P48741	C	Seeded From UniProt	complete
involved_in	GO:0006986	response to unfolded protein	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002321897 RGD:1593284 RGD:2840 SGD:S000001556 SGD:S000003571 UniProtKB:P0DMV8	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002321762 PomBase:SPBC1709.05 RGD:2840 UniProtKB:P0DMV8 UniProtKB:P0DMV9 UniProtKB:P17066 UniProtKB:P34931 UniProtKB:Q0VDF9	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10241 FB:FBgn0266599 MGI:MGI:105384 MGI:MGI:96244 PANTHER:PTN002321897 PomBase:SPCC1739.13 RGD:1311806 RGD:2843 RGD:621725 SGD:S000000004 SGD:S000000905 SGD:S000001106 SGD:S000002388 SGD:S000003947 UniProtKB:O73885 UniProtKB:P08106 UniProtKB:P0DMV8 UniProtKB:P0DMV9 UniProtKB:P17066 UniProtKB:P22953 UniProtKB:Q27975 UniProtKB:Q8IB24 WB:WBGene00002005	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000453103 RGD:2840 UniProtKB:P0DMV8 UniProtKB:P0DMV9	C	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10241 EcoGene:EG12130 PANTHER:PTN002321897 RGD:621725 SGD:S000001556 SGD:S000003947 TAIR:locus:2101222 TAIR:locus:2121022 TAIR:locus:2135897 TAIR:locus:2144801 UniProtKB:P08106 UniProtKB:P0DMV8 UniProtKB:P0DMV9 UniProtKB:P11142 UniProtKB:Q7SX63	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206	C	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0048	C	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Bhat, S et al. (2016) Effect of heat shock protein 70 polymorphism on thermotolerance in Tharparkar cattle. Vet World 9 113-7 PubMed GONUTS page
↑ ^2.0 ^2.1 Nakamura, T et al. (2002) HSP90, HSP70, and GAPDH directly interact with the cytoplasmic domain of macrophage scavenger receptors. Biochem. Biophys. Res. Commun. 290 858-64 PubMed GONUTS page
↑ ^3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 ^3.13 ^3.14 ^3.15 ^3.16 ^3.17 ^3.18 ^3.19 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:27051194-1] Bhat, S et al. (2016) Effect of heat shock protein 70 polymorphism on thermotolerance in Tharparkar cattle. Vet World 9 113-7 PubMed GONUTS page

[PMID:11785981-2] 2.0 ^2.1 Nakamura, T et al. (2002) HSP90, HSP70, and GAPDH directly interact with the cytoplasmic domain of macrophage scavenger receptors. Biochem. Biophys. Res. Commun. 290 858-64 PubMed GONUTS page

[PMID:21873635-3] 3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 ^3.13 ^3.14 ^3.15 ^3.16 ^3.17 ^3.18 ^3.19 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[1]

[2]

[3]

BOVIN:HS71A

Contents

Annotations

Notes

References

a

b

c

d

e

h

l

m

n

o

p

r

t

u

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools