MOUSE:TF65

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Rela (synonyms: Nfkb3)
Protein Name(s)	Transcription factor p65 Nuclear factor NF-kappa-B p65 subunit Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3
External Links
UniProt	Q04207
EMBL	M61909 BC003818 L77155 Z22952
CCDS	CCDS29473.1
PIR	A37932 PC4233 S48113
RefSeq	NP_033071.1
UniGene	Mm.249966
PDB	1BFT 1IKN 1K3Z 1LE5 1LE9 1LEI 1MY5 1MY7 1OY3 1RAM 1VKX 2I9T 2LWW 2RAM
PDBsum	1BFT 1IKN 1K3Z 1LE5 1LE9 1LEI 1MY5 1MY7 1OY3 1RAM 1VKX 2I9T 2LWW 2RAM
DisProt	DP00129
ProteinModelPortal	Q04207
SMR	Q04207
BioGrid	202853
DIP	DIP-6219N
IntAct	Q04207
MINT	MINT-236104
ChEMBL	CHEMBL5902
PhosphoSite	Q04207
MaxQB	Q04207
PaxDb	Q04207
PRIDE	Q04207
Ensembl	ENSMUST00000025867
GeneID	19697
KEGG	mmu:19697
UCSC	uc008gee.1
CTD	5970
MGI	MGI:103290
eggNOG	NOG119056
HOGENOM	HOG000230474
HOVERGEN	HBG017916
InParanoid	Q04207
KO	K04735
OMA	EFSPMVF
OrthoDB	EOG7VHSWT
PhylomeDB	Q04207
TreeFam	TF325632
Reactome	REACT_198700 REACT_199121 REACT_202898 REACT_205561 REACT_206033 REACT_218614 REACT_218887 REACT_219800 REACT_222971 REACT_225145
ChiTaRS	Rela
EvolutionaryTrace	Q04207
NextBio	297048
PRO	PR:Q04207
Proteomes	UP000000589
Bgee	Q04207
ExpressionAtlas	Q04207
Genevestigator	Q04207
GO	GO:0005737 GO:0005829 GO:0071159 GO:0005634 GO:0005667 GO:0071532 GO:0003682 GO:0003677 GO:0019899 GO:0042301 GO:0019901 GO:0000978 GO:0001078 GO:0001077 GO:0000980 GO:0003705 GO:0001205 GO:0000977 GO:0043565 GO:0003700 GO:0006117 GO:0007568 GO:0070301 GO:0071347 GO:0071354 GO:0071222 GO:0071316 GO:0071375 GO:0071356 GO:0019221 GO:0006952 GO:0001942 GO:0006954 GO:0001889 GO:0043066 GO:2001237 GO:0046627 GO:0042177 GO:0070431 GO:0009887 GO:0008284 GO:0032332 GO:0043123 GO:0045084 GO:2000630 GO:0051092 GO:0014040 GO:0045944 GO:0045893 GO:0050727 GO:0043200 GO:0009617 GO:0051591 GO:0033590 GO:0042493 GO:0032868 GO:0009612 GO:0043278 GO:0032495 GO:0032570 GO:0010224
Gene3D	2.60.40.10 2.60.40.340
InterPro	IPR013783 IPR014756 IPR002909 IPR000451 IPR008967 IPR011539
Pfam	PF00554
PRINTS	PR00057
SMART	SM00429
SUPFAM	SSF49417 SSF81296
PROSITE	PS01204 PS50254

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005737	cytoplasm	PMID:19557165^[1]	ECO:0000314			C		Figure 3B by immunostaining shows that in a control cell, p65 is located almost exclusively in the cytoplasm.	complete CACAO 6881
involved_in	GO:0006325	chromatin organization	PMID:29813070^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:30522932^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_transcription_of:(ENSEMBL:ENSMUSG00000065476)	Seeded From UniProt	complete
involved_in	GO:0006351	transcription, DNA-templated	PMID:29813070^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:29813070^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0033234	negative regulation of protein sumoylation	PMID:25152367^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:25152367^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	coincident_with:(ENSEMBL:ENSMUSG00000020542) coincident_with:(SO:0001669)	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:25152367^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_transcription_of:(ENSEMBL:ENSMUSG00000020542) occurs_in:(CL:0002495)	Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:25152367^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(ENSEMBL:ENSMUSG00000020542) occurs_at:(SO:0001952)	Seeded From UniProt	complete
part_of	GO:0035525	NF-kappaB p50/p65 complex	PMID:26764146^[5]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:26764146^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0098586)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:26764146^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0098586)	Seeded From UniProt	complete
enables	GO:0042805	actinin binding	PMID:25411248^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P57780	F	occurs_in:(UBERON:0000074)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19557165^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0071532	ankyrin repeat binding	PMID:21131967^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q5DW34	F		Seeded From UniProt	complete
involved_in	GO:0071356	cellular response to tumor necrosis factor	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04206	P		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	PMID:20547752^[8]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070301	cellular response to hydrogen peroxide	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04206	P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:22244329^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050727	regulation of inflammatory response	PMID:21131967^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04206	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:21131967^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PMID:22244329^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:22244329^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:21131967^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q02956	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:22244329^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8VCN5	F		