MOUSE:NFKB1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Nfkb1
Protein Name(s)	Nuclear factor NF-kappa-B p105 subunit DNA-binding factor KBF1 EBP-1 NF-kappa-B1 p84/NF-kappa-B1 p98 Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Nuclear factor NF-kappa-B p50 subunit
External Links
UniProt	P25799
EMBL	M57999 S89033 S66656 AB119195 AY521462 AY521463 CH466532 BC050841 BC138535 BC138536 AY423849 AK052726 AK089660 AK157915
CCDS	CCDS17858.1
PIR	A35697
RefSeq	NP_032715.2 XP_006501169.1
UniGene	Mm.256765
PDB	1BFS 1IKN 1LE5 1LE9 1LEI 1NFK 1OOA 1U36 1U3J 1U3Y 1U3Z 1U41 1U42 1VKX 2I9T 2V2T 3JV4
PDBsum	1BFS 1IKN 1LE5 1LE9 1LEI 1NFK 1OOA 1U36 1U3J 1U3Y 1U3Z 1U41 1U42 1VKX 2I9T 2V2T 3JV4
ProteinModelPortal	P25799
SMR	P25799
BioGrid	201751
DIP	DIP-85N
IntAct	P25799
MINT	MINT-236136
ChEMBL	CHEMBL1949489
PhosphoSite	P25799
MaxQB	P25799
PaxDb	P25799
PRIDE	P25799
Ensembl	ENSMUST00000029812 ENSMUST00000164430
GeneID	18033
KEGG	mmu:18033
UCSC	uc008rlw.1 uc008rly.1 uc012cyf.1
CTD	4790
MGI	MGI:97312
eggNOG	COG0666
GeneTree	ENSGT00500000044765
HOVERGEN	HBG052613
InParanoid	P25799
KO	K02580
OMA	PGYGFPH
OrthoDB	EOG7W154S
TreeFam	TF325632
Reactome	REACT_198700 REACT_199121 REACT_202898 REACT_205561 REACT_206033 REACT_218614 REACT_218887 REACT_219800 REACT_222971 REACT_224208 REACT_225145
ChiTaRS	Nfkb1
EvolutionaryTrace	P25799
NextBio	293121
PRO	PR:P25799
Proteomes	UP000000589
Bgee	P25799
Genevestigator	P25799
GO	GO:0005737 GO:0005829 GO:0005739 GO:0005634 GO:0043234 GO:0003682 GO:0003677 GO:0003690 GO:0042803 GO:0000975 GO:0043565 GO:0003700 GO:0000976 GO:0006915 GO:0071347 GO:0071354 GO:0071222 GO:0071260 GO:0071316 GO:0071375 GO:0048535 GO:0043066 GO:0010956 GO:0001818 GO:0050728 GO:0045083 GO:0000122 GO:0045892 GO:0090263 GO:1900127 GO:2000630 GO:0045944 GO:0045893 GO:0046688 GO:0006979 GO:0007165 GO:0006351
Gene3D	1.10.533.10 1.25.40.20 2.60.40.10 2.60.40.340
InterPro	IPR002110 IPR020683 IPR011029 IPR000488 IPR013783 IPR014756 IPR002909 IPR000451 IPR008967 IPR011539
Pfam	PF00023 PF12796 PF00531 PF00554
PRINTS	PR00057
SMART	SM00248 SM00005 SM00429
SUPFAM	SSF47986 SSF48403 SSF49417 SSF81296
PROSITE	PS50297 PS50088 PS01204 PS50254

