RAT:MK03

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Mapk3 (synonyms: Erk1, Prkm3)
Protein Name(s)	Mitogen-activated protein kinase 3 MAP kinase 3 MAPK 3 ERT2 Extracellular signal-regulated kinase 1 ERK-1 Insulin-stimulated MAP2 kinase MAP kinase isoform p44 p44-MAPK MNK1 Microtubule-associated protein 2 kinase p44-ERK1
External Links
UniProt	P21708
EMBL	S46779 X65198 AF155236 M61177 M38194 U12008
PIR	JC1451
RefSeq	NP_059043.1
UniGene	Rn.2592
ProteinModelPortal	P21708
SMR	P21708
BioGrid	248427
DIP	DIP-487N
IntAct	P21708
MINT	MINT-100073
STRING	10116.ENSRNOP00000026627
ChEMBL	CHEMBL5809
iPTMnet	P21708
PhosphoSite	P21708
PaxDb	P21708
PRIDE	P21708
Ensembl	ENSRNOT00000087625
GeneID	50689
KEGG	rno:50689
UCSC	RGD:3046
CTD	5595
RGD	3046
eggNOG	KOG0660 ENOG410XNY0
GeneTree	ENSGT00550000074298
HOGENOM	HOG000233024
HOVERGEN	HBG014652
InParanoid	P21708
KO	K04371
OMA	PRYTDLQ
OrthoDB	EOG7M3J0K
PhylomeDB	P21708
TreeFam	TF105097
BRENDA	2.7.11.24
Reactome	R-RNO-110056 R-RNO-112409 R-RNO-1169408 R-RNO-162658 R-RNO-198753 R-RNO-202670 R-RNO-2029482 R-RNO-2559580 R-RNO-2559582 R-RNO-2559585 R-RNO-2871796 R-RNO-3371453 R-RNO-375165 R-RNO-445144 R-RNO-450341 R-RNO-456926 R-RNO-5654726 R-RNO-5654727 R-RNO-5654732 R-RNO-5654733 R-RNO-5663213 R-RNO-5673001 R-RNO-5674135 R-RNO-5674499 R-RNO-5675221 R-RNO-73728 R-RNO-74749 R-RNO-881907 R-RNO-982772
NextBio	610550
PRO	PR:P21708
Proteomes	UP000002494
Genevisible	P21708
GO	GO:0005901 GO:0005856 GO:0005829 GO:0005769 GO:0070062 GO:0005925 GO:0005794 GO:0005770 GO:0015630 GO:0005739 GO:0005635 GO:0005654 GO:0005634 GO:0043234 GO:0031143 GO:0005524 GO:0004707 GO:0004674 GO:0097110 GO:0006915 GO:0019369 GO:0060020 GO:0030509 GO:0061308 GO:0051216 GO:0072584 GO:0007049 GO:0071260 GO:0006975 GO:0070371 GO:0060324 GO:0070498 GO:0035556 GO:0031663 GO:0060425 GO:0000165 GO:0000189 GO:2000657 GO:0042473 GO:0018105 GO:0038083 GO:0031281 GO:0070374 GO:0035066 GO:0033129 GO:0045944 GO:0045893 GO:0045727 GO:0006461 GO:0006468 GO:0051493 GO:2000641 GO:0090170 GO:0051090 GO:0032872 GO:0070849 GO:0043330 GO:0009636 GO:0019233 GO:0048538 GO:0030878 GO:0060440 GO:0006351
InterPro	IPR011009 IPR003527 IPR008349 IPR000719 IPR017441 IPR002290 IPR008271
Pfam	PF00069
PRINTS	PR01770
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS01351 PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0070372	regulation of ERK1 and ERK2 cascade	PMID:27066371^[1]	ECO:0000314			P	Fig.4 shows the effects of active components of Radix Scrophulariae (ACRS) on phospho-specific extracellular signal regulated kinase (ERK 1/2).	complete CACAO 11734
part_of	GO:0005886	plasma membrane	PMID:24567387^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:24567387^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005901	caveola	PMID:24567387^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0097110	scaffold protein binding	PMID:20455999^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q2IBC5	F	Seeded From UniProt	complete
involved_in	GO:0070849	response to epidermal growth factor	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27361	P	Seeded From UniProt	complete
involved_in	GO:0065003	protein-containing complex assembly	PMID:7889942^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	PMID:7889942^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	PMID:7889942^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0046697	decidualization	PMID:21248290^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045727	positive regulation of translation	PMID:15027896^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:12072413^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:15781236^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0019369	arachidonic acid metabolic process	PMID:15027896^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:16955078^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009636	response to toxic substance	PMID:17651772^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007568	aging	PMID:28515230^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:15027896^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:9779826^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17150373^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:15027896^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	PMID:16955078^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	PMID:15027896^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:15027896^[6]	ECO:0000305	curator inference used in manual assertion	GO:0004707	F	Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	PMID:17310240^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071310	cellular response to organic substance	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001172432 RGD:70500	P	Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106908 MGI:MGI:1201387 MGI:MGI:1201408 MGI:MGI:1346865 PANTHER:PTN000622075 RGD:3046 RGD:70500 RGD:71050 UniProtKB:P78362 UniProtKB:Q16539 UniProtKB:Q96SB4 UniProtKB:Q9UPZ9 WB:WBGene00004055 WB:WBGene00004056	P	Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1346861 PANTHER:PTN000622075 UniProtKB:A9T142	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0052703 FB:FBgn0267339 MGI:MGI:1201408 MGI:MGI:1346347 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346861 MGI:MGI:1346862 MGI:MGI:1346863 MGI:MGI:1346865 MGI:MGI:1354946 MGI:MGI:2444559 PANTHER:PTN000622075 PomBase:SPAC24B11.06c PomBase:SPBC119.08 PomBase:SPBC530.14c RGD:3046 RGD:621506 RGD:628847 RGD:70500 RGD:70975 RGD:71050 SGD:S000000112 SGD:S000004103 SGD:S000004829 TAIR:locus:2024887 TAIR:locus:2124943 UniProtKB:A9T142 UniProtKB:O77306 UniProtKB:P28482 UniProtKB:P78362 UniProtKB:Q13164 UniProtKB:Q96SB4 WB:WBGene00002178 WB:WBGene00002187 WB:WBGene00003048 WB:WBGene00003401 WB:WBGene00004056 WB:WBGene00004057	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003256 FB:FBgn0015765 MGI:MGI:1201387 MGI:MGI:1201408 MGI:MGI:1336881 MGI:MGI:1346347 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346861 MGI:MGI:1346865 MGI:MGI:1354946 MGI:MGI:1934157 MGI:MGI:2444559 MGI:MGI:96913 PANTHER:PTN000622075 PomBase:SPAC24B11.06c PomBase:SPAC31G5.09c PomBase:SPBC119.08 PomBase:SPBC530.14c RGD:3046 RGD:3663 RGD:621505 RGD:621506 RGD:628675 RGD:628847 RGD:70496 RGD:70500 SGD:S000000112 SGD:S000001072 SGD:S000003272 SGD:S000003642 SGD:S000004103 TAIR:locus:2024887 TAIR:locus:2124943 UniProtKB:A9T142 UniProtKB:O77306 UniProtKB:P20794 UniProtKB:P28482 UniProtKB:P45983 UniProtKB:P78362 UniProtKB:Q13164 UniProtKB:Q5AZN7 UniProtKB:Q8GYQ5 UniProtKB:Q96SB4 UniProtKB:Q9LV37 UniProtKB:Q9P419 WB:WBGene00002178 WB:WBGene00003048 WB:WBGene00003401 WB:WBGene00004055 WB:WBGene00004057 dictyBase:DDB_G0283903 dictyBase:DDB_G0286353	C	Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015765 FB:FBgn0024846 FB:FBgn0267339 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346865 MGI:MGI:1354946 PANTHER:PTN001172432 PomBase:SPAC31G5.09c PomBase:SPBC119.08 RGD:1309340 RGD:3045 RGD:3046 RGD:621505 RGD:70496 RGD:70500 RGD:70975 SGD:S000000112 SGD:S000003272 SGD:S000006258 UniProtKB:A0A1D8PFT5 UniProtKB:A0A1D8PT38 UniProtKB:O15264 UniProtKB:P27361 UniProtKB:Q15759 UniProtKB:Q16539 WB:WBGene00003401 WB:WBGene00004055 WB:WBGene00004056 dictyBase:DDB_G0286353	F	Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	CGD:CAL0000183747 FB:FBgn0015765 FB:FBgn0024846 FB:FBgn0267339 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346865 MGI:MGI:1354946 PANTHER:PTN002372889 PomBase:SPAC31G5.09c PomBase:SPBC119.08 RGD:1309340 RGD:3045 RGD:3046 RGD:621505 RGD:70496 RGD:70500 RGD:70975 SGD:S000000112 SGD:S000003272 SGD:S000006258 UniProtKB:A0A1D8PFT5 UniProtKB:A0A1D8PT38 UniProtKB:O15264 UniProtKB:P27361 UniProtKB:Q15759 UniProtKB:Q16539 WB:WBGene00003401 WB:WBGene00004055 WB:WBGene00004056 dictyBase:DDB_G0286353	F	Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004708	P	Seeded From UniProt	complete
involved_in	GO:1904355	positive regulation of telomere capping	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27361 ensembl:ENSP00000263025	P	Seeded From UniProt	complete
involved_in	GO:1903351	cellular response to dopamine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27361 ensembl:ENSP00000263025	P	Seeded From UniProt	complete
involved_in	GO:0071276	cellular response to cadmium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27361 ensembl:ENSP00000263025	P	Seeded From UniProt	complete
involved_in	GO:0071260	cellular response to mechanical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27361 ensembl:ENSP00000263025	P	Seeded From UniProt	complete
involved_in	GO:0070849	response to epidermal growth factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27361 ensembl:ENSP00000263025	P	Seeded From UniProt	complete
involved_in	GO:0070498	interleukin-1-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27361 ensembl:ENSP00000263025	P	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27361 ensembl:ENSP00000263025	P	Seeded From UniProt	complete
involved_in	GO:0051973	positive regulation of telomerase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27361 ensembl:ENSP00000263025	P	Seeded From UniProt	complete
involved_in	GO:0051403	stress-activated MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27361 ensembl:ENSP00000263025	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27361 ensembl:ENSP00000263025	P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27361 ensembl:ENSP00000263025	F	Seeded From UniProt	complete
involved_in	GO:0038083	peptidyl-tyrosine autophosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27361 ensembl:ENSP00000263025	P	Seeded From UniProt	complete
involved_in	GO:0035066	positive regulation of histone acetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27361 ensembl:ENSP00000263025	P	Seeded From UniProt	complete
involved_in	GO:0034614	cellular response to reactive oxygen species	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27361 ensembl:ENSP00000263025	P	Seeded From UniProt	complete
involved_in	GO:0034198	cellular response to amino acid starvation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27361 ensembl:ENSP00000263025	P	Seeded From UniProt	complete
involved_in	GO:0033129	positive regulation of histone phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27361 ensembl:ENSP00000263025	P	Seeded From UniProt	complete
involved_in	GO:0032212	positive regulation of telomere maintenance via telomerase	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27361 ensembl:ENSP00000263025	P	Seeded From UniProt	complete
involved_in	GO:0031281	positive regulation of cyclase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27361 ensembl:ENSP00000263025	P	Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27361 ensembl:ENSP00000263025	P	Seeded From UniProt	complete
enables	GO:0019902	phosphatase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27361 ensembl:ENSP00000263025	F	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27361 ensembl:ENSP00000263025	P	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27361 ensembl:ENSP00000263025	P	Seeded From UniProt	complete
involved_in	GO:0006975	DNA damage induced protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27361 ensembl:ENSP00000263025	P	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27361 ensembl:ENSP00000263025	P	Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27361 ensembl:ENSP00000263025	C	Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27361 ensembl:ENSP00000263025	F	Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P27361 ensembl:ENSP00000263025	P	Seeded From UniProt	complete
involved_in	GO:2000657	negative regulation of apolipoprotein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P	Seeded From UniProt	complete
involved_in	GO:1905050	positive regulation of metallopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P	Seeded From UniProt	complete
involved_in	GO:1904417	positive regulation of xenophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P	Seeded From UniProt	complete
involved_in	GO:0071356	cellular response to tumor necrosis factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P	Seeded From UniProt	complete
involved_in	GO:0070371	ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P	Seeded From UniProt	complete
involved_in	GO:0061308	cardiac neural crest cell development involved in heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P	Seeded From UniProt	complete
involved_in	GO:0060440	trachea formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P	Seeded From UniProt	complete
involved_in	GO:0060425	lung morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P	Seeded From UniProt	complete
involved_in	GO:0060324	face development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P	Seeded From UniProt	complete
involved_in	GO:0060020	Bergmann glial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P	Seeded From UniProt	complete
involved_in	GO:0051216	cartilage development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P	Seeded From UniProt	complete
involved_in	GO:0051090	regulation of DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P	Seeded From UniProt	complete
involved_in	GO:0048538	thymus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P	Seeded From UniProt	complete
involved_in	GO:0043330	response to exogenous dsRNA	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P	Seeded From UniProt	complete
involved_in	GO:0042473	outer ear morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P	Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P	Seeded From UniProt	complete
involved_in	GO:0031663	lipopolysaccharide-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P	Seeded From UniProt	complete
part_of	GO:0031143	pseudopodium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	C	Seeded From UniProt	complete
involved_in	GO:0030878	thyroid gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P	Seeded From UniProt	complete
involved_in	GO:0030641	regulation of cellular pH	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P	Seeded From UniProt	complete
involved_in	GO:0030278	regulation of ossification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P	Seeded From UniProt	complete
involved_in	GO:0019233	sensory perception of pain	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P	Seeded From UniProt	complete
involved_in	GO:0014032	neural crest cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P	Seeded From UniProt	complete
involved_in	GO:0010759	positive regulation of macrophage chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P	Seeded From UniProt	complete
involved_in	GO:0009887	animal organ morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P	Seeded From UniProt	complete
involved_in	GO:0006351	transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	C	Seeded From UniProt	complete
enables	GO:0004708	MAP kinase kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	F	Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	F	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	F	Seeded From UniProt	complete
involved_in	GO:0002741	positive regulation of cytokine secretion involved in immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P	Seeded From UniProt	complete