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04206	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21131967^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22244329^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21131967^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:8289784^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0000165)	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:21131967^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001889	liver development	PMID:7603567^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0099527	postsynapse to nucleus signaling pathway	PMID:12947408^[12]	ECO:0006067	fluorescence recovery after photobleaching evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0099527	postsynapse to nucleus signaling pathway	PMID:12947408^[12]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:12947408^[12]	ECO:0006067	fluorescence recovery after photobleaching evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:12947408^[12]	ECO:0006063	over expression analysis evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0011274 FB:FBgn0260632 MGI:MGI:103289 PANTHER:PTN000652441 UniProtKB:Q04206 UniProtKB:Q04864	P		Seeded From UniProt	complete
involved_in	GO:0038061	NIK/NF-kappaB signaling	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103289 PANTHER:PTN000652441	P		Seeded From UniProt	complete
involved_in	GO:0034097	response to cytokine	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000652441 RGD:727889	P		Seeded From UniProt	complete
involved_in	GO:0007249	I-kappaB kinase/NF-kappaB signaling	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000652441 RGD:1311231	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000652441 UniProtKB:Q04206	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103289 MGI:MGI:103290 PANTHER:PTN000652441 RGD:727889 UniProtKB:Q01201 UniProtKB:Q04206	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000652441 UniProtKB:Q01201	C		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103290 PANTHER:PTN000652441 UniProtKB:Q04206	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000652441 ZFIN:ZDB-GENE-040825-4	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0260632 MGI:MGI:103290 PANTHER:PTN000652441 UniProtKB:Q04206	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103290 PANTHER:PTN000652441 UniProtKB:Q04206	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	PMID:22244329^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000630	positive regulation of miRNA metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904996	positive regulation of leukocyte adhesion to vascular endothelial cell	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904385	cellular response to angiotensin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:727889	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902894	negative regulation of pri-miRNA transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901224	positive regulation of NIK/NF-kappaB signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901223	negative regulation of NIK/NF-kappaB signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901222	regulation of NIK/NF-kappaB signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071356	cellular response to tumor necrosis factor	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071354	cellular response to interleukin-6	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071347	cellular response to interleukin-1	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071316	cellular response to nicotine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071224	cellular response to peptidoglycan	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071223	cellular response to lipoteichoic acid	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071222	cellular response to lipopolysaccharide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071222	cellular response to lipopolysaccharide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:727889	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070555	response to interleukin-1	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	P		Seeded From UniProt	complete
enables	GO:0070491	repressing transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070431	nucleotide-binding oligomerization domain containing 2 signaling pathway	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070301	cellular response to hydrogen peroxide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061614	pri-miRNA transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:15790681^[14]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	P		Seeded From UniProt	complete
enables	GO:0051059	NF-kappaB binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050862	positive regulation of T cell receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050727	regulation of inflammatory response	PMID:24501220^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3775205	P		Seeded From UniProt	complete