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0001818	negative regulation of cytokine production	PMID:18566389^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P19838	P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P19838	F		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P19838	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P19838	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000637	positive regulation of gene silencing by miRNA	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70498	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000630	positive regulation of miRNA metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19838	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1990416	cellular response to brain-derived neurotrophic factor stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70498	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904632	cellular response to glucoside	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70498	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904630	cellular response to diterpene	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70498	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904385	cellular response to angiotensin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19838	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70498	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901653	cellular response to peptide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70498	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900127	positive regulation of hyaluronan biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19838	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090263	positive regulation of canonical Wnt signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19838	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071407	cellular response to organic cyclic compound	PMID:19414010^[2]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q63369	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071359	cellular response to dsRNA	PMID:24114535^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857225	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071356	cellular response to tumor necrosis factor	PMID:24349514^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071356	cellular response to tumor necrosis factor	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70498	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071354	cellular response to interleukin-6	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19838	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071347	cellular response to interleukin-1	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70498	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071345	cellular response to cytokine stimulus	PMID:19414010^[2]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q63369	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071322	cellular response to carbohydrate stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70498	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071316	cellular response to nicotine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19838	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071222	cellular response to lipopolysaccharide	PMID:23776175^[5]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19838	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071222	cellular response to lipopolysaccharide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70498	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050728	negative regulation of inflammatory response	PMID:18270204^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:97312	P	regulates_o_has_participant:(CL:0002476)	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:7959007^[7]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19838	F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19838	F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70498	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15728238^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:1278325)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19666510^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:96541)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16081776^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:95663)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19955433^[11]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19838	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19838	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19838	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	PMID:14568984^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045083	negative regulation of interleukin-12 biosynthetic process	PMID:14568984^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19838	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:19404405^[13]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(EMAPA:17373)	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70498	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70498	P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70498	C		Seeded From UniProt	complete
enables	GO:0042805	actinin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19838	F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:15220916^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70498	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19838	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035994	response to muscle stretch	PMID:20442316^[15]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:17701)	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70498	C		Seeded From UniProt	complete
enables	GO:0031072	heat shock protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70498	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014070	response to organic cyclic compound	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70498	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010956	negative regulation of calcidiol 1-monooxygenase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19838	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010629	negative regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19838	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70498	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006979	response to oxidative stress	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70498	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:11931770^[16]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000893)	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19838	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70498	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19838	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:20060382^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19838	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70498	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19838	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21982707^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20060382^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19734906^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19404405^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17373)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15817708^[20]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15728238^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15220916^[14]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000235)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12970181^[21]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11931770^[16]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000893)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:10395695^[22]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057) part_of:(CL:0000001)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19838	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70498	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19838	F		Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70498	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:24434510^[23]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(MGI:MGI:1861437) occurs_in:(CL:0000056) has_direct_input:(MGI:MGI:1861447)	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:22555453^[24]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(MGI:MGI:88263) has_direct_input:(MGI:MGI:88264) occurs_in:(EMAPA:17759) happens_during:(GO:0060056)	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:20442316^[15]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(MGI:MGI:1861447) occurs_in:(EMAPA:17701)	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:23980096^[25]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:19734906^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:16081776^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	has_participant:(MGI:MGI:95663)	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:15944286^[26]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:15845452^[27]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000094)	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:12618484^[28]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:11976687^[29]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:10395695^[22]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000057)	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:19414010^[2]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q63369	F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19838	F		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19838	F		Seeded From UniProt	complete