enables	GO:0001784	phosphotyrosine residue binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	F	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F	Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003527 InterPro:IPR008349	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR003527 InterPro:IPR008349 InterPro:IPR017441	F	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR003527 InterPro:IPR008271 InterPro:IPR008349	P	Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.24	F	Seeded From UniProt	complete
involved_in	GO:2000641	regulation of early endosome to late endosome transport	PMID:19565474^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0090170	regulation of Golgi inheritance	PMID:19565474^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0072584	caveolin-mediated endocytosis	PMID:19565474^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051493	regulation of cytoskeleton organization	PMID:19565474^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032872	regulation of stress-activated MAPK cascade	PMID:19565474^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	PMID:19565474^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005901	caveola	PMID:19565474^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	PMID:19565474^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:19565474^[16] Reactome:R-NUL-997411	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:19565474^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005770	late endosome	PMID:19565474^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005769	early endosome	PMID:19565474^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:19565474^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19565474^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:9779826^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:9779826^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P	Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0035	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Zhang, CC et al. () Active components from Radix Scrophulariae inhibits the ventricular remodeling induced by hypertension in rats. Springerplus 5 358 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Ogata, T et al. (2014) MURC/Cavin-4 facilitates recruitment of ERK to caveolae and concentric cardiac hypertrophy induced by α1-adrenergic receptors. Proc. Natl. Acad. Sci. U.S.A. 111 3811-6 PubMed GONUTS page
↑ Kwon, H et al. (2011) A novel domain of caveolin-2 that controls nuclear targeting: regulation of insulin-specific ERK activation and nuclear translocation by caveolin-2. J. Cell. Mol. Med. 15 888-908 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Gille, H et al. (1995) ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation. EMBO J. 14 951-62 PubMed GONUTS page
↑ Vallejo, G et al. (2011) Ovarian steroid receptors and activated MAPK in the regional decidualization in rats. Biol. Reprod. 84 1063-71 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Gorin, Y et al. (2004) Angiotensin II-induced ERK1/ERK2 activation and protein synthesis are redox-dependent in glomerular mesangial cells. Biochem. J. 381 231-9 PubMed GONUTS page
↑ Schwartz, Z et al. (2002) 1alpha,25-dihydroxyvitamin D(3) and 24R,25-dihydroxyvitamin D(3) modulate growth plate chondrocyte physiology via protein kinase C-dependent phosphorylation of extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase. Endocrinology 143 2775-86 PubMed GONUTS page
↑ Kim, S & Pak, Y (2005) Caveolin-2 regulation of the cell cycle in response to insulin in Hirc-B fibroblast cells. Biochem. Biophys. Res. Commun. 330 88-96 PubMed GONUTS page
↑ ^9.0 ^9.1 Chen, S et al. (2007) Alterations in mammalian target of rapamycin signaling pathways after traumatic brain injury. J. Cereb. Blood Flow Metab. 27 939-49 PubMed GONUTS page
↑ Marin-Kuan, M et al. (2007) MAPK-ERK activation in kidney of male rats chronically fed ochratoxin A at a dose causing a significant incidence of renal carcinoma. Toxicol. Appl. Pharmacol. 224 174-81 PubMed GONUTS page
↑ Isensee, J et al. (2017) Crosstalk from cAMP to ERK1/2 emerges during postnatal maturation of nociceptive neurons and is maintained during aging. J. Cell. Sci. 130 2134-2146 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Kim, SO et al. (1998) Expression of mitogen-activated protein kinase pathways during postnatal development of rat heart. J. Cell. Biochem. 71 286-301 PubMed GONUTS page
↑ Watson, PM et al. (2007) Integrin-binding RGD peptides induce rapid intracellular calcium increases and MAPK signaling in cortical neurons. Mol. Cell. Neurosci. 34 147-54 PubMed GONUTS page
↑ Santos, SD et al. (2007) Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate. Nat. Cell Biol. 9 324-30 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 ^15.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^16.00 ^16.01 ^16.02 ^16.03 ^16.04 ^16.05 ^16.06 ^16.07 ^16.08 ^16.09 ^16.10 ^16.11 ^16.12 ^16.13 Yao, Z & Seger, R () The ERK signaling cascade--views from different subcellular compartments. Biofactors 35 407-16 PubMed GONUTS page

