RAT:OPRK

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Oprk1 (synonyms: Ror-d)
Protein Name(s)	Kappa-type opioid receptor K-OR-1 KOR-1
External Links
UniProt	P34975
EMBL	L22001 D16829 L22536 U00442 D16534 U17995 U17993 U17994
PIR	S36143
RefSeq	NP_058863.1
UniGene	Rn.89571
ProteinModelPortal	P34975
IntAct	P34975
STRING	10116.ENSRNOP00000010255
BindingDB	P34975
ChEMBL	CHEMBL2094129
GuidetoPHARMACOLOGY	318
PhosphoSite	P34975
PaxDb	P34975
Ensembl	ENSRNOT00000010254
GeneID	29335
KEGG	rno:29335
UCSC	RGD:69426
CTD	4986
RGD	69426
eggNOG	KOG3656 ENOG410XRW9
GeneTree	ENSGT00760000118797
HOGENOM	HOG000230486
HOVERGEN	HBG106919
InParanoid	P34975
KO	K04214
OMA	PFQSTEY
OrthoDB	EOG7BKCVQ
PhylomeDB	P34975
TreeFam	TF315737
Reactome	R-RNO-375276 R-RNO-418594
NextBio	608812
PRO	PR:P34975
Proteomes	UP000002494
Genevisible	P34975
GO	GO:0043679 GO:0030425 GO:0016021 GO:0005887 GO:0043025 GO:0043204 GO:0005886 GO:0045202 GO:0038048 GO:0042923 GO:0004985 GO:0031635 GO:0048148 GO:0071222 GO:1990708 GO:0051607 GO:0042755 GO:0044849 GO:0007187 GO:0006955 GO:0007626 GO:0042711 GO:0033685 GO:0007218 GO:0007200 GO:0033603 GO:0040017 GO:1900745 GO:1901381 GO:1903715 GO:2000505 GO:0046877 GO:0051930 GO:1903937 GO:0042220 GO:0043627 GO:0045471 GO:0032868 GO:0043278 GO:0009314 GO:0019233 GO:0050951 GO:0007268
InterPro	IPR000276 IPR017452 IPR000452 IPR001418
Pfam	PF00001
PRINTS	PR00237 PR00532 PR00384
PROSITE	PS00237 PS50262