enables	GO:0047485	protein N-terminus binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:7959007^[16]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046627	negative regulation of insulin receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:727889	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:18505784^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:14568984^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:727889	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045084	positive regulation of interleukin-12 biosynthetic process	PMID:14568984^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:727889	F		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043620	regulation of DNA-templated transcription in response to stress	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:23184950^[19]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(MGI:MGI:5490891)	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:727889	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	P		Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	F		Seeded From UniProt	complete
enables	GO:0042805	actinin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	F		Seeded From UniProt	complete
enables	GO:0042301	phosphate ion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042177	negative regulation of protein catabolic process	PMID:15923614^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035994	response to muscle stretch	PMID:20442316^[21]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:17701)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035924	cellular response to vascular endothelial growth factor stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035729	cellular response to hepatocyte growth factor stimulus	PMID:21072211^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0035525	NF-kappaB p50/p65 complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	C		Seeded From UniProt	complete
enables	GO:0033613	activating transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033209	tumor necrosis factor-mediated signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:727889	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032495	response to muramyl dipeptide	PMID:12527755^[23]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000235)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032332	positive regulation of chondrocyte differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:727889	P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	F		Seeded From UniProt	complete
enables	GO:0031490	chromatin DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019221	cytokine-mediated signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014040	positive regulation of Schwann cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:727889	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010224	response to UV-B	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010033	response to organic substance	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009887	animal organ morphogenesis	PMID:9120401^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1860444	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009617	response to bacterium	PMID:15661922^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:727889	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:727889	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006954	inflammatory response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006952	defense response	PMID:9120401^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1860444	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:11931770^[26]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000893)	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:727889	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:22227519^[27]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19404405^[28]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16643855^[29]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16249387^[30]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:14961764^[31]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12527755^[23]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000235)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11567019^[32]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17544) part_of:(CL:0000117)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:15790681^[14]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:727889	C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21874024^[33]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000084)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19404405^[28]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16643855^[29]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16249387^[30]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15817708^[34]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15661922^[25]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000235)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15220916^[35]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000235)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:14961764^[31]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12527755^[23]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000235)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11931770^[26]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000893)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11567019^[32]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17544) part_of:(CL:0000117)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:10227969^[36]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000545)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15790681^[14]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:727889	