enables	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19838	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:7959007^[7]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19838	F		Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19838	F		Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70498	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19838	P		Seeded From UniProt	complete
involved_in	GO:2000630	positive regulation of miRNA metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19838 ensembl:ENSP00000226574	P		Seeded From UniProt	complete
involved_in	GO:1904385	cellular response to angiotensin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19838 ensembl:ENSP00000226574	P		Seeded From UniProt	complete
involved_in	GO:1900127	positive regulation of hyaluronan biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19838 ensembl:ENSP00000226574	P		Seeded From UniProt	complete
involved_in	GO:0090263	positive regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19838 ensembl:ENSP00000226574	P		Seeded From UniProt	complete
involved_in	GO:0071354	cellular response to interleukin-6	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19838 ensembl:ENSP00000226574	P		Seeded From UniProt	complete
involved_in	GO:0071347	cellular response to interleukin-1	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19838 ensembl:ENSP00000226574	P		Seeded From UniProt	complete
involved_in	GO:0071316	cellular response to nicotine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19838 ensembl:ENSP00000226574	P		Seeded From UniProt	complete
involved_in	GO:0071260	cellular response to mechanical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19838 ensembl:ENSP00000226574	P		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19838 ensembl:ENSP00000226574	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19838 ensembl:ENSP00000226574	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19838 ensembl:ENSP00000226574	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19838 ensembl:ENSP00000226574	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19838 ensembl:ENSP00000226574	F		Seeded From UniProt	complete
enables	GO:0042805	actinin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19838 ensembl:ENSP00000226574	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19838 ensembl:ENSP00000226574	F		Seeded From UniProt	complete
involved_in	GO:0010956	negative regulation of calcidiol 1-monooxygenase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19838 ensembl:ENSP00000226574	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19838 ensembl:ENSP00000226574	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19838 ensembl:ENSP00000226574	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19838 ensembl:ENSP00000226574	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19838 ensembl:ENSP00000226574	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19838 ensembl:ENSP00000226574	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19838 ensembl:ENSP00000226574	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19838 ensembl:ENSP00000226574	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19838 ensembl:ENSP00000226574	F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19838 ensembl:ENSP00000226574	F		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19838 ensembl:ENSP00000226574	F		Seeded From UniProt	complete
enables	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19838 ensembl:ENSP00000226574	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19838 ensembl:ENSP00000226574	F		Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19838 ensembl:ENSP00000226574	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P19838 ensembl:ENSP00000226574	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011539 InterPro:IPR037059	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000451 InterPro:IPR008967 InterPro:IPR011539 InterPro:IPR030503 InterPro:IPR037059	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000451 InterPro:IPR030503	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000451 InterPro:IPR030503	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000451 InterPro:IPR008967 InterPro:IPR011539 InterPro:IPR037059	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030503	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000488	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048535	lymph node development	PMID:10687308^[30]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Bonfield, TL et al. (2008) Peroxisome proliferator-activated receptor-gamma regulates the expression of alveolar macrophage macrophage colony-stimulating factor. J. Immunol. 181 235-42 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Lv, N et al. (2009) JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-kappaB activation and the JAK/STAT pathway. Exp. Cell Res. 315 2064-71 PubMed GONUTS page
↑ Kerur, N et al. (2013) TLR-independent and P2X7-dependent signaling mediate Alu RNA-induced NLRP3 inflammasome activation in geographic atrophy. Invest. Ophthalmol. Vis. Sci. 54 7395-401 PubMed GONUTS page
↑ Lee, H et al. (2013) MicroRNA-494, upregulated by tumor necrosis factor-α, desensitizes insulin effect in C2C12 muscle cells. PLoS ONE 8 e83471 PubMed GONUTS page
↑ Dauphinee, SM et al. (2013) SASH1 is a scaffold molecule in endothelial TLR4 signaling. J. Immunol. 191 892-901 PubMed GONUTS page
↑ Minami, M et al. (2008) Prostaglandin E receptor type 4-associated protein interacts directly with NF-kappaB1 and attenuates macrophage activation. J. Biol. Chem. 283 9692-703 PubMed GONUTS page
↑ ^7.0 ^7.1 Shimizu, H & Yamamoto, K (1994) NF-kappa B and C/EBP transcription factor families synergistically function in mouse serum amyloid A gene expression induced by inflammatory cytokines. Gene 149 305-10 PubMed GONUTS page
↑ ^8.0 ^8.1 Mandal, M et al. (2005) The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival. J. Exp. Med. 201 603-14 PubMed GONUTS page
↑ Guo, L et al. (2009) IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells. Proc. Natl. Acad. Sci. U.S.A. 106 13463-8 PubMed GONUTS page
↑ ^10.0 ^10.1 Corn, RA et al. (2005) Opposing roles for RelB and Bcl-3 in regulation of T-box expressed in T cells, GATA-3, and Th effector differentiation. J. Immunol. 175 2102-10 PubMed GONUTS page
↑ Journiac, N et al. (2009) The nuclear receptor ROR(alpha) exerts a bi-directional regulation of IL-6 in resting and reactive astrocytes. Proc. Natl. Acad. Sci. U.S.A. 106 21365-70 PubMed GONUTS page
↑ ^12.0 ^12.1 Liu, J et al. (2003) Differential regulation of interleukin (IL)-12 p35 and p40 gene expression and interferon (IFN)-gamma-primed IL-12 production by IFN regulatory factor 1. J. Exp. Med. 198 1265-76 PubMed GONUTS page
↑ ^13.0 ^13.1 Esteban, V et al. (2009) Angiotensin-(1-7) and the g protein-coupled receptor MAS are key players in renal inflammation. PLoS ONE 4 e5406 PubMed GONUTS page
↑ ^14.0 ^14.1 Watanabe, T et al. (2004) NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses. Nat. Immunol. 5 800-8 PubMed GONUTS page
↑ ^15.0 ^15.1 Mohamed, JS et al. (2010) Anisotropic regulation of Ankrd2 gene expression in skeletal muscle by mechanical stretch. FASEB J. 24 3330-40 PubMed GONUTS page
↑ ^16.0 ^16.1 Fiorini, E et al. (2002) Peptide-induced negative selection of thymocytes activates transcription of an NF-kappa B inhibitor. Mol. Cell 9 637-48 PubMed GONUTS page
↑ ^17.0 ^17.1 Gu, H et al. (2010) Angiopoietin-1/Tie2 signaling pathway inhibits lipopolysaccharide-induced activation of RAW264.7 macrophage cells. Biochem. Biophys. Res. Commun. 392 178-82 PubMed GONUTS page
↑ Ferron, M et al. (2011) Inositol polyphosphate 4-phosphatase B as a regulator of bone mass in mice and humans. Cell Metab. 14 466-77 PubMed GONUTS page
↑ ^19.0 ^19.1 Chang, M et al. (2009) Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production. Nat. Immunol. 10 1089-95 PubMed GONUTS page
↑ Wilmanski, J et al. (2005) Augmented IL-10 production and redox-dependent signaling pathways in glucose-6-phosphate dehydrogenase-deficient mouse peritoneal macrophages. J. Leukoc. Biol. 78 85-94 PubMed GONUTS page
↑ Lafuente, MJ et al. (2003) Regulation of mature T lymphocyte proliferation and differentiation by Par-4. EMBO J. 22 4689-98 PubMed GONUTS page
↑ ^22.0 ^22.1 Thomas, JA et al. (1999) Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase. J. Immunol. 163 978-84 PubMed GONUTS page
↑ Bean, C et al. (2014) Ankrd2 is a modulator of NF-κB-mediated inflammatory responses during muscle differentiation. Cell Death Dis 5 e1002 PubMed GONUTS page
↑ Arnandis, T et al. (2012) Calpains mediate epithelial-cell death during mammary gland involution: mitochondria and lysosomal destabilization. Cell Death Differ. 19 1536-48 PubMed GONUTS page
↑ Maruyama, K et al. (2013) Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP. J. Exp. Med. 210 1947-60 PubMed GONUTS page
↑ Ossendorp, F et al. (2005) Differential expression regulation of the alpha and beta subunits of the PA28 proteasome activator in mature dendritic cells. J. Immunol. 174 7815-22 PubMed GONUTS page
↑ Rupec, RA et al. (2005) Stroma-mediated dysregulation of myelopoiesis in mice lacking I kappa B alpha. Immunity 22 479-91 PubMed GONUTS page
↑ Chen, S et al. (2003) Functional association of cytokine-induced SH2 protein and protein kinase C in activated T cells. Int. Immunol. 15 403-9 PubMed GONUTS page
↑ Miyamoto, A et al. (2002) Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta. Nature 416 865-9 PubMed GONUTS page
↑ Matsumoto, M (1999) Role of TNF ligand and receptor family in the lymphoid organogenesis defined by gene targeting. J. Med. Invest. 46 141-50 PubMed GONUTS page