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:2000474	regulation of opioid receptor signaling pathway	PMID:27064940^[1]	ECO:0000314			P		The inhibitory effects of dynorphin on pulsatile GnRH secretion may occur either indirectly by actions upon KOR within the KNDy population and/or directly via activation of KOR on GnRH cells.	complete CACAO 11736
involved_in	GO:0046877	regulation of saliva secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P33534	P		Seeded From UniProt	complete
enables	GO:0038048	dynorphin receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41145	F		Seeded From UniProt	complete
involved_in	GO:0031635	adenylate cyclase-inhibiting opioid receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41145	P		Seeded From UniProt	complete
involved_in	GO:0019233	sensory perception of pain	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P33534	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41145	C		Seeded From UniProt	complete
involved_in	GO:0007626	locomotory behavior	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P33534	P		Seeded From UniProt	complete
involved_in	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	PMID:9572309^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41145	C		Seeded From UniProt	complete
enables	GO:0004985	opioid receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41145	F		Seeded From UniProt	complete
part_of	GO:0099056	integral component of presynaptic membrane	PMID:11746715^[3]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0000061) part_of:(UBERON:0002435)	Seeded From UniProt	complete
part_of	GO:0099055	integral component of postsynaptic membrane	PMID:11746715^[3]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0000061) part_of:(UBERON:0002435)	Seeded From UniProt	complete
part_of	GO:0030285	integral component of synaptic vesicle membrane	PMID:11746715^[3]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0000061) part_of:(UBERON:0002435)	Seeded From UniProt	complete
involved_in	GO:1990708	conditioned place preference	PMID:21549821^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904000	positive regulation of eating behavior	PMID:17456590^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903937	response to acrylamide	PMID:22197712^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901381	positive regulation of potassium ion transmembrane transport	PMID:12815037^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900745	positive regulation of p38MAPK cascade	PMID:16648139^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071333	cellular response to glucose stimulus	PMID:27865836^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	PMID:9645969^[10]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051930	regulation of sensory perception of pain	PMID:10908631^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050951	sensory perception of temperature stimulus	PMID:21041644^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048148	behavioral response to cocaine	PMID:24919534^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	PMID:9645969^[10]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	PMID:10554970^[14]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:17120286^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0044849	estrous cycle	PMID:21041644^[12]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043679	axon terminus	PMID:17120286^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043627	response to estrogen	PMID:8904783^[16]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043278	response to morphine	PMID:16753266^[17]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	PMID:17120286^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:17120286^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0042755	eating behavior	PMID:11961051^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042711	maternal behavior	PMID:22641418^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042220	response to cocaine	PMID:9645969^[10]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042220	response to cocaine	PMID:10554970^[14]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0040017	positive regulation of locomotion	PMID:17568430^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033685	negative regulation of luteinizing hormone secretion	PMID:23391862^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0033612	receptor serine/threonine kinase binding	PMID:27865836^[9]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:2062	F		Seeded From UniProt	complete
involved_in	GO:0033603	positive regulation of dopamine secretion	PMID:17568430^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032868	response to insulin	PMID:10995763^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032868	response to insulin	PMID:9645969^[10]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:17120286^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0009314	response to radiation	PMID:22337865^[23]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:17120286^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042277	peptide binding	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001200938 ZFIN:ZDB-GENE-030729-1	F		Seeded From UniProt	complete
enables	GO:0038048	dynorphin receptor activity	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002796230 UniProtKB:P41145	F		Seeded From UniProt	complete
involved_in	GO:0038003	opioid receptor signaling pathway	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000659952 UniProtKB:P41145	P		Seeded From UniProt	complete
involved_in	GO:0019233	sensory perception of pain	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97439 PANTHER:PTN000659952	P		Seeded From UniProt	complete
involved_in	GO:0007218	neuropeptide signaling pathway	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0036789 FB:FBgn0036790 FB:FBgn0266429 MGI:MGI:97438 MGI:MGI:98327 MGI:MGI:98328 PANTHER:PTN000659780	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0266429 MGI:MGI:97439 PANTHER:PTN001200938 UniProtKB:P41145 UniProtKB:P41146 ZFIN:ZDB-GENE-990415-199	C		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1330275 PANTHER:PTN001200938 RGD:3234 UniProtKB:P41146 UniProtKB:Q9Y5Y4	F		Seeded From UniProt	complete
involved_in	GO:0046877	regulation of saliva secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33534 ensembl:ENSMUSP00000125105	P		Seeded From UniProt	complete
involved_in	GO:0019233	sensory perception of pain	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33534 ensembl:ENSMUSP00000125105	P		Seeded From UniProt	complete
involved_in	GO:0007626	locomotory behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33534 ensembl:ENSMUSP00000125105	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33534 ensembl:ENSMUSP00000125105	C		Seeded From UniProt	complete
