MOUSE:MYC

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Myc
Protein Name(s)	Myc proto-oncogene protein Proto-oncogene c-Myc Transcription factor p64
External Links
UniProt	P01108
EMBL	L00039 L00038 X01023 AK087961 AK133952 AK145084 BC006728 K00683
CCDS	CCDS49615.1
PIR	A93337
RefSeq	NP_001170823.1 NP_001170824.1 NP_001170825.1
UniGene	Mm.2444
ProteinModelPortal	P01108
SMR	P01108
BioGrid	201635
DIP	DIP-1064N
IntAct	P01108
PhosphoSite	P01108
MaxQB	P01108
PRIDE	P01108
Ensembl	ENSMUST00000159327 ENSMUST00000160009 ENSMUST00000161976
GeneID	17869
KEGG	mmu:17869
UCSC	uc007vyh.1
CTD	4609
MGI	MGI:97250
eggNOG	NOG42590
GeneTree	ENSGT00510000046414
HOVERGEN	HBG000472
InParanoid	P01108
KO	K04377
OrthoDB	EOG7GJ6CX
PhylomeDB	P01108
Reactome	REACT_223647
ChiTaRS	Myc
NextBio	292641
PRO	PR:P01108
Proteomes	UP000000589
Bgee	P01108
CleanEx	MM_MYC
ExpressionAtlas	P01108
Genevestigator	P01108
GO	GO:0030424 GO:0016604 GO:0005730 GO:0005654 GO:0005634 GO:0005819 GO:0000987 GO:0003677 GO:0070888 GO:0032403 GO:0003700 GO:0006919 GO:0001783 GO:0001658 GO:0060070 GO:0044336 GO:0044337 GO:0006879 GO:0006974 GO:0035690 GO:0006338 GO:0051276 GO:0050910 GO:0008630 GO:0000165 GO:0042474 GO:0051782 GO:0045656 GO:0032091 GO:0000122 GO:0043473 GO:2001235 GO:0002904 GO:0043085 GO:0008284 GO:0043280 GO:2000573 GO:0050679 GO:0048146 GO:0002053 GO:0090096 GO:2001022 GO:0045944 GO:0045893 GO:0016485 GO:0042981 GO:0010468 GO:0032204 GO:0006355 GO:0043279 GO:0010332 GO:0009314 GO:0035914 GO:0048705 GO:0006351 GO:0016055
Gene3D	4.10.280.10
InterPro	IPR011598 IPR003327 IPR002418 IPR012682
Pfam	PF00010 PF02344 PF01056
PIRSF	PIRSF001705
PRINTS	PR00044
SMART	SM00353
SUPFAM	SSF47459
PROSITE	PS50888

