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DROME:Q9V3I2

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) No Information Provided. (synonyms: Drab5 (ECO:0000313 with EMBL:BAA87879.1))
Protein Name(s) Drab5 (ECO:0000313 with EMBL:BAA87879.1)

Rab5 (ECO:0000313 with EMBL:AAN85552.1) Rab5 protein (ECO:0000313 with EMBL:BAA88244.1) Rab5, isoform A (ECO:0000313 with EMBL:AAF51265.1) Rab5, isoform B (ECO:0000313 with EMBL:AAN10422.1) Rab5, isoform C (ECO:0000313 with EMBL:AAN10423.1) Rab5, isoform D (ECO:0000313 with EMBL:AAN10424.1) Rab5, isoform G (ECO:0000313 with EMBL:AGB92462.1) Rab5, isoform H (ECO:0000313 with EMBL:AGB92463.1) Rab5, isoform I (ECO:0000313 with EMBL:AGB92464.1)

External Links
UniProt Q9V3I2
EMBL AE014134
AY060343
AE014134
AE014134
AE014134
AE014134
AE014134
AY081180
AY081181
AE014134
AE014134
AE014134
AB035353
AB035671
BK000968
RefSeq NP_001259925.1
NP_001259926.1
NP_001259927.1
NP_523457.1
NP_722795.1
NP_722796.1
NP_722797.1
NP_722798.1
NP_722799.1
UniGene Dm.6724
MINT MINT-334912
STRING 7227.FBpp0077473
EnsemblMetazoa [example_ID FBtr0077793]
[example_ID FBtr0077794]
[example_ID FBtr0077795]
[example_ID FBtr0077796]
[example_ID FBtr0077797]
[example_ID FBtr0077798]
[example_ID FBtr0330668]
[example_ID FBtr0330669]
[example_ID FBtr0330670]
GeneID 33418
KEGG dme:Dmel_CG3664
UCSC CG3664-RA
CTD 33418
FlyBase FBgn0014010
eggNOG KOG0092
ENOG410YCCP
GeneTree ENSGT00760000119101
KO K07889
OMA GASFFRY
OrthoDB EOG77DJ7M
Reactome R-DME-983231
GenomeRNAi 33418
NextBio 783450
Proteomes UP000000803
GO GO:0005769
GO:0030139
GO:0005811
GO:0043025
GO:0005886
GO:0045202
GO:0031982
GO:0005525
GO:0003924
GO:0048675
GO:0007409
GO:0007298
GO:0007349
GO:0006325
GO:0048813
GO:0046664
GO:0006897
GO:0034058
GO:0060429
GO:0035088
GO:0016321
GO:0007293
GO:0016348
GO:0048803
GO:0007067
GO:0008285
GO:0007220
GO:0048477
GO:0048227
GO:0015031
GO:0032482
GO:0030100
GO:0010906
GO:0050803
GO:0048488
GO:0016189
GO:0016192
GO:0035220
Gene3D 3.40.50.300
InterPro IPR027417
IPR005225
IPR001806
IPR003579
Pfam PF00071
SMART SM00175
SUPFAM SSF52540
TIGRFAMs TIGR00231

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0003924

GTPase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002041

F

Seeded From UniProt

GO:0003924

GTPase activity

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

FB:FBgn0015790

F

Seeded From UniProt

GO:0003924

GTPase activity

GO_REF:0000097

NAS: Non-traceable Author Statement

-

F

Seeded From UniProt

GO:0003924

GTPase activity

PMID:14579253[1]

ISS: Inferred from Sequence or Structural Similarity

With:Not_supplied

F

Seeded From UniProt

GO:0005515

protein binding

PMID:18685079[2]

IPI: Inferred from Physical Interaction

FB:FBgn0261064

F

Seeded From UniProt

GO:0005515

protein binding

PMID:25453831[3]

IPI: Inferred from Physical Interaction

FB:FBgn0001202

F

Seeded From UniProt

GO:0005515

protein binding

PMID:25453831[3]

IPI: Inferred from Physical Interaction

FB:FBgn0031233

F

Seeded From UniProt

GO:0005515

protein binding

PMID:25453831[3]

IPI: Inferred from Physical Interaction

FB:FBgn0039204

F

Seeded From UniProt

GO:0005525

GTP binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001806
InterPro:IPR002041
InterPro:IPR003578
InterPro:IPR003579
InterPro:IPR005225
InterPro:IPR020849

F

Seeded From UniProt

GO:0005525

GTP binding

GO_REF:0000097

NAS: Non-traceable Author Statement

-

F

Seeded From UniProt

GO:0005622

intracellular

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003578

C

Seeded From UniProt

GO:0005769

early endosome

PMID:11136982[4]

NAS: Non-traceable Author Statement

-

C

Seeded From UniProt

GO:0005769

early endosome

PMID:16137758[5]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0005769

early endosome

PMID:18685079[2]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0005769

early endosome

PMID:22648168[6]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0005811

lipid particle

PMID:16979555[7]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0005829

cytosol

PMID:11136982[4]

TAS: Traceable Author Statement

-

C

Seeded From UniProt

GO:0005886

plasma membrane

PMID:19317464[8]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0006325

chromatin organization

PMID:11290718[9]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0006886

intracellular protein transport

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002041

P

Seeded From UniProt

GO:0006897

endocytosis

PMID:16014514[10]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0006897

endocytosis

PMID:19000840[11]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0006913

nucleocytoplasmic transport

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002041

P

Seeded From UniProt

GO:0007067

mitotic nuclear division

PMID:11290718[9]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0007165

signal transduction

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002041
InterPro:IPR020849

P

Seeded From UniProt

GO:0007220

Notch receptor processing

PMID:19000840[11]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0007264

small GTPase mediated signal transduction

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001806
InterPro:IPR003578
InterPro:IPR003579

P

Seeded From UniProt

GO:0007293

germarium-derived egg chamber formation

PMID:24762813[12]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0007298

border follicle cell migration

PMID:15944190[13]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0007298

border follicle cell migration

PMID:16014514[10]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0007298

border follicle cell migration

PMID:21149700[14]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0007298

border follicle cell migration

PMID:22825871[15]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0007349

cellularization

PMID:14588240[16]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0007409

axonogenesis

PMID:18758452[17]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0008285

negative regulation of cell proliferation

PMID:16258546[18]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0010906

regulation of glucose metabolic process

PMID:25994086[19]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0015031

protein transport

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003579

P

Seeded From UniProt

GO:0016020

membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR020849

C

Seeded From UniProt

GO:0016189

synaptic vesicle to endosome fusion

PMID:11136982[4]

TAS: Traceable Author Statement

-

P

Seeded From UniProt

GO:0016189

synaptic vesicle to endosome fusion

PMID:12743108[20]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0016192

vesicle-mediated transport

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

FB:FBgn0015790

P

Seeded From UniProt

GO:0016321

female meiosis chromosome segregation

PMID:11290718[9]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0016348

imaginal disc-derived leg joint morphogenesis

PMID:22736244[21]

IGI: Inferred from Genetic Interaction

FB:FBgn0000499

P

Seeded From UniProt

GO:0030100

regulation of endocytosis

PMID:19050045[22]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0030139

endocytic vesicle

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000634566

C

Seeded From UniProt

GO:0031982

vesicle

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

FB:FBgn0015790

C

Seeded From UniProt

GO:0032482

Rab protein signal transduction

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

FB:FBgn0015790

P

Seeded From UniProt

GO:0034058

endosomal vesicle fusion

PMID:18685079[2]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0035088

establishment or maintenance of apical/basal cell polarity

PMID:16258546[18]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0035220

wing disc development

PMID:19000840[11]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0043025

neuronal cell body

PMID:22000105[23]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0045202

synapse

PMID:22000105[23]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0046664

dorsal closure, amnioserosa morphology change

PMID:21533196[24]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0048227

plasma membrane to endosome transport

PMID:18685079[2]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0048477

oogenesis

PMID:19050045[22]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0048488

synaptic vesicle endocytosis

PMID:11136982[4]

TAS: Traceable Author Statement

-

P

Seeded From UniProt

GO:0048675

axon extension

PMID:25312435[25]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0048803

imaginal disc-derived male genitalia morphogenesis

PMID:21729695[26]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0048813

dendrite morphogenesis

PMID:18758452[17]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0050803

regulation of synapse structure or activity

PMID:12876219[27]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0060429

epithelium development

PMID:24762813[12]

IMP: Inferred from Mutant Phenotype

-

P

Seeded From UniProt

GO:0005769

early endosome

PMID:27064279[28]

IDA: Inferred from Direct Assay

C

Figure 3. showed that full-length APP and C99, but not C83, induced the enlargement of Rab5+ early endosomes in PC12M cells.