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:14568984^[18]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:24768298^[37]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0002476)	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:20442316^[21]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(MGI:MGI:1861447) occurs_in:(EMAPA:17701)	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:19619491^[38]	ECO:0000314	direct assay evidence used in manual assertion		F	has_participant:(MGI:MGI:2385299)\|has_participant:(MGI:MGI:108061)	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:23262141^[39]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:18505784^[17]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:16260493^[40]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000057)	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:16207754^[41]	ECO:0000314	direct assay evidence used in manual assertion		F	has_participant:(MGI:MGI:1347476)	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:15944286^[42]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:15845452^[43]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000094)	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:15684432^[44]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:14961764^[31]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000057)	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:10227969^[36]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000545)	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:15790681^[14]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001942	hair follicle development	PMID:16481354^[45]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	results_in_development_of:(EMAPA:18771)\|results_in_development_of:(EMAPA:17524)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	F		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	F		Seeded From UniProt	complete
enables	GO:0001225	RNA polymerase II transcription coactivator binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	F		Seeded From UniProt	complete
enables	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:727889	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:21402781^[46]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:7959007^[16]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	C		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:727889	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q04206	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:19887633^[47]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q04207	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:19338389^[48]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q04207	F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	F		Seeded From UniProt	complete
involved_in	GO:0043620	regulation of DNA-templated transcription in response to stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	P		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	P		Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	F		Seeded From UniProt	complete
enables	GO:0042805	actinin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	F		Seeded From UniProt	complete
enables	GO:0042301	phosphate ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	F		Seeded From UniProt	complete
involved_in	GO:0035924	cellular response to vascular endothelial growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	P		Seeded From UniProt	complete
part_of	GO:0035525	NF-kappaB p50/p65 complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	C		Seeded From UniProt	complete
enables	GO:0033613	activating transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	F		Seeded From UniProt	complete
involved_in	GO:0033209	tumor necrosis factor-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	F		Seeded From UniProt	complete
enables	GO:0031490	chromatin DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	F		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	P		Seeded From UniProt	complete
involved_in	GO:0010224	response to UV-B	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	P		Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	F		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	F		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	F		Seeded From UniProt	complete
enables	GO:0001225	RNA polymerase II transcription coactivator binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	F		Seeded From UniProt	complete
enables	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	P		Seeded From UniProt	complete
involved_in	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	P		Seeded From UniProt	complete