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0036207	positive regulation of histone gene expression	PMID:26691508^[1]	ECO:0000314			P		Fig. 1C and D shows that Mouse cells treated with c-Myc (Myc) exhibit increased mRNA levels of histone related genes Wdr5 and Actb relative to the control.	complete CACAO 13358
	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:26691508^[1]	ECO:0000314			F		In Figure 1, more specifically 1C, it is shown how Myc proto-oncogene protein/c-Myc in Mus musculus upregulates Wdr5 and Dpy30 expression at the RNA level. With Myc proto-oncogene protein/c-Myc significantly having an impact on how the other transcription factors acted, as shown by Figure 1E. Later in the paper, through the use of this data, it then verifies how direct binding to the promoter sequence caused DNA-binding transcription activator activity.	complete CACAO 13367
	GO:0060261	positive regulation of transcription initiation from RNA polymerase II promoter	PMID:26691508^[1]	ECO:0000314			P		In Figure 1, more specifically 1C and 1D, it is shown how Myc proto-oncogene protein/c-Myc in Mus musculus (Mouse) upregulates Wdr5 and Dpy30 expression at the RNA level. Fig 1H then shows that c-Myc binds to the promoter specifically.	complete CACAO 13418
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:9637678^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSMUSG00000021611)	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01106	F		Seeded From UniProt	complete
involved_in	GO:0051973	positive regulation of telomerase activity	PMID:9637678^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:O70372)	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:22328504^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002322)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22328504^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002322)	Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:22328504^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8BGE7	F	occurs_in:(CL:0002322) occurs_in:(GO:0048471) occurs_in:(GO:0005634)	Seeded From UniProt	complete
part_of	GO:0005719	nuclear euchromatin	PMID:22723415^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002322)	Seeded From UniProt	complete
involved_in	GO:2001022	positive regulation of response to DNA damage stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01106	P		Seeded From UniProt	complete
involved_in	GO:2000573	positive regulation of DNA biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01106	P		Seeded From UniProt	complete
involved_in	GO:0090096	positive regulation of metanephric cap mesenchymal cell proliferation	PMID:19161241^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0070888	E-box binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01106	F		Seeded From UniProt	complete
involved_in	GO:0051782	negative regulation of cell division	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01106	P		Seeded From UniProt	complete
involved_in	GO:0051276	chromosome organization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01106	P		Seeded From UniProt	complete
involved_in	GO:0050679	positive regulation of epithelial cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01106	P		Seeded From UniProt	complete
involved_in	GO:0048146	positive regulation of fibroblast proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01106	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01106	P		Seeded From UniProt	complete
involved_in	GO:0045656	negative regulation of monocyte differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01106	P		Seeded From UniProt	complete
involved_in	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01106	P		Seeded From UniProt	complete
involved_in	GO:0035690	cellular response to drug	PMID:19179467^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(CHEBI:50131)	Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01106	F		Seeded From UniProt	complete
involved_in	GO:0032204	regulation of telomere maintenance	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01106	P		Seeded From UniProt	complete
involved_in	GO:0010332	response to gamma radiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01106	P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01106	P		Seeded From UniProt	complete
involved_in	GO:0006879	cellular iron ion homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01106	P		Seeded From UniProt	complete
involved_in	GO:0006338	chromatin remodeling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01106	P		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01106	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01106	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01106	F		Seeded From UniProt	complete
involved_in	GO:0002053	positive regulation of mesenchymal cell proliferation	PMID:19161241^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001658	branching involved in ureteric bud morphogenesis	PMID:19161241^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01106	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001235	positive regulation of apoptotic signaling pathway	PMID:14517295^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2447604	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001235	positive regulation of apoptotic signaling pathway	PMID:14517295^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001171	positive regulation of ATP biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3130	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001022	positive regulation of response to DNA damage stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01106	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000573	positive regulation of DNA biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01106	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905643	positive regulation of DNA methylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01106	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903862	positive regulation of oxidative phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3130	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901857	positive regulation of cellular respiration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3130	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071456	cellular response to hypoxia	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01106	P		Seeded From UniProt	complete
enables	GO:0071074	eukaryotic initiation factor eIF2 binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01106	F		Seeded From UniProt	complete
enables	GO:0070888	E-box binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01106	F		Seeded From UniProt	complete