[PMID:18566389-1] Bonfield, TL et al. (2008) Peroxisome proliferator-activated receptor-gamma regulates the expression of alveolar macrophage macrophage colony-stimulating factor. J. Immunol. 181 235-42 PubMed GONUTS page

[PMID:19414010-2] 2.0 ^2.1 ^2.2 Lv, N et al. (2009) JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-kappaB activation and the JAK/STAT pathway. Exp. Cell Res. 315 2064-71 PubMed GONUTS page

[PMID:24114535-3] Kerur, N et al. (2013) TLR-independent and P2X7-dependent signaling mediate Alu RNA-induced NLRP3 inflammasome activation in geographic atrophy. Invest. Ophthalmol. Vis. Sci. 54 7395-401 PubMed GONUTS page

[PMID:24349514-4] Lee, H et al. (2013) MicroRNA-494, upregulated by tumor necrosis factor-α, desensitizes insulin effect in C2C12 muscle cells. PLoS ONE 8 e83471 PubMed GONUTS page

[PMID:23776175-5] Dauphinee, SM et al. (2013) SASH1 is a scaffold molecule in endothelial TLR4 signaling. J. Immunol. 191 892-901 PubMed GONUTS page

[PMID:18270204-6] Minami, M et al. (2008) Prostaglandin E receptor type 4-associated protein interacts directly with NF-kappaB1 and attenuates macrophage activation. J. Biol. Chem. 283 9692-703 PubMed GONUTS page

[PMID:7959007-7] 7.0 ^7.1 Shimizu, H & Yamamoto, K (1994) NF-kappa B and C/EBP transcription factor families synergistically function in mouse serum amyloid A gene expression induced by inflammatory cytokines. Gene 149 305-10 PubMed GONUTS page

[PMID:15728238-8] 8.0 ^8.1 Mandal, M et al. (2005) The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival. J. Exp. Med. 201 603-14 PubMed GONUTS page

[PMID:19666510-9] Guo, L et al. (2009) IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells. Proc. Natl. Acad. Sci. U.S.A. 106 13463-8 PubMed GONUTS page

[PMID:16081776-10] 10.0 ^10.1 Corn, RA et al. (2005) Opposing roles for RelB and Bcl-3 in regulation of T-box expressed in T cells, GATA-3, and Th effector differentiation. J. Immunol. 175 2102-10 PubMed GONUTS page