complete
CACAO 11742

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Jékely, G (2003) Small GTPases and the evolution of the eukaryotic cell. Bioessays 25 1129-38 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Morrison, HA et al. (2008) Regulation of early endosomal entry by the Drosophila tumor suppressors Rabenosyn and Vps45. Mol. Biol. Cell 19 4167-76 PubMed GONUTS page
  3. 3.0 3.1 3.2 Gillingham, AK et al. (2014) Toward a comprehensive map of the effectors of rab GTPases. Dev. Cell 31 358-73 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 Entchev, EV et al. (2000) Gradient formation of the TGF-beta homolog Dpp. Cell 103 981-91 PubMed GONUTS page
  5. Emery, G et al. (2005) Asymmetric Rab 11 endosomes regulate delta recycling and specify cell fate in the Drosophila nervous system. Cell 122 763-73 PubMed GONUTS page
  6. Jean, S et al. (2012) Sbf/MTMR13 coordinates PI(3)P and Rab21 regulation in endocytic control of cellular remodeling. Mol. Biol. Cell 23 2723-40 PubMed GONUTS page
  7. Cermelli, S et al. (2006) The lipid-droplet proteome reveals that droplets are a protein-storage depot. Curr. Biol. 16 1783-95 PubMed GONUTS page
  8. Tan, DJ et al. (2009) Mapping organelle proteins and protein complexes in Drosophila melanogaster. J. Proteome Res. 8 2667-78 PubMed GONUTS page
  9. 9.0 9.1 9.2 Dobie, KW et al. (2001) Identification of chromosome inheritance modifiers in Drosophila melanogaster. Genetics 157 1623-37 PubMed GONUTS page
  10. 10.0 10.1 Schober, M et al. (2005) Function of the ETS transcription factor Yan in border cell migration. Development 132 3493-504 PubMed GONUTS page
  11. 11.0 11.1 11.2 Wilkin, M et al. (2008) Drosophila HOPS and AP-3 complex genes are required for a Deltex-regulated activation of notch in the endosomal trafficking pathway. Dev. Cell 15 762-72 PubMed GONUTS page
  12. 12.0 12.1 Berns, N et al. (2014) A genome-scale in vivo RNAi analysis of epithelial development in Drosophila identifies new proliferation domains outside of the stem cell niche. J. Cell. Sci. 127 2736-48 PubMed GONUTS page
  13. Medioni, C & Noselli, S (2005) Dynamics of the basement membrane in invasive epithelial clusters in Drosophila. Development 132 3069-77 PubMed GONUTS page
  14. Assaker, G et al. (2010) Spatial restriction of receptor tyrosine kinase activity through a polarized endocytic cycle controls border cell migration. Proc. Natl. Acad. Sci. U.S.A. 107 22558-63 PubMed GONUTS page
  15. Chen, DY et al. (2012) The Bro1-domain-containing protein Myopic/HDPTP coordinates with Rab4 to regulate cell adhesion and migration. J. Cell. Sci. 125 4841-52 PubMed GONUTS page
  16. Pelissier, A et al. (2003) Trafficking through Rab11 endosomes is required for cellularization during Drosophila embryogenesis. Curr. Biol. 13 1848-57 PubMed GONUTS page
  17. 17.0 17.1 Satoh, D et al. (2008) Spatial control of branching within dendritic arbors by dynein-dependent transport of Rab5-endosomes. Nat. Cell Biol. 10 1164-71 PubMed GONUTS page
  18. 18.0 18.1 Lu, H & Bilder, D (2005) Endocytic control of epithelial polarity and proliferation in Drosophila. Nat. Cell Biol. 7 1232-9 PubMed GONUTS page
  19. Ugrankar, R et al. (2015) Drosophila glucome screening identifies Ck1alpha as a regulator of mammalian glucose metabolism. Nat Commun 6 7102 PubMed GONUTS page
  20. Wucherpfennig, T et al. (2003) Role of Drosophila Rab5 during endosomal trafficking at the synapse and evoked neurotransmitter release. J. Cell Biol. 161 609-24 PubMed GONUTS page
  21. Capilla, A et al. (2012) Planar cell polarity controls directional Notch signaling in the Drosophila leg. Development 139 2584-93 PubMed GONUTS page
  22. 22.0 22.1 Compagnon, J et al. (2009) Interplay between Rab5 and PtdIns(4,5)P2 controls early endocytosis in the Drosophila germline. J. Cell. Sci. 122 25-35 PubMed GONUTS page
  23. 23.0 23.1 Chan, CC et al. (2011) Systematic discovery of Rab GTPases with synaptic functions in Drosophila. Curr. Biol. 21 1704-15 PubMed GONUTS page
  24. Mateus, AM et al. (2011) Endocytic and recycling endosomes modulate cell shape changes and tissue behaviour during morphogenesis in Drosophila. PLoS ONE 6 e18729 PubMed GONUTS page
  25. Sakuma, C et al. (2014) Drosophila Strip serves as a platform for early endosome organization during axon elongation. Nat Commun 5 5180 PubMed GONUTS page
  26. Lee, G et al. (2011) UVRAG is required for organ rotation by regulating Notch endocytosis in Drosophila. Dev. Biol. 356 588-97 PubMed GONUTS page
  27. Shimizu, H et al. (2003) An essential role of Rab5 in uniformity of synaptic vesicle size. J. Cell. Sci. 116 3583-90 PubMed GONUTS page
  28. Xu, W et al. (2016) Amyloid precursor protein-mediated endocytic pathway disruption induces axonal dysfunction and neurodegeneration. J. Clin. Invest. PubMed GONUTS page