enables	GO:0070491	repressing transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01106	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070371	ERK1 and ERK2 cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01106	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060548	negative regulation of cell death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3130	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060252	positive regulation of glial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3130	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051782	negative regulation of cell division	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01106	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051276	chromosome organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01106	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound	PMID:17523175^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2178233,MGI:MGI:2386570	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050679	positive regulation of epithelial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01106	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048705	skeletal system morphogenesis	PMID:17523175^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2178233,MGI:MGI:2386570	P	has_participant:(EMAPA:32806)\|has_participant:(EMAPA:32806)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048661	positive regulation of smooth muscle cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3130	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048147	negative regulation of fibroblast proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01106	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048146	positive regulation of fibroblast proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01106	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048146	positive regulation of fibroblast proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3130	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3130	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046722	lactic acid secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3130	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046325	negative regulation of glucose import	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3130	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17382917^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:18603) regulates_o_occurs_in:(CL:0000192) has_regulation_target:(MGI:MGI:97611)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:23277542^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_transcription_of:(MGI:MGI:95305)\|regulates_transcription_of:(MGI:MGI:88357)\|regulates_transcription_of:(MGI:MGI:3039376)\|regulates_transcription_of:(MGI:MGI:95295)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01106	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3130	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01106	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3130	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045821	positive regulation of glycolytic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3130	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045787	positive regulation of cell cycle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3130	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045656	negative regulation of monocyte differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01106	P		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01106	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0044337	canonical Wnt signaling pathway involved in positive regulation of apoptotic process	PMID:17377531^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88039	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0044336	canonical Wnt signaling pathway involved in negative regulation of apoptotic process	PMID:17377531^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88039	P		Seeded From UniProt	complete
part_of	GO:0044195	nucleoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01106	C		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3130	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043473	pigmentation	PMID:17523175^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2178233,MGI:MGI:2386570	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043388	positive regulation of DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3130	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01106	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043279	response to alkaloid	PMID:12970677^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1931143	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043085	positive regulation of catalytic activity	PMID:17382917^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:18603) regulates_o_occurs_in:(CL:0000192) has_regulation_target:(MGI:MGI:97009)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042981	regulation of apoptotic process	PMID:23277542^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042981	regulation of apoptotic process	PMID:12235125^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042474	middle ear morphogenesis	PMID:17523175^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2178233,MGI:MGI:2386570	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035914	skeletal muscle cell differentiation	PMID:22147266^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	results_in_acquisition_of_features_of:(CL:0002372)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035690	cellular response to drug	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01106	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035457	cellular response to interferon-alpha	PMID:24795346^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0033613	activating transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01106	F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01106	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032986	protein-DNA complex disassembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01106	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032204	regulation of telomere maintenance	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01106	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032091	negative regulation of protein binding	PMID:18045875^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:10482234^[17]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000100)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019087	transformation of host cell by virus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3130	P		Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	PMID:15735755^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016485	protein processing	PMID:12970677^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1931143	P	occurs_in:(EMAPA:18767) occurs_in:(CL:0000236) has_participant:(MGI:MGI:1340806)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016055	Wnt signaling pathway	PMID:19056892^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014911	positive regulation of smooth muscle cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3130	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010918	