enables	GO:0004985	opioid receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P33534 ensembl:ENSMUSP00000125105	F		Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41145 ensembl:ENSP00000265572	P		Seeded From UniProt	complete
enables	GO:0038048	dynorphin receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41145 ensembl:ENSP00000265572	F		Seeded From UniProt	complete
involved_in	GO:0038003	opioid receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41145 ensembl:ENSP00000265572	P		Seeded From UniProt	complete
involved_in	GO:0031635	adenylate cyclase-inhibiting opioid receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41145 ensembl:ENSP00000265572	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41145 ensembl:ENSP00000265572	C		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41145 ensembl:ENSP00000265572	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41145 ensembl:ENSP00000265572	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41145 ensembl:ENSP00000265572	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41145 ensembl:ENSP00000265572	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41145 ensembl:ENSP00000265572	C		Seeded From UniProt	complete
enables	GO:0004985	opioid receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41145 ensembl:ENSP00000265572	F		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276	F		Seeded From UniProt	complete
enables	GO:0004985	opioid receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001418	F		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276 InterPro:IPR000452 InterPro:IPR001418	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276 InterPro:IPR000452 InterPro:IPR001418 InterPro:IPR017452	C		Seeded From UniProt	complete
enables	GO:0038048	dynorphin receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000452	F		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	F		Seeded From UniProt	complete
involved_in	GO:0007610	behavior	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0085	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0807	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Weems, PW et al. (2016) Kappa Opioid Receptor is Co-localized in GnRH and KNDy Cells in the Female Ovine and Rat Brain. Endocrinology en20151763 PubMed GONUTS page
↑ Lee, JW et al. (1998) Differential coupling of mu-, delta-, and kappa-opioid receptors to G alpha16-mediated stimulation of phospholipase C. J. Neurochem. 70 2203-11 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Svingos, AL et al. (2001) Major coexpression of kappa-opioid receptors and the dopamine transporter in nucleus accumbens axonal profiles. Synapse 42 185-92 PubMed GONUTS page
↑ Wu, G et al. (2011) Inhibitory effects of processed Aconiti tuber on morphine-induced conditioned place preference in rats. J Ethnopharmacol 136 254-9 PubMed GONUTS page
↑ Jarosz, PA (2007) The effect of kappa opioid receptor antagonism on energy expenditure in the obese Zucker rat. Biol Res Nurs 8 294-9 PubMed GONUTS page
↑ Seale, SM et al. (2012) Neurobehavioral and transcriptional effects of acrylamide in juvenile rats. Pharmacol. Biochem. Behav. 101 77-84 PubMed GONUTS page
↑ McLaughlin, JP et al. (2003) Phosphorylation of a carboxyl-terminal serine within the kappa-opioid receptor produces desensitization and internalization. J. Biol. Chem. 278 34631-40 PubMed GONUTS page
↑ Bruchas, MR et al. (2006) Kappa opioid receptor activation of p38 MAPK is GRK3- and arrestin-dependent in neurons and astrocytes. J. Biol. Chem. 281 18081-9 PubMed GONUTS page
↑ ^9.0 ^9.1 Chen, X et al. (2017) G protein coupled receptor kinase-2 upregulation causes κ-opioid receptor desensitization in diabetic heart. Biochem. Biophys. Res. Commun. 482 658-664 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Tryoen-Toth, P et al. (1998) Regulation of kappa-opioid receptor mRNA level by cyclic AMP and growth factors in cultured rat glial cells. Brain Res. Mol. Brain Res. 55 141-50 PubMed GONUTS page
↑ Joshi, SK et al. (2000) kappa -opioid receptor agonists modulate visceral nociception at a novel, peripheral site of action. J. Neurosci. 20 5874-9 PubMed GONUTS page
↑ ^12.0 ^12.1 Chakrabarti, S et al. (2010) Formation of mu-/kappa-opioid receptor heterodimer is sex-dependent and mediates female-specific opioid analgesia. Proc. Natl. Acad. Sci. U.S.A. 107 20115-9 PubMed GONUTS page
↑ Groblewski, PA et al. (2015) Repeated stress exposure causes strain-dependent shifts in the behavioral economics of cocaine in rats. Addict Biol 20 297-301 PubMed GONUTS page
↑ ^14.0 ^14.1 Rosin, A et al. (1999) Downregulation of kappa opioid receptor mRNA levels by chronic ethanol and repetitive cocaine in rat ventral tegmentum and nucleus accumbens. Neurosci. Lett. 275 1-4 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 Drake, CT et al. (2007) Kappa opioid receptors in the rostral ventromedial medulla of male and female rats. J. Comp. Neurol. 500 465-76 PubMed GONUTS page
↑ Yukhananov, RY & Handa, RJ (1996) Alterations in kappa opioid receptor mRNA levels in the paraventricular nucleus of the hypothalamus by stress and sex steroids. Neuroreport 7 1690-4 PubMed GONUTS page
↑ Teodorov, E et al. (2006) Preliminary study of the effects of morphine treatment on opioid receptor gene expression in brain structures of the female rat. Neuroscience 141 1225-31 PubMed GONUTS page
↑ Silva, RM et al. (2002) Dynorphin A(1-17)-induced feeding: pharmacological characterization using selective opioid antagonists and antisense probes in rats. J. Pharmacol. Exp. Ther. 301 513-8 PubMed GONUTS page
↑ Teodorov, E et al. (2012) Behavioral meaningful opioidergic stimulation activates kappa receptor gene expression. Braz. J. Med. Biol. Res. 45 982-7 PubMed GONUTS page
↑ ^20.0 ^20.1 Fuentealba, JA et al. (2007) Increased locomotor response to amphetamine induced by the repeated administration of the selective kappa-opioid receptor agonist U-69593. Synapse 61 771-7 PubMed GONUTS page
↑ Mostari, P et al. (2013) dynorphin-kappa opioid receptor signaling partly mediates estrogen negative feedback effect on LH pulses in female rats. J. Reprod. Dev. 59 266-72 PubMed GONUTS page
↑ Appleyard, SM et al. (2000) Tyrosine phosphorylation of the kappa -opioid receptor regulates agonist efficacy. J. Biol. Chem. 275 38281-5 PubMed GONUTS page
↑ Feng, Y et al. (2012) Electrical and manual acupuncture stimulation affect oestrous cyclicity and neuroendocrine function in an 5α-dihydrotestosterone-induced rat polycystic ovary syndrome model. Exp. Physiol. 97 651-62 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 ^24.3 ^24.4 ^24.5 ^24.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:27064940-1] Weems, PW et al. (2016) Kappa Opioid Receptor is Co-localized in GnRH and KNDy Cells in the Female Ovine and Rat Brain. Endocrinology en20151763 PubMed GONUTS page

