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PMID:12970677
| Citation |
de Alborán, IM, Baena, E and Martinez-A, C (2004) c-Myc-deficient B lymphocytes are resistant to spontaneous and induced cell death. Cell Death Differ. 11:61-8 |
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| Abstract |
C-myc gene is a member of the myc family of proto-oncogenes involved in proliferation, differentiation, and apoptosis. Overexpression of c-myc in fibroblasts causes apoptosis under low serum conditions in a process that requires the interaction of CD95 and CD95L on the surface. We have previously reported an in vivo conditional model to inactivate the c-myc gene in B lymphocytes. Here, we show that c-Myc-deficient primary B lymphocytes are resistant to different apoptotic stimuli. Nonactivated c-Myc-deficient B cells are resistant to spontaneous cell death. Upon activation, c-Myc-deficient B lymphocytes express normal surface levels of activation markers, and show resistance to staurosporine and CD95-induced cell death. |
| Links |
PubMed Online version:10.1038/sj.cdd.4401319 |
| Keywords |
Animals; Antibodies, Monoclonal/immunology; Antigens, CD40/immunology; Antigens, CD40/metabolism; Antigens, CD95/immunology; Antigens, CD95/metabolism; Apoptosis/drug effects; Apoptosis/physiology; B-Lymphocytes/drug effects; B-Lymphocytes/metabolism; B-Lymphocytes/pathology; Cell Death/drug effects; Cell Death/physiology; Cells, Cultured; Interleukin-4/pharmacology; Mice; Mice, Knockout; Proto-Oncogene Proteins c-myc/deficiency; Proto-Oncogene Proteins c-myc/genetics |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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