positive regulation of mitochondrial membrane potential	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3130	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010629	negative regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3130	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01106	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010468	regulation of gene expression	PMID:11438662^[20]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000763) has_regulation_target:(MGI:MGI:104738)\|occurs_in(CL:0000763) has_regulation_target:(MGI:MGI:98834)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010468	regulation of gene expression	PMID:21447833^[21]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01106	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010332	response to gamma radiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01106	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009314	response to radiation	PMID:14517295^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2447604	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009314	response to radiation	PMID:14517295^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	PMID:14517295^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2447604	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	PMID:14517295^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	PMID:17596282^[22]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88039	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	PMID:14517295^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	PMID:12235125^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	PMID:15994933^[23]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01106	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01106	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3130	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008283	cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3130	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01106	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3130	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007346	regulation of mitotic cell cycle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3130	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007050	cell cycle arrest	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01106	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007007	inner mitochondrial membrane organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3130	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006974	cellular response to DNA damage stimulus	PMID:20212154^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01106	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:14517295^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006879	cellular iron ion homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01106	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006865	amino acid transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3130	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006848	pyruvate transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3130	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006366	transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3130	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	PMID:8521822^[25]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104987 MGI:MGI:104991 MGI:MGI:96921	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3130	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006352	DNA-templated transcription, initiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3130	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006351	transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3130	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006338	chromatin remodeling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01106	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006006	glucose metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3130	P		Seeded From UniProt	complete
part_of	GO:0005819	spindle	PMID:15509711^[26]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005791	rough endoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01106	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3130	C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01106	C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3130	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01106	C		Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01106	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:23770341^[27]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16846)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19796622^[28]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18625840^[29]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17631878^[30]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:32779) part_of:(CL:0000312)\|part_of:(EMAPA:32779) part_of:(CL:0000646)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11872843^[31]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15994933^[23]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01106	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01106	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3130	C		Seeded From UniProt	complete
enables	GO:0003729	mRNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01106	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01106	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3130	F		Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3130	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:14560010^[32]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:12970171^[33]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3130	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002904	positive regulation of B cell apoptotic process	PMID:11604501^[34]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:99702	P	regulates_o_occurs_in:(CL:0000236)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002082	regulation of oxidative phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3130	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001783	B cell apoptotic process	PMID:12970677^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1931143	P	occurs_in:(EMAPA:18767) occurs_in:(CL:0000236)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01106	F		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01106	F		Seeded From UniProt	complete
enables	GO:0000987	proximal promoter sequence-specific DNA binding	PMID:15511642^[35]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(MGI:MGI:1202709)	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01106	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:18625840^[29]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01106	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01106	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000320	re-entry into mitotic cell cycle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3130	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000165	MAPK cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01106	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:12196193^[36]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:1345275)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01106	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3130	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0007007	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002418 InterPro:IPR003327 InterPro:IPR012682	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002418 InterPro:IPR003327	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002418 InterPro:IPR003327 InterPro:IPR012682	P		Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011598 InterPro:IPR036638	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0188	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0190	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Yang, Z et al. (2015) Physical Interactions and Functional Coordination between the Core Subunits of Set1/Mll Complexes and the Reprogramming Factors. PLoS ONE 10 e0145336 PubMed GONUTS page
↑ ^2.0 ^2.1 Wang, J et al. (1998) Myc activates telomerase. Genes Dev. 12 1769-74 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Sato, T et al. (2012) TRIM6 interacts with Myc and maintains the pluripotency of mouse embryonic stem cells. J. Cell. Sci. 125 1544-55 PubMed GONUTS page
↑ Hoffmeyer, K et al. (2012) Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cells. Science 336 1549-54 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Couillard, M & Trudel, M (2009) C-myc as a modulator of renal stem/progenitor cell population. Dev. Dyn. 238 405-14 PubMed GONUTS page
↑ Höglund, A et al. (2009) Myc sensitizes p53-deficient cancer cells to the DNA-damaging effects of the DNA methyltransferase inhibitor decitabine. Blood 113 4281-8 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 Maclean, KH et al. (2003) c-Myc augments gamma irradiation-induced apoptosis by suppressing Bcl-XL. Mol. Cell. Biol. 23 7256-70 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Wei, K et al. (2007) Neural crest cell deficiency of c-myc causes skull and hearing defects. Genesis 45 382-90 PubMed GONUTS page
↑ ^9.0 ^9.1 Hou, Y et al. (2007) c-Myc is essential for urokinase plasminogen activator expression on hypoxia-induced vascular smooth muscle cells. Cardiovasc. Res. 75 186-94 PubMed GONUTS page
↑ ^10.0 ^10.1 Zhang, Q et al. (2013) Domain-specific c-Myc ubiquitylation controls c-Myc transcriptional and apoptotic activity. Proc. Natl. Acad. Sci. U.S.A. 110 978-83 PubMed GONUTS page
↑ ^11.0 ^11.1 Sansom, OJ et al. (2007) Myc deletion rescues Apc deficiency in the small intestine. Nature 446 676-9 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 de Alborán, IM et al. (2004) c-Myc-deficient B lymphocytes are resistant to spontaneous and induced cell death. Cell Death Differ. 11 61-8 PubMed GONUTS page
↑ ^13.0 ^13.1 Widlund, HR et al. (2002) Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor. J. Cell Biol. 158 1079-87 PubMed GONUTS page
↑ Rajan, S et al. (2012) Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation. Physiol. Genomics 44 183-97 PubMed GONUTS page
↑ Ehninger, A et al. (2014) Posttranscriptional regulation of c-Myc expression in adult murine HSCs during homeostasis and interferon-α-induced stress response. Blood 123 3909-13 PubMed GONUTS page
↑ Alter-Koltunoff, M et al. (2008) Innate immunity to intraphagosomal pathogens is mediated by interferon regulatory factor 8 (IRF-8) that stimulates the expression of macrophage-specific Nramp1 through antagonizing repression by c-Myc. J. Biol. Chem. 283 2724-33 PubMed GONUTS page
↑ Arber, S et al. (1999) Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity. Neuron 23 659-74 PubMed GONUTS page
↑ Cairo, S et al. (2005) PML interacts with Myc, and Myc target gene expression is altered in PML-null fibroblasts. Oncogene 24 2195-203 PubMed GONUTS page
↑ Miranda-Carboni, GA et al. (2008) A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors. Genes Dev. 22 3121-34 PubMed GONUTS page
↑ Eischen, CM et al. (2001) Apoptosis triggered by Myc-induced suppression of Bcl-X(L) or Bcl-2 is bypassed during lymphomagenesis. Mol. Cell. Biol. 21 5063-70 PubMed GONUTS page
↑ Liu, Y et al. (2011) TIP110/p110nrb/SART3/p110 regulation of hematopoiesis through CMYC. Blood 117 5643-51 PubMed GONUTS page
↑ Strom, A et al. (2007) Unique mechanisms of growth regulation and tumor suppression upon Apc inactivation in the pancreas. Development 134 2719-25 PubMed GONUTS page
↑ ^23.0 ^23.1 Huang, A et al. (2005) Identification of a novel c-Myc protein interactor, JPO2, with transforming activity in medulloblastoma cells. Cancer Res. 65 5607-19 PubMed GONUTS page
↑ Cannell, IG et al. (2010) p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication. Proc. Natl. Acad. Sci. U.S.A. 107 5375-80 PubMed GONUTS page
↑ Hurlin, PJ et al. (1995) Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation. EMBO J. 14 5646-59 PubMed GONUTS page
↑ Liu, J et al. (2004) Serine-threonine kinases and transcription factors active in signal transduction are detected at high levels of phosphorylation during mitosis in preimplantation embryos and trophoblast stem cells. Reproduction 128 643-54 PubMed GONUTS page
↑ Nevzorova, YA et al. (2013) Overexpression of c-myc in hepatocytes promotes activation of hepatic stellate cells and facilitates the onset of liver fibrosis. Biochim. Biophys. Acta 1832 1765-75 PubMed GONUTS page
↑ Nishiyama, A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell 5 420-33 PubMed GONUTS page
↑ ^29.0 ^29.1 Bonetti, P et al. (2008) Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7 gamma. J. Cell Biol. 182 19-26 PubMed GONUTS page
↑ Nieuwenhuis, E et al. (2007) Epidermal hyperplasia and expansion of the interfollicular stem cell compartment in mutant mice with a C-terminal truncation of Patched1. Dev. Biol. 308 547-60 PubMed GONUTS page
↑ Velcich, A et al. (2002) Colorectal cancer in mice genetically deficient in the mucin Muc2. Science 295 1726-9 PubMed GONUTS page
↑ Adhikary, S et al. (2003) Miz1 is required for early embryonic development during gastrulation. Mol. Cell. Biol. 23 7648-57 PubMed GONUTS page
↑ Hurlin, PJ et al. (2003) Deletion of Mnt leads to disrupted cell cycle control and tumorigenesis. EMBO J. 22 4584-96 PubMed GONUTS page
↑ Eischen, CM et al. (2001) Bax loss impairs Myc-induced apoptosis and circumvents the selection of p53 mutations during Myc-mediated lymphomagenesis. Mol. Cell. Biol. 21 7653-62 PubMed GONUTS page
↑ Armstrong, L et al. (2004) A role for nucleoprotein Zap3 in the reduction of telomerase activity during embryonic stem cell differentiation. Mech. Dev. 121 1509-22 PubMed GONUTS page
↑ Bowen, H et al. (2002) c-Myc represses the murine Nramp1 promoter. Biochem. Soc. Trans. 30 774-7 PubMed GONUTS page