involved_in	GO:2000630	positive regulation of miRNA metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	P		Seeded From UniProt	complete
involved_in	GO:1904996	positive regulation of leukocyte adhesion to vascular endothelial cell	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	P		Seeded From UniProt	complete
involved_in	GO:1904385	cellular response to angiotensin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	P		Seeded From UniProt	complete
involved_in	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	P		Seeded From UniProt	complete
involved_in	GO:1902894	negative regulation of pri-miRNA transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	P		Seeded From UniProt	complete
involved_in	GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	P		Seeded From UniProt	complete
involved_in	GO:1901224	positive regulation of NIK/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	P		Seeded From UniProt	complete
involved_in	GO:1901223	negative regulation of NIK/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	P		Seeded From UniProt	complete
involved_in	GO:1901222	regulation of NIK/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	P		Seeded From UniProt	complete
involved_in	GO:0071356	cellular response to tumor necrosis factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	P		Seeded From UniProt	complete
involved_in	GO:0071354	cellular response to interleukin-6	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	P		Seeded From UniProt	complete
involved_in	GO:0071347	cellular response to interleukin-1	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	P		Seeded From UniProt	complete
involved_in	GO:0071316	cellular response to nicotine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	P		Seeded From UniProt	complete
involved_in	GO:0071224	cellular response to peptidoglycan	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	P		Seeded From UniProt	complete
involved_in	GO:0071223	cellular response to lipoteichoic acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	P		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	P		Seeded From UniProt	complete
involved_in	GO:0070555	response to interleukin-1	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	P		Seeded From UniProt	complete
enables	GO:0070491	repressing transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	F		Seeded From UniProt	complete
involved_in	GO:0070431	nucleotide-binding oligomerization domain containing 2 signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	P		Seeded From UniProt	complete
involved_in	GO:0070301	cellular response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	P		Seeded From UniProt	complete
involved_in	GO:0061614	pri-miRNA transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	P		Seeded From UniProt	complete
enables	GO:0051059	NF-kappaB binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	F		Seeded From UniProt	complete
involved_in	GO:0050862	positive regulation of T cell receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	P		Seeded From UniProt	complete
enables	GO:0047485	protein N-terminus binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04206 ensembl:ENSP00000384273	F		Seeded From UniProt	complete
involved_in	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	P		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	P		Seeded From UniProt	complete
involved_in	GO:0051591	response to cAMP	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	P		Seeded From UniProt	complete
involved_in	GO:0046627	negative regulation of insulin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	C		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	F		Seeded From UniProt	complete
involved_in	GO:0043278	response to morphine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	P		Seeded From UniProt	complete
involved_in	GO:0043200	response to amino acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	P		Seeded From UniProt	complete
involved_in	GO:0042542	response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	P		Seeded From UniProt	complete
involved_in	GO:0034097	response to cytokine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	P		Seeded From UniProt	complete
involved_in	GO:0033590	response to cobalamin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	C		Seeded From UniProt	complete
involved_in	GO:0032868	response to insulin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	P		Seeded From UniProt	complete
involved_in	GO:0032570	response to progesterone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	P		Seeded From UniProt	complete
involved_in	GO:0032332	positive regulation of chondrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	P		Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	P		Seeded From UniProt	complete
involved_in	GO:0014040	positive regulation of Schwann cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	P		Seeded From UniProt	complete
involved_in	GO:0010035	response to inorganic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	P		Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	P		Seeded From UniProt	complete