[PMID:27066371-1] Zhang, CC et al. () Active components from Radix Scrophulariae inhibits the ventricular remodeling induced by hypertension in rats. Springerplus 5 358 PubMed GONUTS page

[PMID:24567387-2] 2.0 ^2.1 ^2.2 Ogata, T et al. (2014) MURC/Cavin-4 facilitates recruitment of ERK to caveolae and concentric cardiac hypertrophy induced by α1-adrenergic receptors. Proc. Natl. Acad. Sci. U.S.A. 111 3811-6 PubMed GONUTS page

[PMID:20455999-3] Kwon, H et al. (2011) A novel domain of caveolin-2 that controls nuclear targeting: regulation of insulin-specific ERK activation and nuclear translocation by caveolin-2. J. Cell. Mol. Med. 15 888-908 PubMed GONUTS page

[PMID:7889942-4] 4.0 ^4.1 ^4.2 Gille, H et al. (1995) ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation. EMBO J. 14 951-62 PubMed GONUTS page

[PMID:21248290-5] Vallejo, G et al. (2011) Ovarian steroid receptors and activated MAPK in the regional decidualization in rats. Biol. Reprod. 84 1063-71 PubMed GONUTS page

[PMID:15027896-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Gorin, Y et al. (2004) Angiotensin II-induced ERK1/ERK2 activation and protein synthesis are redox-dependent in glomerular mesangial cells. Biochem. J. 381 231-9 PubMed GONUTS page

[PMID:12072413-7] Schwartz, Z et al. (2002) 1alpha,25-dihydroxyvitamin D(3) and 24R,25-dihydroxyvitamin D(3) modulate growth plate chondrocyte physiology via protein kinase C-dependent phosphorylation of extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase. Endocrinology 143 2775-86 PubMed GONUTS page

[PMID:15781236-8] Kim, S & Pak, Y (2005) Caveolin-2 regulation of the cell cycle in response to insulin in Hirc-B fibroblast cells. Biochem. Biophys. Res. Commun. 330 88-96 PubMed GONUTS page

[PMID:16955078-9] 9.0 ^9.1 Chen, S et al. (2007) Alterations in mammalian target of rapamycin signaling pathways after traumatic brain injury. J. Cereb. Blood Flow Metab. 27 939-49 PubMed GONUTS page

[PMID:17651772-10] Marin-Kuan, M et al. (2007) MAPK-ERK activation in kidney of male rats chronically fed ochratoxin A at a dose causing a significant incidence of renal carcinoma. Toxicol. Appl. Pharmacol. 224 174-81 PubMed GONUTS page

[PMID:28515230-11] Isensee, J et al. (2017) Crosstalk from cAMP to ERK1/2 emerges during postnatal maturation of nociceptive neurons and is maintained during aging. J. Cell. Sci. 130 2134-2146 PubMed GONUTS page

[PMID:9779826-12] 12.0 ^12.1 ^12.2 Kim, SO et al. (1998) Expression of mitogen-activated protein kinase pathways during postnatal development of rat heart. J. Cell. Biochem. 71 286-301 PubMed GONUTS page

[PMID:17150373-13] Watson, PM et al. (2007) Integrin-binding RGD peptides induce rapid intracellular calcium increases and MAPK signaling in cortical neurons. Mol. Cell. Neurosci. 34 147-54 PubMed GONUTS page

[PMID:17310240-14] Santos, SD et al. (2007) Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate. Nat. Cell Biol. 9 324-30 PubMed GONUTS page

[PMID:21873635-15] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 ^15.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:19565474-16] 16.00 ^16.01 ^16.02 ^16.03 ^16.04 ^16.05 ^16.06 ^16.07 ^16.08 ^16.09 ^16.10 ^16.11 ^16.12 ^16.13 Yao, Z & Seger, R () The ERK signaling cascade--views from different subcellular compartments. Biofactors 35 407-16 PubMed GONUTS page

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RAT:MK03

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