[PMID:26691508-1] 1.0 ^1.1 ^1.2 Yang, Z et al. (2015) Physical Interactions and Functional Coordination between the Core Subunits of Set1/Mll Complexes and the Reprogramming Factors. PLoS ONE 10 e0145336 PubMed GONUTS page

[PMID:9637678-2] 2.0 ^2.1 Wang, J et al. (1998) Myc activates telomerase. Genes Dev. 12 1769-74 PubMed GONUTS page

[PMID:22328504-3] 3.0 ^3.1 ^3.2 Sato, T et al. (2012) TRIM6 interacts with Myc and maintains the pluripotency of mouse embryonic stem cells. J. Cell. Sci. 125 1544-55 PubMed GONUTS page

[PMID:22723415-4] Hoffmeyer, K et al. (2012) Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cells. Science 336 1549-54 PubMed GONUTS page

[PMID:19161241-5] 5.0 ^5.1 ^5.2 Couillard, M & Trudel, M (2009) C-myc as a modulator of renal stem/progenitor cell population. Dev. Dyn. 238 405-14 PubMed GONUTS page

[PMID:19179467-6] Höglund, A et al. (2009) Myc sensitizes p53-deficient cancer cells to the DNA-damaging effects of the DNA methyltransferase inhibitor decitabine. Blood 113 4281-8 PubMed GONUTS page

[PMID:14517295-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 Maclean, KH et al. (2003) c-Myc augments gamma irradiation-induced apoptosis by suppressing Bcl-XL. Mol. Cell. Biol. 23 7256-70 PubMed GONUTS page

[PMID:17523175-8] 8.0 ^8.1 ^8.2 ^8.3 Wei, K et al. (2007) Neural crest cell deficiency of c-myc causes skull and hearing defects. Genesis 45 382-90 PubMed GONUTS page

[PMID:17382917-9] 9.0 ^9.1 Hou, Y et al. (2007) c-Myc is essential for urokinase plasminogen activator expression on hypoxia-induced vascular smooth muscle cells. Cardiovasc. Res. 75 186-94 PubMed GONUTS page

[PMID:23277542-10] 10.0 ^10.1 Zhang, Q et al. (2013) Domain-specific c-Myc ubiquitylation controls c-Myc transcriptional and apoptotic activity. Proc. Natl. Acad. Sci. U.S.A. 110 978-83 PubMed GONUTS page

[PMID:17377531-11] 11.0 ^11.1 Sansom, OJ et al. (2007) Myc deletion rescues Apc deficiency in the small intestine. Nature 446 676-9 PubMed GONUTS page

[PMID:12970677-12] 12.0 ^12.1 ^12.2 de Alborán, IM et al. (2004) c-Myc-deficient B lymphocytes are resistant to spontaneous and induced cell death. Cell Death Differ. 11 61-8 PubMed GONUTS page

[PMID:12235125-13] 13.0 ^13.1 Widlund, HR et al. (2002) Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor. J. Cell Biol. 158 1079-87 PubMed GONUTS page

[PMID:22147266-14] Rajan, S et al. (2012) Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation. Physiol. Genomics 44 183-97 PubMed GONUTS page

[PMID:24795346-15] Ehninger, A et al. (2014) Posttranscriptional regulation of c-Myc expression in adult murine HSCs during homeostasis and interferon-α-induced stress response. Blood 123 3909-13 PubMed GONUTS page

[PMID:18045875-16] Alter-Koltunoff, M et al. (2008) Innate immunity to intraphagosomal pathogens is mediated by interferon regulatory factor 8 (IRF-8) that stimulates the expression of macrophage-specific Nramp1 through antagonizing repression by c-Myc. J. Biol. Chem. 283 2724-33 PubMed GONUTS page

[PMID:10482234-17] Arber, S et al. (1999) Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity. Neuron 23 659-74 PubMed GONUTS page

[PMID:15735755-18] Cairo, S et al. (2005) PML interacts with Myc, and Myc target gene expression is altered in PML-null fibroblasts. Oncogene 24 2195-203 PubMed GONUTS page

[PMID:19056892-19] Miranda-Carboni, GA et al. (2008) A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors. Genes Dev. 22 3121-34 PubMed GONUTS page

[PMID:11438662-20] Eischen, CM et al. (2001) Apoptosis triggered by Myc-induced suppression of Bcl-X(L) or Bcl-2 is bypassed during lymphomagenesis. Mol. Cell. Biol. 21 5063-70 PubMed GONUTS page

[PMID:21447833-21] Liu, Y et al. (2011) TIP110/p110nrb/SART3/p110 regulation of hematopoiesis through CMYC. Blood 117 5643-51 PubMed GONUTS page

[PMID:17596282-22] Strom, A et al. (2007) Unique mechanisms of growth regulation and tumor suppression upon Apc inactivation in the pancreas. Development 134 2719-25 PubMed GONUTS page

[PMID:15994933-23] 23.0 ^23.1 Huang, A et al. (2005) Identification of a novel c-Myc protein interactor, JPO2, with transforming activity in medulloblastoma cells. Cancer Res. 65 5607-19 PubMed GONUTS page

[PMID:20212154-24] Cannell, IG et al. (2010) p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication. Proc. Natl. Acad. Sci. U.S.A. 107 5375-80 PubMed GONUTS page

[PMID:8521822-25] Hurlin, PJ et al. (1995) Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation. EMBO J. 14 5646-59 PubMed GONUTS page

[PMID:15509711-26] Liu, J et al. (2004) Serine-threonine kinases and transcription factors active in signal transduction are detected at high levels of phosphorylation during mitosis in preimplantation embryos and trophoblast stem cells. Reproduction 128 643-54 PubMed GONUTS page

[PMID:23770341-27] Nevzorova, YA et al. (2013) Overexpression of c-myc in hepatocytes promotes activation of hepatic stellate cells and facilitates the onset of liver fibrosis. Biochim. Biophys. Acta 1832 1765-75 PubMed GONUTS page

[PMID:19796622-28] Nishiyama, A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell 5 420-33 PubMed GONUTS page

[PMID:18625840-29] 29.0 ^29.1 Bonetti, P et al. (2008) Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7 gamma. J. Cell Biol. 182 19-26 PubMed GONUTS page

[PMID:17631878-30] Nieuwenhuis, E et al. (2007) Epidermal hyperplasia and expansion of the interfollicular stem cell compartment in mutant mice with a C-terminal truncation of Patched1. Dev. Biol. 308 547-60 PubMed GONUTS page

[PMID:11872843-31] Velcich, A et al. (2002) Colorectal cancer in mice genetically deficient in the mucin Muc2. Science 295 1726-9 PubMed GONUTS page

[PMID:14560010-32] Adhikary, S et al. (2003) Miz1 is required for early embryonic development during gastrulation. Mol. Cell. Biol. 23 7648-57 PubMed GONUTS page

[PMID:12970171-33] Hurlin, PJ et al. (2003) Deletion of Mnt leads to disrupted cell cycle control and tumorigenesis. EMBO J. 22 4584-96 PubMed GONUTS page

[PMID:11604501-34] Eischen, CM et al. (2001) Bax loss impairs Myc-induced apoptosis and circumvents the selection of p53 mutations during Myc-mediated lymphomagenesis. Mol. Cell. Biol. 21 7653-62 PubMed GONUTS page

[PMID:15511642-35] Armstrong, L et al. (2004) A role for nucleoprotein Zap3 in the reduction of telomerase activity during embryonic stem cell differentiation. Mech. Dev. 121 1509-22 PubMed GONUTS page

[PMID:12196193-36] Bowen, H et al. (2002) c-Myc represses the murine Nramp1 promoter. Biochem. Soc. Trans. 30 774-7 PubMed GONUTS page

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