PMID:17523175

Citation	Wei, K, Chen, J, Akrami, K, Galbraith, GC, Lopez, IA and Chen, F (2007) Neural crest cell deficiency of c-myc causes skull and hearing defects. Genesis 45:382-90
Abstract	The proto-oncogene c-myc has a central role in multiple processes important for embryonic development, including cell proliferation, growth, apoptosis, and differentiation. We have investigated the role of c-myc in neural crest by using Wnt1-Cre-mediated deletion of a conditional mutation of the c-myc gene. c-myc deficiency in neural crest resulted in viable adult mice that have defects in coat color, skull frontal bone, and middle ear ossicle development. Physiological hearing studies demonstrated a significant hearing deficit in the mutant mice. In this report, we focus on the craniofacial and hearing defects. To further examine neural crest cells affected by c-myc deficiency, we fate mapped Wnt1-Cre expressing neural crest cells using the ROSA26 Cre reporter transgene. The phenotype obtained demonstrates the critical role that c-myc has in neural crest during craniofacial development as well as in providing a model for examining human congenital skull defects and deafness.
Links	PubMed Online version:10.1002/dvg.20304
Keywords	Animals; Genes, Reporter; Hearing Loss/genetics; Integrases/genetics; Mice; Mice, Mutant Strains; Neural Crest/chemistry; Neural Crest/cytology; Neural Crest/metabolism; Proteins/genetics; Proto-Oncogene Proteins c-myc/analysis; Proto-Oncogene Proteins c-myc/genetics; Proto-Oncogene Proteins c-myc/physiology; Sequence Deletion; Skull/abnormalities; Wnt1 Protein/genetics
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