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PMID:10395695
| Citation |
Thomas, JA, Allen, JL, Tsen, M, Dubnicoff, T, Danao, J, Liao, XC, Cao, Z and Wasserman, SA (1999) Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase. J. Immunol. 163:978-84 |
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| Abstract |
Stimulation of the type 1 IL-1R (IL-1R1) and the IL-18R by their cognate ligands induces recruitment of the IL-1R-associated kinase (IRAK). Activation of IRAK leads in turn to nuclear translocation of NF-kappaB, which directs expression of innate and adaptive immune response genes. To study IRAK function in cytokine signaling, we generated cells and mice lacking the IRAK protein. IRAK-deficient fibroblasts show diminished activation of NF-kappaB when stimulated with IL-1. Immune effector cells without IRAK exhibit a defective IFN-gamma response to costimulation with IL-18. Furthermore, mice lacking the Irak gene demonstrate an attenuated response to injected IL-1. Deletion of Irak, however, does not affect the ability of mice to develop delayed-type hypersensitivity or clear infection with the intracellular parasite, Listeria monocytogenes. These results demonstrate that although IRAK participates in IL-1 and IL-18 signal transduction, residual cytokine responsiveness operates through an IRAK-independent pathway. |
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| Keywords |
Animals; Cell Line; Cytokines/physiology; Female; Fertility/genetics; Fertility/immunology; Hypersensitivity, Delayed/genetics; Hypersensitivity, Delayed/immunology; Immunologic Deficiency Syndromes/enzymology; Immunologic Deficiency Syndromes/genetics; Immunologic Deficiency Syndromes/immunology; Immunologic Deficiency Syndromes/physiopathology; Interleukin-1/antagonists & inhibitors; Interleukin-1/physiology; Interleukin-1 Receptor-Associated Kinases; Interleukin-18/physiology; Listeriosis/genetics; Listeriosis/immunology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B/metabolism; Protein Kinases/deficiency; Protein Kinases/genetics; Receptors, Interleukin-1/metabolism; Sequence Deletion; Signal Transduction/genetics; Signal Transduction/immunology; Spleen/immunology; Stem Cells; Survival Analysis |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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