involved_in	GO:0009612	response to mechanical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	F		Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	P		Seeded From UniProt	complete
involved_in	GO:0006117	acetaldehyde metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	C		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7TQN4 ensembl:ENSRNOP00000044552	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011539 InterPro:IPR037059	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000451 InterPro:IPR008967 InterPro:IPR011539 InterPro:IPR030495 InterPro:IPR037059	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000451 InterPro:IPR030495	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000451 InterPro:IPR030495	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000451 InterPro:IPR008967 InterPro:IPR011539 InterPro:IPR037059	P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030495	P		Seeded From UniProt	complete
part_of	GO:0071159	NF-kappaB complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030495	C		Seeded From UniProt	complete
part_of	GO:0071159	NF-kappaB complex	PMID:22244329^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:9120401^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Chang, TH et al. (2009) Ebola Zaire virus blocks type I interferon production by exploiting the host SUMO modification machinery. PLoS Pathog. 5 e1000493 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Ramos Pittol, JM et al. (2018) Zbtb7a is a transducer for the control of promoter accessibility by NF-kappa B and multiple other transcription factors. PLoS Biol. 16 e2004526 PubMed GONUTS page
↑ Song, Y et al. (2019) A novel mechanism of synaptic and cognitive impairments mediated via microRNA-30b in Alzheimer's disease. EBioMedicine 39 409-421 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Liao, XH et al. (2014) NF-κB (p65) negatively regulates myocardin-induced cardiomyocyte hypertrophy through multiple mechanisms. Cell. Signal. 26 2738-48 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Sun, S et al. () Argonaute proteins in cardiac tissue contribute to the heart injury during viral myocarditis. Cardiovasc. Pathol. 25 120-6 PubMed GONUTS page
↑ Zhao, X et al. (2015) α-Actinin 4 potentiates nuclear factor κ-light-chain-enhancer of activated B-cell (NF-κB) activity in podocytes independent of its cytoplasmic actin binding function. J. Biol. Chem. 290 338-49 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 Levy, D et al. (2011) Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling. Nat. Immunol. 12 29-36 PubMed GONUTS page
↑ Sharif-Askari, E et al. (2010) Zinc finger protein Gfi1 controls the endotoxin-mediated Toll-like receptor inflammatory response by antagonizing NF-kappaB p65. Mol. Cell. Biol. 30 3929-42 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 Sen, N et al. (2012) Hydrogen sulfide-linked sulfhydration of NF-κB mediates its antiapoptotic actions. Mol. Cell 45 13-24 PubMed GONUTS page
↑ La Rosa, FA et al. (1994) Differential regulation of the c-myc oncogene promoter by the NF-kappa B rel family of transcription factors. Mol. Cell. Biol. 14 1039-44 PubMed GONUTS page
↑ Beg, AA et al. (1995) Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B. Nature 376 167-70 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Meffert, MK et al. (2003) NF-kappa B functions in synaptic signaling and behavior. Nat. Neurosci. 6 1072-8 PubMed GONUTS page
↑ ^13.00 ^13.01 ^13.02 ^13.03 ^13.04 ^13.05 ^13.06 ^13.07 ^13.08 ^13.09 ^13.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 Bettelli, E et al. (2005) Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells. Proc. Natl. Acad. Sci. U.S.A. 102 5138-43 PubMed GONUTS page
↑ Du, W et al. (2014) Deletion of Fanca or Fancd2 dysregulates Treg in mice. Blood 123 1938-47 PubMed GONUTS page
↑ ^16.0 ^16.1 Shimizu, H & Yamamoto, K (1994) NF-kappa B and C/EBP transcription factor families synergistically function in mouse serum amyloid A gene expression induced by inflammatory cytokines. Gene 149 305-10 PubMed GONUTS page
↑ ^17.0 ^17.1 Mitola, S et al. (2008) Angiopoietin-1 mediates the proangiogenic activity of the bone morphogenic protein antagonist Drm. Blood 112 1154-7 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 Liu, J et al. (2003) Differential regulation of interleukin (IL)-12 p35 and p40 gene expression and interferon (IFN)-gamma-primed IL-12 production by IFN regulatory factor 1. J. Exp. Med. 198 1265-76 PubMed GONUTS page
↑ Zhang, J et al. (2013) A newly identified microRNA, mmu-miR-7578, functions as a negative regulator on inflammatory cytokines tumor necrosis factor-α and interleukin-6 via targeting Egr1 in vivo. J. Biol. Chem. 288 4310-20 PubMed GONUTS page
↑ Hertlein, E et al. (2005) RelA/p65 regulation of IkappaBbeta. Mol. Cell. Biol. 25 4956-68 PubMed GONUTS page
↑ ^21.0 ^21.1 Mohamed, JS et al. (2010) Anisotropic regulation of Ankrd2 gene expression in skeletal muscle by mechanical stretch. FASEB J. 24 3330-40 PubMed GONUTS page