[PMID:9572309-2] Lee, JW et al. (1998) Differential coupling of mu-, delta-, and kappa-opioid receptors to G alpha16-mediated stimulation of phospholipase C. J. Neurochem. 70 2203-11 PubMed GONUTS page

[PMID:11746715-3] 3.0 ^3.1 ^3.2 Svingos, AL et al. (2001) Major coexpression of kappa-opioid receptors and the dopamine transporter in nucleus accumbens axonal profiles. Synapse 42 185-92 PubMed GONUTS page

[PMID:21549821-4] Wu, G et al. (2011) Inhibitory effects of processed Aconiti tuber on morphine-induced conditioned place preference in rats. J Ethnopharmacol 136 254-9 PubMed GONUTS page

[PMID:17456590-5] Jarosz, PA (2007) The effect of kappa opioid receptor antagonism on energy expenditure in the obese Zucker rat. Biol Res Nurs 8 294-9 PubMed GONUTS page

[PMID:22197712-6] Seale, SM et al. (2012) Neurobehavioral and transcriptional effects of acrylamide in juvenile rats. Pharmacol. Biochem. Behav. 101 77-84 PubMed GONUTS page

[PMID:12815037-7] McLaughlin, JP et al. (2003) Phosphorylation of a carboxyl-terminal serine within the kappa-opioid receptor produces desensitization and internalization. J. Biol. Chem. 278 34631-40 PubMed GONUTS page

[PMID:16648139-8] Bruchas, MR et al. (2006) Kappa opioid receptor activation of p38 MAPK is GRK3- and arrestin-dependent in neurons and astrocytes. J. Biol. Chem. 281 18081-9 PubMed GONUTS page

[PMID:27865836-9] 9.0 ^9.1 Chen, X et al. (2017) G protein coupled receptor kinase-2 upregulation causes κ-opioid receptor desensitization in diabetic heart. Biochem. Biophys. Res. Commun. 482 658-664 PubMed GONUTS page

[PMID:9645969-10] 10.0 ^10.1 ^10.2 ^10.3 Tryoen-Toth, P et al. (1998) Regulation of kappa-opioid receptor mRNA level by cyclic AMP and growth factors in cultured rat glial cells. Brain Res. Mol. Brain Res. 55 141-50 PubMed GONUTS page

[PMID:10908631-11] Joshi, SK et al. (2000) kappa -opioid receptor agonists modulate visceral nociception at a novel, peripheral site of action. J. Neurosci. 20 5874-9 PubMed GONUTS page

[PMID:21041644-12] 12.0 ^12.1 Chakrabarti, S et al. (2010) Formation of mu-/kappa-opioid receptor heterodimer is sex-dependent and mediates female-specific opioid analgesia. Proc. Natl. Acad. Sci. U.S.A. 107 20115-9 PubMed GONUTS page

[PMID:24919534-13] Groblewski, PA et al. (2015) Repeated stress exposure causes strain-dependent shifts in the behavioral economics of cocaine in rats. Addict Biol 20 297-301 PubMed GONUTS page

[PMID:10554970-14] 14.0 ^14.1 Rosin, A et al. (1999) Downregulation of kappa opioid receptor mRNA levels by chronic ethanol and repetitive cocaine in rat ventral tegmentum and nucleus accumbens. Neurosci. Lett. 275 1-4 PubMed GONUTS page

[PMID:17120286-15] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 Drake, CT et al. (2007) Kappa opioid receptors in the rostral ventromedial medulla of male and female rats. J. Comp. Neurol. 500 465-76 PubMed GONUTS page

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RAT:OPRK

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