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PMID:27065466
| Citation |
'Sassoon, CS, Zhu, E, Fang, L, Subramanian, VS and Said, HM (2016) Inhibition of Intestinal Thiamin Transport in Rat Model of Sepsis. Crit. Care Med. ' |
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| Abstract |
Thiamin deficiency is highly prevalent in patients with sepsis, but the mechanism by which sepsis induces thiamin deficiency is unknown. This study aimed to determine the influence of various severity of sepsis on carrier-mediated intestinal thiamin uptake, level of expressions of thiamin transporters (thiamin transporter-1 and thiamin transporter-2), and mitochondrial thiamin pyrophosphate transporter. |
| Links |
PubMed Online version:10.1097/CCM.0000000000001745 |
| Keywords |
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Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0015888: thiamine transport |
ECO:0000314: |
P |
Both cell membrane thiamin transporters and mitochondrial thiamin pyrophosphate transporter expression levels were suppressed after 2 days of induced Sepsis. Sepsis inhibits carrier-mediated intestinal thiamin uptake as a function of sepsis severity |
complete | ||||
Notes
See also
References
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