↑ Coudriet, GM et al. (2010) Hepatocyte growth factor modulates interleukin-6 production in bone marrow derived macrophages: implications for inflammatory mediated diseases. PLoS ONE 5 e15384 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 Girardin, SE et al. (2003) Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J. Biol. Chem. 278 8869-72 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 Doi, TS et al. (1997) NF-kappa B RelA-deficient lymphocytes: normal development of T cells and B cells, impaired production of IgA and IgG1 and reduced proliferative responses. J. Exp. Med. 185 953-61 PubMed GONUTS page
↑ ^25.0 ^25.1 O'Connell, RM et al. (2005) Immune activation of type I IFNs by Listeria monocytogenes occurs independently of TLR4, TLR2, and receptor interacting protein 2 but involves TNFR-associated NF kappa B kinase-binding kinase 1. J. Immunol. 174 1602-7 PubMed GONUTS page
↑ ^26.0 ^26.1 Fiorini, E et al. (2002) Peptide-induced negative selection of thymocytes activates transcription of an NF-kappa B inhibitor. Mol. Cell 9 637-48 PubMed GONUTS page
↑ Song, H et al. (2012) Ablation of Rassf2 induces bone defects and subsequent haematopoietic anomalies in mice. EMBO J. 31 1147-59 PubMed GONUTS page
↑ ^28.0 ^28.1 Esteban, V et al. (2009) Angiotensin-(1-7) and the g protein-coupled receptor MAS are key players in renal inflammation. PLoS ONE 4 e5406 PubMed GONUTS page
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↑ ^30.0 ^30.1 Ahn, E et al. (2006) LIME acts as a transmembrane adapter mediating BCR-dependent B-cell activation. Blood 107 1521-7 PubMed GONUTS page
↑ ^31.0 ^31.1 ^31.2 Liu, L et al. (2004) Nucling mediates apoptosis by inhibiting expression of galectin-3 through interference with nuclear factor kappaB signalling. Biochem. J. 380 31-41 PubMed GONUTS page
↑ ^32.0 ^32.1 Kim, RH et al. (2001) SNIP1 inhibits NF-kappa B signaling by competing for its binding to the C/H1 domain of CBP/p300 transcriptional co-activators. J. Biol. Chem. 276 46297-304 PubMed GONUTS page
↑ Chang, M et al. (2011) The ubiquitin ligase Peli1 negatively regulates T cell activation and prevents autoimmunity. Nat. Immunol. 12 1002-9 PubMed GONUTS page
↑ Wilmanski, J et al. (2005) Augmented IL-10 production and redox-dependent signaling pathways in glucose-6-phosphate dehydrogenase-deficient mouse peritoneal macrophages. J. Leukoc. Biol. 78 85-94 PubMed GONUTS page
↑ Watanabe, T et al. (2004) NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses. Nat. Immunol. 5 800-8 PubMed GONUTS page
↑ ^36.0 ^36.1 Hoshino, K et al. (1999) Cutting edge: generation of IL-18 receptor-deficient mice: evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor. J. Immunol. 162 5041-4 PubMed GONUTS page
↑ Luan, B et al. (2014) Leptin-mediated increases in catecholamine signaling reduce adipose tissue inflammation via activation of macrophage HDAC4. Cell Metab. 19 1058-65 PubMed GONUTS page
↑ Zhang, Y et al. (2009) Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction. Dev. Cell 17 49-61 PubMed GONUTS page
↑ Ahn, G et al. (2013) The JNk/NFkappaB pathway is required to activate murine lymphocytes induced by a sulfated polysaccharide from Ecklonia cava. Biochim. Biophys. Acta 1830 2820-9 PubMed GONUTS page
↑ Shim, JH et al. (2005) TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes Dev. 19 2668-81 PubMed GONUTS page
↑ Sawada, A et al. (2005) Tead proteins activate the Foxa2 enhancer in the node in cooperation with a second factor. Development 132 4719-29 PubMed GONUTS page
↑ Ossendorp, F et al. (2005) Differential expression regulation of the alpha and beta subunits of the PA28 proteasome activator in mature dendritic cells. J. Immunol. 174 7815-22 PubMed GONUTS page
↑ Rupec, RA et al. (2005) Stroma-mediated dysregulation of myelopoiesis in mice lacking I kappa B alpha. Immunity 22 479-91 PubMed GONUTS page
↑ Makowski, L et al. (2005) The fatty acid-binding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity. Macrophage expression of aP2 impacts peroxisome proliferator-activated receptor gamma and IkappaB kinase activities. J. Biol. Chem. 280 12888-95 PubMed GONUTS page
↑ Schmidt-Ullrich, R et al. (2006) NF-kappaB transmits Eda A1/EdaR signalling to activate Shh and cyclin D1 expression, and controls post-initiation hair placode down growth. Development 133 1045-57 PubMed GONUTS page
↑ Benlhabib, H & Mendelson, CR (2011) Epigenetic regulation of surfactant protein A gene (SP-A) expression in fetal lung reveals a critical role for Suv39h methyltransferases during development and hypoxia. Mol. Cell. Biol. 31 1949-58 PubMed GONUTS page
↑ Bergqvist, S et al. (2009) Kinetic enhancement of NF-kappaBxDNA dissociation by IkappaBalpha. Proc. Natl. Acad. Sci. U.S.A. 106 19328-33 PubMed GONUTS page
↑ van Essen, D et al. (2009) Two modes of transcriptional activation at native promoters by NF-kappaB p65. PLoS Biol. 7 e73 PubMed GONUTS page

[PMID:19557165-1] 1.0 ^1.1 Chang, TH et al. (2009) Ebola Zaire virus blocks type I interferon production by exploiting the host SUMO modification machinery. PLoS Pathog. 5 e1000493 PubMed GONUTS page

[PMID:29813070-2] 2.0 ^2.1 ^2.2 Ramos Pittol, JM et al. (2018) Zbtb7a is a transducer for the control of promoter accessibility by NF-kappa B and multiple other transcription factors. PLoS Biol. 16 e2004526 PubMed GONUTS page

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