[PMID:19955433-11] Journiac, N et al. (2009) The nuclear receptor ROR(alpha) exerts a bi-directional regulation of IL-6 in resting and reactive astrocytes. Proc. Natl. Acad. Sci. U.S.A. 106 21365-70 PubMed GONUTS page

[PMID:14568984-12] 12.0 ^12.1 Liu, J et al. (2003) Differential regulation of interleukin (IL)-12 p35 and p40 gene expression and interferon (IFN)-gamma-primed IL-12 production by IFN regulatory factor 1. J. Exp. Med. 198 1265-76 PubMed GONUTS page

[PMID:19404405-13] 13.0 ^13.1 Esteban, V et al. (2009) Angiotensin-(1-7) and the g protein-coupled receptor MAS are key players in renal inflammation. PLoS ONE 4 e5406 PubMed GONUTS page

[PMID:15220916-14] 14.0 ^14.1 Watanabe, T et al. (2004) NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses. Nat. Immunol. 5 800-8 PubMed GONUTS page

[PMID:20442316-15] 15.0 ^15.1 Mohamed, JS et al. (2010) Anisotropic regulation of Ankrd2 gene expression in skeletal muscle by mechanical stretch. FASEB J. 24 3330-40 PubMed GONUTS page

[PMID:11931770-16] 16.0 ^16.1 Fiorini, E et al. (2002) Peptide-induced negative selection of thymocytes activates transcription of an NF-kappa B inhibitor. Mol. Cell 9 637-48 PubMed GONUTS page

[PMID:20060382-17] 17.0 ^17.1 Gu, H et al. (2010) Angiopoietin-1/Tie2 signaling pathway inhibits lipopolysaccharide-induced activation of RAW264.7 macrophage cells. Biochem. Biophys. Res. Commun. 392 178-82 PubMed GONUTS page

[PMID:21982707-18] Ferron, M et al. (2011) Inositol polyphosphate 4-phosphatase B as a regulator of bone mass in mice and humans. Cell Metab. 14 466-77 PubMed GONUTS page

[PMID:19734906-19] 19.0 ^19.1 Chang, M et al. (2009) Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production. Nat. Immunol. 10 1089-95 PubMed GONUTS page

[PMID:15817708-20] Wilmanski, J et al. (2005) Augmented IL-10 production and redox-dependent signaling pathways in glucose-6-phosphate dehydrogenase-deficient mouse peritoneal macrophages. J. Leukoc. Biol. 78 85-94 PubMed GONUTS page

[PMID:12970181-21] Lafuente, MJ et al. (2003) Regulation of mature T lymphocyte proliferation and differentiation by Par-4. EMBO J. 22 4689-98 PubMed GONUTS page

[PMID:10395695-22] 22.0 ^22.1 Thomas, JA et al. (1999) Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase. J. Immunol. 163 978-84 PubMed GONUTS page

[PMID:24434510-23] Bean, C et al. (2014) Ankrd2 is a modulator of NF-κB-mediated inflammatory responses during muscle differentiation. Cell Death Dis 5 e1002 PubMed GONUTS page

[PMID:22555453-24] Arnandis, T et al. (2012) Calpains mediate epithelial-cell death during mammary gland involution: mitochondria and lysosomal destabilization. Cell Death Differ. 19 1536-48 PubMed GONUTS page

[PMID:23980096-25] Maruyama, K et al. (2013) Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP. J. Exp. Med. 210 1947-60 PubMed GONUTS page

[PMID:15944286-26] Ossendorp, F et al. (2005) Differential expression regulation of the alpha and beta subunits of the PA28 proteasome activator in mature dendritic cells. J. Immunol. 174 7815-22 PubMed GONUTS page

[PMID:15845452-27] Rupec, RA et al. (2005) Stroma-mediated dysregulation of myelopoiesis in mice lacking I kappa B alpha. Immunity 22 479-91 PubMed GONUTS page

[PMID:12618484-28] Chen, S et al. (2003) Functional association of cytokine-induced SH2 protein and protein kinase C in activated T cells. Int. Immunol. 15 403-9 PubMed GONUTS page

[PMID:11976687-29] Miyamoto, A et al. (2002) Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta. Nature 416 865-9 PubMed GONUTS page

[PMID:10687308-30] Matsumoto, M (1999) Role of TNF ligand and receptor family in the lymphoid organogenesis defined by gene targeting. J. Med. Invest. 46 141-50 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

[21]

[22]

[23]

[24]

[25]

[26]

[27]

[28]

[29]

[30]

MOUSE:NFKB1

Contents

Annotations

Notes

References

a

c

d

e

g

h

i

l

m

n

o

p

r

s

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools